Spherical Crystallization of an Antiviral Drug

Spherical Crystallization of an Antiviral Drug

Efavirenz is an anti-viral agent drug which is poorly water soluble drug.

Author: Amit P Shelke

Publisher:

ISBN: 9798740255330

Category:

Page: 72

View: 474

Efavirenz is an anti-viral agent drug which is poorly water soluble drug. In the present study micromeritics properties and dissolution behavior of drug significantly improved by spherical crystallization. PVP K 30 used as polymer and chloroform, used as bridging liquid in this study. Dichloromethane and water used as goo solvent and bad solvent respectively. Dissolution studies carried out on the formulations. Improvement in dissolution behavior observed in formulation batches as compared to pure drug.The significant improvement in micromeritics properties observed due to size enlargement and spherical shape it revealed that the change in the crystal habit. Pure drug and formulation batches analyzed using spectroscopic methods and DSC, FTIR studies carried out and it indicates no any chemical interaction between drug and polymer.Differential scanning colorimetry and powder x- ray powder diffraction studies reveals that drug retained their crystallinity. SEM studies carried out and it indicates modification in size and shape.On the basis flowability and dissolution studies of spherical agglomerates among the different formulation A2 (Efavirenz spherical crystals with PVP K30) was further compressed in tablet and its evaluation properties was performed.In the present study micromeritics properties and dissolution improvement occurred due to overall effect of hydrophilic nature of polymer, solvents, spherical shape. Also prepared tablet shows good physicochemical properties.
Categories:

Cumulated Index Medicus

Cumulated Index Medicus

( Rus ) Host influence on the antigenic composition of the ( Crystallization of head protein of the bacteriophage ... DNA - dependent RNA - directed protein synthesis in Ukr Biokhim Zh 41 : 587-9 , 1969 ( Ukr ) DRUG EFFECTS vitro . IV .

Author:

Publisher:

ISBN: IND:30000106783693

Category: Medicine

Page:

View: 529

Categories: Medicine

Cecil Textbook of Medicine

Cecil Textbook of Medicine

TAXONOMY OF HUMAN VIRUSES- cont'd FAMILY SUBFAMILY GENUS MORPHOLOGY ENVELOPE Icosahedral Pleomorphic Spherical + + ... With the exception of human immunodeficiency virus ( HIV ) infection , only a few antiviral agents of proven clinical ...

Author:

Publisher:

ISBN: UCSD:31822033576000

Category: Internal medicine

Page:

View: 757

Categories: Internal medicine

Structure and Physics of Viruses

Structure and Physics of Viruses

Many of the structures available correspond to potential targets for antiviral drugs and structural virology has had ... the largest spherical viruses, despite they are not yet amenable to high resolution X-ray crystal studies [47, 48].

Author: Mauricio G. Mateu

Publisher: Springer Science & Business Media

ISBN: 9789400765528

Category: Medical

Page: 728

View: 424

This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology.
Categories: Medical

Cecil Textbook of Medicine

Cecil Textbook of Medicine

TAXONOMY OF HUMAN VIRUSES — cont'd FAMILY SUBFAMILY GENUS MORPHOLOGY ENVELOPE Icosahedral Pleomorphic Spherical + + ... With the exception of human immunodeficiency virus ( HIV ) infection , only a few antiviral agents of proven ...

Author: Russell La Fayette Cecil

Publisher:

ISBN: 9997638166

Category: Internal medicine

Page: 2506

View: 529

Categories: Internal medicine

AIDS and Other Manifestations of HIV Infection

AIDS and Other Manifestations of HIV Infection

These inhibitors have been extremely effective antiviral agents, and because they target a distinct enzyme and distinct step in ... The MA proteins of HIV-1 and SIV have been shown to form trimers in crystallization studies (402,403), ...

Author: Gary Wormser

Publisher: Elsevier

ISBN: 008047196X

Category: Medical

Page: 1000

View: 436

Extensively revised and updated, the new edition of AIDS and Other Manifestations of HIV Infection is an essential reference resource providing a comprehensive overview of the biological properties of this etiologic viral agent, its clinicopathological manifestations, the epidemiology of its infection, and present and future therapeutic options. Expanded section on clinical manifestations includes new chapters on cardiovascular, renal and dermatologic manifestations of HIV infection Additional chapters on molecular diagnostic techniques, the role of host genetic variation in HIV infection and its manifestations, the discovery and development of new HIV medicines, analysis of HIV dynamics using mathematical models, toxicities of antiretroviral therapy, HIV drug susceptibility testing, practical therapeutics and the global impact of HIV and AIDS
Categories: Medical

Comprehensive Clinical Nephrology E Book

Comprehensive Clinical Nephrology E Book

Crystal casts are an important diagnostic element in crystalluric forms of AKI, such as acute urate nephropathy. ... 4-4, J)24; the antiviral agents acyclovir and indinavir (Fig. 4-4, K); the vasodilators pyridoxylate and naftidrofuryl ...

Author: Richard J. Johnson

Publisher: Elsevier Health Sciences

ISBN: 9780323242875

Category: Medical

Page: 1320

View: 176

Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. The right amount of basic science and practical clinical guidance assists in making efficient and informed decisions. Extensive updates on key topics keep you at the forefront of the field. New chapters on glomerulonephritis associated with complement disorders, interventional treatments for hypertension, renal disease and cancer, and epidemiology and prognostic impact of acute kidney injury. Over 1,500 color illustrations highlight key topics and detail pathogenesis for a full range of kidney conditions and clinical management. Hundreds of color coded algorithms promote quick reference and to help you retain concepts. Over 400 NEW self-assessment questions available at Expert Consult.
Categories: Medical

Delivery System Handbook for Personal Care and Cosmetic Products

Delivery System Handbook for Personal Care and Cosmetic Products

Marine sponge collagen particles, with a spherical shape and a size ranging from 120300 nm, have been shown to ... used as a polymer for creation of matrix-type nanoparticles used to entrap the antiviral drugs cidofovir, and acyclovir.

Author: Meyer Rosen

Publisher: William Andrew

ISBN: 9780815516828

Category: Technology & Engineering

Page: 1095

View: 850

Novel delivery systems designed to facilitate the use of ôfountain of youthö and other functional actives is an idea whose time has come. In a rapidly growing global market eager for products that really work, accelerating market pull forces and technology push have set the stage for this foundation text. This ômust haveö book has been carefully designed for training, development and synergistic technology transfer across the personal care, cosmetic and pharmaceutical industries. It is not only intended for scientists and technologists but will also be of high interest to market development and business personnel. This book will cause a breakthrough in effective interaction among technology and marketing. It is a showcase for understanding, using and marketing the technology of why and how delivery systems work as well as current, emerging/potential applications and working formulations. Each chapter is written by one or more experts in the field. A wide range of companies serving the global marketplace are represented. These companies offer numerous types of delivery systems containing highly desirable functional actives, delivery system technology development services, and opportunities for technology licensing, mergers and acquisitions. A unique feature of the book is the use of Mind MapÖ technology to capture and present the essence of the thinking of over 80 authors in a ôBook-at-a-Glanceö Executive Overview section. This section has been specifically designed to empower decision making leading to the development of innovative product differentiation in a global context.
Categories: Technology & Engineering

Prediction of Protein Structure and the Principles of Protein Conformation

Prediction of Protein Structure and the Principles of Protein Conformation

... L., Jones, T. A., and Strandberg, B., 1983a, Structural comparisons of some small spherical plant viruses, J. Mol. ... The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating, Science 233:1286–1293.

Author: G.D. Fasman

Publisher: Springer Science & Business Media

ISBN: 9781461315711

Category: Science

Page: 798

View: 567

The prediction of the conformation of proteins has developed from an intellectual exercise into a serious practical endeavor that has great promise to yield new stable enzymes, products of pharmacological significance, and catalysts of great potential. With the application of predic tion gaining momentum in various fields, such as enzymology and immunology, it was deemed time that a volume be published to make available a thorough evaluation of present methods, for researchers in this field to expound fully the virtues of various algorithms, to open the field to a wider audience, and to offer the scientific public an opportunity to examine carefully its successes and failures. In this manner the practitioners of the art could better evaluate the tools and the output so that their expectations and applications could be more realistic. The editor has assembled chapters by many of the main contributors to this area and simultaneously placed their programs at three national resources so that they are readily available to those who wish to apply them to their personal interests. These algorithms, written by their originators, when utilized on pes or larger computers, can instantaneously take a primary amino acid sequence and produce a two-or three-dimensional artistic image that gives satisfaction to one's esthetic sensibilities and food for thought concerning the structure and function of proteins. It is in this spirit that this volume was envisaged.
Categories: Science

The FASEB Journal

The FASEB Journal

Reviews Neutralization of small RNA viruses by antibodies and antiviral agents MICHAEL G. ROSSMANN Department of Biological ... to study animal ( 3 , 7 , 8 ) as well as insect ( 9 ) Key Words : diffraction pattern . crystallization .

Author:

Publisher:

ISBN: UCSD:31822009505694

Category: Biology

Page:

View: 209

Categories: Biology