Introduction to Protein Structure

Author: Carl Ivar Branden,John Tooze

Publisher: Garland Science

ISBN: 1136969896

Category: Science

Page: 424

View: 9626

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The VitalBook e-book of Introduction to Protein Structure, Second Edition is inly available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815323051Introduction to Protein Structure provides an account of the principles of protein structure, with examples of key proteins in their bio
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Introduction to protein structure

Author: Carl Branden,John Tooze

Publisher: Textbooks

ISBN: N.A

Category: Science

Page: 302

View: 3966

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A contemporary account of the principles of protein structure, with examples of proteins in their biological context. Includes chapters on the general principles, specific examples of structures and on determining and predicting.
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Introduction to Protein Structure Prediction

Methods and Algorithms

Author: Huzefa Rangwala,George Karypis

Publisher: John Wiley & Sons

ISBN: 9781118099469

Category: Science

Page: 520

View: 5150

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A look at the methods and algorithms used to predict proteinstructure A thorough knowledge of the function and structure of proteinsis critical for the advancement of biology and the life sciences aswell as the development of better drugs, higher-yield crops, andeven synthetic bio-fuels. To that end, this reference sheds lighton the methods used for protein structure prediction and revealsthe key applications of modeled structures. This indispensable bookcovers the applications of modeled protein structures and unravelsthe relationship between pure sequence information andthree-dimensional structure, which continues to be one of thegreatest challenges in molecular biology. With this resource, readers will find an all-encompassingexamination of the problems, methods, tools, servers, databases,and applications of protein structure prediction and they willacquire unique insight into the future applications of the modeledprotein structures. The book begins with a thorough introduction tothe protein structure prediction problem and is divided into fourthemes: a background on structure prediction, the prediction ofstructural elements, tertiary structure prediction, and functionalinsights. Within those four sections, the following topics arecovered: Databases and resources that are commonly used for proteinstructure prediction The structure prediction flagship assessment (CASP) and theprotein structure initiative (PSI) Definitions of recurring substructures and the computationalapproaches used for solving sequence problems Difficulties with contact map prediction and how sophisticatedmachine learning methods can solve those problems Structure prediction methods that rely on homology modeling,threading, and fragment assembly Hybrid methods that achieve high-resolution proteinstructures Parts of the protein structure that may be conserved and usedto interact with other biomolecules How the loop prediction problem can be used for refinement ofthe modeled structures The computational model that detects the differences betweenprotein structure and its modeled mutant Whether working in the field of bioinformatics or molecularbiology research or taking courses in protein modeling, readerswill find the content in this book invaluable.
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Introduction to Proteins

Structure, Function, and Motion, Second Edition

Author: Amit Kessel,Nir Ben-Tal

Publisher: CRC Press

ISBN: 1498747213

Category: Computers

Page: 932

View: 2636

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Praise for the first edition "This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins [...] [This is] a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure–function relationships." —David Sheehan, ChemBioChem, 2011 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. [...] this is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." —Eric Martz, Biochemistry and Molecular Biology Education, 2012 Introduction to Proteins shows how proteins can be analyzed in multiple ways. It refers to the roles of proteins and enzymes in diverse contexts and everyday applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. New features in the thoroughly-updated second edition: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms Animations of protein dynamics and conformational changes, accessible via embedded QR codes Additional features Extensive discussion of the energetics of protein folding, stability and interactions A comprehensive view of membrane proteins, with emphasis on structure-function relationship Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions Exploration of industrial applications of protein engineering and rational drug design Approximately 300 color images Downloadable solutions manual available at www.crcpress.com _ For more information, including powerpoint presentations and exercises for each chapter, please visit the author's website.
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Proteins

Structure and Function

Author: David Whitford

Publisher: John Wiley & Sons

ISBN: 1118685725

Category: Science

Page: 520

View: 8088

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Proteins: Structure and Function is a comprehensive introduction to the study of proteins and their importance to modern biochemistry. Each chapter addresses the structure and function of proteins with a definitive theme designed to enhance student understanding. Opening with a brief historical overview of the subject the book moves on to discuss the ‘building blocks’ of proteins and their respective chemical and physical properties. Later chapters explore experimental and computational methods of comparing proteins, methods of protein purification and protein folding and stability. The latest developments in the field are included and key concepts introduced in a user-friendly way to ensure that students are able to grasp the essentials before moving on to more advanced study and analysis of proteins. An invaluable resource for students of Biochemistry, Molecular Biology, Medicine and Chemistry providing a modern approach to the subject of Proteins.
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Fundamentals of Protein Structure and Function

Author: Engelbert Buxbaum

Publisher: Springer

ISBN: 331919920X

Category: Science

Page: 521

View: 6916

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This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.
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Introduction to Protein Science

Architecture, Function, and Genomics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0199541302

Category: Education

Page: 455

View: 7967

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Introduction to Protein Science provides a broad introduction to the contemporary study of proteins in health and disease, suitable for students on biological, biochemical, and biomedical degrees internationally. The book relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics.
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Introduction to Bioinformatics

Author: Anna Tramontano

Publisher: CRC Press

ISBN: 9781584885696

Category: Science

Page: 192

View: 3188

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Guiding readers from the elucidation and analysis of a genomic sequence to the prediction of a protein structure and the identification of the molecular function, Introduction to Bioinformatics describes the rationale and limitations of the bioinformatics methods and tools that can help solve biological problems. Requiring only a limited mathematical and statistical background, the book shows how to efficiently apply these approaches to biological data and evaluate the resulting information. The author, an expert bioinformatics researcher, first addresses the ways of storing and retrieving the enormous amount of biological data produced every day and the methods of decrypting the information encoded by a genome. She then covers the tools that can detect and exploit the evolutionary and functional relationships among biological elements. Subsequent chapters illustrate how to predict the three-dimensional structure of a protein. The book concludes with a discussion of the future of bioinformatics. Even though the future will undoubtedly offer new tools for tackling problems, most of the fundamental aspects of bioinformatics will not change. This resource provides the essential information to understand bioinformatics methods, ultimately facilitating in the solution of biological problems.
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Protein Structure and Function

Author: Gregory A. Petsko,Dagmar Ringe

Publisher: New Science Press

ISBN: 1405119225

Category: Science

Page: 195

View: 5769

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Each title in the 'Primers in Biology' series is constructed on a modular principle that is intended to make them easy to teach from, to learn from, and to use for reference.
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Introduction to Protein Science

Architecture, Function and Genomics

Author: Arthur M. Lesk

Publisher: Oxford University Press, USA

ISBN: N.A

Category: Science

Page: 310

View: 6430

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Useful for students on biosciences degrees, this book provides an introduction to the study of proteins. It contains the aspects related to genomics and proteomics that have paved the way for an explosion of interest in protein structure and function.
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