133: R 162699b Biochem. characterization of an immunodominant minor histocompatibility antigen and structural features of its recognition, 132: 193241e
CD33 and CD34 gene polymorphisms as source of minor histocompatibility antigens ...
4.4.2 Minor histocompatibility antigens , including H - Y CTLs are also specific for
cell surface minor histocompatibility antigens , of which there are approximately
50 in the mouse ( Graff and Bailey , 1973 ) . These CTLs ( anti - minors ' ) are just
Author: B. Parham
Category: Juvenile Nonfiction
The Major Histocompatibility Complex (MHC) was discovered as a con sequence of the chronic problem encountered by cancer biologists in the early years of this century: the failure to maintain tumor lines by serial passage in outbred mice. A number of observations pointed to genetic similarity being a prerequisite for successful transplantation and they were incorporated into a genetic theory of transplantation by C.C. Little. This prompted scientists like Little to initiate breeding experiments designed to test his hypothesis and produce genetically identical mice which would permit the growth of trans planted tumors. Most inbred strains of mice commonly used in immunology derive from those efforts. Transplantation of normal tissues obeyed the same rules found for malignant tissues and rejection was shown to be an immunological phenomenon. G.D. Snell showed that a single genetic locus determined rapid rejection of skin grafts. This was initially called the Major Histocompatibility Locus but was subsequently shown to include many functionally related genes and renamed the Major Histocompatibility Complex (MHC). In mouse this is the H-2 complex and man the HLA complex. During this same period P.A.
Author: Frederick R. AppelbaumPublish On: 2011-09-26
Minor histocompatibility antigens (mHAs)–one of the principal targets for GVHD –
fall into this category. T-cell specificity also encompasses reactivity to allo (foreign
, nonself) MHC molecules . GVHD to MHC alloantigens is intense and ...
Author: Frederick R. Appelbaum
Publisher: John Wiley & Sons
This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases. The book also now includes a fully searchable CD with PDFs of the entire content.
All virus or minor histocompatibility antigen specific, HLA-A2.1 restricted CTL
populations cross react poorly, if at all, with the minor subtype antigens,
suggesting that the vast majority of HLA-A2.1 specific restriction epitopes have
CHAPTER 4 MINOR HISTOCOMPATIBILITY ANTIGENS INTRODUCTION n a
previous chapter , we dealt with major histocompatibility antigens . IThese
antigens are able to trigger T - cell responses specifically occurring after
Author: Nelson J. Chao
Publisher: R G Landes Company
This reference presents comprehensive coverage of graft-versus-host disease. A historical overview of graft-versus-host disease is provided, followed by a description of the major histo-compatibility complex. The results of the experimental models of graft-versus-host disease are also described. The second half of the book examines both acute and chronic graft-versus-host disease, as well as clinical trials involved in both of these entities. Promising approaches for the prevention and treatment of graft-versus-host disease are also investigated.
The HO - SAL antigen experiments have been performed in which does not
appear to be related to the minor resistance of August rats to SAL leukemia histocompatibility antigens responsible for was transferred by inoculation of
thoracic graft ...
The minor histocompatibility antigen HA - 1 : a diallelic gene with a single amino
acid polymorphism . Science 1998 ; 279 : 1054-1047 . 17. Meadows L , et al . The
HLA - A * 0201 - restricted H - Y antigen contains a posttranslationally modified ...
Immunodominance in the graft - vs - host disease T cell response to minor histocompatibility antigens . ... Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen
processing defective ...
The Human Minor Histocompatibility Antigens Minor histocompatibility antigens
are processed peptides naturally derived from normal cellular proteins that
associate with HLA molecules . 33 Minor histocompatibility antigens are inherited
Author: Jeffrey J. McCullough
Publisher: Churchill Livingstone
Presents a practical approach to the diagnosis and management of the most common disorders of red blood cells, white blood cells, and hemostasis. Each disease state is discussed in terms of underlying pathophysiology, clinical features which suggest the diagnosis, the use of state-of-the-art lab tests in the diagnosis and differential diagnosis of the condition, and current management.
Neither of the CTL populations lyse DBA / 1 targets , but they do lyse ( DBA / 1R
BALB / c ) F , targets , indicating that they are indeed H - 24 - restricted and
specific for DBA minor histocompatibility antigens , some of which are also
The results of such experiments reveal that there are as many as 30–40
histocompatibility loci in certain strain combinations . The other loci capable of
causing graft rejection encode antigens referred to as minor histocompatibility antigens to ...
The problems caused by the nature of minor histocompatibility antigens can be
solved in several ways. For example, if a genetic marker has been linked to a
minor histocompatibility system, prospective identification of minor antigens can
CHARACTERISTICS OF MAJOR AND MINOR HISTOCOMPATIBILITY ANTIGENS * Type of Histocompatibility Locus / Antigen Major Minor Strong Weak
antigens seem to potentiate transplantation reactions via mechanisms that are as
Moreover , these antigens have been implicated in the phenomenon of
histocompatibility restriction of cell - mediated lysis of virus - infected and minor histocompatibility antigen - bearing cells ( see p . 57 ) . In this phenomenon , killer
Author: American Association of Blood BanksPublish On: 1997
Identification of a graft versus host disease - associated human minor histocompatibility antigen . Science 1995 ; 268 : 1476-80 . 52. Marjit WAF ,
Kernan NA , Diaz - Barrientos TH , et al . Multiple minor histocompatibility antigen
- specific ...
500.600+ D24.61 1.216.705.552.600+ 90 X Histocompatibility Antigens, Minor X Minor Histocompatibility Peptides Minor Histocompatibility Loci G4.6 10.626.590
G 14.330.620 83 X Histocompatibility Loci, Minor Minor Histocompatibility ...