Protein Actions Principles and Modeling

Protein Actions  Principles and Modeling

These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.

Author: Ivet Bahar

Publisher: Garland Science

ISBN: 9781351815017

Category: Science

Page: 336

View: 916

Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
Categories: Science

Principles of Protein Structure

Principles of Protein Structure

Author: Ivet Bahar

Publisher: Garland Science

ISBN: 0815341776

Category: Science

Page: 544

View: 654

Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
Categories: Science

IRC SET 2018

IRC SET 2018

Protein actions: Principles and modeling. New York: Garland Science. 4. Hendry,
E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R. V., Lapthorn, A. J., et al.
(2010). Ultrasensitive detection and characterization of biomolecules using ...

Author: Huaqun Guo

Publisher: Springer Nature

ISBN: 9789813298286

Category: Medical

Page: 427

View: 279

This book highlights cutting-edge research in multidisciplinary areas of Engineering, Physics, Medicine and Healthcare presented at the 4th IRC Conference on Science, Engineering and Technology (IRC-SET 2018), which was held at the Agency for Science Technology and Research (A*STAR), Singapore. The book also contains excerpts of the speeches made by eminent personalities who attended the occasion, thereby providing a written documentation of the event.
Categories: Medical

Molecular Modeling

Molecular Modeling

Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling calculations.

Author: Hans-Dieter Höltje

Publisher: John Wiley & Sons

ISBN: 9783527614769

Category: Science

Page: 206

View: 297

Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling calculations. Its main objective is the description of the various pitfalls to be avoided. Without unnecessary overhead it leads the reader from simple calculations on small molecules to the modeling of proteins and other relevant biomolecules. A textbook for beginners as well as an invaluable reference for all those dealing with molecular modeling in their daily work!
Categories: Science

Principles of Protein Structure

Principles of Protein Structure

The following sections discuss known mechanisms of protein action using
enzymes as examples. ... and enzyme (section 10.2, page 209) and the catalytic
process itself which is described in terms of chemical “model” reactions (see
below).

Author: G.E. Schulz

Publisher: Springer Science & Business Media

ISBN: 9781461261377

Category: Science

Page: 320

View: 556

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical thermodynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses.
Categories: Science

Introduction to Proteins

Introduction to Proteins

This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways.

Author: Amit Kessel

Publisher: CRC Press

ISBN: 1439810729

Category: Medical

Page: 654

View: 794

As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
Categories: Medical

Dictionary of Scientific Principles

Dictionary of Scientific Principles

PALAIS-SMALE CONDITION Conte's Principle; Fermat's Principle; Least Time
Principle; Principle of Caratheodony; ... Principle of Information; Frieden-Soffer
Principle; Gibbs Principle; Inference Principle; Internal Model Principle; Jaynes' ...
Schwinger's Quantum Action Principle PARASITOLOGY Hopkins' Host Selection
Principle; Host Selection Principle; Similia Principle of Homeopathy
PARATHYROID HORMONE RELATED PROTEIN Type II Cell Stretch-organizing
Principle; Timing ...

Author: Stephen Marvin

Publisher: John Wiley & Sons

ISBN: 9781118582398

Category: Science

Page: 648

View: 758

Dictionary of Scientific Principles presents a unique and timeless collection of (almost) all known rules or laws commonly called principles, identified throughout the history of scientific development, their definition, and use. Exploring a broad range of disciplines, the book first lists more than 2,000 principles organized in a standard alphabetical order, then provides a list of subject headings for which related principles are identified. A staple addition to every library, the dictionary will also be of interest to scientists and general readers.
Categories: Science

Electron Paramagnetic Resonance

Electron Paramagnetic Resonance

8 EPR and ENDOR of Metalloproteins BY J. HÚTTERMANN AND R. KAPPL 1
Introduction The elucidation of structural and electronic aspects of the metal ion
coordination in metalloproteins and related model compounds is a topic of
widespread interest. ... of electronic and spatial structures of metal ions and their
ligands or of mechanistic aspects of protein action. ... The metal ion has proven to
be a useful order-principle in sorting the data despite its limits in mixed metalion
proteins.

Author: M. J. Davies

Publisher: Royal Society of Chemistry

ISBN: 0854043101

Category: Reference

Page: 346

View: 740

Reflecting the growing volume of published work in this field, researchers will find this book an invaluable source of information on current methods and applications.
Categories: Reference

Principles of Endocrine Pharmacology

Principles of Endocrine Pharmacology

It has been proposed that the early actions of thyroid hormone are due principally
to protein synthesis brought about by ... In vitro experimental models have
provided evidence of interactions between the iodothyronines and the
mitochondria.

Author: John A. Thomas

Publisher: Springer Science & Business Media

ISBN: 9781468450361

Category: Medical

Page: 310

View: 972

The authors have provided an overview of the relationships between hormones that are physiologic constituents of the body as well as their pharmacologic use in replacement therapies and related endocrine dys function. Principles of Endocrine Pharmacology concerns itself with the ther apeutic use of hormones, and hormone like substances, or drugs that can act either by suppressing or enhancing the metabolism of certain glands of internal secretion. Other drugs used for nonendocrine ther apies can likewise affect the endocrine system. Endocrine pharmacology emerged in the early 1900s with the use of crude pituitary extracts. By the mid-1900s several investigators had isolated and begun to synthesize hormones or hormonelike substances. Recognizing the limited supply of hormones that could be obtained both from animal sources and human autopsy material, the search for so called hormone substitutes also began early in the 1900s. Recently, re combinant DNA technologies have been used to provide alternative therapeutic sources of human insulin and human growth hormone. Aside from insulin, perhaps no other use of hormonally-active sub stance is better exemplified by those drugs which affect fertility. The synthesis of an orally-effective steroid represented one of the first major breakthroughs in the chemical suppression of ovulation. Since the orally active 19-norsteroids were introduced in the 1950s, several oral contra ceptive steroid preparations have been marketed. Indeed, the advent of oral contraceptives for birth control has led to a renewed interest in endocrine pharmacology.
Categories: Medical

Molecular Basis for Microcirculatory Disorders

Molecular Basis for Microcirculatory Disorders

In a canine model using pericardial injection, although sustained pericardial
VEGF expression was observed, it failed to improve ... trials with immunogenic
viral vectors, plasmid based DNA approaches have advantages for initial
therapeutic proof of principle. ... As a secreted, diffusible protein with a strong
efficiency in inducing angiogenesis, VEGF protein action is not limited to the
transfected cells.

Author: Geert W. Schmid-Schönbein

Publisher: Springer Science & Business Media

ISBN: 9782817807614

Category: Medical

Page: 625

View: 227

A large number of cardiovascular diseases are accompanied by inflammation. This volume on the molecular basis of microcirculatory disorders gives a comprehensive summary of key steps in the inflammatory cascade. Leading investigators present a state-of-the-art analysis of the molecular determinants of leukocyte-endothelial cell adhesion, mechanotransduction in endothelial and inflammatory cells, mechanisms of cell activation, microvascular apoptosis with applications to ischemia-reperfusion in the brain, the heart and in venous disease, diabetes and hypertension. The book provides the latest thinking in these important cardiovascular problems, with the most contemporary literature and a look at the increasingly complex events during inflammation. Molecular biology tools, microvascular and modern bioengineering analysis are seamlessly integrated into the analysis of clinical problems. The book helps not only newcomers to gain entry into the interesting problems associated with microvascular disorders, but lays the foundation for the design of new therapeutic interventions.
Categories: Medical

Principles of Molecular Oncology

Principles of Molecular Oncology

Mouse models confirm the antitumorigenic roles of TGF- signaling. ... Other
extracellular proteins can inhibit Wnt actions by competing for a Wnt coreceptor (
244), and glycoproteins are required for Wnts to interact productively with
receptors ...

Author: Miguel H. Bronchud

Publisher: Springer Science & Business Media

ISBN: 9781592596645

Category: Medical

Page: 709

View: 214

At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
Categories: Medical

Understanding Insulin Action

Understanding Insulin Action

Principles and Molecular Mechanisms J. Espinal ... In the first such model
glucose binds to a membrane protein — a classical receptor' — which transmits
this signal intracellularly to the various pathways involved in insulin secretion.

Author: J. Espinal

Publisher: Springer Science & Business Media

ISBN: 0412022613

Category: Science

Page: 129

View: 553

Every year between three and four hundred papers are published on the topic of insulin action. This extraordinary publication rate prevents any author from includ ing an exhaustive bibliography in any review or book. Perhaps due to this there is no single text that attempts to cover the effects and the mechanism of action of insulin. This book is such an attempt. I intend to present a review of the physiological effects of insulin, the pathology of defects in the action of insulin, and the current views on the mechanism of action of this hormone. I make no apology for the fact that the bibliography will not be extensive and that the amount of experimental detail and data discussed will be kept to a relevant minimum. This book is not intended for the expert in the field, but for the second- or third-year undergraduate and graduate student of medicine, biochemistry, physiology or related disciplines, and will be valuable as a reference source for research workers. The book is presented as a guide, a summary of the ideas and facts; it will present a reader with a foretaste of a fascinating and ever-changing field. I have attempted to be up-to-date with published research work. Any significant contributions to the field not included in the first draft have been added as footnotes. I assume a basic knowledge of the metabolic pathways of carbohydrates, fats and proteins.
Categories: Science

Principles and Practice of Spine Surgery

Principles and Practice of Spine Surgery

The use of coralline hydroxyapatite with bone marrow , autogenous bone graft ,
or osteoinductive bone protein extract for posterolateral ... 1999 . tion of bone
morphogenetic protein action during rat osteoblast differentiation in vitro ,
Endocrinology 137 : 3401 - 3407 , 1996 . 9 . ... invasive lumbar spinal fusion
technique in the rabbit and nonhuman primate ( rhesus ) models , Spine 21 :
2689 - 2697 , 1996 .

Author: Alexander R. Vaccaro

Publisher: Mosby Incorporated

ISBN: UOM:39015055888146

Category: Medical

Page: 864

View: 909

Here's all the practical, must-know information needed to diagnose and manage a full range of spinal disorders. Written with the busy practitioner in mind, this brand-new resource provides a comprehensive overview of contemporary spine surgery, focusing on the key information and procedures needed in the day-to-day practice of spine surgery. Features the expertise of 106 highly renowned clinicians from a wide range of disciplines including orthopaedics, neurosurgery, pediatric neurosurgery, pain management, rehabilitation, and more. Comprehensively covers the full range of spinal pathologies in adults and children. Presents information in brief, highly illustrated chapters, enabling readers to quickly find the information they need. User-friendly format features hundreds of boxes that highlight key concepts in the text. Includes a wealth of tables that summarize disease processes.Explores hot topics in the field such as spinal deformities in osteoporosis · spinal infections · primary spinal tumors · anterior minimally invasive techniques of the lumbar spine · and more. Provides a wealth of clear line drawings on surgical technique. With 112 additional contributors+
Categories: Medical

Revue roumaine de biochimie

Revue roumaine de biochimie

G. E. SCHULZ , R. H. SCHIRMER , Principles of Protein Structure , in Springer
Advanced Texts in Chemistry , C. R. Cantor , editor ... These principles are the
first step in understanding the relationships between the chemical structure and
the action of proteins in the organism . ... of folding and association of polypeptide
chains , prediction of secondary structure of proteins , models of protein
structures .

Author:

Publisher:

ISBN: UIUC:30112009724359

Category: Biochemistry

Page:

View: 930

Categories: Biochemistry

Protein Folding

Protein Folding

Various theoretical models have been given to elucidate protein folding
pathways and their principles. ... Protein folding is the cooperative action of
foldons (small unfolding/refolding units) which defines the unit steps in folding
pathway.

Author: Alka Dwevedi

Publisher: Springer

ISBN: 9783319125923

Category: Science

Page: 55

View: 813

The book will discuss classes of proteins and their folding, as well as the involvement of bioinformatics in solving the protein folding problem. In vivo and in vitro folding mechanisms are examined, as well as the failures of in vitro folding, a mechanism helpful in understanding disease caused by misfolding. The role of energy landscapes is also discussed and the computational approaches to these landscapes.
Categories: Science

The Principles of Physiology

The Principles of Physiology

See also entries under Bioenergetics ; Catalysis ; Metabolism ; Protein . action ,
mechanism , of 913 action , template or " lock and key , ” model of , 913 activators
of , 917 catalysis by , 14 , 48 , 927 classification of , 909 complex , 908 ...

Author: David Jensen

Publisher:

ISBN: UOM:39015004437201

Category: Mammals

Page: 1328

View: 547

Categories: Mammals

Engineering Principles in Physiology

Engineering Principles in Physiology

The instantaneous concentrations of FT3 and FT4 in the plasma (the outputs) are
determined by the net action of all of these ... An equivalent THBDD model is
illustrated diagrammatically in Fig. 4. ... completely because the rate at which
each of the thyroid hormones is bound to proteins depends on the instantaneous
free ...

Author: J. H. U. Brown

Publisher: Academic Press

ISBN: 9781483216645

Category: Medical

Page: 318

View: 579

Engineering Principles in Physiology, Volume I covers the various aspects of biomedical engineering. This volume is organized into three parts encompassing 12 chapters that consider a holistic approach to physiology and the principles of communication and control, including energy input and output. The first part deals with the physiological information and related concepts, as well as the overall integration in the living body. The second part highlights the communication integration of the central nervous system as a whole with the body's various sense organs. The third part focuses on the diversity of function and modeling of various glandular functions of the endocrine system. This part briefly deals with the cardiovascular system as a system of communication and control. This book will prove useful to physiologists, biomedical engineers, and workers in the related fields.
Categories: Medical

Anatomy and Physiology E Book

Anatomy and Physiology   E Book

For example, some hormone-receptor interactions initiate synthesis of new
proteins. ... the nucleoplasm, this model of hormone action has been called the
mobile-receptor model, or the nuclearreceptor model. ... Chapter 25 Endocrine
Regulation 567 How hormones work General principles of hormone action
Mechanism of ...

Author: Kevin T. Patton

Publisher: Elsevier Health Sciences

ISBN: 9780323316873

Category:

Page: 1264

View: 137

Anatomy and Physiology - E-Book
Categories:

Endocrinology E Book

Endocrinology   E Book

suggest that the C-terminal portion of PTH interacts specifically with a novel
receptor/binding protein that is distinct from the PTH1R. ... about the signal
transduction systems that might mediate the actions of these midregional/C-
terminal PTH fragments. ... might affect calcium homeostasis and other
physiologic processes remains to be determined, but in a rat model study, ... In
Bilezikian JP, Raisz lG, Rodan RA, editors: Principles of bone biology, New York,
1996, Academic Press. 6.

Author: J. Larry Jameson

Publisher: Elsevier Health Sciences

ISBN: 9781455711260

Category: Medical

Page: 3064

View: 779

ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.
Categories: Medical

Pediatric Allergy Principles and Practice E Book

Pediatric Allergy  Principles and Practice E Book

... 2,3-dioxygenase in murine models Produce a protein Transduction of protein
gene into target cells Adenoviral transfer of ... but the entire immune system, and
produce distant actions on unmodified and apparently unrelated components.

Author: Donald Y. M. Leung

Publisher: Elsevier Health Sciences

ISBN: 9781437737783

Category: Medical

Page: 704

View: 781

Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.
Categories: Medical