The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.

Author: Richard B. Silverman

Publisher: Academic Press

ISBN: 0123820308

Category: Medical

Page: 517

View: 562

Standard medicinal chemistry courses and textbooks are organized by classes of drugs with an emphasis on descriptions of their biological and pharmacological effects. This textbook represents a novel and unique approach based on physical organic chemical principles and reaction mechanisms that rationalize drug action and allow the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. The Third Edition reflects significant changes in the drug industry and the process of drug design over...
Categories: Medical

The Organic Chemistry of Drug Design and Drug Action

The Organic Chemistry of Drug Design and Drug Action

Ten years have rolled by since the publication of the second edition, and the field of medicinal chemistry has ... in the third edition has not changed, namely, an emphasis on general principles of drug design and drug action from an ...

Author: Richard B. Silverman

Publisher: Academic Press

ISBN: 9780123820310

Category: Medical

Page: 536

View: 846

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Categories: Medical

Textbook of Drug Design and Discovery Third Edition

Textbook of Drug Design and Discovery  Third Edition

The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration.

Author: Tommy Liljefors

Publisher: CRC Press

ISBN: 0415282888

Category: Medical

Page: 596

View: 706

Building on the success of the previous editions, Textbook of Drug Design and Discovery has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The book follows drug design from the initial lead identification through optimization and structure-activity relationship with reference to the final processes of clinical evaluation and registration. Chapters investigate the design of enzyme inhibitors and drugs for particular cellular targets such as ion channels and receptors, and also explore specific classes of drug such as peptidomimetics, antivirals and anticancer agents. The use of gene technology in pharmaceutical research, computer modeling techniques, and combinatorial approaches are also included.
Categories: Medical

Drug Design and Action

Drug Design and Action

Wiley-VCH, Verlag GmbH & Co., KGaA (First Edition), Weinheim, Germany. 2011. Silverman, Richard B., Mark W. Holladay. The Organic Chemistry of Drug Design and Drug Action. Elsevier Academic Press (Third Edition). 2014.

Author: Joaquín M. Campos Rosa

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 9783110528480

Category: Science

Page: 186

View: 847

This two volume book is an excellent introduction to this interdisciplinary area, lying on the interface between organic chemistry, biochemistry and medicine. The authors give a comprehensive overview of the field and outline the actual challenges in pharmaceutical science and industry. Volume 1 introduces the concepts of drug design and drug metabolic processes as well as antibacterial, antiviral and anticancer agents.
Categories: Science

The Organic Chemistry of Drug Design and Drug Action Power PDF

The Organic Chemistry of Drug Design and Drug Action  Power PDF

In the next chapter we examine the design and mechanism of action of enzyme inhibitors as drugs. 4.5 General References Enzyme Catalysis: Boyer, P. D. (Ed.) The Enzymes, 3rd ed., Academic, New York, 1970—1987.

Author: Richard B. Silverman

Publisher: Elsevier

ISBN: 9780080575384

Category: Medical

Page: 738

View: 538

This CD-ROM edition of Silverman's Organic Chemisry of Drug Design and Drug Action, Second Edition reflects the significant changes in the drug industry in recent years, using an accessible interactive approach. This CD-ROM integrates the author's own PowerPoint slides, indexed and linked to the book pages in PDF format. The three-part structure includes an all-electronic text with full-text search capabilites and nearly 800 powerpoint slides. This is a unique and powerful combination of electronic study guide and full book pages. Users can hyperlink seamlessly from the main text to key points and figures on the outline and back again. It serves as a wonderful supplement for instructors as well as a fully integrated text and study aid for students. * Three-part package includes 1) powerpoint, 2) integrated powerpoint and pdf-based text, and 3) fully searchable PDF-based text with index * Includes new full-color illustrations, structures, schemes, and figures as well as extensive chapter problems and exercises * User-friendly buttons transition from overview (study-guide) format to corresponding book page and back with the click of a mouse * Full-text search capabality an incomparable tool for researchers seeking specific references and/or unindexed phrases
Categories: Medical

Smith and Williams Introduction to the Principles of Drug Design and Action Third Edition

Smith and Williams  Introduction to the Principles of Drug Design and Action  Third Edition

Anti - cancer Drug Design 7 , 95-105 . Scientific American ( Special Issue ) ( 1996 ) What You Need to Know About Cancer 275 , 4-167 . Silverman , R.B. ( 1992 ) The Organic Chemistry of Drug Design and Drug Action .

Author: H. John Smith

Publisher: CRC Press

ISBN: 9057020378

Category: Medical

Page: 578

View: 353

The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Categories: Medical

Handbook of Drug Metabolism Third Edition

Handbook of Drug Metabolism  Third Edition

The Organic Chemistry of Drug Design and Drug Action. 2nd ed. Boston, Massachusetts: Elsevier. Silverman, R.B. and C.Z. Ding. “Chemical model for a mechanism of inactivation of monoamine oxidase by heterocylic compounds.

Author: Paul G. Pearson

Publisher: CRC Press

ISBN: 9781482262049

Category: Medical

Page: 750

View: 857

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments. It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of drugs. Some chapters have been prepared by new authors who have emerged as subject area experts in the decade that has passed since publication of the first edition.
Categories: Medical

Computing Handbook Third Edition

Computing Handbook  Third Edition

The Organic Chemistry of Drug Design and Drug Action, 2nd Edn. New York: Elsevier Academic Press. Silverstein, R.M., Bassler, G.C., and Morrill, TC. 1991. Spectrometric Identification ofOrganic Compounds, 5th Edn. New York: Iohn Wiley 8 ...

Author: Teofilo Gonzalez

Publisher: CRC Press

ISBN: 9781439898529

Category: Mathematics

Page: 2330

View: 190

Computing Handbook, Third Edition: Computer Science and Software Engineering mirrors the modern taxonomy of computer science and software engineering as described by the Association for Computing Machinery (ACM) and the IEEE Computer Society (IEEE-CS). Written by established leading experts and influential young researchers, the first volume of this popular handbook examines the elements involved in designing and implementing software, new areas in which computers are being used, and ways to solve computing problems. The book also explores our current understanding of software engineering and its effect on the practice of software development and the education of software professionals. Like the second volume, this first volume describes what occurs in research laboratories, educational institutions, and public and private organizations to advance the effective development and use of computers and computing in today’s world. Research-level survey articles provide deep insights into the computing discipline, enabling readers to understand the principles and practices that drive computing education, research, and development in the twenty-first century.
Categories: Mathematics

Surfactants from Renewable Raw Materials

Surfactants from Renewable Raw Materials

... Organic Chemistry of Drug Design and Drug Action: Third Edition. Elsevier. h ps://doi.org/10.1016/C2009-0-64537-2 3. Silakari, O. (2018). Key Heterocycle Cores for Designing Multitargeting Molecules.

Author: Divya Bajpai Tripathy

Publisher: CRC Press

ISBN: 9781000511895

Category: Science

Page: 272

View: 306

Surfactants are often completely invisible to us and yet they are present in almost every chemical that we use in our daily life. They are found in toothpastes, cosmetics, sunscreens, mayonnaise, detergents, and an array of cleaning products. Traditional surfactants are known to have adverse environmental impacts spurring research into eco-friendly and cost-effective surfactants from renewable resources. Surfactants from Renewable Raw Materials examines the class of surfactants synthesized using plant-based raw materials detailing their properties, applications, bioavailability, and biodegradability. The concluding chapter reviews patent activity over the last decade. Additional features include: Addresses the tremendous variation found in the raw materials used to synthesize commercially available surfactants. Explores the selection of raw materials based upon the desired hydrophobic group or hydrophilic group to be incorporated into the product. Examines the characteristics and medicinal applications of pulmonary surfactants in preterm babies as well as their probable contribution in COVID-19 Discusses the biodegradability of surfactants to assist with the determination of truly green surfactants. This comprehensive reference will prove indispensable for professional and academic researchers creating or working with bio-based surfactants.
Categories: Science

An Introduction to Medicinal Chemistry

An Introduction to Medicinal Chemistry

Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Part one of the book introduces the principles of drug action via targets such as receptors and enzymes.

Author: Graham Patrick

Publisher: Oxford University Press

ISBN: 9780198749691

Category: Pharmaceutical chemistry

Page: 832

View: 576

For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?An Introduction to Medicinal Chemistry, sixthedition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Inaddition to covering the key principles of drug design and drug action, the text also discusses important current topics in medicinal chemistry. The subject is brought to life throughout by engaging case studies highlighting particular classes of drugs, and the stories behind their discovery and development.
Categories: Pharmaceutical chemistry