Role of RNA and DNA in Brain Function

Role of RNA and DNA in Brain Function

True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.

Author: Antonio Giuditta

Publisher: Springer

ISBN: 1461294274

Category: Medical

Page: 322

View: 531

There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.
Categories: Medical

Role of RNA and DNA in Brain Function

Role of RNA and DNA in Brain Function

True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.

Author: Antonio Giuditta

Publisher: Springer Science & Business Media

ISBN: 9781461323211

Category: Medical

Page: 322

View: 457

There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.
Categories: Medical

Role of RNA and DNA in Brain Function

Role of RNA and DNA in Brain Function

True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.

Author: Antonio Giuditta

Publisher: Springer

ISBN: 0898388147

Category: Medical

Page: 322

View: 331

There was once an old Chinese man working on a hill with a boy. On the plain, near the sea, rested the village, the inhabitants eagerly engaged in their daily activities. Suddenly, the old man noticed that a huge wave, far distant in the sea, was approaching the shore endangering all. The only safe place was the hill. So, he began waving his hands and screaming aloud, to no avail. The villagers were too busy with their own work and paid little heed to the old man, who was considered a bit eccentric. But soon flames were on the hill, the wheat fields ablaze. The old man had resorted to this ultimate step to alert his fellow citizens. Now, they all went running towards him, angry about their burning crop, and in the process, avoided the imminent danger. For some mysterious reason, my mind focused on this story prior to the Symposium on the Role of DNA, which took place in Ravello, Italy at the end of May 1985. Having made a call for people to meet and reflect for a few days, the analogy began to take shape. Ravello was indeed a hill, magically overlooking the sea from medieval quarters. True, its countryside is filled with vineyards, not wheat fields, but that is an improvement on the story. However, what was the wave? Perhaps, the growing amount of data on cloned brain genes that threatens to engulf neurobiologists.
Categories: Medical

Regulation of Gene Expression and Brain Function

Regulation of Gene Expression and Brain Function

This volume presents a didactic approach to the understanding of the basic processes of gene expression and their involvement in certain brain diseases, such asAlzheimer's disease and schizophrenia.

Author: Paul J. Harrison

Publisher: Springer Science & Business Media

ISBN: 9783642784583

Category: Science

Page: 64

View: 455

Gene expression converts the information coded by our genes into proteins. These determine the structure and function of an organ such as the brain. Itis therefore an essential process, linking molecular genetics with neurochemistry and behavioral neuroscience. This volume presents a didactic approach to the understanding of the basic processes of gene expression and their involvement in certain brain diseases, such asAlzheimer's disease and schizophrenia. Generously illustrated, the contributions provide a valuable outline of this key aspect of molecular neurobiology and clinical neuroscience.
Categories: Science

Physiological Research

Physiological Research

MAREŠ V . : DNA synthesis and cell number bomeostasis in the brain . In : Role
of RNA and DNA in Brain Functions . A Molecular Biological Approach . G .
GIUDITTA , B . B . KAPLAN , C . ZOMZELY - NEURATH ( eds ) , Martinus Nijhoff
Publ .

Author:

Publisher:

ISBN: UCAL:B4330221

Category: Physiology

Page:

View: 228

Categories: Physiology

Macromolecules and Behavior

Macromolecules and Behavior

I. Introduction.- 1. Introduction.- II. Products of DNA Activation.- 2. Macromolecules-Functional and Biochemical Correlates.- 3. Brain Function and RNA.- 4. Macromolecules and Brain Function.- 5.

Author: John Gaito

Publisher: Springer Science & Business Media

ISBN: 9781468460421

Category: Juvenile Nonfiction

Page: 398

View: 472

I. Introduction.- 1. Introduction.- II. Products of DNA Activation.- 2. Macromolecules-Functional and Biochemical Correlates.- 3. Brain Function and RNA.- 4. Macromolecules and Brain Function.- 5. Inhibitors of Cerebral Protein or RNA Synthesis and Memory.- 6. Biological Assays for the Molecular Coding of Acquired Information.- 7. Biological Activity of Antibrain Antibody-an Introduction to Immunoneurology.- 8. Correlation of the S-100 Brain Protein with Behavior.- III. Macromolecules and Intracellular, Intercellular, and Synaptic Events.- 9. Axoplasmic Flow-The Fast Transport System in Mammal.
Categories: Juvenile Nonfiction

In Situ Hybridization in Brain

In Situ Hybridization in Brain

This volume should be of interest to individuals seeking an introduction to these methods, as well to those desiring an up to date precis of work in this burgeoning area.

Author: George Uhl

Publisher: Springer Science & Business Media

ISBN: 9781461594864

Category: Juvenile Nonfiction

Page: 300

View: 888

The explosion of interest in specific molecules important for brain function and dysfunction has drawn individuals from diverse backgrounds toward the use of in situ hybridization techniques. Study of the brain demands the anatomic precision and biochemical specificity that this approach can potentially bring. Workers with backgrounds in peptide neuroanatomy, neuropharmacology, molecular biology, neurovirology, neuropathology, and neurophysiology have joined together in this volume to discuss their initial experiences in applying ill situ hybridization techniques to the study of the brain. The work, although still in an early phase of development, is worthy of initial summary and dissemination. In the area of neuropeptide gene expression alone, investigators represented here describe studies of vasopressin, opiate peptides, oxytocin, vasoactive intestinal peptide, cholecystokinin, and somatostatin. Other contributions provide insight into applications of the technique to studies of the expression of genes for neurotransmitter synthesizing enzymes, viral-encoded genes, trophic factor genes, and the genes selected on the basis of their special roles in the brain. The authors provide an important series of technical perspectives, and describe specific experimental protocols. This volume should be of interest to individuals seeking an introduction to these methods, as well to those desiring an up to date precis of work in this burgeoning area. Dr. Uhl, with the sponsorship of the Howard Hughes Medical Institute, has done a superb job of assembling the leaders in this area, and in organizing the presen ta tion of their perspecti ves herein. Joseph B. Martin, M.D., Ph.D.
Categories: Juvenile Nonfiction

The Molecular Biology of Neurological Disease

The Molecular Biology of Neurological Disease

(1986) Messenger RNA in the brain. In: Role of RNA and DNA in Brain Function, edited by A. Giuditta, B. Kaplan and C. Zomzely-Neurath, pp. 10—22.

Author: Roger N. Rosenberg

Publisher: Butterworth-Heinemann

ISBN: 9781483163307

Category: Health & Fitness

Page: 276

View: 186

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.
Categories: Health & Fitness

The Brain Code

The Brain Code

This book provides stimulating reading for students of psychology, artificial intelligence and neurophysiology, as well as anyone interested in the broader question of how the brain works.

Author: Norman D. Cook

Publisher: Routledge

ISBN: 9780429954825

Category: Psychology

Page: 272

View: 894

Originally published in 1986, this stimulating and unorthodox book integrates the major findings of hemispheric research with the larger questions of how the brain stores and transmits information – the ‘brain code’. Norman Cook emphasizes how the two cerebral hemispheres communicate information over the corpus callosum, the largest single nerve tract of the human brain. Excitatory mechanisms are involved in the duplication of information between the hemispheres; in contrast, inhibitory mechanisms are implicated in the production of hemispheric asymmetries and, crucially, in high-level cognitive phenomena such as the right hemisphere’s role in providing the ‘context’ within which left hemispheric verbal information is placed. These callosal mechanisms of information transfer are not only fundamental to the brain code; they are the simplest and most easily demonstrated ways in which the neocortex ‘talks to itself’. The Brain Code demonstrates how popular topics within psychology at the time, such as laterality, hemisphere differences and the psychology of left and right, are central to further progress in understanding the human brain. This book provides stimulating reading for students of psychology, artificial intelligence and neurophysiology, as well as anyone interested in the broader question of how the brain works.
Categories: Psychology

The Journal of Pharmacology and Experimental Therapeutics

The Journal of Pharmacology and Experimental Therapeutics

The present findings are that RNA and DNA levels in the brain are significantly
reduced during alcohol - pyrazole ... The functional significance of the
macromolecules like RNA , DNA and proteins with regard to the neuronal activity
is not well ...

Author:

Publisher:

ISBN: UCAL:B5014714

Category: Pharmacology

Page:

View: 472

Categories: Pharmacology

RNA Based Regulation in Human Health and Disease

RNA Based Regulation in Human Health and Disease

We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.

Author:

Publisher: Academic Press

ISBN: 9780128171943

Category: Medical

Page: 444

View: 168

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field
Categories: Medical

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research

Molecular Genetic and Statistical Techniques for Behavioral and Neural Research

Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

Author: Robert T. Gerlai

Publisher: Academic Press

ISBN: 9780128041161

Category: Medical

Page: 708

View: 125

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists. Focuses on new techniques, including electrocorticography, functional mapping, stereo EEG, motor evoked potentials, optical coherence tomography, magnetoencephalography, laser evoked potentials, transmagnetic stimulation, and motor evoked potentials Presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior Written and edited by leading international experts
Categories: Medical

National Library of Medicine Current Catalog

National Library of Medicine Current Catalog

8606693 ROUND LIGAMENT see under ADNEXA UTERI Role of RNA and DNA in brain function : a molecular biological approach / edited by Antonio Giuditta , Barry ...

Author: National Library of Medicine (U.S.)

Publisher:

ISBN: MINN:31951M01375428B

Category: Medicine

Page:

View: 394

Categories: Medicine

The DNA RNA and Histone Methylomes

The DNA  RNA  and Histone Methylomes

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes.

Author: Stefan Jurga

Publisher: Springer Nature

ISBN: 9783030147921

Category: Medical

Page: 624

View: 633

This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Categories: Medical

Retrotransposition Diversity and the Brain

Retrotransposition  Diversity and the Brain

The book results from a fascinating and stimulating exchange of ideas at the interface of the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility.

Author: Fred H. Gage

Publisher: Springer Science & Business Media

ISBN: 9783540749660

Category: Medical

Page: 123

View: 381

This Fondation IPSEN Colloque Médecine et Recherche was devoted to the interface between the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. The goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases.
Categories: Medical

Genes Brain Function and Behavior

Genes  Brain Function  and Behavior

New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior.

Author: Douglas Wahlsten

Publisher: Academic Press

ISBN: 9780128128336

Category: Science

Page: 299

View: 648

Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources
Categories: Science

Brain Behavior and Epigenetics

Brain  Behavior and Epigenetics

To what extent is the epigenome plastic and malleable in response to environmental influences? This volume demonstrates that such questions can now be explored in an experimental molecular biology laboratory.

Author: Arturas Petronis

Publisher: Springer Science & Business Media

ISBN: 3642174264

Category: Medical

Page: 320

View: 326

Biomedical research in the first decade of the 21st century has been marked by a rapidly growing interest in epigenetics. The reasons for this are numerous, but primarily it stems from the mounting realization that research programs focused solely on DNA sequence variation, despite their breadth and depth, are unlikely to address all fundamental aspects of human biology. Some questions are evident even to non-biologists. How does a single zygote develop into a complex multicellular organism composed of dozens of different tissues and hundreds of cell types, all genetically identical but performing very different functions? Why do monozygotic twins, despite their stunning external similarities, often exhibit significant differences in personality and predisposition to disease? If environmental factors are solely the cause of such variation, why are similar differences also observed between genetically identical animals housed in a uniform environment? Over the last couple of decades, epigenetics has undergone a significant metamorphosis from an abstract developmental theory to a very dynamic and rapidly developing branch of molecular biology. This volume represents a compilation of our current understanding about the key aspects of epigenetic processes in the brain and their role in behavior. The chapters in this book bring together some of the leading researchers in the field of behavioral epigenetics. They explore many of the epigenetic processes which operate or may be operating to mediate neurobiological functions in the brain and describe how perturbations to these systems may play a key role in mediating behavior and the origin of brain diseases.
Categories: Medical

Life as We Do Not Know It

Life as We Do Not Know It

What about DNA? When did it first appear? Could it have appeared before proteins so that it co-opted the “brainfunctions from RNA, relegating RNA to the ...

Author: Peter Ward

Publisher: Penguin

ISBN: 9781440628566

Category: Science

Page: 320

View: 818

An engrossing and revelatory first look at the search for alien life—on Earth and beyond For the past twenty years, Peter Ward has been at the forefront of popular science writing, with books such as the influential and controversial Rare Earth. In Life as We Do Not Know It, Ward, with his signature blend of eloquence, humor, and learned insight, vividly details the latest scientific findings, cutting-edge research, and intrepid new theories on the subject of alien life and the possible extraterrestrial origins of life on Earth. In lucid, entertaining, and bold prose, Peter Ward once again challenges our notions of life on earth (and beyond).
Categories: Science