This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.
Author: Keiko Hiyama
Publisher: Springer Science & Business Media
Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985. In 1990s, it was proven that this enzyme also plays a key role in the infinite proliferation of human cancer cells. Now telomere and telomerase are widely accepted as important factors involved in cancer biology, and as promising diagnostic tools and therapeutic targets. Recently, role of telomerase in “cancer stem cells” has become another attractive story. Until now, there are several good books on telomere and telomerase focusing on biology in ciliates, yeasts, and mouse or basic sciences in human, providing basic scientists or students with updated knowledge.
INHIBITING TELOMERASE AS A THERAPY FOR TREATING CANCER Because telomerase activity is detected in almost all ... Since the mode of action of telomerase inhibitors may require further telomeric shortening of cancer cells
Also included are protocols for the study of telomeres themselves and methods for the identification of regulators of telomerase function.
Author: John A. Double
Publisher: Springer Science & Business Media
The enzyme telomerase provides a mechanism that ensures chromosome stability in both normal and neoplastic cells. This reference covers methods of dentral importance in the analysis of telomerase function and activity for all cell and molecular biologists. These range from the standard telomerase activity (TRAP) assay through to many more novel approaches such as the use of real-time PCR, in-situ PCR and non-PCR based assays of telomerase activity. Also included are protocols for the study of telomeres themselves and methods for the identification of regulators of telomerase function.
Nice way of making cancer!" Weinberg fears that telomerase could breathe new
life into pre-malignant cells that would otherwise be too old to cause trouble. "I
think it could unleash a whole torrent of malignant changes," he warns. And that
Popular Science gives our readers the information and tools to improve their technology and their world. The core belief that Popular Science and our readers share: The future is going to be better, and science and technology are the driving forces that will help make it better.
In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction. A special focus of the book is on adult stem cells.
Author: K. Lenhard Rudolph
Publisher: Springer Science & Business Media
Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.
Second , their the tumor is derived . The exciting finding that the great majority telomeres could recover their former lengths and regain normal ( > 85 % ) of
human cancers have activated telomerase ( 1-3 ) sug function . However ,
"Summaries of papers" contained in the journal accompany each issue, 19--
The ability of human cancer cells to infinitely replicate is due , at least in part , to
the activity of the telomerase enzyme . Telomerase synthesizes the addition of
DNA repeats ( for humans , 5 ' - TTAGGG - 3 ) to the ends of telomeres using an ...
Telomere / telomerase hypotheses of aging and cancer Major milestones in telomere research TELOMERES , TELOMERASE AND CANCER • Cancer facts •
Senescence , cell division , and cancer TELOMERES , TELOMERASE AND
telomerase in normal telomerase - negative somatic cells results in extended cell
proliferation ( Bodnar et al . , 1998 ) . Unlimited cell proliferation is a characteristic
of cancer cells , implying that cancers have active telomerase or have ...
Limited Proliferation and Telomere Dysfunction following Telomerase Inhibition
in Immortal Murine Fibroblasts Jessica ... Sloan - Kettering Cancer Center , New
York , New York 10021 ABSTRACT of human cancers , have high telomerase ...
This suggests that tumor - derived cancer cells are committed to a telomerase -
dependent immortalization pathway , remaining as such rather than relying on an
alternate telomere maintenance pathway . Therefore , while it seems plausible in
Author: M.P. Mattson
Publisher: Elsevier Science Limited
This volume of Advances in Cell Aging and Gerontology critically reviews the rapidly advancing area of telomerase research with a focus at the molecular and cellular levels. The clearly established function of telomerase is to maintain chromosome ends during successive rounds of cell division by adding a six base DNA repeat on to the telomeric ends of chromosomes. As presented in the chapters of this volume, the mechanisms that regulate telomerase expression and activity are complex. Moreover, emerging data suggest additional roles for telomerase in the regulation of cell differentiation and survival. It is expected that this quite comprehensive volume will provide a valuable resource for graduate students and postdocs in the telomerase field and for established investigators in other fields who are beginning to study telomerase in their particular research program. With an increasing number of proteins being brought into the fold of telomerase research (e.g., DNA damage and repair response proteins, heat-shock proteins, and proteins in various signal transduction cascades) many new scientists are beginning to study this enzyme from novel vantage points.
Telomeres and telomerase in senescence , cancer , and stem cells Telomerase
was first detected in Tetrahymena as an activity capable of extending
oligonucleotide substrates in vitro , which requires both protein and RNA
times . It is also possible that alterations in telomere structure , and decreases in telomerase activity may be useful as prognostic indicators for response to
chemotherapy.18 , 23 VI . Telomerase inhibition as an anti - cancer therapy If telomere ...
The telomerase RNA component is es - telomerase activation was necessary for
the imsential as a template to elongate telomere se - mortal growth of cancer
cells . Hence telomerase quences from 5 ' to the 3 ' end of the chromosome
Author: Eiichi Tahara
Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.
demonstration that inducing telomerase expression in normal cells can prevent
shortening of their telomeres , and extend their life span , strongly supports ...
There also appears to be a correlation between tumor stage and telomerase
Nat Med 1 : 249-255 , 1995 . 6 Hiyama E , Yokoyama T , Tatsumoto N , Hiyama K
, Imamura Y , Murakami Y , Kodama T , Piatyszek MA , Shay JW and Matsuura Y : Telomerase activity in gastric cancer . Cancer Res 55 : 32583262 , 1995 .
Interestingly , stable clones from cisplatin - resistant cells , having lost their telomerase activity , displayed increased ... by telomere attrition alone , and that
treatment of some drug - resistant cancers may be improved by anti - telomerase
Author: Ian J. Jacobs
Publisher: Oxford University Press, USA
Ovarian cancer provides an up-to-date and comprehensive synthesis of clinical management and research progress in the field of epithelial ovarian cancer. The book has its origins in two separate but complementary initiatives. One initiative was a series of reviews commissioned to cover thespectrum of clinical management of ovarian cancer from prevention, screening and diagnosis to surgery, chemotherapy and palliative care. The reviews were invited from an international panel of clinicians with expertise in the management of ovarian cancer. The second initiative was co-ordinated bythe Helene Harris Memorial Trust (HHMT) which has organised key biennial meetings on ovarian cancer for the last 12 years. Attendance at the meetings is by invitation to a small group of international authorities on research aspects of ovarian cancer. Setting the clinically focused reviewsalongside the HHMT research focused chapters has created a unique book. First, the book is unusually up-to-date and presents recent advances not included in other books in this field. Second, the contents are comprehensive and cover aetiology, pathology, screening, prevention, diagnosis,prognostic techniques, surgery, adjuvant therapy and palliative care. Third, the review chapters are set alongside more detailed coverage of recent clinical and basis science developments. Examples of this are the coverage of familial cancer, prevention, screening, and current therapy which areconsequently much more topical and exciting. Fourth, there are sections on 'tumour biology' and 'novel therapies' which have not been covered in comparable books about ovarian cancer. Finally, the contributions are from a representative spectrum of experts from both research and clinicalbackgrounds and with a truly international perspective.
However , these cells that normal cells immortalized with telomerase do not
generally have a longer than average telomere length and develop additional cancer - associated changes . In cells are much more slowly dividing than tumour
Author: Malcolm Alison
Publisher: Nature Publishing Group
Provides a comprehensive overview of all major areas of cancer research and oncology. Bridging the gap between the molecular biology of cancer and clinical diagnosis and treatment, this online reference work provides a resource for medical and life sciences students, as well as all scientists, clinicians and researchers working in the cancer field and related biomedical areas.
Overwhelming evidence for a connection between cancer , telomeres and telomerase awaited the arrival of the highly sensitive PCR - based TRAP assay in
1994 ( Kim et al . , 1994 ) . This allowed many groups to measure telomerase
Specific association of human telomerase activity with immortal cells and cancer
Science . 266 : 2011-5 . 20. Kohlstaedt , L. A. , J. Wang , J. M. Friedman , P. A.
Rice , and T. A. Steitz 1992 . Crystal structure at 3.5 A resolution of HIV - 1