The Amide Linkage

The Amide Linkage

An authoritative reference to an important and ubiquitous chemical linkage The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, ...

Author: Arthur Greenberg

Publisher: John Wiley & Sons

ISBN: 0471420255

Category: Science

Page: 653

View: 376

An authoritative reference to an important and ubiquitous chemical linkage The amide linkage is one of the most fundamental and widespread chemical bonds in nature, underlying the properties of a vast array of organic molecules, polymers, and materials, including peptides and proteins. Arthur Greenberg, Curt Breneman, and Joel Liebman's peerless text provides comprehensive coverage of the experimental, structural, and computational findings that shed light on the chemical and physical properties of the amide linkage, as well as its emerging applications in materials and biotechnology. Chapters in The Amide Linkage highlight how this chemical bond factors in the design of enzyme inhibitors, cyclic peptides, antibacterial agents, and emerging nanotechnology applications. This one-of-a-kind study also: * Discusses selected aspects of chemical reactions, structure, bonding, and energetics of the amide bond, including amide rotational barriers, stereochemistry, complexation, spectroscopy, and thermochemistry * Presents specific applications to supramolecular and stereospecific synthesis * Discusses key aspects of peptide and protein chemistry-such as molecular recognition, conformation, and folding-in terms of the amide linkage * Includes chapters contributed by numerous eminent chemists and biochemists Organic, medicinal, polymer, and physical chemists, as well as biochemists and materials scientists, will find The Amide Linkage to be an invaluable addition to their professional libraries.
Categories: Science

Amide Bond Activation

Amide Bond Activation

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides.

Author: Michal Szostak

Publisher: MDPI

ISBN: 9783039212033

Category: Science

Page: 466

View: 201

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.
Categories: Science

Amide Bond Activation

Amide Bond Activation

The amide bond represents a privileged motif in chemistry.

Author: Michal Szostak

Publisher:

ISBN: 3039212044

Category: Chemistry

Page: 466

View: 667

The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N-C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.
Categories: Chemistry

Clinical Ophthalmic Pharmacology

Clinical Ophthalmic Pharmacology

The intermediate link may be an ester linkage (an acid and an amine alcohol) or an amide linkage (an aromatic amine and an amino acid). The amide-linked anesthetics are the most stable. Aromatic (lipophilic) Amine (hydrophilic) portion ...

Author: David W. Lamberts

Publisher: Little Brown & Company

ISBN: UOM:39015012536614

Category: Medical

Page: 588

View: 383

Categories: Medical

Proceedings

Proceedings

Further there is no reason to believe that the process of facet formation is only influenced by the amide-linkage (--CONH—) ... some amino acids which do not possess such linkage, are more effective than some ureids and acid amides.

Author: Egyptian Academy of Sciences

Publisher:

ISBN: CHI:73701249

Category: Science

Page:

View: 745

Categories: Science