The Art of Drug Synthesis

The Art of Drug Synthesis

This text features contributions from seventeen leading medicinal and process chemists who show you how it is done.

Author: Douglas S. Johnson

Publisher: John Wiley & Sons

ISBN: 9781118678466

Category: Science

Page: 350

View: 613

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.
Categories: Science

Innovative Drug Synthesis

Innovative Drug Synthesis

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them.

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 9781118820056

Category: MEDICAL

Page: 360

View: 957

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery
Categories: MEDICAL

Modern Drug Synthesis

Modern Drug Synthesis

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students.

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 9781118701249

Category: Science

Page: 355

View: 219

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.
Categories: Science

Drug Synthesis Book Set

Drug Synthesis Book Set

This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic ...

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 1119185653

Category: Science

Page: 1272

View: 883

This set presents the authoritative and acclaimed Drug Synthesis books edited by Jie Jack Li and Douglas Johnson: Contemporary Drug Synthesis, The Art of Drug Synthesis, Modern Drug Synthesis, and Innovative Drug Synthesis. This book set will be enormously useful to pharmaceutical industry labs, research scientists in lead optimization and process development, and graduate students and courses in organic chemistry, synthetic organic chemistry, heterocyclic chemistry, medicinal chemistry, and drug synthesis courses.
Categories: Science

Medicinal Chemistry for Practitioners

Medicinal Chemistry for Practitioners

Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry.

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 9781119607281

Category: Medical

Page: 400

View: 369

Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Categories: Medical

Drug Discovery

Drug Discovery

Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments ...

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 9781118354469

Category: Medical

Page: 570

View: 505

Sets forth the history, state of the science, and future directions of drug discovery Edited by Jie Jack Li and Nobel laureate E. J. Corey, two leading pioneers in drug discovery and medicinal chemistry, this book synthesizes great moments in history, the current state of the science, and future directions of drug discovery into one expertly written and organized work. Exploring all major therapeutic areas, the book introduces readers to all facets and phases of drug discovery, including target selection, biological testing, drug metabolism, and computer-assisted drug design. Drug Discovery features chapters written by an international team of pharmaceutical and medicinal chemists. Contributions are based on a thorough review of the current literature as well as the authors' firsthand laboratory experience in drug discovery. The book begins with the history of drug discovery, describing groundbreaking moments in the field. Next, it covers such topics as: Target identification and validation Drug metabolism and pharmacokinetics Central nervous system drugs In vitro and in vivo assays Cardiovascular drugs Cancer drugs Each chapter features a case study, helping readers understand how science is put into practice throughout all phases of drug discovery. References at the end of each chapter serve as a gateway to groundbreaking original research studies and reviews in the field. Drug Discovery is ideal for newcomers to medicinal chemistry and drug discovery, providing a comprehensive overview of the field. Veterans in the field will also benefit from the perspectives of leading international experts in all aspects of drug discovery.
Categories: Medical

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 9781118354421

Category: Science

Page: 720

View: 354

Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.
Categories: Science

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery

This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal ...

Author: Larry Yet

Publisher: John Wiley & Sons

ISBN: 9781118145661

Category: Medical

Page: 560

View: 887

A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application.
Categories: Medical

Fundamentals of Industrial Chemistry

Fundamentals of Industrial Chemistry

The Art of Drug Synthesis. New York: Wiley; 2007:130. C Smith, J Vane. The
FASEB Journal 2003; 17(8):788–789. ... Top Drugs, Top Synthetic Routes. Oxford
University Press; 2000:22. E Altan, et al. Expert Opin. Emerging Drugs 2012 ...

Author: John A. Tyrell

Publisher: John Wiley & Sons

ISBN: 9781118708668

Category: Science

Page: 264

View: 167

This book discusses the connectivity between major chemicals, showing how a chemical is made along with why and some of the business considerations. The book helps smooth a student’s transition to industry and assists current professionals who need to understand the larger picture of industrial chemistry principles and practices. The book: Addresses a wide scope of content, emphasizing the business and polymer / pharmaceutical / agricultural aspects of industrial chemistry Covers patenting, experimental design, and systematic optimization of experiments Written by an author with extensive industrial experience but who is now a university professor, making him uniquely positioned to present this material Has problems at the end of chapters and a separate solution manual available for adopting professors Puts chemical industry topics in context and ties together many of the principles chemistry majors learn across more specific courses
Categories: Science

Name Reactions for Carbocyclic Ring Formations

Name Reactions for Carbocyclic Ring Formations

This book continues the well-established and authoritative series on name reactions in organic chemistry by focusing on name reactions on ring formation.

Author: Jie Jack Li

Publisher: John Wiley & Sons

ISBN: 9780470872208

Category: Science

Page: 772

View: 922

This book continues the well-established and authoritative series on name reactions in organic chemistry by focusing on name reactions on ring formation. Ring formating reactions have found widespread applicability in traditional organic synthesis, medicinal/pharmaceuticals, agricultural, fine chemicals, and of late, especially in polymer science.
Categories: Science

Carbohydrates as Drugs

Carbohydrates as Drugs

Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of ...

Author: Peter H. Seeberger

Publisher: Springer

ISBN: 9783319086750

Category: Science

Page: 237

View: 606

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Categories: Science

Biocatalysis for the Pharmaceutical Industry

Biocatalysis for the Pharmaceutical Industry

Written by a team of leading experts, the book offers deep insight into this cutting edge field.

Author: Junhua (Alex) Tao

Publisher: John Wiley & Sons

ISBN: 9780470823156

Category: Science

Page: 250

View: 714

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.
Categories: Science

Pharmaceutical Process Chemistry for Synthesis

Pharmaceutical Process Chemistry for Synthesis

Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale
-Up, By Peter J. Harrington Copyright Ó ... conceptualized at a most unlikely
place: at a visit to an Inspiring Impressionism exposition at the Denver Art
Museum in ...

Author: Peter J. Harrington

Publisher: John Wiley & Sons

ISBN: 0470922869

Category: Science

Page: 376

View: 780

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.
Categories: Science

An Introduction to Drug Design

An Introduction to Drug Design

The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties.

Author: S. N. Pandeya

Publisher: New Age International

ISBN: 8122409431

Category: Drugs

Page: 214

View: 662

The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.
Categories: Drugs

Triumph of the Heart

Triumph of the Heart

But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins.

Author: Jie Jack Li

Publisher: Oxford University Press

ISBN: 9780199886654

Category: Medical

Page: 224

View: 846

Over 25 million people in the U.S. alone have benefited from statins--such drugs as Lipitor, Zocor, Crestor, Pravachol, and other cholesterol-lowering medicines--in preventing stroke, heart attack, and other forms of coronary heart disease. But how did these remarkable, life-saving drugs come into being? In Triumph of the Heart, Dr. Jie Jack Li, a medicinal chemist and expert on drug discovery, tells for the first time the fascinating story of statins. Drawn from discussions with many scientists involved in the discovery and development of these drugs, the book illuminates the human side of science by revealing the role played by persistence, luck, and sudden insight that characterize major discoveries. For scientists in the drug industry, health care professionals, students of medicine, and all those intrigued by the basic human drive to explore and discover, Triumph of the Heart offers a compelling view of one of the most important drug discoveries of our time.
Categories: Medical

Name Reactions Series

Name Reactions Series

These are key reactions that have found widespread application in all areas of organic synthesis: medicinal / pharmaceutical, agricultural, fine chemicals, and polymer science.

Author: Jie Jack Li

Publisher: Wiley

ISBN: 0470940328

Category: Science

Page: 3718

View: 548

This set collects all the volumes in the well-established and authoritative series on name reactions in organic chemistry. These are key reactions that have found widespread application in all areas of organic synthesis: medicinal / pharmaceutical, agricultural, fine chemicals, and polymer science.
Categories: Science

The Organic Chemistry of Drug Synthesis

The Organic Chemistry of Drug Synthesis

12 Six - Membered Heterocycles Fused to One Benzene Ring The prevalence of
heterocyclic rings among drugs and biochemical agents of mammalian origin can
lead to the erroneous assumption that the presence of such rings in drugs ...

Author: Daniel Lednicer

Publisher: John Wiley & Sons

ISBN: 0471043923

Category: Medical

Page: 544

View: 846

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.
Categories: Medical

Contemporary Drug Synthesis

Contemporary Drug Synthesis

2 Synthesis of Racemic Atorvastatin3 - 7 Because the art of enantioselective drug
synthesis was still in the early stages of development in the 1980s , especially on
the scale required for a complex commercial process , many of the early ...

Author: Jie Jack Li

Publisher: Wiley-Interscience

ISBN: UOM:39015059188220

Category: Science

Page: 221

View: 834

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.
Categories: Science

Robert Burns Woodward and the Art of Organic Synthesis

Robert Burns Woodward and the Art of Organic Synthesis

RBW obtained from Biemann extremely accurate molecular weights that he used
to determine the structures of several molecules , including streptonigrin , a
cancer drug ( 1963 ) , and tetrodotoxin , the globe or puffer fish poison ( 1964 ) .

Author: Mary Ellen Bowden

Publisher: Chemical Heritage Foundation

ISBN: 0941901084

Category: Science

Page: 48

View: 975

This is the companion book to the former CHF traveling exhibit by the same name. "This multifaceted portrait of an extraordinary human being, teacher, and consummate organic chemist should inspire more young persons to pursue scientific careers, provide chemists with deep insight into the creative mind of a 'legendary architect of molecules, ' and enhance the public's understanding of chemistry and its research methods." - Journal of Chemical Education.
Categories: Science

Chemistry and Medicines

Chemistry and Medicines

1.5 THE SYNTHESIS OF A DRUG Synthetic organic chemistry is one of the
corner stones of medicinal chemistry. There are a number of criteria by which a
synthesis may be evaluated in a medicinal chemistry context. A convergent
synthesis ...

Author: James Ralph Hanson

Publisher: Royal Society of Chemistry

ISBN: 9780854046454

Category: Medical

Page: 156

View: 893

Providing a general introduction to this fascinating subject, this book is aimed at those studying advanced undergraduate and postgraduate courses in medicinal chemistry.
Categories: Medical