Modern Solvents in Organic Synthesis

Modern Solvents in Organic Synthesis

This book tries to cover the more recent and important new solvents or solvent systems for both academic and industrial applications.

Author: Paul Knochel

Publisher: Springer

ISBN: 9783540486640

Category: Science

Page: 210

View: 717

In recent years the choice of a given solvent for performing a reaction has become increasingly important. More and more, selective reagents are used for chemical transformations and the choice of the solvent may be determining for reaching high reaction rates and high selectivities. The toxicity and recycling considerations have also greatly influenced the nature of the solvents used for industrial reactions. Thus, the development of reactions in water is not only important on the laboratory scale but also for industrial applications. The p- formance of metal-catalyzed reactions in water for example has led to several new hydrogenation or hydroformylation procedures with important industrial applications. The various aspects of organic chemistry in water will be prese- ed in this book. Recently, novel reaction media such as perfluorinated solvents or supercritical carbon dioxide has proven to have unique advantages leading to more practical and more efficient reactions. Especially with perfluorinated solvents, new biphasic catalyses and novel approaches to perform organic reactions have been developed. These aspects will be examined in detail in this volume. Finally, the performance of reactions in the absence of solvents will show practical alternatives for many reactions. More than ever before, the choice of the solvent or the solvent system is ess- tial for realizing many chemical transformations with the highest efficiency. This book tries to cover the more recent and important new solvents or solvent systems for both academic and industrial applications.
Categories: Science

Modern Solvents in Organic Synthesis

Modern Solvents in Organic Synthesis

This book tries to cover the more recent and important new solvents or solvent systems for both academic and industrial applications.

Author: Paul Knochel

Publisher: Springer

ISBN: 3540662138

Category: Science

Page: 210

View: 657

In recent years the choice of a given solvent for performing a reaction has become increasingly important. More and more, selective reagents are used for chemical transformations and the choice of the solvent may be determining for reaching high reaction rates and high selectivities. The toxicity and recycling considerations have also greatly influenced the nature of the solvents used for industrial reactions. Thus, the development of reactions in water is not only important on the laboratory scale but also for industrial applications. The p- formance of metal-catalyzed reactions in water for example has led to several new hydrogenation or hydroformylation procedures with important industrial applications. The various aspects of organic chemistry in water will be prese- ed in this book. Recently, novel reaction media such as perfluorinated solvents or supercritical carbon dioxide has proven to have unique advantages leading to more practical and more efficient reactions. Especially with perfluorinated solvents, new biphasic catalyses and novel approaches to perform organic reactions have been developed. These aspects will be examined in detail in this volume. Finally, the performance of reactions in the absence of solvents will show practical alternatives for many reactions. More than ever before, the choice of the solvent or the solvent system is ess- tial for realizing many chemical transformations with the highest efficiency. This book tries to cover the more recent and important new solvents or solvent systems for both academic and industrial applications.
Categories: Science

Modern Solvents in Organic Synthesis

Modern Solvents in Organic Synthesis

This book tries to cover the more recent and important new solvents or solvent systems for both academic and industrial applications.

Author: Paul Knochel

Publisher: Springer

ISBN: 3662156350

Category: Science

Page: 210

View: 577

In recent years the choice of a given solvent for performing a reaction has become increasingly important. More and more, selective reagents are used for chemical transformations and the choice of the solvent may be determining for reaching high reaction rates and high selectivities. The toxicity and recycling considerations have also greatly influenced the nature of the solvents used for industrial reactions. Thus, the development of reactions in water is not only important on the laboratory scale but also for industrial applications. The p- formance of metal-catalyzed reactions in water for example has led to several new hydrogenation or hydroformylation procedures with important industrial applications. The various aspects of organic chemistry in water will be prese- ed in this book. Recently, novel reaction media such as perfluorinated solvents or supercritical carbon dioxide has proven to have unique advantages leading to more practical and more efficient reactions. Especially with perfluorinated solvents, new biphasic catalyses and novel approaches to perform organic reactions have been developed. These aspects will be examined in detail in this volume. Finally, the performance of reactions in the absence of solvents will show practical alternatives for many reactions. More than ever before, the choice of the solvent or the solvent system is ess- tial for realizing many chemical transformations with the highest efficiency. This book tries to cover the more recent and important new solvents or solvent systems for both academic and industrial applications.
Categories: Science

Modern Organic Synthesis in the Laboratory

Modern Organic Synthesis in the Laboratory

1. FUNDAMENTAL TECHNIQUES. 2. FUNCTIONAL GROUP MANIPULATIONS. 3. OXIDATION. 4. REDUCTION. 5. CARBON-CARBON BOND FORMATION. 6. PROTECTING GROUPS.

Author: Jie Jack Li

Publisher: OUP USA

ISBN: 9780195187984

Category: Science

Page: 198

View: 965

1. FUNDAMENTAL TECHNIQUES. 2. FUNCTIONAL GROUP MANIPULATIONS. 3. OXIDATION. 4. REDUCTION. 5. CARBON-CARBON BOND FORMATION. 6. PROTECTING GROUPS.
Categories: Science

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, ...

Author: Wei Zhang

Publisher: John Wiley & Sons

ISBN: 9781119288169

Category: Science

Page: 728

View: 606

Green Techniques FOR Organic Synthesis AND Medicinal Chemistry An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique's features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, 2nd Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Categories: Science

Microwaves in Organic Synthesis Two Volume Set

Microwaves in Organic Synthesis  Two Volume Set

58 A. Loupy, Modern Solvents in Organic Synthesis. Topics Curr. Chem., 1999.
206, 155-207. 59 K. Tanaka and F. Toda, Chem. Rev.. 2000, 100. 1025-1074. 60
G. W. V. Cave, C. L. Raston and J. L. Scott, J. Chem. Soc., Chem. Commun., 2001
 ...

Author: André Loupy

Publisher: Wiley-VCH

ISBN: UCSD:31822035320241

Category: Science

Page: 1007

View: 299

The long awaited new edition of this comprehensive two-volume reference has been completely updated and expanded by 30% to include chapters on ionic liquids, carbohydrate chemistry, multicomponent reactions, solid phase peptide synthesis, carbon nanotubes and fullerenes. Written by the most eminent scientists in their respective fields, the chapters, which complement one another, now also include eight new fields of application, such as heterocyclic chemistry, cycloadditions and carbohydrate chemistry. In addition, very promising techniques under development are treated, resulting from the application of microwave irradiation to combinatorial chemistry, radiochemistry and photochemistry. The standard reference in this booming field. Andre Loupy received his PhD in 1975 from Paris-South University under Dr. Jacqueline Seyden-Penne at the Centre National de la Recherche Scientifique (CNRS) in Thiais, France. He joined the Laboratory of Selective Reactions on Supports in Paris-South University, Center of Orsay, before becoming the first class director of research at CNRS, where he led this lab until the end of 2005. He has some 280 publications and 10 chapters in several books to his name, and is a recipient of the M.J. Collins Award. Together with Georges Bram, Dr. Loupy has been concerned with microwave activation since 1987, especially when coupled to solvent-free conditions ("green chemistry") and the non-alimentary valorization of products from agriculture. His current research interests focus on medium effects in organic synthesis including solvent and salt effects, solvent-free conditions with a special interest in supported reactions and phase transfer catalysis.
Categories: Science

Some Modern Methods of Organic Synthesis

Some Modern Methods of Organic Synthesis

The general plan of the book follows that of the second edition, but the opportunity has been taken to bring the book up to date and to take account of advances in knowledge and of new reactions which have come into use since publication of ...

Author: W. Carruthers

Publisher: Cambridge University Press

ISBN: 0521311179

Category: Science

Page: 526

View: 443

The general plan of the book follows that of the second edition, but the opportunity has been taken to bring the book up to date and to take account of advances in knowledge and of new reactions which have come into use since publication of the earlier editions.
Categories: Science

Comprehensive Organic Synthesis

Comprehensive Organic Synthesis

The second edition of Comprehensive Organic Synthesis-winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers-builds upon the highly respected first edition in drawing together the new ...

Author: Paul Knochel

Publisher: Elsevier

ISBN: 0080977421

Category: Science

Page: 10000

View: 906

The second edition of "Comprehensive Organic Synthesis" winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find "Comprehensive Organic Synthesis, Second Edition" an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American PublishersContains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reductionIncludes more than10,000 schemes and images Fully revised and updated; important growth areas including combinatorial chemistry, new technological, industrial, and green chemistry developments are covered extensively"
Categories: Science

Acid Catalysis in Modern Organic Synthesis

Acid Catalysis in Modern Organic Synthesis

"This two-volume set covers all new developments and, in addition, includes the hot concept of combined Bronsted and Lewis acid catalysis, developed by Hisashi Yamamoto himself.

Author: Hisashi Yamamoto

Publisher:

ISBN: UOM:39015079204049

Category: Acids

Page: 24

View: 814

"This two-volume set covers all new developments and, in addition, includes the hot concept of combined Bronsted and Lewis acid catalysis, developed by Hisashi Yamamoto himself. The excellent editorial team has put together an equally top team of expert authors, resulting in a true treasure trove of essential information -- making this a must for every chemist working in organic chemistry and catalysis, in academia as well as in industry."--Publisher's description.
Categories: Acids

Biotransformations in Organic Chemistry

Biotransformations in Organic Chemistry

The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry.

Author: Kurt Faber

Publisher: Springer Science & Business Media

ISBN: 3642173934

Category: Science

Page: 423

View: 205

The use of biocatalysts, employed either as isolated enzymes or whole microbial cells, offers a remarkable arsenal of highly selective transformations for state-of-the-art synthetic organic chemistry. Over the last two decades, this methodology has become an indispensable tool for asymmetric synthesis, not only at the academic level, but also on an industrial scale. This well-established textbook on biocatalysis provides a basis for undergraduate and graduate courses in modern organic chemistry, as well as a condensed introduction into this field. After a basic introduction into the use of biocatalysts—principles of stereoselective transformations, enzyme properties and kinetics—the different types of reactions are explained according to the 'reaction principle', such as hydrolysis, reduction, oxidation, C–C bond formation, etc. Special techniques, such as the use of enzymes in organic solvents, immobilization techniques and modified or artificial enzymes, are treated in a separate section. A final chapter deals with thebasic rules for the safe and practical handling of biocatalysts. In this completely revised 6th edition, emphasis has been given to an improved didactic style including colored graphics in order to facilitate a deeper understanding of the underlying principles. New developments, such as transamination, enzyme promiscuity and applications on industrial scale within the field of 'white biotechnology' are included.
Categories: Science

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis

This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Author: Inamuddin

Publisher: Springer Nature

ISBN: 9783030441760

Category: Science

Page: 499

View: 741

Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.
Categories: Science

Modern Organic Synthesis

Modern Organic Synthesis

This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts ...

Author: George S. Zweifel

Publisher: John Wiley & Sons

ISBN: 9781119086765

Category: Science

Page: 416

View: 184

This book bridges the gap between sophomore and advanced / graduate level organic chemistry courses, providing students with a necessary background to begin research in either an industry or academic environment. • Covers key concepts that include retrosynthesis, conformational analysis, and functional group transformations as well as presents the latest developments in organometallic chemistry and C–C bond formation • Uses a concise and easy-to-read style, with many illustrated examples • Updates material, examples, and references from the first edition • Adds coverage of organocatalysts and organometallic reagents
Categories: Science

Handbook of Reagents for Organic Synthesis Reagents for High Throughput Solid Phase and Solution Phase Organic Synthesis

Handbook of Reagents for Organic Synthesis  Reagents for High Throughput Solid Phase and Solution Phase Organic Synthesis

1997, 62,450. (b) Maul, J. P; Ostrowski, P.; Ublacker, G. A.; Curran, D. P.; Linclau,
B. In Modern Solvents in Organic Synthesis, Top. Cur. Chem.; Knochel, P., Ed.;
1999; Vol. 206, p. 80. (a) Park, S.-U.; Chung, S.-K.; Newcomb, M. J. Am. Chem.

Author: Peter Wipf

Publisher: John Wiley & Sons

ISBN: CHI:70670685

Category: Science

Page: 392

View: 134

Since its discovery in 1963 by R. B. Merrifield, solid-phase synthesis, or polymer-supported synthesis, has become an essential technique with its wide use in the synthesis of peptides and other oligomers. Solid-Phase Reactions provides extensive and comprehensive information on this form of synthesis in a format ideal for those working in the laboratory. As part of the Handbook of Reagents in Organic Synthesis Series, this new addition extends the wealth of information available to the chemist at the bench. All content has been expertly collected and presented by an internationally recognised and respected editorial board led by Professor Peter Wipf.
Categories: Science

Oxidation

Oxidation

This volume covers all methods of oxidation for use in organic synthesis. Emphasis has been placed on selectivity and functional group compatibility together with practical utility and applications.

Author: Barry M. Trost

Publisher: Elsevier

ISBN: 9780080912509

Category: Science

Page:

View: 538

This volume covers all methods of oxidation for use in organic synthesis. Emphasis has been placed on selectivity and functional group compatibility together with practical utility and applications. The volume is broadly divided to cover oxidation of unactivated carbon-hydrogen bonds, oxidation of activated carbon-hydrogen bonds, that is to say those adjacent to activating substituents and adjacent to heteroatoms, and oxidation of carbon-carbon double bonds. The volume also covers oxidation of C-X bonds, carbon-carbon single bonds, heteroatom oxidation and a number of special topics such as electrochemical methods, oxidative rearrangements, solid supported reagents, electron transfer oxidation, and biological methods.
Categories: Science

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis

This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Author: Inamuddin

Publisher: Springer

ISBN: 3030441784

Category: Science

Page: 499

View: 524

Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.
Categories: Science

Advances in Organic Synthesis

Advances in Organic Synthesis

"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating ...

Author: Atta-ur-Rahman

Publisher: Bentham Science Publishers

ISBN: 9781608051984

Category: Science

Page: 601

View: 357

"The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electrophilic and nucleophilic, fluorinating agents. It brings t"
Categories: Science

Modern Rhodium Catalyzed Organic Reactions

Modern Rhodium Catalyzed Organic Reactions

This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at ...

Author: P. Andrew Evans

Publisher: John Wiley & Sons

ISBN: 9783527604098

Category: Science

Page: 496

View: 200

Rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations, with quite often-unique selectivity. Hydrogenation, C-H activation, allylic substitution, and numerous other reactions are catalyzed by this metal, which presumably accounts for the dramatic increase in the number of articles that have recently emerged on the topic. P. Andrew Evans, the editor of this much-needed book, has assembled an internationally renowned team to present the first comprehensive coverage of this important area. The book features contributions from leaders in the field of rhodium-catalyzed reactions, and thereby provides a detailed account of the most current developments, including: Rhodium-Catalyzed Asymmetric Hydrogenation (Zhang) Rhodium-Catalyzed Hydroborations and Related Reactions (Brown) Rhodium-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron Deficient Olefins (Hayashi) Recent Advances in Rhodium(I)-Catalyzed Asymmetric Olefin Isomerization and Hydroacylation Reactions (Fu) Stereoselective Rhodium(I)-Catalyzed Hydroformylation and Silylformylation Reactions and Their Application to Organic Synthesis (Leighton) Carbon-Carbon Bond-Forming Reactions Starting from Rh-H or Rh-Si Species (Matsuda) Rhodium(I)-Catalyzed Cycloisomerization and Cyclotrimerization Reactions (Ojima) The Rhodium(I)-Catalyzed Alder-ene Reaction (Brummond) Rhodium-Catalyzed Nucleophilic Ring Cleaving Reactions of Allylic Ethers and Amines (Fagnou) Rhodium(I)-Catalyzed Allylic Substitution Reactions and their Applications to Target Directed Synthesis (Evans) Rhodium(I)-Catalyzed [2+2+1] and [4+1] Carbocyclization Reactions (Jeong) Rhodium(I)-Catalyzed [4+2] and [4+2+2] Carbocyclizations (Robinson) Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis (Wender) Rhodium(II)-Stabilized Carbenoids Containing both Donor and Acceptor Substituents (Davies) Chiral Dirhodium(II)Carboxamidates for Asymmetric Cyclopropanation and Carbon-Hydrogen Insertion Reactions (Doyle) Cyclopentane Construction by Rhodium(II)-Mediated Intramolecular C-H Insertion (Taber) Rhodium(II)-Catalyzed Oxidative Amination (DuBois) Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)-Catalyzed Carbene-Transfer (West) Rhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions (Austin) "Modern Rhodium-Catalyzed Organic Reactions" is an essential reference text for researchers at all levels in the general area of organic chemistry. This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at pharmaceutical/agrochemical companies.
Categories: Science

Quantum Chemistry of Organic Compounds

Quantum Chemistry of Organic Compounds

And very much up to date. That this contemporary work should emerge from a regional university in a country in which science has been highly centralized and organic chemistry not very modern, invites reflection.

Author: Vladimir I. Minkin

Publisher: Springer Science & Business Media

ISBN: 9783642756795

Category: Science

Page: 270

View: 366

Chemistry is the science of substances (today we would say molecules) and their transformations. Central to this science is the complexity of shape and function of its typical representatives. There lies, no longer dependent on its vitalistic antecedents, the rich realm of molecular possibility called organic chemistry. In this century we have learned how to determine the three-dimensional structure of molecules. Now chemistry as whole, and organic chemistry in particular, is poised to move to the exploration of its dynamic dimension, the busy business of transformations or reactions. Oh, it has been done all along, for what else is synthesis? What I mean is that the theoretical framework accom panying organic chemistry, long and fruitfully laboring on a quantum chemical understanding of structure, is now making the first tentative motions toward building an organic theory of reactivity. The Minkin, Simkin, Minyaev book takes us in that direction. It incorporates the lessons of frontier orbital theory and of Hartree-Fock SCF calculations; what chemical physicists have learned about trajectory calculations of selected reactions, and a simplified treatment of all-important solvent effects. It is written by professional, accomplished organic chemists for other organic chemists; it is consistently even-toned in its presentation of contending approaches. And very much up to date. That this contemporary work should emerge from a regional university in a country in which science has been highly centralized and organic chemistry not very modern, invites reflection.
Categories: Science