Mitochondria in Health and Disease

Mitochondria in Health and Disease

This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore ...

Author: Ray Griffiths

Publisher: Singing Dragon

ISBN: 9780857012883

Category: Health & Fitness

Page: 304

View: 946

What are the functions of mitochondria in the human body? Why might they stop working properly and what can happen as a result? How can personalized nutrition help to optimize mitochondrial function and prevent or address chronic conditions? This innovative book explores the incredibly complex biochemical roles of mitochondria in health and disease. When healthy, mitochondria provide us with ninety percent of our body's energy. When unhealthy, this can lead to many chronic and degenerative conditions including cancer and Alzheimer's disease. This guide helps practitioners to identify the mitochondrial dysfunction underlying a wide range of health complaints, and provides inspiration about relevant and emerging mitochondria-supportive dietary regimes and nutrients to explore within the model of personalized nutrition.
Categories: Health & Fitness

Mitochondria in Health and Disease

Mitochondria in Health and Disease

Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses f

Author: Carolyn D. Berdanier

Publisher: CRC Press

ISBN: 9781420028843

Category: Medical

Page: 640

View: 639

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.
Categories: Medical

Mitochondria in Health and in Sickness

Mitochondria in Health and in Sickness

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the ...

Author: Andrea Urbani

Publisher: Springer Nature

ISBN: 9789811383670

Category: Science

Page: 277

View: 548

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.
Categories: Science

Mitochondria in Health Disease

Mitochondria in Health   Disease

This is not only useful for students persuing higher education but even for students obtaining their graduation degree. This book is not only for medical students but also for any biology student persuing degree in any branch of biology.

Author: Priyanka Agarwal

Publisher: LAP Lambert Academic Publishing

ISBN: 3659480479

Category:

Page: 104

View: 836

"THE MITOCHONDRIA IN HEALTH AND DISEASE" is an attempt to include the various aspects of mitochondria ''the powerhouse of cell." It starts the evolutionary aspects and ends with the recent advances, including structure, its genome, role in metabolic cycles, and many other important aspects. This is not only useful for students persuing higher education but even for students obtaining their graduation degree. This book is not only for medical students but also for any biology student persuing degree in any branch of biology.
Categories:

Mitochondria and the Future of Medicine

Mitochondria and the Future of Medicine

In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells.

Author: Lee Know

Publisher: Chelsea Green Publishing

ISBN: 9781603587686

Category: Medical

Page: 272

View: 352

With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.
Categories: Medical

Mitochondrial Function in Lung Health and Disease

Mitochondrial Function in Lung Health and Disease

Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and ...

Author: Viswanathan Natarajan

Publisher: Springer

ISBN: 9781493908295

Category: Medical

Page: 222

View: 957

Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
Categories: Medical

Mitochondria in Skeletal Muscle Health Aging and Diseases

Mitochondria in Skeletal Muscle Health  Aging and Diseases

Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass.

Author: Gilles Gouspillou

Publisher: Frontiers Media SA

ISBN: 9782889450732

Category: Electronic book

Page:

View: 377

Skeletal muscle is the most abudant tissue of the human body, making up to 40 to 50% of the human body mass. While the importance of optimal muscle function is well recognized in the athletic field, its significance for general health is often underappreciated. In fact, the evidence that muscle mass, strength and metabolism are essential for our overall health is overwhelming. As the largest protein reservoir in the human body, muscles are essential in the acute response to critical illness such as sepsis, advanced cancer, and traumatic injury. Loss of skeletal muscle mass has also been associated with weakness, fatigue, insulin resistance, falls, fractures, frailty, disability, several chronic diseases and death. As a consequence, maintaining skeletal muscle mass, strength and metabolism throughout the lifespan is critical to the maintenance of whole body health. Mitochondria are fascinating organelles regulating many critical cellular processes for skeletal muscle physiology, including for instance energy supply, reactive oxygen species production, calcium homeostasis and the regulation of apoptosis. It is therefore not surprising that mitochondrial dysfunction has been implicated in a large number of adverse events/conditions and pathologies affecting skeletal muscle health. While the importance of normal mitochondrial function is well recognized for muscle physiology, there are important aspects of mitochondrial biology that are still poorly understood. These include mitochondrial dynamics (fusion and fission processes), morphology and processes involved in mitochondrial quality control (mitophagy). Defining the mechanisms regulating these different aspects of mitochondrial biology, their importance for muscle physiology, as well as the interrelations will be critical for expanding understanding of the role played by mitochondria in skeletal muscle physiology and health. The present research topic provides readers with novel experimental approaches, knowledge, hypotheses and findings related to all aspects of mitochondrial biology in healthy and diseased muscle cells.
Categories: Electronic book

Mitochondrial Signaling in Health and Disease

Mitochondrial Signaling in Health and Disease

The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Author: Sten Orrenius

Publisher: CRC Press

ISBN: 9781439880029

Category: Medical

Page: 528

View: 120

Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.
Categories: Medical

Techniques to Investigate Mitochondrial Function in Neurons

Techniques to Investigate Mitochondrial Function in Neurons

This volume describes a broad spectrum of experimental approaches for investigating structure, function, and transport of neuronal mitochondria in health and disease.

Author: Stefan Strack

Publisher: Humana

ISBN: 1493983296

Category: Medical

Page: 344

View: 720

This volume describes a broad spectrum of experimental approaches for investigating structure, function, and transport of neuronal mitochondria in health and disease. Most of these approaches were only recently developed and range from electron tomography-based 3D reconstruction of mitochondrial cristae to patch clamp recording from mitochondria in intact neurons. The chapters in this book cover topics such as mitochondrial proteomics, fluorescence lifetime imaging, respirometry and mitophagy, as well as optical approaches based on the use of genetically engineered fluorescent sensors for monitoring synaptic ATP and axonal ROS generation, mitochondrial Ca2+ cycling and pH changes, and mitochondrial dynamics and axonal trafficking in live neurons. Each chapter also discusses difficulties, tips, tricks, and precautions to take. Neuromethods series style chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Techniques to Investigate Mitochondrial Function in Neurons is a valuable and useful resource for a broad range of investigators interested in the function of neuronal mitochondria in health and disease states.
Categories: Medical

Nuclear Genes in Mitochondrial Health and Disease

Nuclear Genes in Mitochondrial Health and Disease

This book deals with genetic mutation of mitochondria. By laying out a multifaceted genetics led strategy for discoveries in mitochondrial medicine, this book explores the fundamental basis of empirical observations.

Author: Ayo Toye

Publisher: Academic Press

ISBN: 0123914574

Category: Science

Page: 304

View: 924

Mitochondria, the powerhouses in each human cell, have the crucial job of generating energy for use throughout the body. With advancing age and cumulative free radical attack mitochondria can become less efficient, leading to degenerative changes associated with aging. Maintaining healthy mitochondrial function is critically important in preventing disease and promoting longevity. These little organelles follow a different drummer when implementing orders from DNA. Unlike other components of the cell, mitochondria have their own DNA. Mitochondrial medicine, a relatively new area, deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book deals with genetic mutation of mitochondria. By laying out a multifaceted genetics led strategy for discoveries in mitochondrial medicine, this book explores the fundamental basis of empirical observations. It presents the current technologies and resources, identifies the constraints of working with human specimens, and discusses the benefits of working with non-human models to provide an overview of existing practice and an understanding of how additional studies can advance the science. Discusses limitations in current knowledge to highlight effects of interaction between genes, interactions between genes and the environment, and proper preparation methods Considers advanced high through-put technologies and recent systematic studies of functional biology in health and disease to provide practical perspective for further studies Includes analysis on defining, detecting, and marking phenotype variants of important to studies in cell lines and tissues of diverse origin including humans
Categories: Science

Mitochondrial Medicine

Mitochondrial Medicine

The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases.

Author: Pankaj Prasun

Publisher: Academic Press

ISBN: 9780128170076

Category: Medical

Page: 138

View: 803

Mitochondrial Medicine: A Primer for Health Care Providers and Translational Researchers is an applied, holistic resource that addresses the evolving and multidisciplinary area of mitochondrial disease. The book discusses the fundamentals of mitochondrial medicine in humans, as well as the pathophysiology, diagnosis and treatment of mitochondrial diseases. Three all-inclusive sections examine the role of mitochondria in common medical conditions, such as diabetes, heart failure and the full range of inherited mitochondrial diseases. Sections cover the genetic and biochemical basis of both mitochondrial DNA deletion syndromes and point mutation syndromes, their clinical presentation, treatment plans, genetic counseling, prenatal testing, and ongoing research. While providing a solid foundation in its topic area, each chapter in the book is written in an accessible format with illustrative case studies, thus making it a quick bedside or clinical laboratory reference. Includes a basic introduction to mitochondria and their misfunctions in human disease Presents current practice and research in mitochondrial medicine, with an emphasis on clinical presentation, diagnosis, treatment, genetic counseling and prenatal testing Features short, accessible chapters with illustrative case studies for quick reference Provides thorough coverage of inherited mitochondrial disorders, as well as the role of mitochondria in common medical conditions
Categories: Medical

Handbook of Mitochondrial Dysfunction

Handbook of Mitochondrial Dysfunction

Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book.

Author: Shamim I. Ahmad

Publisher: CRC Press

ISBN: 9780429811777

Category: Medical

Page: 480

View: 432

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.
Categories: Medical

Mitochondria in Health and Disease

Mitochondria in Health and Disease

Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress. ... The emerging functions of UCP2 in health, disease, and therapeutics. Antioxid.

Author: Paolo Bernardi

Publisher: Frontiers Media SA

ISBN: 9782889712519

Category: Science

Page:

View: 550

Categories: Science