DRUG RESISTANCE IN CANCER CHEMOTHERAPY IAN D. HICKSON * and
DANIEL HOCHHAUSER Imperial Cancer Research Fund Laboratories , Institute
of Molecular Medicine , University of Oxford , John Radcliffe Hospital , Oxford
OX3 ...
Author: Hayes
Publisher: CRC Press
ISBN: 9057021676
Category: Science
Page: 412
View: 150
Molecular Biology of Antineoplastic Drug Resistance Craig R . Fairchild , PhD ,
Merrill E . Goldsmith , PhD , and Kenneth H . Cowan , MD , PhD One of the most
troubling problems in cancer chemotherapy is the relative ease with which tumor
...
Author: Jeffrey Cossman
Publisher: Elsevier Publishing Company
ISBN: UOM:39015018515224
Category: Cancer
Page: 465
View: 839
However , to date , the horizontal transfer of an actual pesticide resistance gene
has not been observed or inferred to have ... Concluding Perspective of Antibiotic
and Pesticide Resistance The deployment of antibiotics in medicine and ...
Author: Thomas Miller Brown
Publisher: Amer Chemical Society
ISBN: UOM:39015038037142
Category: SCIENCE
Page: 265
View: 911
Applications of molecular genetics in combatting pesticide resistance: an overviview. Molecular genetics of target-site resistance to acetolactate synthase inhibiting herbicides. Molecular genetics of acetylcholinesterase in insecticide resistant Drosophila melanogaster. The molecular basis of plant resistance to photosystem II herbicides. Molecular genetics of resistance in fungi to azole fungicides. Evolution and population genetics. Ecology transgenesis, and regulatory issues.The biochemistry and genetics of antibiotic resistance are far better known than
the equally important events underlying the ... Currently, impressive advances in
understanding the molecular biology of antibiotic resistance contrast with general
...
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 9780470515365
Category: Medical
Page: 260
View: 377
Antibiotic Resistance: Origins, Evolution, Selection and Spread Chairman: Stuart B. Levy, 1997 Over the last 50 years, the rapid increase in the use of antibiotics, not only in people, but also in animal husbandry and agriculture, has delivered a selection unprecedented in the history of evolution. Consequently, society is facing one of its gravest public health problems-the emergence of infectious bacteria with resistance to many, and in some cases all, available antibiotics. This book brings together a multidisciplinary group of experts to discuss this problem. It begins by examining the origins of resistance and goes on to look at how the use of antibiotics in human medicine and farming/agriculture has selected for resistant bacteria. Separate chapters describe the evolution of resistance determinants and how these are spread both within and between bacterial species. Finally, the book contains discussions on strategies for countering the threat of antibiotic resistance. A major re-thinking of our approach to the treatment of infectious diseases is proposed-that antibiotic resistance should be seen as a problem created by the disruption of normal microbial ecology. To restore efficacy to earlier antibiotics, and to maintain the success of new antibiotics that are introduced, we need to use these drugs in a way that ensures an ecological balance that favours the predominance of susceptible bacteria.Two approaches to the genetic analysis of drug resistance in parasitic protozoa
are discussed . Beverley presents data supporting a model for the amplification of
the dihydrofolate reductase gene leading to resistance to antifolates . Ullman ...
Author: Mervyn J. Turner
Publisher: Cold Spring Harbor Laboratory Press
ISBN: UOM:39015013566289
Category: Medical
Page: 170
View: 609
However , chloramphenicol resistant M . xanthus showed a slower growth rate
than sensitive cells and is rapidly lost in the absence of the drug . This indicates
that the CM gene has not stably integrated into the myxobacterial chromosome .
Author: Terrance Leighton
Publisher:
ISBN: UCAL:B4456669
Category: Science
Page: 478
View: 263
50 . Telenti A . Genetics of drug resistance in tuberculosis . Clin Chest Med 1997 ;
18 : 55 - 64 . 51 . Takiff HE . The molecular mechanisms of drug resistance in M .
tuberculosis ( Chapter 6 ) . In : Bastian I , Portaels F , eds . Multi - drug Resistant ...
Author: Mario C. Raviglione
Publisher: CRC PressI Llc
ISBN: UOM:39015064805958
Category: Medical
Page: 1246
View: 599
Thoroughly examining tuberculosis from historical, theoretical, and clinical perspectives, this Third Edition merges state-of-the-art research developments with principles of programmatic TB management. Each of the 50 chapters analyze current studies on TB mechanisms and treatment and will meet the needs of all who work in the field of TB control, whether in low-income, high-prevalence areas or in low-prevalence industrialized countries.plasmid , although plasmid - borne resistance to some drugs such as nalidixic
acid and the related 4 - quinolones does not seem to occur . The antibiotic
resistance genes themselves are many and varied : resistance to penicillins
occurs by ...
Author: Jeremy Dale
Publisher: John Wiley & Son Limited
ISBN: UOM:39015040371588
Category: Science
Page: 310
View: 650
Molecular Genetics of Bacteria Third Edition Jeremy W. Dale School of Biological Sciences, University of Surrey, UK This third edition of Jeremy Dale's successful book provides a thoroughly updated and revised introduction to the molecular biology and genetics of bacteria. Molecular Genetics of Bacteria presents both the basic concepts and the most exciting recent developments in a form which is suitable for the needs of students studying microbiology, biotechnology, molecular biology, biochemistry, genetics and related biomedical sciences. The structure of the third edition has undergone a major reorganization and incorporates: * New material on the concept of adaptive mutation, bacterial differentiation, intercellular signalling, conjugative transposons and integrons. * Enhanced coverage of supercoiling, reporter genes, sporulation, PCR and genome sequencing projects. Reviews of the Second Edition: "I recommend this book strongly for the purpose for which it was designed, namely as an introductory text with broad coverage of the subject." Simon Baumberg, University of Leeds, Society for General Microbiology Quarterly ". a text that is readable and attractive to people who may be daunted by more-detailed works." Trends in MicrobiologyGEDEBOU , M . and TASSEW , A . 1980 . Neisseria gonorrhoeae isolates from
Ethiopia . 2 . Pair correlations between minimal inhibitory concentration values of
5 antibiotics and frequency of multiple antibiotic resistance . Bull . Wld . Hlth . Org
...
Author: Umakant Sinha
Publisher:
ISBN: UOM:39015036382482
Category: Genetic engineering
Page: 158
View: 541
Selected papers of the International Symposium on Gene Cloning and Recombinant DNA Technology, 1983, Patna, India, organized by the UGC Centre of Special Assistance, and the Dept. of Botany, Patna University.Genetics, Biochemistry, and Molecular Biology Susumu Mitsuhashi. deviation
from its conclusion then seemed like a regression toward Lamarckism ! ) . No
doubt any additional peculiar features of drug resistance being discovered today
are ...
Author: Susumu Mitsuhashi
Publisher: Thieme Medical Publishers
ISBN: UOM:39015006028024
Category: Bacteria
Page: 429
View: 882
Clones of P . mallei Ts - 5 carrying recombinant plasmid DNAs in autonomous
and integrated states produced by conjugation and transformation were studied
with regard to retention of plasmid markers of antibiotic resistance during
passages ...
Author:
Publisher:
ISBN: PSU:000066296690
Category: Microbiology
Page:
View: 655
TRANS DOMINANT MUTANTS OF THE katG GENE INDUCE ISONIAZID
RESISTANCE IN MYCOBACTERIUM BOVIS ( BCG ) . ... The emergence of
multidrug resistant strains has sharpened the need for defining the molecular
mechanisms of ...
Author:
Publisher:
ISBN: PSU:000031016766
Category: Bacterial genetics
Page:
View: 811
TRANS DOMINANT MUTANTS OF THE katG GENE INDUCE ISONIAZID
RESISTANCE IN MYCOBACTERIUM BOVIS ( BCG ) . ... The emergence of
multidrug resistant strains has sharpened the need for defining the molecular
mechanisms of ...
Author:
Publisher:
ISBN: UVA:X004126962
Category: Bacterial genetics
Page: 178
View: 116
However, tools for molecular genetic analysis, such as gene fusions, counter-
selectable markers, allelic exchange and transposon mutagenesis have been
recently constructed, moreover, the genome sequence has been completed,
which ...
Author: R. C. Mahajan
Publisher: CRC Press
ISBN: 0849309832
Category: Medical
Page: 282
View: 205
The recent appearance of multi-drug resistant phenotypes has complicated the efforts to completely eradicate diseases such as tuberculosis and malaria, thus underscoring the need for new and innovative scientific approach to the problem. Multi-Drug Resistance in Emerging and Re-Emerging Diseases highlights the state-of-the-art in microbial/parasite control and containment, and discusses ways and means of avoiding development of drug resistance. It explores strategies to combat the nightmare of microbial aggression and resistance and to overcome multiple drug resistance when it emerges in microbial organisms or in cancer cells exposed to chemotherapy. Written by a panel of experts, the book gives you the benefits of both field and clinical experience as well as an in-depth know-how of the pathology of these drug resistant diseases. Topics include malaria, tuberculosis, cholera, leprosy, diarrhoeal diseases, nosocomial diseases, plague, and drug resistance and cancer. Multi-Drug Resistance in Emerging and Re-Emerging Diseases provides a foundation for new initiatives and more collaborative efforts in the fight against resistance to antibiotics by micro-organisms.[18] Ramaswamy S and Musser JM (1998). Molecular genetic basis of
antimicrobial agent resistance in Mycobacterium tuberculosis, 1998 update.
Tuber. Lung Dis . 9:3-29. [19] Telenti A, Imboden P, Marchesi P,Marchesi nF,
Schmidheinin T, ...
Author: Adriel R. Bonilla
Publisher: Nova Biomedical Books
ISBN: UCSD:31822037476868
Category: Medical
Page: 527
View: 712
Antibiotic resistance is the ability of a micro-organism to withstand the effects of antibiotics. There are three mechanisms that can cause antibiotic resistance: prevention of interaction of drug with target, decreased uptake due to either an increased efflux or a decreased influx of the antimicrobial agent and enzymatic modification or destruction of the compound. In the past couple years, antibiotic resistance has become an increasing public health concern. Tuberculosis, gonorrhoea, malaria and childhood ear infections are just a few of the diseases that have become hard to treat with antibiotic drugs. This book addresses the concern that over the past few years, there has been a major rise in resistance to antibiotics among gram-negative bacteria. New antibacterial drugs with novel modes of actions are urgently required in order to fight against infection. Novel antibiotics such as linezolid, carbapenem ertapenem, daptomycin and gemifloxacin are examined in this book. The genetic approaches used in risk assessment of antibiotic resistance dissemination are looked at as well. Furthermore, this book discusses the present studies on the use of veterinary antibiotics in agriculture, on the occurrence of antibiotic compounds and resistant bacteria in soil and water and clearly demonstrates the need for further studies.Genetics and molecular biology of industrial microorganisms . American Society
for ... The expression of Streptomyces and Escherichia drug resistance
determinants cloned into the Streptomyces phage 6C31 . Gene 19 : 21-32 . 8.
Distler , J.
Author: Trifon Adamidis
Publisher:
ISBN: MSU:31293010251092
Category: Antibiosis
Page: 332
View: 513
15 Central Lancashire , APPLIED BIOLOGY , MPhil / PhD ; areas of research
interest inc : light reaction and molecular biol ... technique ; photoperiodism and
flowering ; studies on modification of cell membranes in relation to drug
resistance .
Author:
Publisher:
ISBN: STANFORD:36105131057072
Category: Research
Page:
View: 360
appears to be the mechanism responsible for regulating the expression of
antibiotic resistance in the antibiotic producer . When the respective antibiotic is
not produced , antibiotic resistance is unnecessary . However , as antibiotic
production ...
Author: Paul Rudolph August
Publisher:
ISBN: MINN:31951P00505125Z
Category:
Page: 384
View: 284
These results suggest that PGP plays an important role in the intrinsic drug
resistance of RCCs in the clinical setting . CONCLUSION Among genetic events
during tumorigenesis of RCC , aberrations involving loci of the short arm of ...
Author: Carl A. Olsson
Publisher:
ISBN: UOM:39015029532325
Category: Medical
Page: 173
View: 910
