Reverse Pharmacology

Reverse Pharmacology

Part B also includes chemical structures and unpublished material which are the salient features of this book.

Author: Amritpal Singh Saroya

Publisher: CRC Press

ISBN: 9781351712248

Category: Health & Fitness

Page: 210

View: 573

Reverse Pharmacology: Phytocannabinoids, Banned and Restricted Herbals will serve as a tailormade reference guide for the manufacturers and practitioners of herbal drugs. Part A deals with Reverse Pharmacology & Nanophytomedicine and Part B with Phytocannabinoids and description of banned or restricted herbal drugs. Part B also includes chemical structures and unpublished material which are the salient features of this book. The work is an invaluable resource for professionals in the manufacturing of herbal and pharmaceutical products as well as those persons in regulatory affairs.
Categories: Health & Fitness

Reverse Pharmacology

Reverse Pharmacology

CHAPTER 3 Reverse Pharmacology and Ayurvedic Medicine 3.1 Definition Reverse pharmacology is the science of integrating documented clinical/experiential ...

Author: Amritpal Singh Saroya

Publisher: CRC Press

ISBN: 9781351712255

Category: Health & Fitness

Page: 210

View: 499

Reverse Pharmacology: Phytocannabinoids, Banned and Restricted Herbals will serve as a tailormade reference guide for the manufacturers and practitioners of herbal drugs. Part A deals with Reverse Pharmacology & Nanophytomedicine and Part B with Phytocannabinoids and description of banned or restricted herbal drugs. Part B also includes chemical structures and unpublished material which are the salient features of this book. The work is an invaluable resource for professionals in the manufacturing of herbal and pharmaceutical products as well as those persons in regulatory affairs.
Categories: Health & Fitness

Pharmacology

Pharmacology

The search for new pharmacological agents historically has followed two general pathways: forward pharmacology and reverse pharmacology (Figure 21.2).

Author: Miles Hacker

Publisher: Academic Press

ISBN: 0080919227

Category: Medical

Page: 608

View: 410

Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool
Categories: Medical

Chinese Herbal Drug Research Trends

Chinese Herbal Drug Research Trends

... a series of research work surrounding the pharmacological mechanism of the ... from reverse pharmacology was applied in this pharmacological study .

Author: Felix M. Ching

Publisher: Nova Publishers

ISBN: 1600219284

Category: Health & Fitness

Page: 267

View: 782

Chinese Herbal Medicine -- part of a larger healing system called Traditional Chinese Medicine (TCM), which also includes acupuncture, massage dietary advice and exercise. TCM is a popular method of treatment -- is actually called Chinese Drug Therapy in China because it uses a wide variety of substances and therapeutic modalities. Plant, animal and mineral substances are all included in the Materia Medica of Chinese Drug Therapy. The earliest uses date back at least 4000 years to the Shang dynasty. Characters representing medicinal substances have been found carved into oracular bone fragments. These were used diagnostically by the Wu Shaman of this time. The earliest materia Medica, the Sheng Nung Peng Tsao, recorded over 10,000 medicinal substances. While there seems to be an almost unlimited amount of medicinal substances, the most commonly used number around 200. Increased attention has begun being given to the field due to several factors: The apparent success stories in many cases; The failure of Western medicine in many disorders; and Realisation on the part of Western researchers that successful drugs can be designed on the basis of Chinese herbal drugs. This new book presents the latest research in the field.
Categories: Health & Fitness

GPCR Molecular Pharmacology and Drug Targeting

GPCR Molecular Pharmacology and Drug Targeting

Reverse Pharmacology From the early days of GPCR cDNA cloning in the late 1980s until now, the reverse pharmacology strategy participated in the ...

Author: Annette Gilchrist

Publisher: John Wiley & Sons

ISBN: 1118035178

Category: Medical

Page: 544

View: 770

G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.
Categories: Medical

Evidence Based Validation of Traditional Medicines

Evidence Based Validation of Traditional Medicines

Indication Type 2 diabetes mellitus Table 22.6 Leads and indication from reverse pharmacology Plants Activity/lead Enicostemma littorale Antioxidant DNA ...

Author: Subhash C. Mandal

Publisher: Springer Nature

ISBN: 9789811581274

Category: Electronic books

Page: 1134

View: 771

Categories: Electronic books

Ethnopharmacology

Ethnopharmacology

Reverse pharmacology is a research strategy based on observations of traditional treatments that is a trans-disciplinary approach integrating traditional ...

Author: Michael Heinrich

Publisher: John Wiley & Sons

ISBN: 9781118930731

Category: Medical

Page: 464

View: 745

Ethnopharmacology is one of the world’s fastest-growing scientific disciplines encompassing a diverse range of subjects. It links natural sciences research on medicinal, aromatic and toxic plants with socio-cultural studies and has often been associated with the development of new drugs. The Editors of Ethnopharmacology have assembled an international team of renowned contributors to provide a critical synthesis of the substantial body of new knowledge and evidence on the subject that has emerged over the past decade. Divided into three parts, the book begins with an overview of the subject including a brief history, ethnopharmacological methods, the role of intellectual property protection, key analytical approaches, the role of ethnopharmacology in primary/secondary education and links to biodiversity and ecological research. Part two looks at ethnopharmacological contributions to modern therapeutics across a range of conditions including CNS disorders, cancer, bone and joint health and parasitic diseases. The final part is devoted to regional perspectives covering all continents, providing a state-of-the –art assessment of the status of ethnopharmacological research globally. A comprehensive, critical synthesis of the latest developments in ethnopharmacology. Includes a section devoted to ethnopharmacological contributions to modern therapeutics across a range of conditions. Contributions are from leading international experts in the field. This timely book will prove invaluable for researchers and students across a range of subjects including ethnopharmacology, ethnobotany, medicinal plant research and natural products research. Ethnopharmacology- A Reader is part of the ULLA Series in Pharmaceutical Sciences www.ullapharmsci.org
Categories: Medical

Evidence Based Validation of Herbal Medicine

Evidence Based Validation of Herbal Medicine

Drug discovery and development: Conventional versus reverse pharmacology approach Discovery phase Conventional: Time, investment and risk intensive ...

Author: Pulok K. Mukherjee

Publisher: Elsevier

ISBN: 9780128009963

Category: Medical

Page: 556

View: 430

Evidence-Based Validation of Herbal Medicines brings together current thinking and practice in the areas of characterization and validation of natural products. This book reviews all aspects of evaluation and development of medicines from plant sources, including their cultivation, collection, phytochemical and phyto-pharmacological evaluation, and therapeutic potential. Emphasis is placed on describing the full range of evidence-based analytical and bio-analytical techniques used to characterize natural products, including –omic technologies, phyto-chemical analysis, hyphenated techniques, and many more. Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques Covers biosynthesis, synthesis, and biological activity related to natural products Consolidates information to save time and money in research Increases confidence levels in quality and validity of natural products
Categories: Medical

Herbalism Phytochemistry and Ethnopharmacology

Herbalism  Phytochemistry and Ethnopharmacology

Chapter 2 Reverse Pharmacology 2.1 Introduction Reverse pharmacology is the science of integrating documented clinical/ experiential hits, into leads by ...

Author: Amritpal Singh

Publisher: CRC Press

ISBN: 9781439853610

Category: Health & Fitness

Page: 440

View: 264

Bridging the gap between the ancient art of herbalism and the emerging sciences of ethnopharmocology and phytopharmacotherapy, this book highlights the major breakthroughs in the history of the field and focuses on future directions in the discovery and application of herb-derived medicines. Implementing the concept of reverse pharmacology, it inte
Categories: Health & Fitness

Botanical Drug Products

Botanical Drug Products

In current circumstances techniques like Reverse Pharmacology and Translational Medicine can be helpful in designing new drugs and cut down the risk of drug ...

Author: Jayant N. Lokhande

Publisher: CRC Press

ISBN: 9781315352282

Category: Health & Fitness

Page: 274

View: 858

Botanicals, which have been part of human food and medicine for thousands of years, are perceived as being safer than synthetic pharmaceuticals. The global botanical drug market was expected to reach $26.6 billion by 2017. In terms of FDA regulations, botanical drugs are no different from non-botanical products, having to meet the safety and effectiveness standards of a new drug in accordance. This book comprises a complete start-to-end process from drug-idea conception, to drug development process.
Categories: Health & Fitness

Reverse Pharmacology on Corydalis Yanhusuo

Reverse Pharmacology on Corydalis Yanhusuo

In the first part of the dissertation, a traditional Chinese medicine, Corydalis yanhusuo, which is widely used for pain treatment, was systematically evaluated in three standardized pain assays and its mechanism of action in terms of ...

Author: Lien Wang

Publisher:

ISBN: 1339527200

Category:

Page: 203

View: 786

In the first part of the dissertation, a traditional Chinese medicine, Corydalis yanhusuo, which is widely used for pain treatment, was systematically evaluated in three standardized pain assays and its mechanism of action in terms of antinociceptive effects was further studied. The results show that Corydalis yanhusuo extract effectively attenuates acute nociceptive pain, persistent inflammatory pain and chronic neuropathic pain, without causing tolerance. The effects on acute and neuropathic pain but not inflammatory pain are at least partially mediated through dopamine D2 receptor antagonism. By applying pharmacological approach which is used to identify compounds acting at G protein-coupled receptors, one compound, dehydrocorybulbine (DHCB) was identified from Corydalis yanhusuo extact. DHCB was synthesized and it is shown displaying weak mu-opioid receptor agonist and moderate dopamine receptor antagonist activities. DHCB is effective at alleviating thermally induced acute pain. By using selective pharmacological compounds and dopamine receptor knockout mice, the results show that the antinociceptive effect relies upon DHCB's antagonist activity at the dopamine D2 receptor but not on its agonist activity at ?-opioid receptor. DHCB is further demonstrated to be effective against inflammatory pain and injury-induced neuropathic pain and furthermore causes no antinociceptive tolerance. Moreover, the antipsychotic effects of DHCB were evaluated by using apomorphine and MK-801 induced schizophrenia-like symptoms in mice and the extended pharmacological profile of DHCB was screened through radioligand receptor binding assays. DHCB is shown effectively attenuating positive, negative and cognitive symptoms in apomorphine and MK-801 induced animal models of schizophrenia. These effects are thought to be mediated through dopamine receptor antagonism but also other receptor activities such as serotonin-7 and sigma-1 receptors. In the second part of the dissertation, administration of l-methionine to adult mice for 7 days induces behavioral responses that reflect three types of schizophrenia-like symptoms. These responses are differentially reversed by typical and atypical antipsychotics in ways that parallel their effects in schizophrenics. Further, the male offspring from the prenatal l-methionine treatment exhibit behavioral responses that reflect three types of schizophrenia-like symptoms. Moreover, these mice show reduced excitatory synaptic connection and dysregulated expression of several neuronal activity-regulated genes that are known to be involved in the neurodevelopment, synaptic plasticity and learning and memory function.
Categories:

Ethnobotany of India 5 Volume Set

Ethnobotany of India  5 Volume Set

14.5.1 REVERSE PHARMACOLOGY Ethnopharmacology not only applies forward-translational research but also back-translational research, starting with ...

Author: T. Pullaiah

Publisher: CRC Press

ISBN: 9781351737661

Category: Medical

Page: 2242

View: 760

This new 5-volume set, Ethnobotany of India, provides an informative overview of human-plant interrelationships in India, focusing on the regional plants and their medicinal properties and uses. Each volume focuses on a different significant region of India, including Volume 1: Eastern Ghats and Deccan Volume 2: Western Ghats and West Coast of Peninsular India Volume 3: North-East India and Andaman and Nicobar Islands Volume 4: Western and Central Himalaya Volume 5: The Indo-Gangetic Region and Central India With chapters written by experts in the field, the book provides comprehensive information on the tribals (the indigenous populations of the region) and knowledge on plants that grow around them. Each volume includes an introductory chapter with an overview of the region and then goes on to cover ethnic diversity and culture of the ethnic tribes plants used for healing and medical purposes for humans and animals ethnic food plants and ethnic food preparation specific information on the ethnomedicinal plants, the parts used, and the diseases cured other uses of plants by the ethnic tribes, such as for fiber, dyes, flavor, and recreation conservation, documentation, and management efforts of the ethnic communities and their plant knowledge The books include the details of the plants used, their scientific names, the parts used, and how the plants are used, providing the what, how, and why of plant usage. The volumes are well illustrated with over 100 color and 130 b/w illustrations. Together, the five volumes in the Ethnobotany of India series bring together the available ethnobotanical knowledge of India in one place. India is one of the most important regions of the old world, and its ancient and culturally rich and diverse knowledge of ethnobotany will be valuable to many in the fields of botany and plant sciences, pharmacognosy and pharmacology, nutraceuticals, and others. The books also consider the threat to plant biodiversity imposed by environmental degradation, which impacts cultural diversity.
Categories: Medical

Herbal Drugs and Fingerprints

Herbal Drugs and Fingerprints

Table 1.4 Search for new pharmacological agents; general pathways [14] Fig. ... In reverse pharmacology approach process, safety remains the most important ...

Author: Devi Datt Joshi

Publisher: Springer Science & Business Media

ISBN: 9788132208044

Category: Medical

Page: 252

View: 285

Evidence based herbal drugs are on hi-acceptance day by day due to health friendly nature compared to synthetic drugs. The active ingredients in herbal drugs are different chemical classes, e.g. alkaloids, coumarins, flavonoids, glycosides, phenols, steroids, terpenes etc., are identified at molecular level using current analytical practices, which are unique characteristic, as finger, so known as fingerprints. The fingerprints are used for assessment of quality consistency and stability by visible observation and comparison of the standardized fingerprint pattern, have scientific potential to decipher the claims made on these drugs for authenticity and reliability of chemical constituents, with total traceability, which starts from the proper identification, season and area of collection, storage, their processing, stability during processing, and rationalizing the combinational in case of polyherbal drugs. These quality oriented documents have ample scientific logics so well accepted globally by regulatory authorities and industries, to determine intentional/ unintentional contamination, adulteration, pollutants, stability, quality, etc. parameters. Based on geo-climatic factors, a same plant species has different pharmacological properties due to different ingredients; such regional and morphological variations are identified by fingerprints, at the time of collection of the medicinal herb. The chromatographic (TLC, HPTLC, HPLC, GC,) and spectral (UV-Vis., FTIR, MNR, MS, LC-MS, GC-MS etc.) techniques have world-wide strong scientific approval as validated methods to generate the fingerprints of different chemical classes of active ingredients of herbal drugs. Presently there is a need for a book having all the fingerprinting techniques for herbal drugs at a place with theory, case studies and art to discover patentable forms. The present book is a mile stone in the subject, to be utilized by Scientists, Medical Doctors, Technicians, Industrialists, Researchers, and Students both in PG and UG levels.
Categories: Medical

Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery

In: Proceedings of the ICMR Strategic Thrust Symposium on Translational Research and Reverse Pharmacology. The Interface of Basic Sciences with Traditional ...

Author: Bhushan Patwardhan

Publisher: Academic Press

ISBN: 9780128018224

Category: Medical

Page: 480

View: 758

Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery
Categories: Medical

Making Medicines in Africa

Making Medicines in Africa

Opportunities for reverse pharmacology and traditional medicine for local drug development Reverse pharmacology Reverse pharmacology (RP) integrates ...

Author: Maureen Mackintosh

Publisher: Springer

ISBN: 9781137546470

Category: Political Science

Page: 334

View: 356

This book is open access under a CC-BY license. The importance of the pharmaceutical industry in Sub-Saharan Africa, its claim to policy priority, is rooted in the vast unmet health needs of the sub-continent. Making Medicines in Africa is a collective endeavour, by a group of contributors with a strong African and more broadly Southern presence, to find ways to link technological development, investment and industrial growth in pharmaceuticals to improve access to essential good quality medicines, as part of moving towards universal access to competent health care in Africa. The authors aim to shift the emphasis in international debate and initiatives towards sustained Africa-based and African-led initiatives to tackle this huge challenge. Without the technological, industrial, intellectual, organisational and research-related capabilities associated with competent pharmaceutical production, and without policies that pull the industrial sectors towards serving local health needs, the African sub-continent cannot generate the resources to tackle its populations' needs and demands. Research for this book has been selected as one of the 20 best examples of the impact of UK research on development. See http://www.ukcds.org.uk/the-global-impact-of-uk-research for further details.
Categories: Political Science

Green Chemistry Strategies for Drug Discovery

Green Chemistry Strategies for Drug Discovery

Several broad questions are often posed when comparing reverse pharmacology to rational drug discovery. These questions are: Are medicines from traditional ...

Author: Emily A. Peterson

Publisher: Royal Society of Chemistry

ISBN: 9781849739610

Category: Medical

Page: 322

View: 164

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Edited by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Currently employed as well as emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery. Moreover, important surrounding issues such as intellectual property are included. This book will serve as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.
Categories: Medical

Ethnobotany of India Volume 2

Ethnobotany of India  Volume 2

6.7.2 REVERSE PHARMACOLOGY The traditional knowledgeinspired reverse pharmacology described here relates to reversing the routine 'laboratorytoclinic' ...

Author: T. Pullaiah

Publisher: CRC Press

ISBN: 9781315341927

Category: Medical

Page: 368

View: 819

This is the second of a five-volume set. This series of volumes on the ethnobotany of different regions of India melds important knowledge in one place. India is one of the most important regions of the old world and has culturally rich and diverse knowledge systems. The expert authors have been selected to summarize information on the various aspects of ethnobotany of India, such as ethnoecology, traditional agriculture, cognitive ethnobotany, material sources, traditional pharmacognosy, ethnoconservation strategies, bioprospection of ethnodirected knowledge, and protection of ethnobotanical knowledge.
Categories: Medical

Essential CNS Drug Development

Essential CNS Drug Development

Identifying (NS drug targets Reverse pharmacology and multi-target agents ... pharmacological understanding of the mechanism of action of known agents.

Author: Amir Kalali

Publisher: Cambridge University Press

ISBN: 9781139576529

Category: Medical

Page:

View: 637

Central Nervous System disorders have an enormous impact on individuals and on society as a whole. The development of better treatments is crucial and is a major focus of pharmaceutical and biotechnology companies. This book explains the complicated process of CNS drug development in a way that is engaging for any interested professional or student. Chapters cover each stage of drug development, from pre-clinical research through all phases of clinical trials, to reporting to the regulatory authorities. Other key issues covered include strategic considerations, regulatory constraints, dissemination of results and ethical considerations. The user-friendly format and style enable readers to find important information quickly and easily. Written and edited by experts from different sectors actively engaged in CNS drug development, this is a unique resource for drug developers, investigators, academics and clinicians.
Categories: Medical

Artemisia annua Pharmacology and Biotechnology

Artemisia annua   Pharmacology and Biotechnology

Frank van der Kooy 14.1 Introduction 14.1.1 Drug Discovery and Reverse Pharmacology There are various ways in which new drugs can be developed.

Author: Tariq Aftab

Publisher: Springer Science & Business Media

ISBN: 9783642410277

Category: Science

Page: 292

View: 420

Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.
Categories: Science