Mononuclear Phagocytes

Mononuclear Phagocytes

Among the cells originating in the bone marrow, the mononuclear phagocytes constitute a separate cell line.

Author: R. van Furth

Publisher: Springer

ISBN: 9400987951

Category: Medical

Page: 1961

View: 325

The term mononuclear phagocyte covers a group of cells including the macrophages in the tissues and the ancestors of these cells, i. e. , the monocytes in the peripheral blood, and their precursors in the bone marrow, the promonocytes and monoblasts. Among the cells originating in the bone marrow, the mononuclear phagocytes constitute a separate cell line. The effector cell of this line is the macrophage, which plays an important role in the host defence against infective agents and neoplastic cells as well as in the removal of antigens, antigen-antibody complexes, effete cells, and damaged tissues. Metchnikoff ( r 892) was the first to describe the macrophage and the microphage, the latter now being called polymorphonuclear leucocyte or granulocyte, and to recognize that phagocytes not only serve as scavengers, but also play an important role in the host defence against micro-organisms. However, Haeckel ( r862) had made the first observa tion of endocytosis 30 years before. In his book 'Die Radiolaren' published in r862, Haeckel wrote: I first observed this phenomenon in May, 1859, in a specimen of Thetis fimbria, which I had injected with an aqueous suspension of fine Indigo particles in connection with a study of the vascular system.
Categories: Medical

Mononuclear Phagocytes

Mononuclear Phagocytes

, Bull. WHO, 1972, 46: 845-852). The paradigm of the MPS has the advantage of being much more consistent than the Reticuloendothelial System (RES) (L. Aschoff, Ergebn. Inn. Med.

Author: R. van Furth

Publisher: Springer

ISBN: 9401087237

Category: Medical

Page: 830

View: 461

Sixteen years have passed since the first Leiden Conference on Mononuclear Phagocytes. That first meeting led to new nomenclature, i. e. , the Mononuclear Phagocytes System (MPS), which was published in the Bulletin of the World Health Organization (R. van Furth, et aI. , Bull. WHO, 1972, 46: 845-852). The paradigm of the MPS has the advantage of being much more consistent than the Reticuloendothelial System (RES) (L. Aschoff, Ergebn. Inn. Med. Kinderheilk. 1924, 26:1), because cells with similar characteristics can be classified in the same category. The essence ota new concept is, according to Popper, that it must be susceptible to falsification. This has been attempted several times for the MPS by those who adhere to the RES. However, in biology no one can be certain of truth. Any theory must be based on experimental observations and/or theoretical consider ations and both should be presented in such a way that others can try to refute it, then or later. One may have a theoretical or a pragmatic preference for a theory which at a given time is regarded as possibly truc, but later it may be shown to be false. In other words, what we present in this volume is regarded as true at this moment, but others may consider it as not true and try to disprove it. Controversies often stimulate new research.
Categories: Medical

Mononuclear Phagocytes

Mononuclear Phagocytes

Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.

Author: R. van Furth

Publisher: Springer Science & Business Media

ISBN: 9789401580700

Category: Medical

Page: 668

View: 841

Mononuclear phagocytes, which include macrophages, monocytes and their precursor cells, are the most important cells in the host defence against micro-organisms and tumor cells. During the last twenty-five years research on the biology of mononuclear phagocytes has increased tremendously. This motivated Professor R. van Furth to organize five international conferences on this subject in Leiden, the Netherlands. The edited proceedings of these meethings were published: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- Functional Aspects; and in 1985 Mononuclear Phagocytes -- Characteristics, Physiology and Function. Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.
Categories: Medical

The Multiplication of Mycobacterium Tuberculosis Within Mononuclear Phagocytes of Experimental Animals

The Multiplication of Mycobacterium Tuberculosis Within Mononuclear Phagocytes of Experimental Animals

Rabbit mononuclear cells in vitro inhibited the Intracellular multiplication of a virulent strain of human tabarole bao 1111 to a greater degree than mononuclear phagocytes from normal guinea pige . An attempt was made to determine ...

Author: ALBERT ARCHER GROVER

Publisher:

ISBN: UOM:39015025271449

Category: Mycobacterium tuberculosis

Page: 134

View: 375

Categories: Mycobacterium tuberculosis

Methods for Studying Mononuclear Phagocytes

Methods for Studying Mononuclear Phagocytes

The book is divided into 11 parts arranged according to the sequence of steps that would generally be followed to study a given population of mononuclear phagocytes: (I) methods for obtaining and culturing populations of human and animal ...

Author: Dolph Adams

Publisher: Elsevier

ISBN: 9780323140690

Category: Science

Page: 1048

View: 197

Methods for Studying Mononuclear Phagocytes is a practical guide to the study of mononuclear phagocytes that brings together various well-established and useful methods for examining these cells. The technical protocols have been made detailed, specific, practical, and inclusive of the necessary mystique for immediate and direct application in the laboratory. The book is divided into 11 parts arranged according to the sequence of steps that would generally be followed to study a given population of mononuclear phagocytes: (I) methods for obtaining and culturing populations of human and animal mononuclear phagocytes; (II) methods for separating populations of leukocytes to enrich or deplete their content of mononuclear phagocytes; (II) criteria and techniques for identifying mononuclear phagocytes; (IV) methods for quantifying the number of mononuclear phagocytes; (V) techniques for studying the morphology of mononuclear phagocytes; (VI) methods for quantifying the biochemical constituents of mononuclear phagocytes; (VII) methods of quantifying phagocytosis, pinocytosis, and chemotaxis; (VIII) methods for quantifying the secretory products of mononuclear phagocytes; (IX) procedures for quantifying the destruction of tumor cells and of microorganisms by mononuclear phagocytes; (X) methods for studying the cell biology of mononuclear phagocytes; and (XI) techniques for studying mononuclear phagocytes in vivo, including procedures for estimating their kinetics, accumulation, identification, and microbicidal properties.
Categories: Science

Mononuclear Phagocytes

Mononuclear Phagocytes

Author: Ralph van Furth

Publisher: Wiley-Blackwell

ISBN: UOM:39015000801459

Category: Immunity

Page: 654

View: 446

Categories: Immunity

Mononuclear Phagocytes in Cell Biology

Mononuclear Phagocytes in Cell Biology

I. INTRODUCTION The mononuclear phagocyte system is a host - wide collection of cells that has been frequently seen as the front line of nonspecific immune defense against invasion of the host by foreign materials both living and ...

Author: Gabriel Lopez-Berestein

Publisher: CRC Press

ISBN: 0849347068

Category: Medical

Page: 256

View: 127

Mononuclear Phagocytes in Cell Biology provides a state-of-the-art review of the biological, biochemical, and molecular processes involved in macrophage activation. The book focuses on the role of macrophage "signals" in health and disease, which are discussed with particular attention to the physiological role of macrophages in homeostasis. The role played by macrophages in bone metabolism and the role of cytokines in diseases affecting the macrophage (e.g., HIV and leishmaniasis) are covered as well. The book also exploits the potential of macrophage "mimicry" as a therapeutic tool. Mononuclear Phagocytes in Cell Biology is a practical reference for cell biologists, medical microbiologists, molecular biologists, immunologists, hematologists, immunogeneticists, immunopharmacologists, and other basic and clinical researchers interested in macrophage development, biology, and differentiation.
Categories: Medical

Mononuclear Phagocytes

Mononuclear Phagocytes

Furth, R. van & M. Fedorko (1976) Ultrastructure of mouse mononuclear phagocytes in bone marrow colonies grown in vitro. Laboratory Investigation 34, 440. Furth, R. van, Hirsch, J.G. & M.E. Fedorko (1970) Morphology and peroxidase ...

Author: R. van Furth

Publisher: Springer Science & Business Media

ISBN: 9789400987937

Category: Medical

Page: 1961

View: 362

Categories: Medical

Mononuclear Phagocytes

Mononuclear Phagocytes

Author: Ralph van Furth

Publisher: Blackwell Science

ISBN: UOM:39015003218271

Category: Immunity

Page: 1062

View: 642

Categories: Immunity