The Molecular Biology of Down Syndrome

The Molecular Biology of Down Syndrome

This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry.

Author: G. Lubec

Publisher: Springer Science & Business Media

ISBN: 3211833773

Category: Medical

Page: 380

View: 741

This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.
Categories: Medical

The Molecular Biology of Down Syndrome

The Molecular Biology of Down Syndrome

Preface There is abundant literature on Down Syndrome but work on Down Syndrome brain is limited. New technologies of biochemistry and molecular biology including gene hunting methods are powerful tools for brain research but have been ...

Author: G. Lubec

Publisher: Springer Science & Business Media

ISBN: 9783709163801

Category: Medical

Page: 366

View: 126

This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology.
Categories: Medical

Molecular Biology of Aging

Molecular Biology of Aging

Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's.

Author: Avril D. Woodhead

Publisher: Springer Science & Business Media

ISBN: 0306420848

Category: Psychology

Page: 516

View: 193

It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.
Categories: Psychology

Molecular Biology of Aging

Molecular Biology of Aging

This broad ranging study explores the recent findings in the dynamic field of molecular biogerontology. It examines the numerous molecular changes which occur during senescence and pinpoints the basic biological pacemakers of aging.

Author: University of California, Los Angeles

Publisher: Wiley-Liss

ISBN: UOM:39015017993919

Category: Science

Page: 458

View: 626

This broad ranging study explores the recent findings in the dynamic field of molecular biogerontology. It examines the numerous molecular changes which occur during senescence and pinpoints the basic biological pacemakers of aging. Investigators examine the importance of DNA damage and the extent of differential gene expression during aging. There are discussions of attempts to manipulate the lifespans of various model organisms through gene transfer and regulated gene expression. Throughout, the contributors stress that the genome holds the ultimate key to understanding the limits of lifespan and the determinants of senescence.
Categories: Science

Molecular Biology Quick Study Guide Workbook

Molecular Biology Quick Study Guide   Workbook

Molecular Biology Quick Study Guide & Workbook: Trivia Questions Bank, Worksheets to Review Homeschool Notes with Answer Key PDF (Molecular Biology Revision Notes, Terminology & Concepts about Self-Teaching/Learning) includes revision notes ...

Author: Arshad Iqbal

Publisher: Bushra Arshad

ISBN:

Category: Science

Page: 81

View: 726

Molecular Biology Quick Study Guide & Workbook: Trivia Questions Bank, Worksheets to Review Homeschool Notes with Answer Key PDF (Molecular Biology Revision Notes, Terminology & Concepts about Self-Teaching/Learning) includes revision notes to solve problems with hundreds of trivia questions. "Molecular Biology Study Guide" PDF covers basic concepts and analytical assessment tests. "Molecular Biology Questions" bank PDF helps to practice workbook questions from exam prep notes. Molecular biology quick study guide with answers includes self-learning guide with verbal, quantitative, and analytical past papers quiz questions. Molecular Biology trivia questions and answers PDF download, a book to review questions and answers on chapters: Aids, bioinformatics, biological membranes and transport, biotechnology and recombinant DNA, cancer, DNA replication, recombination and repair, environmental biochemistry, free radicals and antioxidants, gene therapy, genetics, human genome project, immunology, insulin, glucose homeostasis and diabetes mellitus, metabolism of xenobiotics, overview of bioorganic and biophysical chemistry, prostaglandins and related compounds, regulation of gene expression, tools of biochemistry, transcription and translation worksheets for college and university revision notes. Molecular Biology workbook PDF download with free sample book covers beginner's questions, textbook's study notes to practice worksheets. Biology quick study guide PDF includes high school workbook questions to practice worksheets for exam. "Molecular biology Workbook" PDF, a quick study guide with chapters' notes for NEET/MCAT/MDCAT/SAT/ACT competitive exam. "Molecular Biology Revision Notes" PDF covers problem solving exam tests from life sciences practical and textbook's chapters as: Chapter 1: AIDS Worksheet Chapter 2: Bioinformatics Worksheet Chapter 3: Biological Membranes and Transport Worksheet Chapter 4: Biotechnology and Recombinant DNA Worksheet Chapter 5: Cancer Worksheet Chapter 6: DNA Replication, Recombination and Repair Worksheet Chapter 7: Environmental Biochemistry Worksheet Chapter 8: Free Radicals and Antioxidants Worksheet Chapter 9: Gene Therapy Worksheet Chapter 10: Genetics Worksheet Chapter 11: Human Genome Project Worksheet Chapter 12: Immunology Worksheet Chapter 13: Insulin, Glucose Homeostasis and Diabetes Mellitus Worksheet Chapter 14: Metabolism of Xenobiotics Worksheet Chapter 15: Overview of bioorganic and Biophysical Chemistry Worksheet Chapter 16: Prostaglandins and Related Compounds Worksheet Chapter 17: Regulation of Gene Expression Worksheet Chapter 18: Tools of Biochemistry Worksheet Chapter 19: Transcription and Translation Worksheet Practice "AIDS Study Guide" PDF, practice test 1 to solve questions bank: Virology of HIV, abnormalities, and treatments. Practice "Bioinformatics Study Guide" PDF, practice test 2 to solve questions bank: History, databases, and applications of bioinformatics. Practice "Biological Membranes and Transport Study Guide" PDF, practice test 3 to solve questions bank: Chemical composition and transport of membranes. Practice "Biotechnology and Recombinant DNA Study Guide" PDF, practice test 4 to solve questions bank: DNA in disease diagnosis and medical forensics, genetic engineering, gene transfer and cloning strategies, pharmaceutical products of DNA technology, transgenic animals, biotechnology and society. Practice "Cancer Study Guide" PDF, practice test 5 to solve questions bank: Molecular basis, tumor markers and cancer therapy. Practice "DNA Replication, Recombination and Repair Study Guide" PDF, practice test 6 to solve questions bank: DNA and replication of DNA, recombination, damage and repair of DNA. Practice "Environmental Biochemistry Study Guide" PDF, practice test 7 to solve questions bank: Climate changes and pollution. Practice "Free Radicals and Antioxidants Study Guide" PDF, practice test 8 to solve questions bank: Types, sources and generation of free radicals. Practice "Gene Therapy Study Guide" PDF, practice test 9 to solve questions bank: Approaches for gene therapy. Practice "Genetics Study Guide" PDF, practice test 10 to solve questions bank: Basics, patterns of inheritance and genetic disorders. Practice "Human Genome Project Study Guide" PDF, practice test 11 to solve questions bank: Birth, mapping, approaches, applications and ethics of HGP. Practice "Immunology Study Guide" PDF, practice test 12 to solve questions bank: Immune system, cells and immunity in health and disease. Practice "Insulin, Glucose Homeostasis and Diabetes Mellitus Study Guide" PDF, practice test 13 to solve questions bank: Mechanism, structure, biosynthesis and mode of action. Practice "Metabolism of Xenobiotics Study Guide" PDF, practice test 14 to solve questions bank: Detoxification and mechanism of detoxification. Practice "Overview of Bioorganic and Biophysical Chemistry Study Guide" PDF, practice test 15 to solve questions bank: Isomerism, water, acids and bases, buffers, solutions, surface tension, adsorption and isotopes. Practice "Prostaglandins and Related Compounds Study Guide" PDF, practice test 16 to solve questions bank: Prostaglandins and derivatives, prostaglandins and derivatives. Practice "Regulation of Gene Expression Study Guide" PDF, practice test 17 to solve questions bank: Gene regulation-general, operons: LAC and tryptophan operons. Practice "Tools of Biochemistry Study Guide" PDF, practice test 18 to solve questions bank: Chromatography, electrophoresis and photometry, radioimmunoassay and hybridoma technology. Practice "Transcription and Translation Study Guide" PDF, practice test 19 to solve questions bank: Genome, transcriptome and proteome, mitochondrial DNA, transcription and translation, transcription and post transcriptional modifications, translation and post translational modifications.
Categories: Science

Preimplantation Genetic Diagnosis

Preimplantation Genetic Diagnosis

This book contains research from leading scientists and clinicians within this field.

Author: Joyce C. Harper

Publisher: John Wiley & Sons

ISBN: 0471985007

Category: Medical

Page: 290

View: 329

Preimplantation Genetic Diagnosis (PGD) is the detection and screening of genetic abnormality in gametes prior to fertilisation and embryos fertilised in vitro prior to implantation. This exciting new text provides an introduction and overview of the principles of PGD. An exciting fusion of prenatal diagnosis (PD) with in vitro fertilisation (IVF), this book is will appeal to both the prenatal diagnosis community, of clinical geneticists and foetal medicine specialists within obstetrics and gynaecology, and the IVF community within reproductive medicine. It is also an essential introduction to PD, clinical genetics and IVF for non-specialists. A concise introduction to the field of PGD Detailed explanations of the techniques and procedures used The law and ethical implications of PGD Future uses of PGD
Categories: Medical

Protein Expression in Down Syndrome Brain

Protein Expression in Down Syndrome Brain

Becker LE , Armstrong DL , Chan F ( 1986 ) Dendritic atrophy in children with Down's Syndrome . Ann Neurol 20 : 520-532 Berndt P ... In : Lubec G ( ed ) The molecular biology of Down syndrome . Springer , Wien New York , pp 75-86 Greber ...

Author: G. Lubec

Publisher: Springer Science & Business Media

ISBN: 3211837329

Category: Medical

Page: 390

View: 686

When we worked on Down Syndrome brain in the past we have been focus ing on adult brain. This was a major step forwards as most work on Down Syndrome was carried out on fibroblasts or other tissues and, moreover, we introduced proteomics to identify and quantify brain protein expression. We considered evaluation of brain protein expression in Down Syndrome brain by and by more important than gene hunting at the nucleic acid level realiz ing the long unpredictable way from RNA to protein. The availability of fetal samples along with the proteomic appproach stimulated and reinforced studies on Down Syndrome brain. And indeed, it was found out that some observations on aberrant protein expression in adult Down Syndrome brain could not be verified in the fetal samples indi cating that neurodegeneration in adult Down Syndrome brain may have been responsible rather than trisomy 21. Using brains from the early second trimester of gestation led to the generation of a series of clues for the under standing of aberrant wiring of the brain in Down Syndrome and enabled the determination of altered key functions in early life; e. g. undetectably low drebrin was observed in Down Syndrome cortex, an integral constituent and marker for dendritic spines, main effectors of cross-talk between neurons. In addition, evaluation of the nature of the neuronal deficits in terms of neuro transmission markers could be established as well as neuronal density in fetal Down Syndrome cortex.
Categories: Medical

Down Syndrome From Understanding the Neurobiology to Therapy

Down Syndrome  From Understanding the Neurobiology to Therapy

The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus ...

Author: Mara Dierssen

Publisher: Elsevier

ISBN: 9780444542991

Category: Medical

Page: 273

View: 745

Down syndrome (DS) is the most common example of neurogenetic aneuploid disorder leading to mental retardation. In most cases, DS results from an extra copy of chromosome 21 (HSA21) producing deregulated gene expression in brain that gives raise to subnormal intellectual functioning. The topic of this volume is of broad interest for the neuroscience community, because it tackles the concept of neurogenomics, that is, how the genome as a whole contributes to a neurodevelopmental cognitive disorders, such as DS, and thus to the development, structure and function of the nervous system. This volume of Progress in Brain Research discusses comparative genomics, gene expression atlases of the brain, network genetics, engineered mouse models and applications to human and mouse behavioral and cognitive phenotypes. It brings together scientists of diverse backgrounds, by facilitating the integration of research directed at different levels of biological organization, and by highlighting translational research and the application of the existing scientific knowledge to develop improved DS treatments and cures. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist
Categories: Medical