Redox Genome Interactions in Health and Disease

Redox Genome Interactions in Health and Disease

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a ...

Author: Jürgen Fuchs

Publisher: CRC Press

ISBN: 0824740483

Category: Medical

Page: 640

View: 688

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.
Categories: Medical

Redox Genome Interactions in Health and Disease

Redox Genome Interactions in Health and Disease

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a ...

Author: Jürgen Fuchs

Publisher: CRC Press

ISBN: 9780824756611

Category: Medical

Page: 640

View: 803

At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.
Categories: Medical

Resveratrol in Health and Disease

Resveratrol in Health and Disease

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases, edited by Luc Montagnier, René Olivier, and Catherine Pasquier 2. ... edited by Catherine A. RiceEvans and Lester Packer RedoxGenome Interactions in Health and Disease, ...

Author: Bharat B. Aggarwal

Publisher: CRC Press

ISBN: 9781000611182

Category: Medical

Page: 712

View: 429

Practicing evidenced-based medicine some 25 centuries ago, Hippocrates proclaimed "Let food be thy medicine and medicine be thy food." This advice parallels the common American saying, "You are what you eat," and is supported by a National Institute of Health recommendation to consume as many as eight servings of fruits and vegetables daily to prev
Categories: Medical

Hydrogen Peroxide Metabolism in Health and Disease

Hydrogen Peroxide Metabolism in Health and Disease

RedoxGenome Interactions in Health and Disease, edited by Jürgen Fuchs, Maurizio Podda, and Lester Packer 11. Thiamine: Catalytic Mechanisms in Normal and Disease States, edited by Frank Jordan and Mulchand S. Patel 12.

Author: Margreet C M Vissers

Publisher: CRC Press

ISBN: 9781498776165

Category: Medical

Page: 456

View: 365

Much of the biology of oxidative stress and oxidative signalling centres on the generation and handling of hydrogen peroxide. The overall aim for this book would be to provide an insightful and useful forum to assist with the understanding of the relevance of hydrogen peroxide generation and how this is managed in human biology. The target audience would be those who currently have an interest in the generation of ROS, but who do not have expertise in chemistry, as well as those experts in the chemistry of oxidative stress, but without detailed understanding of the biologically relevant setting. We would aim to bridge the gap in understanding between chemistry and biology.
Categories: Medical

Phytochemicals in Health and Disease

Phytochemicals in Health and Disease

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases, edited by Luc Montagnier, René Olivier, and Catherine ... RedoxGenome Interactions in Health and Disease, edited by Jürgen Fuchs, Maurizio Podda, and Lester Packer 11.

Author: Yongping Bao

Publisher: CRC Press

ISBN: 9780824751876

Category: Medical

Page: 384

View: 385

"... well-written and the content is clearly presented. ... There are plentiful figures and tables, which are effectively labeled and adequately support the content. ...highly recommended for academic and special libraries. ...effectively presents current research on phytochemicals in a readable manner." - E-Streams "This landmark volume shows how far the field has advanced ... . This important volume is filled with reports on what the editors term as the 'new era' in the study of phytochemicals, in which we move from the 'eat more vegetable and fruit' admonition to more detailed information on the biology, molecular biology, regulatory function, and role in human health of phytochemicals. ... All workers in phytochemicals should get themselves a copy of this valuable book."
Categories: Medical

Hormesis in Health and Disease

Hormesis in Health and Disease

... edited by Catherine A. Rice-Evans and Lester Packer RedoxGenome Interactions in Health and Disease, edited by Jürgen Fuchs, Maurizio Podda, and Lester Packer Thiamine: Catalytic Mechanisms in Normal and Disease States, ...

Author: Suresh I. S. Rattan

Publisher: CRC Press

ISBN: 9781482205466

Category: Medical

Page: 382

View: 401

Some mild stresses have positive effects on survival and aging as shown in animal models. There is also a large body of research that demonstrates these hormetic effects on aging, health, and resistance to severe stresses and diseases in human beings. However, the data are dispersed in the literature and are not always interpreted as hormetic effects. Hormesis in Health and Disease reviews the evidence for hormesis in humans as achieved through a variety of stresses or stimuli, and discusses mechanisms of hormesis and its ethical and legal issues. Divided into four sections, this book presents the current state of research, including questions, debates, doubts, and controversies in hormesis. Section I covers the history and terminology of hormesis, describing its main features and providing necessary background information. Section II shows that hormetic effects can be caused by various stresses—including physical exercise, nutritional components, fasting, micronutrients, irradiation, heat, ischemia, and mental challenge—and can be observed both in organs and at the organism level. Section III reviews possible mechanisms of hormesis that have been elucidated at this point. Section IV discusses the wider consequences hormesis may have for everyone. This book demonstrates that health beneficial hormetic effects do exist in human beings. It offers information to inspire key players to initiate new strategies to elucidate the strengths and limits of the dual nature of stress.
Categories: Medical

Lipid Oxidation in Health and Disease

Lipid Oxidation in Health and Disease

... edited by Catherine A. Rice-Evans and Lester Packer RedoxGenome Interactions in Health and Disease, edited by Jürgen Fuchs, Maurizio Podda, and Lester Packer Thiamine: Catalytic Mechanisms in Normal and Disease States, ...

Author: Corinne M. Spickett

Publisher: CRC Press

ISBN: 9781482202861

Category: Medical

Page: 440

View: 887

Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.
Categories: Medical

Mitochondria in Health and Disease

Mitochondria in Health and Disease

... edited by Catherine A. Rice-Evans and Lester Packer RedoxGenome Interactions in Health and Disease, edited by Jürgen Fuchs, Maurizio Podda, and Lester Packer Thiamine: Catalytic Mechanisms in Normal and Disease States, ...

Author: Carolyn D. Berdanier

Publisher: CRC Press

ISBN: 9781420028843

Category: Medical

Page: 640

View: 581

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.
Categories: Medical

Diversity of Selenium Functions in Health and Disease

Diversity of Selenium Functions in Health and Disease

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases, edited by Luc Montagnier, René Olivier, and Catherine Pasquier 2. ... edited by Catherine A. Rice-Evans and Lester Packer RedoxGenome Interactions in Health and Disease, ...

Author: Regina Brigelius-Flohe

Publisher: CRC Press

ISBN: 9781482251272

Category: Medical

Page: 430

View: 808

Named after Selene, Greek goddess of the moon, selenium (Se) has moved has moved from being thought of as a toxicant to being considered an essential nutrient with the potential to reduce cancer risk in the span of seven decades. Diversity of Selenium Functions in Health and Disease focuses on current knowledge of aspects of Se research relevant to its medical use, and particularly to chemoprevention of cancer. It covers how Se is integrated into selenoproteins, selenium compounds with individual functions and dual functions, and unexpected links to Se such as with diabetes. The text ends with a discussion of polymorphisms and mutations in genes of selenoproteins. The chapters elucidate why studies undertaken to prevent diseases with selenium ended with disappointing outcomes and often with the opposite result, i.e. disease promotion. They show that benefit, failure, or side effects depend on: The chemical form and dose of selenium The selenium status of the individual ingesting selenium The capacity of selenium form to serve as a source for selenoprotein biosynthesis The function of selenoproteins reacting to a change in the selenium status The stage of the disease (mainly cancer) at the time point of intervention The genetic background of individuals to be treated Bringing together the accumulated evidence regarding selenium biochemistry, the book covers aspects not found in available general monographs. The narrow focus on medical uses of Se helps resolve the present confusion about potential benefits and hazards of selenium in human health. The book gives you a solid scientific basis for optimum use of selenium in preventing or treating human diseases and answering the questions: Why is selenium essential? How much is required? What are the health consequences of low selenium and can selenium reduce cancer risk?
Categories: Medical

Mitochondrial Signaling in Health and Disease

Mitochondrial Signaling in Health and Disease

Flavonoids in Health and Disease: Second Edition, Revised and Expanded, edited by Catherine A. Rice-Evans and Lester Packer RedoxGenome Interactions in Health and Disease, edited by Jürgen Fuchs, Maurizio Podda, and Lester Packer ...

Author: Sten Orrenius

Publisher: CRC Press

ISBN: 9781439880029

Category: Medical

Page: 528

View: 330

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Categories: Medical