Maturation Phenomenon in Cerebral Ischemia III

Maturation Phenomenon in Cerebral Ischemia III

The Maturation Phenomenon, described by Ito et al. in 1975 [3) on the basis of his to logical observations in the hippocampus as well as other portions of the cerebral hemisphere, refers to the hours or days of delay in the development of ...

Author: Umeo Ito

Publisher: Springer Science & Business Media

ISBN: 3540650237

Category: Medical

Page: 343

View: 238

The Maturation Phenomenon, described by Ito et al. in 1975 [3) on the basis of his to logical observations in the hippocampus as well as other portions of the cerebral hemisphere, refers to the hours or days of delay in the development of pathological changes in various parameters of ischemic injury following the restoration of blood flow to the ischemic brain. There is a direct relationship between the intensity of ischemic insult and the speed and rate of maturation of ischemic injury, a lesser intensity being associated with slower and less severe development of the lesions. The delayed neuronal death of CAl pyramidal cells of the hippocampus [8) is a classic example. In the cerebral cortex, with increasing intensity of the ischemic insult, the maturation phenomenon of ischemic injuries intensifies, seamlessly, from less exten sive to more extensive disseminated selective neuronal necrosis (DSNN), and then further to cerebral infarction upon reaching a critical threshold [1,2,4,6,7). We also have found that following ischemic insults just under the threshold level required to induce infarction, only disseminated selective neuronal necrosis (DSNN) progresses, while following ischemic insults at the threshold level, initially only DSNN develops, followed by the evolution of a gradually enlarging infarcted focus [5, 7). The reporting of this phenomenon boosted research in the field, as it became evi dent that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention.
Categories: Medical

Maturation Phenomenon in Cerebral Ischemia II

Maturation Phenomenon in Cerebral Ischemia II

Agenerallaw isthatthe lengthof delayin the development ofpostischemic changes
isdirectly related to the intensity ofthe ... we organized the first international
symposium onthe “Maturation Phenomenon in Cerebral Ischemia” as thesatellite
 ...

Author: Umeo Ito

Publisher: Springer Science & Business Media

ISBN: 9783642605468

Category: Medical

Page: 225

View: 796

Many nerve cells of the brain which are not killed outright may suffer delayed death or recovery after ischemic insult. This fact has led to the concept of "maturation phenomenon" of neuronal injuries. Since the 1st International Symposium on Maturation Phenomenon in 1990, new developments, particularly in molecular biology, have been rapidly bringing new information about molecular nature and mechanisms of cell death. This book contains the presentations of the 2nd International Symposium held in Tokyo in April 1996. The latest developments in maturation phenomenon and the present status of investigation are described and further stimulation of research in this field is provided.
Categories: Medical

Maturation Phenomenon in Cerebral Ischemia IV

Maturation Phenomenon in Cerebral Ischemia IV

Hanyu S,ItoU, HakamataY, YoshidaM (1995)Transition from ischemic neuronal
necrosis to infarction in repeated ischemia. Brain Res 686:44–48 2.ItoU, SpatzM,
WalkerJ Jr,KlatzoI(1975) Experimental cerebralischemia in mongolian gerbils.

Author: N.G. . Bazan

Publisher: Springer Science & Business Media

ISBN: 9783642594465

Category: Medical

Page: 284

View: 216

The maturation phenomenon, first described by Ito et al. in 1975, refers to postischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CA1 pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evident that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention. Since then a growing number of studies have improved our knowledge on mechanisms of cell death and recovery. This volume contains the presentations of the 4th international symposium, held in New Orleans in October/November 1999, grouped in sections covering apoptosis and/or necrosis, neuronal recovery vs. death, and protection against infarction. It outlines the present status of investigations and provides further stimulation for research in this field.
Categories: Medical

Maturation Phenomenon in Cerebral Ischemia

Maturation Phenomenon in Cerebral Ischemia

damage also showed the maturation phenomenon associated with ischemic
brain edema ([10, 11]; Hayashi and ... 18. 19. 20. 1. Ames IIIA, Wright RL,
Kowada M, Thurston JM, Majno G (1968) Cerebral ischemia. II. The noreflow
phenomenon.

Author: U. Ito

Publisher: Springer Science & Business Media

ISBN: 9783642771347

Category: Medical

Page: 208

View: 202

It has been well recognized that following an ischemic insult many nerve cells of the brain are not killed outright, but may suffer a "delayed neuronal death" or even recover. This led to the concept of "maturation phenomenon" with its main implication that the maturation of ischemic lesions may provide a "window of opportunity" i.e. a period of time when the injury to neuronal elements is still reversible, and during which an application of proper therapeutic measures might be successful. The symposium on Maturation Phenomenon in Cerebral Ischemia was the first international meeting focussed primarily on this subject and the resulting publication contains presentations and discussionsby prominent researchers engaged in this field. This book should stimulate further research on potential of brain tissue for recovery, and particularly with regard to a functional recovery of neurons suffering from chronic ischemic injury.
Categories: Medical

National Library of Medicine Current Catalog

National Library of Medicine Current Catalog

9303658 Thrombolytic therapy in acute ischemic stroke II / Gregory J. del Zoppo ,
Etsuro Mori , Werner Hacke ( eds . ) . ... 9316985 Maturation phenomenon in
cerebral ischemia : proceedings of the satellite symposium of the XIth
International ...

Author: National Library of Medicine (U.S.)

Publisher:

ISBN: MINN:31951D010928702

Category: Medicine

Page:

View: 427

Categories: Medicine

Proceedings in Print

Proceedings in Print

1 & 2 . 1996 . Available from the NASA Center for AeroSpace Information ,
Linthicum Heights , MD . 93084 - Materials ... Proceedings : Maturation
phenomenon in cerebral ischemia II : neuronal recovery & plasticity , ed . by U .
Ito , T . Kirino , T ...

Author:

Publisher:

ISBN: UCLA:L0090615394

Category: Aeronautics

Page:

View: 395

Categories: Aeronautics

The Cumulative Book Index

The Cumulative Book Index

Author:

Publisher:

ISBN: UOM:39015058373922

Category: American literature

Page:

View: 666

A world list of books in the English language.
Categories: American literature

American Book Publishing Record

American Book Publishing Record

2 . Arthritis Religious aspects — Christianity — Popular works . 3 . Spiritual
healing - Popular works . 1 . Title . 1 . Diabetes ... International Symposium on
Maturation Phenomenon in Cerebral Ischemia ( 5th : 2002 : Banff , Alta . ) New
York ...

Author:

Publisher:

ISBN: UOM:39015066043186

Category: American literature

Page:

View: 787

Categories: American literature

Principles and Practice of Neuropathology

Principles and Practice of Neuropathology

Understanding of the pathophysiology of brain ischemia is still fragmentary , but
according to Raichle “ 2 three ... 17-9 ) . 13,42 Whether selective vulnerability and
the maturation phenomenon are features of the lesion that develops in the brain ...

Author: James S. Nelson

Publisher: Mosby Incorporated

ISBN: UOM:39015029742866

Category: Medical

Page: 625

View: 547

The thoroughly updated and revised Second Edition of this highly praised book features new chapters on laboratory methods, neuroimaging, and Alzheimer's disease. Production values have been enhanced, including the use of color illustrations. Book jacket.
Categories: Medical

Doklady

Doklady

It should be stressed that the expression of certainstructural reactions in the
braindepends on the stage of ischemia and individual and typological features of
animals. 2. Ito, U., Yamaguchi, T., Tomita, H., et al., in Maturation Phenomenon in
 ...

Author: Akademii͡a nauk SSSR.

Publisher:

ISBN: STANFORD:36105020285479

Category: Biology

Page:

View: 698

Categories: Biology

Cerebral Revascularization for Stroke

Cerebral Revascularization for Stroke

2 and 3 ) . ' All neurons that died in the gerbil brain did not do so immediately
after ischemia . In different parts of the brain ... ischemic changes of the neuron
were designated by us as “ maturation phenomenon " described elsewhere .

Author: Robert Friedrich Spetzler

Publisher: Thieme-Stratton Corporation

ISBN: UOM:39015007132783

Category: Medical

Page: 613

View: 613

Categories: Medical

Stroke

Stroke

Academic Press , New York . 7. Chiang , J. , Kowada , M. , Ames , A. , Wright ,
R. L. , and Majno , G. ( 1968 ) : Cerebral ischemia . III . ... Klatzo , I. , Ito , U. ,
Mrsulja , B. B. , and Spatz , M. ( 1976 ) : The “ maturationphenomenon in
cerebral ischemia . J. Neuropathol . ... Yu , M. C. , Bakay , L. , and Lee , C. ( 1972
) : Ultrastructure of the central nervous system after prolonged hypoxia . II .
Neuroglia and blood ...

Author: Richard A. Thompson

Publisher:

ISBN: UCSC:32106002635198

Category: Medical

Page: 237

View: 479

Categories: Medical

Microcirculatory Stasis in the Brain

Microcirculatory Stasis in the Brain

2 . Rosenblum WJ . Lab Invest 1986 ; 55 : 252 — 268 . 3 . Korpachev WG ,
Lysenkov SP , Tiel LZ . Patol Fizjol Exp Ter 1982 ; 3 : 78 – 80 . 4 . ... In : Ito U ,
Kirino T , Kuroiwa T , Klatzo I ( eds ) Maturation Phenomenon in Cerebral
Ischemia .

Author: Minoru Tomita

Publisher:

ISBN: UOM:39015032823166

Category: Medical

Page: 598

View: 530

Aims to define the subject of microcirculatory stasis and thus give a better understanding of ischemic tissue damage. The work covers four major themes: blood events, vessel changes, feedback from ischemically damaged tissue, and clinical relevance.
Categories: Medical

Advances in Neurology

Advances in Neurology

Hossman , K . A . , and Olsson , Y . ( 1971 ) : The effect of transient cerebral
ischemia on the vascular permeability to protein tracers . Acta Neuropathol . ...
Mrsulja , B . B . , and Spatz , M . ( 1976 ) : The “ maturationphenomenon in
cerebral ischemia . ... Yu , M . C . , Bakay , L . , and Lee , C . ( 1972 ) :
Ultrastructure of the central nervous system after prolonged hypoxia . II .
Neuroglia and blood vessels .

Author: Richard A. Thompson

Publisher:

ISBN: UOM:39015003793729

Category: Cerebrovascular disease

Page: 237

View: 716

Categories: Cerebrovascular disease

Heat Shock Proteins in the Nervous System

Heat Shock Proteins in the Nervous System

In Pharmacology of Cerebral Ischaemia 1988 : Proceedings of the Second
International Symposium on the Pharmacology of ... In Maturation Phenomenon
in Cerebral Ischaemia ( ed Ito , U. , Kirino , T. , Kuroiwa , T. & Klatzo , I. ) , pp 121-
128 .

Author: R. J. Mayer

Publisher: Academic Press

ISBN: UOM:39015032504253

Category: Medical

Page: 297

View: 922

Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Cells respond to temperature elevation and other traumas by inducing a set of genes (cell stream genes) encoding cell stress (heat shock) proteins which may play important roles in cellular repair and/or protective mechanisms. This book surveys the current state of knowledge concerning the expression of heat shock genes and proteins in the nervous system following such traumatic events as hyperthermia, ischemia, and tissue wounding. The possible neuroprotective effects of the heat shock response are discussed. In addition to reviewing progress in animal model systems, this book discusses heat shock proteins such as ubiquitin in relation to human neurodegenerative diseases. Each chapter presents an overview of a specific subject area and includes current results from each authors laboratory and a viewpoint on future research directions. The book is organized in two parts: the first part deals with cell stress genes and their protein products; the second part deals with ubiquitin and the nervous system. The chapters are grouped so that each of the two sections begins with a description of the basic molecular cell biology of heat shock proteins or ubiquitin. Whether you are a new recruit to neuroscience or an established expert, look to this series for one-stop sources for the historical, physiological, pharmacological, biochemical, molecular biology and therapeutic aspects of your chosen research areas.
Categories: Medical

International Symposium on the Need for Treatment for Stroke and Alzheimer s Disease and Abnormal Brain Aging

International Symposium on the Need for Treatment for Stroke and Alzheimer s Disease and Abnormal Brain Aging

KEYWORDS Cerebral ischemia , selective vulnerability , hippocampus , gerbil
INTRODUCTION The experimental model of cerebral ischemia is ... Such
protracted development of ischemic lesions has been described as the "
maturation phenomenon " ( Ito et al 1975 , Klatzo ... To interpret the phenomenon
of selective vulnerability two theories have been developed : One theory ,
proposed by Spielmeyer ...

Author: Niels A. Lassen

Publisher:

ISBN: UCLA:L0051320638

Category:

Page: 255

View: 987

Categories:

Neurological Research

Neurological Research

REFERENCES Ito U , Spatz M , Walker JT Jr , Klatzo I. Experimental cerebral
ischemia in Mongolian gerbils . I. Light microscopic ... ischemia in the rat . 2. A 2 -
vessel occlusion model ... Maturation Phenomenon in Cerebral Ischemia .

Author:

Publisher:

ISBN: NWU:35558003069966

Category: Neurology

Page:

View: 469

Categories: Neurology