The small size and fast pace of “Pocket Guide to Biomolecular NMR” makes the book a perfect companion to traditional biophysics and biochemistry textbooks, but the book's unique perspective will provide even seasoned spectroscopists ...
Author: Michaeleen Doucleff
Publisher: Springer Science & Business Media
Steering clear of quantum mechanics and product operators, "Pocket Guide to Biomolecular NMR" uses intuitive, concrete analogies to explain the theory required to understand NMR studies on the structure and dynamics of biological macromolecules. For example, instead of explaining nuclear spin with angular momentum equations or Hamiltonians, the books describes nuclei as "bells" in a choir, ringing at specific frequencies depending on the atom type and their surrounding electromagnetic environment.This simple bell analogy, which is employed throughout the book, has never been used to explain NMR and makes it surprisingly easy to learn complex, bewildering NMR concepts, such as dipole-dipole coupling and CPMG pulse sequences. Other topics covered include the basics of multi-dimensional NMR, relaxation theory, and Model Free analysis. The small size and fast pace of “Pocket Guide to Biomolecular NMR” makes the book a perfect companion to traditional biophysics and biochemistry textbooks, but the book's unique perspective will provide even seasoned spectroscopists with new insights and handy “thought” short-cuts.
Mirau, P.K. A Practical Guide to Understanding the NMR of Polymers. New York,
USA, Wiley, 2004. For a light-hearted text on NMR spectroscopy, see Doucleff M,
Hatcher-Skeers, M, Crane NJ. Pocket guide to biomolecular NMR. New York ...
Author: Mu-Ping Nieh
Publisher: Walter de Gruyter GmbH & Co KG
The study of membranes has become of high importance in the fields of biology, pharmaceutical chemistry and medicine, since much of what happens in a cell or in a virus involves biological membranes. The current book is an excellent introduction to the area, which explains how modern analytical methods can be applied to study biological membranes and membrane proteins and the bioprocesses they are involved to.
The NMR experiments suggested that the ligands are highly dynamic in the
bound state, potentially explaining the unexpectedly low potency. ... derived from
such a study could be used to guide molecular-docking efforts even in the
absence of the sequential assignment. ... of myristate in its binding pocket and
the attendant activation of the enzyme.34 By selectively 15N-labelling valine
residues of Abl, ...
Author: Marius Clore
Publisher: Royal Society of Chemistry
NMR spectroscopy is widely used in biomolecular science particularly for structure determination of proteins, nucleic acids and carbohydrates. Much of the innovation within NMR spectroscopy has been within the field of protein NMR spectroscopy, an important technique in structural biology. Filling a gap in the literature, this book draws together experts in the field to discuss the real advances in NMR methods that have occurred or have an impact on the biomolecular field in the last few years. The coverage includes recent developments in using NMR for determination of protein structures, membrane proteins, the dynamics of RNA and advances in NMR in drug discovery. Edited by leading biological NMR spectroscopists, the book is essential reference for researchers in industry and academia interested in or joining this bioanalytical field.
Using deuteration to increase sensitivity to small amplitude dispersion profiles (
2H,15N-CypA) combined with high field NMR investigation at 900 ... of an
enzyme were evolutionarily selected for its catalytic function, which should help guide future protein engineering work. ... concentrated in the vicinity of the active
site pocket, flexible sites are nevertheless observed more than 20 Å away from
the catalytic ...
Author: Andrew J. Dingley
Publisher: IOS Press
Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful technique for characterization of biomolecular structures at atomic resolution in the solution state. This timely book, entitled "Biomolecular NMR Spectroscopy," focuses on the latest state-of-the-art NMR techniques for characterization of biological macromolecules in the solid and solution state. The editors, Dr. Andrew Dingley (University of Auckland, New Zealand) and Dr. Steven Pascal (Massey University, New Zealand) have organized the book into four sections, covering the following topics: sample preparation, structure and dynamics of proteins, structure and dynamics of nucleic acids and protein-nucleic acid complexes, and rapid and hybrid techniques--
New in 1995 Biomolecular NMR Spectroscopy Jeremy N.S. Evans • The first
textbook for students of chemistry and ... An Introduction to their electronic
structure and properties P.A. Cox ' ... the book can be recommended for all those
Solid - state 2H NMR data provided the orientation of retinal within the rhodopsin
binding pocket as well as its conformation . Extension of the approach to other
membrane receptors can yield knowledge of their mechanisms of activation as a guide for ligand - based drug design . Published ... Biomolecular applications of NMR typi - cally rely on the availability of suitable isotopically labeled compounds
The zymogen ' s low catalytic activity arises from a distortion of its specificity pocket and oxyanion hole , so that it is unable to productively bind substrate or
preferentially bind ... Structure - based drug design uses the X - ray and NMR
structures of drug candidates in complex with their target proteins , together with
a variety of molecular modeling tools , to guide the search for improved drug
Author: Donald Voet
Biochemistry is a modern classic that had been thoroughly revised. Explains biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. This edition has been updated to reflect the enormous advances in molecular and protein structure. Features a new chapter on nucleic acids, gene expression, and recombinant DNA technology, as well as a new chapter on nucleotide metabolism. Integrated Biochemical Interactions CD.
... to world cheeses 5917 ANEP 98 European Petroleum year book 6748 Angel ,
H. The Natural history of Britain and Ireland 2414 Angelé ... historical series 6753
Annual register of pharmaceutical chemists 3651 Annual reports on NMR
spectroscopy 1289 Annual reports on ... of astronomy and astrophysics 711
Annual review of biochemistry 2333 Annual review of biophysics and biomolecular structure ...
Author: Albert John Walford
Publisher: London : Library Association Pub.
A revised and updated guide to reference material. It contains selective and evaluative entries to guide the enquirer to the best source of reference in each subject area, be it journal article, CD-ROM, on-line database, bibliography, encyclopaedia, monograph or directory. It features full critical annotations and reviewers' comments and comprehensive author-title and subject indexes. The contents include: mathematics; astronomy and surveying; physics; chemistry; earth sciences; palaeontology; anthropology; biology; natural history; botany; zoology; patents and interventions; medicine; engineering; transport vehicles; agriculture and livestock; household management; communication; chemical industry; manufactures; industries, trades and crafts; and the building industry.
In addition , we now have a greater ability to understand drug action at the biomolecular level , and trial - and - error drug ... When one calculation takes that
long , you are not in a position to explore many Nuclear magnetic resonance ( NMR ) ... drug design is that biological knowledge at the molecular level can be
used to guide the drug discovery process . ... of the drug and the binding pocket
are complementary determines the degree of “ stickiness ” between the
molecules , as well as ...
Issues in General Science and Scientific Theory and Method: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science and Scientific Theory and Method.
Issues in General Science and Scientific Theory and Method: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science and Scientific Theory and Method. The editors have built Issues in General Science and Scientific Theory and Method: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Science and Scientific Theory and Method in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Science and Scientific Theory and Method: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
... is not available experimentally , was generated from the structure of isomer A
by rotating the heme about the a - y axis in the heme pocket ... We have also
performed MD simulations with two starting structures taken from the ensemble of
twelve NMR structures ... W. R. R .; Tironi , I. G. Biomolecular Simulations : The
GROMOS96 Manual and User Guide ; Hochschulverlag AG an der ETH Zürich ,