Molecular and Cell Biology of Muscular Dystrophy

Molecular and Cell Biology of Muscular Dystrophy

Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough which has been achieved in our understanding of the Duchenne/Becker muscular dystrophies and of the consequences ...

Author: T. Partridge

Publisher: Springer Science & Business Media

ISBN: 9789401115285

Category: Science

Page: 344

View: 412

Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough which has been achieved in our understanding of the Duchenne/Becker muscular dystrophies and of the consequences and ramifications of this breakthrough.
Categories: Science

Facioscapulohumeral Muscular Dystrophy FSHD

Facioscapulohumeral Muscular Dystrophy  FSHD

This volume summarizes the current understanding of the disorder, including clinical, molecular and therapeutic aspects.

Author: David Cooper

Publisher: Garland Science

ISBN: 9780203483671

Category: Medical

Page: 250

View: 889

Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder involving slowly progressive muscle degeneration in which the muscles of the face, shoulder blades and upper arms are among the most severely affected. It is the third most common inherited muscular dystrophy, affecting 1 in 20,000. The search for the molecular basis of the disease is of interest to all genetic researchers, involving a deletion outside a coding region resulting in over-expression of adjacent genes. This volume summarizes the current understanding of the disorder, including clinical, molecular and therapeutic aspects.
Categories: Medical

Molecular and Cell Biology of Muscular Dystrophy

Molecular and Cell Biology of Muscular Dystrophy

Molecular and Cell Biology of Muscular Dystrophy gives a series of accounts of various aspects of the remarkable breakthrough which has been achieved in our understanding of the Duchenne/Becker muscular dystrophies and of the consequences ...

Author: T. Partridge

Publisher:

ISBN: 940111529X

Category:

Page: 364

View: 563

Categories:

FSHD Facioscapulohumeral Muscular Dystrophy

FSHD Facioscapulohumeral Muscular Dystrophy

This volume summarizes the current understanding of the disorder, including clinical, molecular and therapeutic aspects.

Author: Meena Upadhyaya

Publisher: Taylor & Francis

ISBN: 1859962440

Category: Medical

Page: 392

View: 532

Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disorder involving slowly progressive muscle degeneration in which the muscles of the face, shoulder blades and upper arms are among the most severely affected. It is the third most common inherited muscular dystrophy, affecting 1 in 20,000. The search for the molecular basis of the disease is of interest to all genetic researchers, involving a deletion outside a coding region resulting in over-expression of adjacent genes. This volume summarizes the current understanding of the disorder, including clinical, molecular and therapeutic aspects.
Categories: Medical

Muscular Dystrophies

Muscular Dystrophies

The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies.

Author: Robert C. Griggs

Publisher: Elsevier

ISBN: 9780444534897

Category: Medical

Page: 284

View: 662

The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications. Starting with an overview of muscular dystrophies, the book’s 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery-Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies. This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders. Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders
Categories: Medical

Skeletal Muscle Muscular Dystrophy

Skeletal Muscle   Muscular Dystrophy

This is because adult skeletal muscle contains a stem cell, the satellite cell, which lies beneath the basement membrane surrounding the muscle fibers. [The multinucleation of cardiac muscle arises from karyokinesis without cytokinesis.] A ...

Author: Donald Fischman

Publisher: Biota Publishing

ISBN: 9781615040049

Category: Science

Page: 56

View: 788

Histologically, muscle is conveniently divided into two groups, striated and nonstriated, based on whether the cells exhibit cross-striations in the light microscope (Figure 3). Smooth muscle is involuntary: its contraction is controlled by the autonomic nervous system. Striated muscle includes both cardiac (involuntary) and skeletal (voluntary). The former is innervated by visceral efferent fibers of the autonomic nervous system, whereas the latter is innervated by somatic efferent fibers, most of which have their cell bodies in the ventral, motor horn of the spinal cord. Smooth muscle is designed to have slow, relatively sustained contractions, while striated muscle contracts rapidly and usually phasically. Both cardiac and smooth muscle cells are mononucleated, whereas skeletal muscle cells (fibers) are multinucleated. [In aging hearts or hypertrophied hearts, cardiac muscle cells are often binucleated.] Multinucleation of skeletal muscle arises during development by the cytoplasmic fusion of muscle precursor cells, myoblasts. Adult skeletal muscle cells do not divide; that is also true of most cardiac myocytes. However, skeletal muscle exhibits a considerable amount of regeneration after injury. This is because adult skeletal muscle contains a stem cell, the satellite cell, which lies beneath the basement membrane surrounding the muscle fibers. [The multinucleation of cardiac muscle arises from karyokinesis without cytokinesis.] A diagrammatic series of enlargements of skeletal muscle are shown in Figure 4. A bundle of muscle fibers (fasciculus) is cut from the deltoid muscle. Each muscle cell is termed a myofiber or muscle fiber. Each muscle fiber contains contractile organelles termed myofibrils, which contain the contractile units of muscle termed sarcomeres. The sarcomeres are composed of myofilaments, which in turn are composed of contractile proteins. Muscle connective tissue layers are organized in concentric layers that are important in the entry and exit of vessels and nerves to and from the tissue. These are shown in Figure 5. The outermost layer is the epimysium or muscle sheath. Connective tissue septae (perimysium) run radially into the muscle tissue, dividing it into muscle fascicles. The deepest layer, surrounding each of the muscle fibers is the endomysium. The endomysium is in direct contact with a basal lamina that ensheathes each muscle fiber. It surrounds the plasma membrane of the muscle fiber termed the sarcolemma.
Categories: Science

Dystrophin

Dystrophin

This is the first book to address the structure, function, and distribution of dystrophin and its associated proteins in muscle and brain, rather than concentratiing primarily on the disease.

Author: Susan C.. Brown

Publisher: Cambridge University Press

ISBN: 0521550335

Category: Medical

Page: 338

View: 910

The absence of dystrophin is the underlying cause of Duchenne muscular dystrophy. This is the first book to address the structure, function, and distribution of dystrophin and its associated proteins in muscle and brain, rather than concentratiing primarily on the disease. It covers an exciting and rapidly expanding field that promises to have important and widespread implications for many aspects of cell biology.
Categories: Medical

Genetic Analysis of the X Chromosome

Genetic Analysis of the X Chromosome

The present volume contains the edited transcript of a collo quium sponsored by the Muscular Dystrophy Association and held at Mountain Shadows Inn, Scottsdale, Arizona, December 14-16, 1981.

Author: Henry F. Epstein

Publisher: Springer Science & Business Media

ISBN: 9781468443462

Category: Science

Page: 203

View: 566

The present volume contains the edited transcript of a collo quium sponsored by the Muscular Dystrophy Association and held at Mountain Shadows Inn, Scottsdale, Arizona, December 14-16, 1981. The participants, geneticists, molecular biologists, bio chemists and clinicians, explored in open dialogue ways and means of identifying and characterizing the genetic alterations responsible for X-linked muscular dystrophies, especially the Duchenne type. The clinicians, who urged the use of properly diagnosed and documented case material for study, emphasized the troublesome fact that the primary phenotypic expression of the gene (or genes) involved in the muscular dystrophies is yet to be identified. Discussions centered on the applicability of recent methodol ogical advances in DNA chemistry and molecular biology, cytogenetics and cell biology to mapping the X chromosome. Despite ignorance of the basic disorder in the muscular dystrophies, DNA technologies and chromosome mapping strategies for the discovery of genetic defects and phenotypic expressions were proposed. Beyond its stimulating intellectual exchange, the colloquium yielded important benefits. The participants agreed to share needed cell lines and endonuclease restriction enzymes and to organize interlaboratory communication and collaborative efforts to accelerate progress in the quest for the genetic lesion in Duchenne muscular dystrophy. The discussions were recorded, transcribed, edited and to some extent, rearranged to fit into a sequence of chapters. The editors are grateful to Joy Colarusso Lowe whose unusual skill, patience and persistence made it possible to convert a highly specialized technical discussion into a coherent manuscript.
Categories: Science

Myogenesis in Development and Disease

Myogenesis in Development and Disease

Myogenesis in Development and Disease, Volume 126, the latest volume in the Current Topics in Developmental Biology series, covers major topics of research in myogenesis, with a particular emphasis on regeneration and muscle disease.

Author:

Publisher: Academic Press

ISBN: 9780128094945

Category: Science

Page: 334

View: 107

Myogenesis in Development and Disease, Volume 126, the latest volume in the Current Topics in Developmental Biology series, covers major topics of research in myogenesis, with a particular emphasis on regeneration and muscle disease. It includes contributions from an international board of authors, providing a comprehensive set of reviews. Covers major topics of research in myogenesis Contains invaluable contributions from an international board of authors Provides a comprehensive set of reviews
Categories: Science

The Molecular Biology of Neurological Disease

The Molecular Biology of Neurological Disease

This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry ...

Author: Roger N. Rosenberg

Publisher: Butterworth-Heinemann

ISBN: 9781483163307

Category: Health & Fitness

Page: 276

View: 218

The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.
Categories: Health & Fitness

Frontiers in Skeletal Muscle Wasting Regeneration and Stem Cells

Frontiers in Skeletal Muscle Wasting  Regeneration and Stem Cells

Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.

Author: Carlos Hermano J. Pinheiro

Publisher: Frontiers Media SA

ISBN: 9782889198320

Category:

Page:

View: 542

The search for knowledge on cellular and molecular mechanisms involved in skeletal muscle mass homeostasis and regeneration is an exciting scientific area and extremely important to develop therapeutic strategies for neuromuscular disorders and conditions related to muscle wasting. The mechanisms involved in the regulation of skeletal muscle mass and regeneration consist of molecular signaling pathways modulating protein synthesis and degradation, bioenergetics alterations and preserved function of muscle stem cells. In the last years, different kinds of stem cells has been reported to be localized into skeletal muscle (satellite cells, mesoangioblasts, progenitor interstitial cells and others) or migrate from non-muscle sites, such as bone marrow, to muscle tissue in response to injury. In addition, myogenic progenitor cells are also activated in skeletal muscle wasting disorders. The goal of this research topic is to highlight the available knowledge regarding skeletal muscle and stem cell biology in the context of both physiological and pathological conditions. Our purpose herein is to facilitate better dissemination of research into skeletal muscle physiology field. Frontiers in Physiology is a journal indexed in: PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef.
Categories:

International Review of Cytology

International Review of Cytology

Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Author: Kwang W. Jeon

Publisher: Elsevier

ISBN: 0080560938

Category: Science

Page: 312

View: 939

International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Categories: Science

Muscle Proteins Advances in Research and Application 2011 Edition

Muscle Proteins  Advances in Research and Application  2011 Edition

Muscle Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Muscle Proteins in a concise format.

Author:

Publisher: ScholarlyEditions

ISBN: 9781464933196

Category: Medical

Page: 77

View: 538

Muscle Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Muscle Proteins in a concise format. The editors have built Muscle Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Muscle Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Muscle Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Medical

Molecular Mechanisms of Muscular Dystrophies

Molecular Mechanisms of Muscular Dystrophies

It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters cover

Author: Steve J. Winder

Publisher: CRC Press

ISBN: 9781498713962

Category: Science

Page: 250

View: 223

There is no doubt that the study of the muscular dystrophies in recent years has been exciting and rewarding. It has attracted the attention of many investigators of international repute, and this is reflected in the various contributions to this volume. Molecular Mechanisms of Muscular Dystrophies represents a personal collection of chapters cover
Categories: Science

Duchenne Muscular Dystrophy New Insights for the Healthcare Professional 2012 Edition

Duchenne Muscular Dystrophy  New Insights for the Healthcare Professional  2012 Edition

You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Author:

Publisher: ScholarlyEditions

ISBN: 9781464979682

Category: Medical

Page: 27

View: 256

Duchenne Muscular Dystrophy: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Duchenne Muscular Dystrophy in a compact format. The editors have built Duchenne Muscular Dystrophy: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Duchenne Muscular Dystrophy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Duchenne Muscular Dystrophy: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Medical

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal.

Author: Kwang W. Jeon

Publisher: Academic Press

ISBN: 9780124058514

Category: Science

Page: 336

View: 910

International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2011: 4.481. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists
Categories: Science

Biochemistry and Cell Biology

Biochemistry and Cell Biology

New therapies for muscular dystrophy : cautious optimism . Trends Mol . Med . 10
: 516–520 . doi : 10.1016 / j.molmed . 2004.08.007 . PMID : 15464452 . Dennis ,
C.L. , Tinsley , J.M. , Deconinck , A.E. , and Davies , K.E. 1996. Molecular and ...

Author:

Publisher:

ISBN: OSU:32435077993954

Category: Biochemistry

Page:

View: 958

Categories: Biochemistry