The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style.
Author: G Michael Blackburn
Publisher: Royal Society of Chemistry
The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
A structure is proposed for the TMV protein in which the 158 component amino
acids are disposed along a flat spiral ... Phage W - 31 adsorbed equally to both
Fand F + cells and injected its nucleic acid equally into cells of either mating type
The final chapters explore the nucleic acid metabolism, with a special emphasis on the effect of radiation on the process. This book is of value to organic chemists and biochemists.
Author: Erwin Chargaff
The Nucleic Acids, Volume III covers the significant progress in understanding the chemistry and biological importance of the nucleic acids. This volume is composed of 12 chapters, and begins with an overview of the general principles of the determination of weight, shape, and dimension of large molecules in solution. These topics are followed by discussions on the photochemistry of nucleic acids and its constituents; chemical and enzymic synthesis of polynucleotides; and nucleic acid content and dynamics of bacterial viruses. The next chapters describe the biosynthesis of purine and pyrimidine nucleotides. A chapter examines the relationship of nucleic acid and protein synthesis through considering cell-free systems, particularly those derived from mammalian tissues. Another chapter looks into the protein biosynthesis in intact bacterial cells. The final chapters explore the nucleic acid metabolism, with a special emphasis on the effect of radiation on the process. This book is of value to organic chemists and biochemists.
Considers all of the major nucleic acid based techniques that are revolutionizing bacterial classification and identification. Also provides a comparison of methods for converting molecular data to phylogenetic trees.
Author: Erko Stackebrandt
Publisher: John Wiley & Son Limited
One of a series whose aim is to identify specialist areas in microbiology and to provide up-to-date methodological information for laboratory microbiologists, active researchers and graduate students. This volume addresses nucleic acid techniques in bacterial systematics.
This book gives the pertinent information on the high pressure liquid chromatography (HPLC) analyses of all the compounds of interest in nucleic acid metabolism.
Author: Phyllis R. Brown
Publisher: CRC Press
This book gives the pertinent information on the high pressure liquid chromatography (HPLC) analyses of all the compounds of interest in nucleic acid metabolism. It aids chromatographers, biochemists, biomedical researchers, and chemists by giving information on applications of HPLC technique.
This edited book, "Nucleic Acids - From Basic Aspects to Laboratory Tools", contains a series of chapters that highlight the development and status of the various aspects of the nucleic acids related to DNA chemistry and biology and the ...
Author: Marcelo Larramendy
Publisher: BoD – Books on Demand
This edited book, "Nucleic Acids - From Basic Aspects to Laboratory Tools", contains a series of chapters that highlight the development and status of the various aspects of the nucleic acids related to DNA chemistry and biology and the molecular application of these small DNA molecules and related synthetic analogues within biological systems. Furthermore, it is hoped that the information in the present book will be of value to those directly engaged in the handling and use of nucleic acids, and that this book will continue to meet the expectations and needs of all who are interested in the different fascinating aspects of molecular biology.
Supplement. Nucleic acids Mukerjea , A.K .; and Sen , A.K. , ribonucleic acid
depoly 1968 b merizing enzyme present in Entamoeba histolytica Mucleic acids
Sharma , N. N .; Albach , R. A .; RNA and DNA comparison , and Shaffer , J. G. ,
Supplements 1-14 have Authors sections only; supplements 15- include an additional section: Parasite-subject catalogue.
This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids.
Author: J. Andrew McCammon
Publisher: Cambridge University Press
This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Guiding readers through the ever-increasing jungle of nucleic acid science and technology, the book distills the key information out of the large body of primary literature and presents it in a single volume.
Author: Sabine M¿ller
Publisher: John Wiley & Sons
Concise but complete, this mini-encyclopedia contains over 1,500 entries covering all important concepts, compounds, techniques and acronyms for quick and easy reference. Guiding readers through the ever-increasing jungle of nucleic acid science and technology, the book distills the key information out of the large body of primary literature and presents it in a single volume. A first-stop resource for everyone, from students to established researchers, as both a desktop and library reference.
A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression.
Author: Fritz Eckstein
Publisher: Springer Science & Business Media
A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. A number of authors address the subject of RNA, including the difficult but important subject of its chemical synthesis, the complexities of its structures and the mechanisms of transcript splicing. The probing of DNA structure is reviewed in papers on the application of hydroxyl radical and 1,10 phenanthroline copper cleavages. A number of important DNA-protein interactions are discussed, including DNA polymerase, the tryptophan and deoR repressors, and the resolvase enzymes which cleave Holliday junctions in recombination. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos. Finally, the plant kingdom has not been forgotten with articles on development and transposition in plants.
While this revolution has been taking place in the field of nucleic acids research, the protein chemist has at the same time developed fresh methodology to keep pace with the requirements of present day molecular bi- ogy.
Author: John M. Walker
Publisher: Boom Koninklijke Uitgevers
In recent years there has been a tremendous increase in our understanding of the functioning of the cell at the molecular level. This has been achieved in the main by the invention and development of new methodology, parti- larly in that area generally referred to as "genetic en- neering". While this revolution has been taking place in the field of nucleic acids research, the protein chemist has at the same time developed fresh methodology to keep pace with the requirements of present day molecular bi- ogy. Today's molecular biologist can no longer be content with being an expert in one particular area alone. He/she needs to be equally competent in the laboratory at h- dling DNA, RNA, and proteins, moving from one area to another as required by the problem he/she is trying to solve. Although many of the new techniques in molecular biology are relatively easy to master, it is often difficult for a researcher to obtain all the relevant information nec- sary for setting up and successfully applying a new te- nique. Information is of course available in the research l- erature, but this often lacks the depth of description that the new user requires. This requirement for in-depth pr- tical details has become apparent by the considerable - mand for places on our Molecular Biology Workshops held at Hatfield each summer.
Author: Victor A. BloomfieldPublish On: 2000-04-17
This is a comprehensive and up-to-date account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function.
Author: Victor A. Bloomfield
Publisher: Sterling Publishing Company
NucleicAcids presents an up-to-date and comprehensive account of thestructures and physical chemistry properties of nucleic acids,with special emphasis on biological function. With a targetedaudience of 1)molecular biologists, 2)physical biochemists, and3)physical chemists, the book has been carefully organized toreach three different audiences while requiring only introductoryphysical chemistry and molecular biology as prerequisites. NucleicAcidswill serve as a textbook in physical biochemistry andbiophysical chemistry classes, as well as a supplemental text incourses on nucleic acid biochemistry or molecular biology, and asa personal reference for students and researchers in thesefields. KeyFeatures Organized according to a systematic consideration of techniques used in the study of nucleic acid structure and properties. Key topics--such as protein-DNA and protein-drug complexes, conformational transitions, characterization of nucleic acids by gel and solution techniques, and behavior of supercoiled DNA--are covered in great detail as veritable mini-monographs. Heavily illustrated with diagrams, graphs, and molecular structures, including nearly 2 dozen color figures. Includes numerous figures, tables and an extensive bibliography to facilitate use as a reference volume.
Author: Britannica Educational PublishingPublish On: 2010-10-01
This volume examines the structure and function of each of these fascinating elements and the interrelationships between them, which nurture all existence.
Author: Britannica Educational Publishing
Publisher: Britannica Educational Publishing
Category: Juvenile Nonfiction
The building blocks of all lifehuman and otherwiseare basic chemical molecules common to all organisms that simultaneously unite all species and set them apart. Together, nucleic acids, amino acids, proteins, lipids, and carbohydrates determine our genetic makeup, power our movements, and generally enable some of the most vital and complex chemical reactions of the body. This volume examines the structure and function of each of these fascinating elements and the interrelationships between them, which nurture all existence.
Analysis of fifteen of these copper preparations by Herlant [ 1900 ] , Alsberg (
1904 ) , and Schmiedeberg [ 1907 ] showed a striking resemblance in elementary
composition between various animal nucleic acids which is very different from the