Turning up the Heat on Pain: TRPV1 Receptors in Pain and Inflammation

Author: Annika B. Malmberg,Keith R. Bley

Publisher: Springer Science & Business Media

ISBN: 3764373792

Category: Medical

Page: 249

View: 5660


Despite tremendous advances in the understanding of the sensory nervous system which have accompanied the recent explosive growth of the neurosciences, rema- ably few innovative medicines directed towards pain and inflammation are ava- able. Indeed, many patients are still prescribed analgesic and anti-inflammatory medications that were identified long ago as components of herbal remedies. Si- larly, potential new medicines in clinical evaluation based on capsaicin and the c- saicin receptor are both grounded firmly on folk traditions and yet rely upon the most contemporary techniques of drug discovery and delivery. The first formal report of the pain-relieving properties of capsaicin appeared in 1850 [1]. However, for centuries before this, capsaicin-containing extracts had been used as folk medicines in cultures with access to pepper plants, much in the same way as poppy or willow-bark extracts were. Despite widespread use, it was not until 1878 that the selective action of capsaicin on the sensory nervous system was r- ognized [2]. In Chapter 1 of this volume, Janos Szolcsányi reviews this early research, which culminated with the seminal studies of Nicholas Jansco and his c- leagues in Hungary in the 1940s. Since then, capsaicin and related vanilloid c- pounds have played a prominent role in analgesia and inflammation investigations because of their ability to selectively activate a subpopulation of sensory neurons and produce sensations of pain and localized erythema.

On Pain of Speech

Fantasies of the First Order and the Literary Rant

Author: Dina Al-Kassim

Publisher: Univ of California Press

ISBN: 0520945794

Category: Literary Criticism

Page: 304

View: 5495


On Pain of Speech tracks the literary rant, an expression of provocation and resistance that imagines the power to speak in its own name where no such right is granted. Focusing on the "politics of address," Dina Al-Kassim views the rant through the lens of Michel Foucault's notion of the biopolitical subject and finds that its abject address is an essential yet overlooked feature of modernism. Deftly approaching disparate fields—decadent modernism, queer studies, subjection, critical psychoanalysis, and postcolonial avant-garde—and encompassing both Euro-American and Francophone Arabic modernisms, she offers an ambitious theoretical perspective on the ongoing redefinition of modernism. She includes readings of Jane Bowles, Abdelwahab Meddeb, and Oscar Wilde, and invokes a wide range of ideas, including those of Theodor Adorno, Sigmund Freud, Jacques Lacan, Judith Butler, Jean Laplanche, and Eve Kosofsky Sedgwick.

The American Society of Addiction Medicine Handbook on Pain and Addiction

Author: Ilene R. Robeck,Melvin Pohl,Herbert Malinoff,Michael Weaver

Publisher: Oxford University Press

ISBN: 0190265361

Category: Medical

Page: 448

View: 1621


The American Society of Addiction Medicine Handbook on Pain and Addiction provides clinical considerations and guidelines for the clinician treating patients with pain and addiction. Produced by the largest medical society dedicated to the improvement of addiction care, the book takes an evidence-based approach and uses articles from both the literature and well-regarded organizations and government agencies including NIDA, CDC, SAMHSA, PCSS-O, and ASAM itself. The ASAM Handbook is structured in five sections that cover the core concepts of addressing pain and addiction; diagnosis and treatment; treating pain in patients with, or at risk for, co-occuring addiction; treating substance use disorders (SUD) and addiction in patients with co-occuring pain; and adapting treatment to the needs of specific populations. Each chapter ends with suggestions for further reading on the topics discussed. This book is ideal for primary care providers, mental health clinicians, SUD clinicians, and pain clinicians who wish to bridge the knowledge gaps related to treating patients with pain and addiction. To learn more about the American Society of Addiction Medicine, and its commitment to providing the best resources for addiction clinicians, please visit http://www.asam.org.

Hold On Pain Ends

Author: Rosa Olivia Sanchez Salazar

Publisher: Xlibris Corporation

ISBN: 1499051719

Category: Fiction

Page: 268

View: 7187


After what 17 year old Hope Scott thinks was an awful dreadful dream of her suicide the afternoon before she finds herself being awaken by her parents grieving argument as they walk in the house after having gone through the awful process of identifying their daughter at the local morgue. Confused of their behavior Hope runs after her father as this one goes for a walk. Crossing the street she discovers she’s a ghost as a car runs through her. Scared Hope runs back home finding her grieving mother drinking and crying regretting not having been there for her. Hope proceeds to explain to her about years of depression, self harm and self loathing that lead the girl to her actions the night before. The purpose of this story is not to praise self harm nor suicidal tendencies that often come along with Depression but to help other teens going through this terrible illness know they are not alone and hopefully to stop and reflect before they act on their suicidal thoughts if they are going through any.

Pain and Disability

Clinical, Behavioral, and Public Policy Perspectives

Author: Committee on Pain, Disability, and Chronic Illness Behavior,Institute of Medicine

Publisher: National Academies Press

ISBN: 0309542677

Category: Medical

Page: 296

View: 6052


Pain--it is the most common complaint presented to physicians. Yet pain is subjective--it cannot be measured directly and is difficult to validate. Evaluating claims based on pain poses major problems for the Social Security Administration (SSA) and other disability insurers. This volume covers the epidemiology and physiology of pain; psychosocial contributions to pain and illness behavior; promising ways of assessing and measuring chronic pain and dysfunction; clinical aspects of prevention, diagnosis, treatment, and rehabilitation; and how the SSA's benefit structure and administrative procedures may affect pain complaints.

On Pain

Author: Ernst Jünger

Publisher: Telos Press

ISBN: 9780914386407

Category: History

Page: 47

View: 7641



Biomedical Acupuncture for Pain Management - E-Book

Author: Yun-tao Ma,Zang Hee Cho

Publisher: Elsevier Health Sciences

ISBN: 1455726184

Category: Medical

Page: 288

View: 2093


Synthesizing biomedicine and traditional acupuncture, this unique clinical manual allows medical professionals to learn acupuncture and implement it immediately into practice with ease. Biomedical Acupuncture for Pain Management explains the biomedical mechanism of acupuncture, as well as the non-specific nature of acupuncture and its neuro-psycho-immunological modulation. This straightford system of acupuncture – termed INMAS by the authors – provides a quantitative method to predict the effectiveness of treatment for each patient and an individually adjustable protocol for pain patients. Introduction to the Integrative Neuromuscular Acupoint System (INMAS), as well as the Homeostatic Acupoint System (HAS), help western-trained acupuncturists understand classical techniques A 16-point evaluation method provides a reliable quantitative method to accurately arrive at prognosis Clinically relevant, integrative treatment approach in user-friendly language Numerous detailed tables, photos, and line drawings to help readers understand the anatomy, symptomatic signs, and clinical procedures Clear chapters organized by regional condition for easy readability and flow Case studies to assist with application of concepts in clinical practice Unique, clinical procedures for pain management with sections on examination and needling methods Two appendices for quick reference of acronyms, abbreviations, and the 24 homeostatic acupoints Up-to-date information on the latest techniques, including a chapter on electroacupuncture

Intrathecal Drug Delivery for Pain and Spasticity E-Book

A Volume in the Interventional and Neuromodulatory Techniques for Pain Management Series

Author: Asokumar Buvanendran,Sudhir Diwan,Timothy Deer

Publisher: Elsevier Health Sciences

ISBN: 1455733989

Category: Medical

Page: 224

View: 9846


Intrathecal Drug Delivery for Pain and Spasticity - a volume in the new Interventional and Neuromodulatory Techniques for Pain Management series - presents state-of-the-art guidance on the full range of intrathecal drug delivery techniques performed today. Asokumar Buvanendran, MD and Sudhir Diwan, MD, offer expert advice on a variety of procedures to treat chronic non-malignant pain, cancer pain, and spasticity. Comprehensive, evidence-based coverage on selecting and performing these techniques - as well as weighing relative risks and complications - helps you ensure optimum outcomes. Understand the rationale and scientific evidence behind intrathecal drug delivery techniques and master their execution. Optimize outcomes, reduce complications, and minimize risks by adhering to current, evidence-based practice guidelines. Apply the newest techniques in intrathecal pump placement, cancer pain management, use of baclofen pumps, and compounding drugs. Quickly find the information you need in a user-friendly format with strictly templated chapters supplemented with illustrative line drawings, images, and treatment algorithms.