Treatment Response and Resistance in Schizophrenia

Treatment Response and Resistance in Schizophrenia

Part of the Oxford Psychiatry Library, this useful pocket book is an invaluable resource and quick reference for psychiatrists, psychiatry trainees, and other mental health practitioners, as well as clinical psychologists, primary care ...

Author: Oliver Howes

Publisher: Oxford University Press

ISBN: 9780192563910

Category: Medical

Page: 240

View: 934

Treatment resistant schizophrenia (TRS) is common, affecting approximately a third of patients diagnosed. Despite the prevalence of TRS, the best approach to practical management is often unclear to clinicians and patients. Treatment Response and Resistance in Schizophrenia offers a practical, clinically focused guide to TRS and the real-world challenges faced by those impacted. Over 14 chapters this resource covers the principles and practice of TRS, from the definition, epidemiology, and clinical assessment, to the pharmacological, physical, and psychological management of treatment resistance. All chapters have been written by internationally leading experts in the field to ensure busy clinicians have high-quality, applicable content that is rooted in real clinical experiences. A chapter of case studies is included to link real-life scenarios to each of the instructive chapters, illustrating approaches to practical management and application. Part of the Oxford Psychiatry Library, this useful pocket book is an invaluable resource and quick reference for psychiatrists, psychiatry trainees, and other mental health practitioners, as well as clinical psychologists, primary care physicians, and specialist nurses.
Categories: Medical

Therapy Resistant Schizophrenia

Therapy Resistant Schizophrenia

This volume presents the latest research and recommendations on the definition, causes and therapy of treatment-resistant schizophrenia (TRS). Methods for identification and optimal management of TRS are reviewed.

Author: H. Elkis

Publisher: Karger Medical and Scientific Publishers

ISBN: 9783805595124

Category: Medical

Page: 210

View: 854

The psychotic symptoms of up to 30% of schizophrenic patients do not respond adequately to treatment with antipsychotic drugs, other than clozapine. These refractory patients are generally among the most disabled of all people with schizophrenia and require special assessment and treatment. This volume presents the latest research and recommendations on the definition, causes and therapy of treatment-resistant schizophrenia (TRS). Methods for identification and optimal management of TRS are reviewed. Clozapine and other atypical antipsychotic drugs which are the primary treatment for TRS, as well as non-pharmacologic treatments such as transcranial magnetic stimulation, cognitive behavior therapy and ECT are discussed in depth. Potential causative factors and identifying features such as genetic factors, poor premorbid functioning, longer duration of untreated psychosis, and biological measures such as structural and functional brain abnormalities are also reviewed in depth in the present volume.
Categories: Medical

Treatment Refractory Schizophrenia

Treatment   Refractory Schizophrenia

In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients.

Author: Peter F. Buckley

Publisher: Springer Science & Business Media

ISBN: 9783642452574

Category: Medical

Page: 230

View: 131

Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.
Categories: Medical

Handbook of Treatment resistant Schizophrenia

Handbook of Treatment resistant Schizophrenia

The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management.

Author: Leslie Citrome

Publisher: Springer Science & Business Media

ISBN: 9781908517883

Category: Medical

Page: 66

View: 836

Handbook of Treatment-resistant Schizophrenia is a concise review of treatment-resistant schizophrenia’s definition, measurement tools, adherence issues, substance abuse, optimal dosing, clinician–patient relationships, and current management approaches. The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management. The book explores many aspects of the background and practice- and research-based evidence for treating this complex subset of schizophrenia, including psychopharmacological, somatic, and nonpharmacological treatment approaches. While exploring the various therapies for treatment-resistant schizophrenia, Dr Citrome also emphasizes the importance of building strong and trusting relationships between patients and their clinicians so the clinician can best manage their patient’s adherence and overall treatment.
Categories: Medical

The Journal of Karnatak University

The Journal of Karnatak University

( 1990 ) modified this by emphasizing both positive and negative symptoms .
Brenner et al . ( 1987 ) proposed a definition of treatment refractioness with a 7
point rating scale of treatment , response and resistance in schizophrenia .

Author: Karnatak University

Publisher:

ISBN: UVA:X030215784

Category: India

Page:

View: 821

Categories: India

Journal of Social Sciences

Journal of Social Sciences

( 1990 ) modified this by emphasizing both positive and negative symptoms .
Brenner et al . ( 1987 ) proposed a definition of treatment refractioness with a 7
point rating scale of treatment , response and resistance in schizophrenia .

Author:

Publisher:

ISBN: UCAL:B5099914

Category: India

Page:

View: 747

Categories: India

Schizophrenia Bulletin

Schizophrenia Bulletin

Kane , J.M .; Honigfeld , G .; Singer , J .; and Meltzer , H. Clozapine for the
treatment - resistant schizophrenic : A double ... M .; and Borenstein , M. Time
course and biologic correlates of treatment response in first - episode
schizophrenia .

Author:

Publisher:

ISBN: COLUMBIA:HR01905368

Category: Schizophrenia

Page:

View: 568

Categories: Schizophrenia

Treatment Resistance in Psychiatry

Treatment Resistance in Psychiatry

This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response.

Author: Yong-Ku Kim

Publisher: Springer

ISBN: 9789811043581

Category: Medical

Page: 416

View: 612

This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.
Categories: Medical

Management of Difficult to Treat Patients with Schizophrenia

Management of Difficult to Treat Patients with Schizophrenia

assessment of schizophrenic patients experiencing their first episode of illness
presented an oppor - tunity to answer this ... Lieberman et al ( 1992 , 1993a , b )
examined their cohort of first episode and chronic treatment resistant schizo ...

Author: Robert Kerwin

Publisher:

ISBN: UCSC:32106012827439

Category: Schizophrenia

Page: 51

View: 424

Categories: Schizophrenia

The American Journal of Psychiatry

The American Journal of Psychiatry

Similarity of clozapine and olanzapine effects in patients with treatmentresistant
schizophrenia was recently demonstrated in ... This study cannot answer the
question of whether patients who do not respond to risperidone or olanzapine
would ...

Author:

Publisher:

ISBN: UOM:39015081537063

Category: Psychiatry

Page:

View: 902

Categories: Psychiatry

Disabilities and Circumstances of Schizophrenic Patients

Disabilities and Circumstances of Schizophrenic Patients

In Treatment Resistance in Schizophrenia ( eds S . J . Dencker & F . Kulhanek ) ,
pp . 83 - 97 . ... CROW , T . J . , FRITH , C . D . , et al ( 1988 ) The Northwick Park '
Functional Psychosis Study : diagnosis and treatment response . Lancet , ii , 119
 ...

Author: Eve C. Johnstone

Publisher:

ISBN: UCSC:32106010555677

Category: Schizophrenia

Page: 46

View: 285

Categories: Schizophrenia

Current Medical Research and Opinion

Current Medical Research and Opinion

Conclusion This study found that treatment - resistant patients with schizophrenia
or schizoaffective disorder could be safely and ... In particular , patients with a
history of substance abuse may have a better response to olanzapine or
clozapine ...

Author:

Publisher:

ISBN: UCLA:L0088715875

Category: Medicine

Page:

View: 853

Categories: Medicine

Clinical Use of Neuroleptic Plasma Levels

Clinical Use of Neuroleptic Plasma Levels

... Benes FB , Baldessarini RJ : Atypical neuroleptics , dose response
relationships and treatment - resistant psychosis . ... occupancy as assessed with
positron emission tomography in medicated but therapy - resistant schizophrenic
patients .

Author: Stephen R. Marder

Publisher: Amer Psychiatric Pub Incorporated

ISBN: UOM:39015029855866

Category: Medical

Page: 152

View: 694

In recent years, the study of drug levels in patients and animals has allowed key parameters of absorption, metabolism, distribution, and elimination to be defined for many medications. The knowledge of these parameters has been essential for designing and interpreting studies of drug action. However, searching for the best dosage of neuroleptics for a particular patient can be a challenge for even the most experienced clinician. Clinical Use of Neuroleptic Plasma Levels is the first book to gather the latest information in this area into one concise collection of clinically relevant information. It contains contribution from the top researchers in the field today.
Categories: Medical

Atypical Antipsychotics in the Treatment of Schizophrenic Patients

Atypical Antipsychotics in the Treatment of Schizophrenic Patients

Therefore the pharmacologic treatment guidelines for treatment non - response
will vary depending on whether the first treatment ... Furthermore , controlled
studies with treatment resistant schizophrenia patients demonstrate that less than
5 ...

Author:

Publisher:

ISBN: UOM:39015058816631

Category: Mexico

Page: 352

View: 689

Categories: Mexico

The British Journal of Psychiatry

The British Journal of Psychiatry

In Treatment Resistance in Schizophrenia ( eds S. J. Dencker & F. Kulhanek ) ,
pp . 83-97 . Wiesbaden ... Crow , T. J. , FRITH , C. D. , et al ( 1988 ) The Northwick
Park ' Functional Psychosis Study : diagnosis and treatment response . Lancet , ii
 ...

Author:

Publisher:

ISBN: UCLA:L0067161042

Category:

Page:

View: 943

Categories:

Proceedings of the Scientific Sessions

Proceedings of the Scientific Sessions

In these patients and in the postlobotomized subjects of this study , we would
suggest the defect may be the basis for their lack of response to treatment . This
defect in therapy - resistant schizophrenics could be either acquired or of genetic
 ...

Author: Society of Biological Psychiatry

Publisher:

ISBN: PSU:000018650297

Category: Psychiatry

Page:

View: 758

Categories: Psychiatry

Prediction in Psychopharmacology

Prediction in Psychopharmacology

One might argue that the relationship between treatment response and CT
variables may reflect the unspecific sedative , rather ... KANE , J . , HONIGFELD ,
G . , SINGER , J . , et al ( 1988 ) Clozapine for the treatment - resistant
schizophrenic .

Author: Mohammed T. Abou-Saleh

Publisher:

ISBN: UCAL:B4529164

Category: Prognosis

Page: 54

View: 877

Categories: Prognosis

JCP Monograph

JCP Monograph

Duration of a clozapine trial in neurolepticresistant schizophrenia ( letter ) . Arch
Gen Psychiatry 1989 ; 46 : 672 3. Lieberman JA , Safferman AZ , Pollack S , et al .
Clinical effects of clozapine in chronic schizophrenia : response to treatment ...

Author:

Publisher:

ISBN: UCLA:L0076181023

Category: Psychiatry

Page:

View: 559

Categories: Psychiatry

Canadian Journal of Psychiatry

Canadian Journal of Psychiatry

Extrapyramidal signs and clinical symptoms in first - episode schizophrenia :
response to low - dose risperidone . ... Clozapine for the treatment - resistant
schizophrenic : a double - blind comparison with chlorpromazine . Arch Gen
Psychiatry ...

Author:

Publisher:

ISBN: NWU:35558005288705

Category: Psychiatry

Page:

View: 792

Categories: Psychiatry

Australian Family Physician

Australian Family Physician

Inevitably some patients with first episode psychosis will not respond to first line
treatments and in these cases it is important to recognise resistance and treat
early using medication such as clozapine , CBT , and active psychosocial ...

Author:

Publisher:

ISBN: UCSD:31822018122374

Category: Family medicine

Page:

View: 968

Categories: Family medicine