Molecular Genetics of Drug Resistance

Molecular Genetics of Drug Resistance

DRUG RESISTANCE IN CANCER CHEMOTHERAPY IAN D. HICKSON * and
DANIEL HOCHHAUSER Imperial Cancer Research Fund Laboratories , Institute
of Molecular Medicine , University of Oxford , John Radcliffe Hospital , Oxford
OX3 ...

Author: Hayes

Publisher: CRC Press

ISBN: 9057021676

Category: Science

Page: 412

View: 150

Categories: Science

Molecular Genetics in Cancer Diagnosis

Molecular Genetics in Cancer Diagnosis

Molecular Biology of Antineoplastic Drug Resistance Craig R . Fairchild , PhD ,
Merrill E . Goldsmith , PhD , and Kenneth H . Cowan , MD , PhD One of the most
troubling problems in cancer chemotherapy is the relative ease with which tumor
 ...

Author: Jeffrey Cossman

Publisher: Elsevier Publishing Company

ISBN: UOM:39015018515224

Category: Cancer

Page: 465

View: 839

Categories: Cancer

Molecular Genetics and Evolution of Pesticide Resistance

Molecular Genetics and Evolution of Pesticide Resistance

However , to date , the horizontal transfer of an actual pesticide resistance gene
has not been observed or inferred to have ... Concluding Perspective of Antibiotic
and Pesticide Resistance The deployment of antibiotics in medicine and ...

Author: Thomas Miller Brown

Publisher: Amer Chemical Society

ISBN: UOM:39015038037142

Category: SCIENCE

Page: 265

View: 911

Applications of molecular genetics in combatting pesticide resistance: an overviview. Molecular genetics of target-site resistance to acetolactate synthase inhibiting herbicides. Molecular genetics of acetylcholinesterase in insecticide resistant Drosophila melanogaster. The molecular basis of plant resistance to photosystem II herbicides. Molecular genetics of resistance in fungi to azole fungicides. Evolution and population genetics. Ecology transgenesis, and regulatory issues.
Categories: SCIENCE

Antibiotic Resistance

Antibiotic Resistance

The biochemistry and genetics of antibiotic resistance are far better known than
the equally important events underlying the ... Currently, impressive advances in
understanding the molecular biology of antibiotic resistance contrast with general
 ...

Author: Derek J. Chadwick

Publisher: John Wiley & Sons

ISBN: 9780470515365

Category: Medical

Page: 260

View: 377

Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy, 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.
Categories: Medical

Molecular Genetics of Parasitic Protozoa

Molecular Genetics of Parasitic Protozoa

Two approaches to the genetic analysis of drug resistance in parasitic protozoa
are discussed . Beverley presents data supporting a model for the amplification of
the dihydrofolate reductase gene leading to resistance to antifolates . Ullman ...

Author: Mervyn J. Turner

Publisher: Cold Spring Harbor Laboratory Press

ISBN: UOM:39015013566289

Category: Medical

Page: 170

View: 609

Categories: Medical

The Molecular Genetics of Development

The Molecular Genetics of Development

However , chloramphenicol resistant M . xanthus showed a slower growth rate
than sensitive cells and is rapidly lost in the absence of the drug . This indicates
that the CM gene has not stably integrated into the myxobacterial chromosome .

Author: Terrance Leighton

Publisher:

ISBN: UCAL:B4456669

Category: Science

Page: 478

View: 263

Categories: Science

Reichman and Hershfield s Tuberculosis

Reichman and Hershfield s Tuberculosis

50 . Telenti A . Genetics of drug resistance in tuberculosis . Clin Chest Med 1997 ;
18 : 55 - 64 . 51 . Takiff HE . The molecular mechanisms of drug resistance in M .
tuberculosis ( Chapter 6 ) . In : Bastian I , Portaels F , eds . Multi - drug Resistant ...

Author: Mario C. Raviglione

Publisher: CRC PressI Llc

ISBN: UOM:39015064805958

Category: Medical

Page: 1246

View: 599

Thoroughly examining tuberculosis from historical, theoretical, and clinical perspectives, this Third Edition merges state-of-the-art research developments with principles of programmatic TB management. Each of the 50 chapters analyze current studies on TB mechanisms and treatment and will meet the needs of all who work in the field of TB control, whether in low-income, high-prevalence areas or in low-prevalence industrialized countries.
Categories: Medical

Molecular Genetics of Bacteria

Molecular Genetics of Bacteria

plasmid , although plasmid - borne resistance to some drugs such as nalidixic
acid and the related 4 - quinolones does not seem to occur . The antibiotic
resistance genes themselves are many and varied : resistance to penicillins
occurs by ...

Author: Jeremy Dale

Publisher: John Wiley & Son Limited

ISBN: UOM:39015040371588

Category: Science

Page: 310

View: 650

Molecular Genetics of Bacteria Third Edition Jeremy W. Dale School of Biological Sciences, University of Surrey, UK This third edition of Jeremy Dale's successful book provides a thoroughly updated and revised introduction to the molecular biology and genetics of bacteria. Molecular Genetics of Bacteria presents both the basic concepts and the most exciting recent developments in a form which is suitable for the needs of students studying microbiology, biotechnology, molecular biology, biochemistry, genetics and related biomedical sciences. The structure of the third edition has undergone a major reorganization and incorporates: * New material on the concept of adaptive mutation, bacterial differentiation, intercellular signalling, conjugative transposons and integrons. * Enhanced coverage of supercoiling, reporter genes, sporulation, PCR and genome sequencing projects. Reviews of the Second Edition: "I recommend this book strongly for the purpose for which it was designed, namely as an introductory text with broad coverage of the subject." Simon Baumberg, University of Leeds, Society for General Microbiology Quarterly ". a text that is readable and attractive to people who may be daunted by more-detailed works." Trends in Microbiology
Categories: Science

Trends in Molecular Genetics

Trends in Molecular Genetics

GEDEBOU , M . and TASSEW , A . 1980 . Neisseria gonorrhoeae isolates from
Ethiopia . 2 . Pair correlations between minimal inhibitory concentration values of
5 antibiotics and frequency of multiple antibiotic resistance . Bull . Wld . Hlth . Org
 ...

Author: Umakant Sinha

Publisher:

ISBN: UOM:39015036382482

Category: Genetic engineering

Page: 158

View: 541

Selected papers of the International Symposium on Gene Cloning and Recombinant DNA Technology, 1983, Patna, India, organized by the UGC Centre of Special Assistance, and the Dept. of Botany, Patna University.
Categories: Genetic engineering

Drug Resistance in Bacteria

Drug Resistance in Bacteria

Genetics, Biochemistry, and Molecular Biology Susumu Mitsuhashi. deviation
from its conclusion then seemed like a regression toward Lamarckism ! ) . No
doubt any additional peculiar features of drug resistance being discovered today
are ...

Author: Susumu Mitsuhashi

Publisher: Thieme Medical Publishers

ISBN: UOM:39015006028024

Category: Bacteria

Page: 429

View: 882

Categories: Bacteria

Molecular Genetics Microbiology and Virology

Molecular Genetics  Microbiology and Virology

Clones of P . mallei Ts - 5 carrying recombinant plasmid DNAs in autonomous
and integrated states produced by conjugation and transformation were studied
with regard to retention of plasmid markers of antibiotic resistance during
passages ...

Author:

Publisher:

ISBN: PSU:000066296690

Category: Microbiology

Page:

View: 655

Categories: Microbiology

Multi Drug Resistance in Emerging and Re Emerging Diseases

Multi Drug Resistance in Emerging and Re Emerging Diseases

However, tools for molecular genetic analysis, such as gene fusions, counter-
selectable markers, allelic exchange and transposon mutagenesis have been
recently constructed, moreover, the genome sequence has been completed,
which ...

Author: R. C. Mahajan

Publisher: CRC Press

ISBN: 0849309832

Category: Medical

Page: 282

View: 205

The recent appearance of multi-drug resistant phenotypes has complicated the efforts to completely eradicate diseases such as tuberculosis and malaria, thus underscoring the need for new and innovative scientific approach to the problem. Multi-Drug Resistance in Emerging and Re-Emerging Diseases highlights the state-of-the-art in microbial/parasite control and containment, and discusses ways and means of avoiding development of drug resistance. It explores strategies to combat the nightmare of microbial aggression and resistance and to overcome multiple drug resistance when it emerges in microbial organisms or in cancer cells exposed to chemotherapy. Written by a panel of experts, the book gives you the benefits of both field and clinical experience as well as an in-depth know-how of the pathology of these drug resistant diseases. Topics include malaria, tuberculosis, cholera, leprosy, diarrhoeal diseases, nosocomial diseases, plague, and drug resistance and cancer. Multi-Drug Resistance in Emerging and Re-Emerging Diseases provides a foundation for new initiatives and more collaborative efforts in the fight against resistance to antibiotics by micro-organisms.
Categories: Medical

Antibiotic Resistance

Antibiotic Resistance

[18] Ramaswamy S and Musser JM (1998). Molecular genetic basis of
antimicrobial agent resistance in Mycobacterium tuberculosis, 1998 update.
Tuber. Lung Dis . 9:3-29. [19] Telenti A, Imboden P, Marchesi P,Marchesi nF,
Schmidheinin T, ...

Author: Adriel R. Bonilla

Publisher: Nova Biomedical Books

ISBN: UCSD:31822037476868

Category: Medical

Page: 527

View: 712

Antibiotic resistance is the ability of a micro-organism to withstand the effects of antibiotics. There are three mechanisms that can cause antibiotic resistance: prevention of interaction of drug with target, decreased uptake due to either an increased efflux or a decreased influx of the antimicrobial agent and enzymatic modification or destruction of the compound. In the past couple years, antibiotic resistance has become an increasing public health concern. Tuberculosis, gonorrhoea, malaria and childhood ear infections are just a few of the diseases that have become hard to treat with antibiotic drugs. This book addresses the concern that over the past few years, there has been a major rise in resistance to antibiotics among gram-negative bacteria. New antibacterial drugs with novel modes of actions are urgently required in order to fight against infection. Novel antibiotics such as linezolid, carbapenem ertapenem, daptomycin and gemifloxacin are examined in this book. The genetic approaches used in risk assessment of antibiotic resistance dissemination are looked at as well. Furthermore, this book discusses the present studies on the use of veterinary antibiotics in agriculture, on the occurrence of antibiotic compounds and resistant bacteria in soil and water and clearly demonstrates the need for further studies.
Categories: Medical

Molecular Genetic Analysis of Regulation of Antibiotic Biosynthesis in Streptomyces Coelicolor

Molecular Genetic Analysis of Regulation of Antibiotic Biosynthesis in Streptomyces Coelicolor

Genetics and molecular biology of industrial microorganisms . American Society
for ... The expression of Streptomyces and Escherichia drug resistance
determinants cloned into the Streptomyces phage 6C31 . Gene 19 : 21-32 . 8.
Distler , J.

Author: Trifon Adamidis

Publisher:

ISBN: MSU:31293010251092

Category: Antibiosis

Page: 332

View: 513

Categories: Antibiosis

The Directory of Graduate Studies

The Directory of Graduate Studies

15 Central Lancashire , APPLIED BIOLOGY , MPhil / PhD ; areas of research
interest inc : light reaction and molecular biol ... technique ; photoperiodism and
flowering ; studies on modification of cell membranes in relation to drug
resistance .

Author:

Publisher:

ISBN: STANFORD:36105131057072

Category: Research

Page:

View: 360

Categories: Research

Molecular Genetic and Biochemical Studies of Mitomycin C Resistance and Biosynthesis in Streptomyces Lavendulae

Molecular Genetic and Biochemical Studies of Mitomycin C Resistance and Biosynthesis in Streptomyces Lavendulae

appears to be the mechanism responsible for regulating the expression of
antibiotic resistance in the antibiotic producer . When the respective antibiotic is
not produced , antibiotic resistance is unnecessary . However , as antibiotic
production ...

Author: Paul Rudolph August

Publisher:

ISBN: MINN:31951P00505125Z

Category:

Page: 384

View: 284

Categories:

Oncogenes and Molecular Genetics of Urological Tumours

Oncogenes and Molecular Genetics of Urological Tumours

These results suggest that PGP plays an important role in the intrinsic drug
resistance of RCCs in the clinical setting . CONCLUSION Among genetic events
during tumorigenesis of RCC , aberrations involving loci of the short arm of ...

Author: Carl A. Olsson

Publisher:

ISBN: UOM:39015029532325

Category: Medical

Page: 173

View: 910

Categories: Medical