Physical Biology of the Cell

Author: Rob Phillips,Jane Kondev,Julie Theriot,Hernan Garcia

Publisher: Garland Science

ISBN: 1134111584

Category: Science

Page: 1088

View: 4777


Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that

Molecular Biology of the Cell, 5th Ed, 2008


Author: Garland Science

Publisher: Bukupedia


Category: Science

Page: 1725

View: 5671


In many respects,w e understand the structure of the universeb etter than the workings of living cells. Scientists can calculate the age of the Sun and predict when it will cease to shine, but we cannot explain how it is that a human being may live for eighty years but a mouse for only two. We know the complete genomes equenceso f thesea nd many other speciesb, ut we still cannot predict how a cell will behave if we mutate a previously unstudied gene. Stars may be l0a3 times bigger, but cells are more complex, more intricately structured, and more astonishingp roducts of the laws of physicsa nd chemistry.T hrough heredity and natural selection, operating from the beginnings of life on Earth to the presentd ay-that is, for about 20Voo f the ageo f the universe-living cellsh ave been progressively refining and extending their molecular machinery and recording the results of their experiments in the genetic instructions they pass on to their progeny. With each edition of this book, we marvel at the new information that cell biologists have gathered in just a few years. But we are even more amazed and daunted at the sophistication of the mechanisms that we encounter. The deeper we probe into the cell,t he more we reafizeh ow much remainst o be understood. In the days of our innocence, working on the first edition, we hailed the identification of a single protein-a signal receptol say-as a great step forward' Now we appreciate that each protein is generally part of a complexwith many others, working together as a system, regulating one another's activities in subtle ways, and held in specific positions by binding to scaffold proteins that give the chemical factory a definite spatial structure. Genome sequencing has given us virtually complete molecular parts-lists for many different organisms; genetics and biochemistry have told us a great deal about what those parts are capable of individually and which ones interact with which others; but we have only the most primitive grasp of the dynamics of these biochemical systems, with all their interlocking control loops. Therefore, although there are great achievements to report, cell biologistsf ace eveng reaterc hallengesf or the future. In this edition, we have included new material on many topics, ranging from epigeneticsh, istonem odificationss, mall RNAs,a nd comparativeg enomicst,o geneticn oise,c ytoskeletadl lmamics,c ell-cyclec ontrol, apoptosis,s tem cells, and novel cancer therapies. As in previous editions, we have tried above all to give readers a conceptual framework for the mass of information that we now have about cells. This means going beyond the recitation of facts. The goal is to learn how to put the facts to use-to reason, to predict, and to control the behavior of living systems. To help readers on the way to an active understanding, we have for the first time incorporatede nd-of-chapterp roblems,w ritten by Iohn Wilson and Tim Hunt. These emphasize a quantitative approach and the art of reasoning from experiments.A companion volume, MolecularB iologyo f the CelI,F ifth Edition: TheP roblemsB ook0 SBN9 78-0-8153-4110-9b)y, t he samea uthors,g ivesc omplete answerst o thesep roblemsa nd alsoc ontainsm ore than 1700a dditional problems and solutions. A further major adjunct to the main book is the attached Media DVD-ROM disc. This provides hundreds of movies and animations, including manythat are new in this edition, showing cells and cellular processesin action and bringing the text to life; the disc also now includes all the figures and tables from the main book,p re-loadedin to [email protected] esentationsO. thera ncillariesa vailablefo r the book include a bank of test questions and lecture outlines, available to qualified instructors,a nd a seto f 200f ull-coloro verheadtr ansparencies. Perhaps the biggest change is in the physical structure of the book. In an effort to make the standard Student Edition somewhat more portable, we are providing chapters 2r-25, covering multicellular systems, in electronic (pDF) form on the accompanying disc, while retaining in the printed volume chapters l-20, covering the core of the usual cell biology curriculum. But we should emphasize that the final chapters have been revised and updated as thoroughly as the rest of the book and we sincerely hope that they will be read! A Reference Edition (ISBN9 7s-0-8153-4r11-6c)o, ntainingt he full seto f chaptersa sp rinred pages, is also available for those who prefer it. Full details of the conventions adopted in the book are given in the Note to the Readert hat follows this PrefaceA. s explainedt here,w e have taken a drastic approach in confronting the different rules for the writing of gene names in different species: throughout this book, we use the same style, regardless of speciesa, nd often in defianceo fthe usuals pecies-specifcico nventions. As always,w e are indebted to many people. Full acknowledgmentsfo r scientific help are given separatelyb, ut we must here singleo ut somee xceptionally important contributions: Iulie Theriot is almost entirely responsible for chapters 16 (cytoskeleton)a nd 24 (PathogensI,n fection, and Innate Immunity), and David Morgan likewise for chapter 17 (cell cycle). wallace Marshall and Laura Attardi provided substantialh elp with chapters 8 and 20, respectively,a s did Maynardo lson for the genomicss ectiono f chapter4 ,X iaodongwangf or chapter 18, and Nicholas Harberd for the plant section of Chapter 15. we also owe a huge debt to the staff of Garland science and others who helped convert writers' efforts into a polished final product. Denise schanck directed the whole enterprise and shepherded the wayward authors along the road with wisdom, skill, and kindness. Nigel orme put the artwork into its final form and supervisedt he visuala spectso f the book,i ncluding the backc over,w ith his usual flair. Matthew Mcclements designed the book and its front cover. Emma Jeffcockla id out its pagesw ith extraordinarys peeda nd unflappablee fficiency, d ealingi mpeccablywith innumerablec orrections.M ichaelM oralesm anaged the transformation of a mass of animations, video clips, and other materials into a user-friendly DVD-ROM. Eleanor Lawrence and sherry Granum updatedand enlargedt he glossaryJ. ackieH arbor and SigridM assonk ept us organized. Adam Sendroffkept us aware ofour readers and their needs and reactions. Marjorie Anderson, Bruce Goatly, and sherry Granum combed the text for obscurities, infelicities, and errors. we thank them all, not only for their professional skill and dedication and for efficiency far surpassing our own, but also for their unfailing helpftrlnessa nd friendship:t hey havem adei t a pleasuret o work on the book. Lastly, and with no less gratitude, we thank our spouses, families, friends and colleaguesw. ithout their patient,e ndurings upport,w e couldn ot havep roduced any of the editions of this book. MolecularB iologyo f the Cell BruceA lberts AlexandeJro hnson JulianL ewis Martin Raff Keith Roberts PeteWr alter Withp roblemsb y John Wilson Tim Hunt GarlandS cience Taylo&r FranciGs roup

Biological Physics of the Developing Embryo

Author: Gabor Forgacs,Stuart A. Newman

Publisher: Cambridge University Press

ISBN: 9781139447317

Category: Science

Page: N.A

View: 8389


During development cells and tissues undergo changes in pattern and form that employ a wider range of physical mechanisms than at any other time in an organism's life. This book shows how physics can be used to analyze these biological phenomena. Written to be accessible to both biologists and physicists, major stages and components of the biological development process are introduced and then analyzed from the viewpoint of physics. The presentation of physical models requires no mathematics beyond basic calculus. Physical concepts introduced include diffusion, viscosity and elasticity, adhesion, dynamical systems, electrical potential, percolation, fractals, reaction-diffusion systems, and cellular automata. With full-color figures throughout, this comprehensive textbook teaches biophysics by application to developmental biology and is suitable for graduate and upper-undergraduate courses in physics and biology.

Using the Biological Literature

A Practical Guide, Fourth Edition

Author: Diane Schmidt

Publisher: CRC Press

ISBN: 1466558571

Category: Language Arts & Disciplines

Page: 412

View: 2170


The biological sciences cover a broad array of literature types, from younger fields like molecular biology with its reliance on recent journal articles, genomic databases, and protocol manuals to classic fields such as taxonomy with its scattered literature found in monographs and journals from the past three centuries. Using the Biological Literature: A Practical Guide, Fourth Edition is an annotated guide to selected resources in the biological sciences, presenting a wide-ranging list of important sources. This completely revised edition contains numerous new resources and descriptions of all entries including textbooks. The guide emphasizes current materials in the English language and includes retrospective references for historical perspective and to provide access to the taxonomic literature. It covers both print and electronic resources including monographs, journals, databases, indexes and abstracting tools, websites, and associations—providing users with listings of authoritative informational resources of both classical and recently published works. With chapters devoted to each of the main fields in the basic biological sciences, this book offers a guide to the best and most up-to-date resources in biology. It is appropriate for anyone interested in searching the biological literature, from undergraduate students to faculty, researchers, and librarians. The guide includes a supplementary website dedicated to keeping URLs of electronic and web-based resources up to date, a popular feature continued from the third edition.

Proceedings of the 240 Conference

Science's Great Challenges

Author: Aaron R. Dinner

Publisher: John Wiley & Sons

ISBN: 1118959612

Category: Science

Page: 368

View: 1701


Based on the '240' Conference held at the University of Chicagoin September of 2012, this special volume of The Advances inChemical Physics series celebrates scientific researchcontributions and careers of R. Stephen Berry, Stuart A. Rice andJoshua Jortner. In addition to continuing the chemicalphysics field with a forum for critical, authoritative evaluationsof advances in the discipline, Volume 157 exploresthe following topics: The Emergence and Breakdown of Complexity Dynamics at Extremes Grand Questions Regarding Biomolecular Homochirality in the Originand Evolution of Life The book: celebrates the scientific research contributions andcareers of R. Stephen Berry, Stuart A. Rice and Joshua Jortner contributes to the only series available that presents thecutting edge of research in chemical physics includes contributions from experts in this field ofresearch structured with an editorial framework that makes the book anexcellent supplement to an advanced graduate class in physicalchemistry or chemical physics


Life in the 21st Century

Author: Sakari Tamminen,Professor Andrew Webster,Professor Niki Vermeulen

Publisher: Ashgate Publishing, Ltd.

ISBN: 1409494977

Category: Medical

Page: 240

View: 9371


Increasing knowledge of the biological is fundamentally transforming what life itself means and where its boundaries lie. New developments in the biosciences - especially through the molecularisation of life - are (re)shaping healthcare and other aspects of our society. This cutting edge volume studies contemporary bio-objects, or the categories, materialities and processes that are central to the configuring of 'life' today, as they emerge, stabilize and circulate through society. Examining a variety of bio-objects in contexts beyond the laboratory, Bio-Objects: Life in the 21st Century explores new ways of thinking about how novel bio-objects enter contemporary life, analysing the manner in which, among others, the boundaries between human and animal, organic and non-organic, and being 'alive' and the suspension of living, are questioned, destabilised and in some cases re-established. Thematically organised around questions of changing boundaries; the governance and regulation of bio-objects; and changing social, economic and political relations, this book presents rich new case studies from Europe that will be of interest to scholars of science and technology studies, social theory, sociology and law.

Physical Biology

From Atoms to Medicine

Author: Ahmed H. Zewail

Publisher: Imperial College Press

ISBN: 1848161999

Category: Science

Page: 567

View: 6940


This title brings about the confluence of various concepts and tools to address significant problems of our time in physical biology and adjacent disciplines.

Aspects of Physical Biology

Biological Water, Protein Solutions, Transport and Replication

Author: Giancarlo Franzese,Miguel Rubi

Publisher: Springer Science & Business Media

ISBN: 9783540787648

Category: Science

Page: 233

View: 8958


The application to Biology of the methodologies developed in Physics is attracting an increasing interest from the scientific community. It has led to the emergence of a new interdisciplinary field, called Physical Biology, with the aim of reaching a better understanding of the biological mechanisms at molecular and cellular levels. Statistical Mechanics in particular plays an important role in the development of this new field. For this reason, the XXth session of the famous Sitges Conference on Statistical Physics was dedicated to "Physical Biology: from Molecular Interactions to Cellular Behavior". As is by now tradition, a number of lectures were subsequently selected, expanded and updated for publication as lecture notes, so as to provide both a state-of-the-art introduction and overview to a number of subjects of broader interest and to favor the interchange and cross-fertilization of ideas between biologists and physicists. The present volume focuses on three main subtopics (biological water, protein solutions as well as transport and replication), presenting for each of them the on-going debates on recent results. The role of water in biological processes, the mechanisms of protein folding, the phases and cooperative effects in biological solutions, the thermodynamic description of replication, transport and neural activity, all are subjects that are revised in this volume, based on new experiments and new theoretical interpretations.

Creating a Physical Biology

The Three-Man Paper and Early Molecular Biology

Author: Phillip R. Sloan,Brandon Fogel

Publisher: University of Chicago Press

ISBN: 0226767825

Category: Science

Page: 319

View: 6851


Despite its historical impact on the biological sciences, the paper entitled 'On the Nature of Gene Mutation and Gene Structure' has remained largely inaccessible because it was only published in a short-lived German periodical. This book makes the 'Three Man' Paper available in English for the first time.

Biophysical Techniques

Author: Iain Campbell

Publisher: Oxford University Press

ISBN: 0199642141

Category: Medical

Page: 353

View: 2402


Biophysical Techniques explains in a readily-accessible way the basics of the various biophysical methods available so students can understand the principles behind the different methods used, and begin to appreciate which tools can be used to probe different biological questions, and the pros and cons of each.