Perhaps Dr. Klaus is infecting his subjects with some form of altered rabies virus, and his “superserum” is able to counteract its e›ects. Interesting. What Is Wrong with the Biological Science Presented: Way too many people think that ...
Author: Mark C. Glassy
Category: Performing Arts
Science fiction films of the 1930s and 1940s were often set in dark laboratories that had strange looking glass containers with bubbling fluids and mad scientists conducting glandular and hormonal experiments. In the 1950s, films were more focused on radiation induced mutations. The 1960s and 1970s brought more sophisticated biological sciences to the movies and focused on such relatively new concepts as immunology, cyrobiology, and biochemistry. In the 1980s and 1990s, the focus of science fiction films has been DNA. This work of film criticism relates 71 science fiction films to the biological sciences. The author covers cell biology, pharmacology, endocrinology, hematology, and entomology, to name just a few topics. An analysis of each film includes a brief plot synopsis, the author’s favorite quotations, the biological principles involved, the accuracy of the laboratory, and correct and incorrect biological information. In his analyses, the author sets out what would be required to achieve in real life the results seen in the movies and whether these experiments or events could actually happen.
Rabies. virus. William. H. Wunnera,. Karl-Klaus. Conzelmannb. aThe Wistar Institute, Philadelphia, PA, United States bMax von Pettenkofer Institute Virologie, Medical Faculty & Gene Center, Ludwig-Maximilians University of Munich, ...
Author: Anthony R. Fooks
Publisher: Academic Press
Rabies: Basis of the Disease and Its Management, Fourth Edition is an authoritative reference on the current status of rabies, including the virological, clinical, and public health aspects and management recommendations. Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this disease, rabies has become a re-emergent infection in the resource-constrained countries. The Fourth Edition updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, immunology, vaccines, public health aspects, and epidemiology of rabies and is completely revised, with new chapters that will cover historical developments in rabies intervention strategies, the evolution of rabies virus, modeling rabies control, and on the strategy for rabies elimination. Rabies, Fourth Edition, provides physicians, veterinarians, public health advisors, epidemiologists, and research scientists with a single source for authoritative and up-to-date information on the diagnosis, treatment, control, and prevention of this fatal infectious virus.
Acta Neuropathol 1997;94(1):73–7. Jackson AC, Park H. Experimental rabies virus infection of p75 neurotrophin receptor-deficient mice. Acta Neuropathol 1999;98(6):641–4. Christine T, Klaus S, Christelle L, ...
Author: Alimuddin Zumla
Publisher: Elsevier Health Sciences
It is extremely important that physicians be aware of the wide spectrum of tropical, infectious and parasitic diseases their patients may have been exposed to while traveling abroad. This volume of the ID Clinics is edited by 3 internationally renowned infectious disease physicians and provides an authoritative and comprehensive treatise on Travel Medicine.
Karl-Klaus Conzelmann Abstract The neurotropic rabies virus (RABV) is a prototype member of the Mononegavirales order of viruses and is the most significant human pathogen of the Rhabdoviridae family. A reverse genetics system for RABV ...
Author: Yoshiyuki Nagai
Publisher: Springer Science & Business Media
Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.
... Steffen and Graham Simmons Rabies Virus Replication and Pathogenesis Andrew W. Hudacek and Matthias J. Schnell Activation and Evasion of Innate Immune Response by Rhabdoviruses Karl-Klaus Conzelmann Rabies Virus Vaccines Ying Huang, ...
Author: Asit K Pattnaik
Publisher: World Scientific
Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents. Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included. This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis. Contents:Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)Rhabdovirus Structure (Ming Luo)The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)VSV RNA Transcription and Replication (Jacques Perrault)Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe) Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology. Key Features:The book describes the most recent advances in our understanding of cellular and molecular aspects of replication and pathogenic mechanisms of these two important viral pathogensUnlike other existing textbooks published earlier, this book brings together several major topics of research such as replication, host response to viral replication and viral countermeasures, viral evolution and emerging viruses, viral vectors, vaccines and antivirals, etcThe chapters in the book are written by renowned researchers in these fieldsKeywords:Negative-Strand RNA Virus;Mononegavirales;Rhabdovirus;Filovirus;VSV;Rabies Virus;Marburg Virus;Ebola Virus;Replication and Transcription;Virus Structure;Viral Pathogenesis;Epidemiology;Virus Entry;Virus Assembly and Budding;Cytopathogenesis;Neuronal Tracers;Viral Vectors;Oncolytic Viruses;Evolution;Emerging Viruses;Innate Immune Responses;Vaccines;Antivirals
A rather inconclusive analysis of strategic intelligence (which attempts to estimate actual and potential threats) by Klaus Knorr mainly raises Rabies and Wildlife D. W. Macdonald Rabies is a topic of concern and interest to everyone.
New Scientist magazine was launched in 1956 "for all those men and women who are interested in scientific discovery, and in its industrial, commercial and social consequences". The brand's mission is no different today - for its consumers, New Scientist reports, explores and interprets the results of human endeavour set in the context of society and culture.
Author: National Medical Audiovisual CenterPublish On: 1981
Kidney Neoplasms - radiography - motion pictures I. Ranninger , Klaus , 1926– II . Turner , David A. , 1940 III . American College of Radiology . see Periodontal Ramfjord , Sigurd P. , 1911examination ROCOM see Rocom see Rabies see ...
Author: Elizabeth S. WilliamsPublish On: 2008-02-28
Diseases. CHARLES E. RUPPRECHT, KLAUS STOHR, AND COURTNEY MEREDITH FIG. 1.1—World map depicting geographic distribution of rabies (not to ... Rabies is an acute fatal viral encephalomyelitis. The etiologic agents belong to the genus ...
Author: Elizabeth S. Williams
Publisher: John Wiley & Sons
Infectious Diseases of Wild Mammals, Third Edition presents the latest information on the diagnosis and treatment of infectious disease in both free-ranging and captive wild mammals. Editors Elizabeth Williams and Ian Barker have recruited 71 contributors, all noted experts in their fields, to update this new edition. This reference provides valuable information on each disease, including Etiology History Distribution Epidemiology Clinical signs Pathology Immunity Diagnosis Treatment Control This latest edition is a leading reference book for Wildlife biologists, managers, and rehabilitators Biology students Conservationists Public health workers