Crosstalk Between DNA Repair and Cancer Stem Cell CSC Associated Intracellular Pathways

Crosstalk Between DNA Repair and Cancer Stem Cell  CSC  Associated Intracellular Pathways

This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.

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ISBN: OCLC:1051860316

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View: 566

Abstract: DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.
Categories:

Journal of the National Cancer Institute

Journal of the National Cancer Institute

... 7 / ADR cell cultures were enriched in cells Stem cells are presumed to be drug
resistant because they have with the cancer stem cell phenotype ( ie , CD44 + /
CD24- cells ) , an enhanced capacity for DNA repair , decreased apoptosis , and
 ...

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ISBN: NYPL:33433078242454

Category: Cancer

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View: 378

Categories: Cancer

Cancer Stem Cells in Solid Tumors

Cancer Stem Cells in Solid Tumors

One recurring mechanism of radioresistance found in CSCs is increased DNA
repair capacity. Bao et al. demonstrated that glioma stem cells appear to be
relatively radioresistance due to preferential activation of the DNA damage
checkpoint ...

Author: Alison L. Allan

Publisher: Springer Science & Business Media

ISBN: 9781617792465

Category: Science

Page: 478

View: 162

The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.
Categories: Science

Cancer Research

Cancer Research

Cancer Res 2007 ; 67 : 4010-5 . 4. Bao S , Wu Q , McLendon RE , et al . Glioma
stem cells promote radioresistance by preferential activation of the DNA damage
response . Nature 2006 ; 444 : 756-60 . 5. Singh SK , Hawkins C , Clarke ID , et al
 ...

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ISBN: NWU:35558005676859

Category: Cancer

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View: 346

Categories: Cancer

Stem Cells and Cancer

Stem Cells and Cancer

Coordinate activation of DNA repair and detoxifying systems such as the mixed
function oxidases of Cytochrome P450 can ... Tumors are thought to contain a
small population of cancer stem cells in addition to their “ differentiated ” offspring
 ...

Author: Devon W. Parsons

Publisher: Nova Science Pub Incorporated

ISBN: PSU:000061070899

Category: Science

Page: 284

View: 950

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book brings together leading research from throughout the world with particular focus on stem cells and cancer research.
Categories: Science

Stem Cells and Cancer Stem Cells Volume 1

Stem Cells and Cancer Stem Cells  Volume 1

Stem Cells and Cancer Stem Cells, Therapeutic Applications in Disease and
Injury: Volume 1 M.A. Hayat ... through preferential activation of the DNA damage
checkpoint response and an increase in DNA repair capacity (Bao et al., 2006).

Author: M.A. Hayat

Publisher: Springer Science & Business Media

ISBN: 9400717091

Category: Medical

Page: 200

View: 510

Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain tumors, including their role in brain tumor therapy and the role of CD133 stem cell antigen in glioma patients, is emphasized. Therapeutic role of bone marrow-derived stem cells in myocardial infarction and the role of mesenchymal stem cells in orthopedics are explained. Transplantation of umbilical cord hematopoietic stem cells and allogeneic hematopoietic stem cell transplantation followed by graft-versus-host disease are presented. Role of cancer stem cells specifically in glioblastoma and medulloblastoma is included. It is also emphasized that CD133 is an appropriate stem cell marker for gliomas. Targeting of cancer cells is also explained.
Categories: Medical

Advances in DNA Repair

Advances in DNA Repair

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance.

Author: Clark Chen

Publisher: BoD – Books on Demand

ISBN: 9789535122098

Category: Medical

Page: 496

View: 436

This book edition is intended to provide a concise summary for select topics in DNA repair, a field that is ever-expanding in complexity and biologic significance. The topics reviewed ranged from fundamental mechanisms of DNA repair to the interface between DNA repair and a spectrum on cellular process to the clinical relevance of DNA repair in oncologic paradigms. The information in this text should provide a foundation from which one can explore the various topics in depth. The book serve as a supplementary text in seminar courses with focus on DNA repair as well as a general reference for scholars with an interest in DNA repair.
Categories: Medical

International Journal of Oncology

International Journal of Oncology

The presence of cancer stem cells in both solid and hematopoietic malignancies ,
has been recently linked to their ... and increased expression of the stem cell -
related genes such as Nanog , OCT3 / 4 SOX2 and DNA repair enzyme genes ...

Author: Fondation nationale de la recherche scientifique (Grèce).

Publisher:

ISBN: 10196439

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View: 859

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Stochastic Dynamics of Cancer Stem Cells

Stochastic Dynamics of Cancer Stem Cells

Sehl M , Sawhney R , Naeim A . Physiologic aspects of aging : impact on cancer
management and decision making , part II . ... Associations between single
nucleotide polymorphisms ( SNPs ) in double strand DNA repair pathway genes
and ...

Author: Mary Elizabeth Sehl

Publisher:

ISBN: UCLA:L0098909674

Category:

Page: 310

View: 131

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Anticancer Research

Anticancer Research

... IKK 1 | p53 NF - kB Bad | Bcl - XL Bim Fas L p130027 Cyclin D1 Myc mTORCI
elF - 4E S6K1 Cell cycle arrest Apoptosis Cell cycle Apoptosis Growth DNA
repair Figure 1 . ... PTEN , Cancer Stem Cells and mTOR the phosphatase
activities .

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ISBN: UCLA:L0098923659

Category: Cancer

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View: 861

Categories: Cancer

Radiation Damage in Biomolecular Systems

Radiation Damage in Biomolecular Systems

Principally , ionizing radiation kills cancer cells through causing DNA damage by
producing single and double strand ... cell types , matrix and signal proteins that
contribute to regulation and maintenance of cancer stem cell pool [ 61-63 ] .

Author: Károly Tokési

Publisher: Amer Inst of Physics

ISBN: UCSD:31822036967719

Category: Medical

Page: 220

View: 227

The objective of the meeting was to review our progress in obtaining a detailed understanding of the fundamental interaction processes initiated by the deposition of various types of radiation within biological material. The program represents a strong interdisciplinary approach, covering the range from photon-, electron- and ion-molecule interactions, to the clinical applications.
Categories: Medical

Understanding Transformation and Tumor Initiation in the Context of Mesenchymal Stem Cells and Osteosarcoma

Understanding Transformation and Tumor Initiation in the Context of Mesenchymal Stem Cells and Osteosarcoma

But , origin of these cancer stem cells is an area of ongoing debate [ 28 ] , since
cancer stem cells and stem cell cancer may ... Their ability to express drug
transporters , robust DNA repair mechanisms , quiescent cell cycle kinetics ,
asymmetric ...

Author: Manish Neupane

Publisher:

ISBN: MSU:31293030631380

Category: Medicine, Comparative

Page: 552

View: 457

Categories: Medicine, Comparative

Advances in Stem Cell Aging

Advances in Stem Cell Aging

Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis.

Author: K.L. Rudolph

Publisher: Karger Medical and Scientific Publishers

ISBN: 9783318021714

Category: Science

Page: 134

View: 445

Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kröner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.
Categories: Science

The Economist

The Economist

In 1997 he isolated what looked like stem cells from a blood cancer called acute
myeloid leukaemia (AML). ... all the tumour cells suffered equal amounts of DNA
damage from the radiation, the stem cells were better able to repair this damage.

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ISBN: IND:30000115765673

Category: Economic history

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View: 775

Categories: Economic history

Biennial Report International Agency for Research on Cancer

Biennial Report  International Agency for Research on Cancer

Book Chapter « Stem Cells & Regenerative Medicine » Springer Science (
Humana ) Press . In press . ... on the road to cancer . Mutation Research , 642 (
12 ) : 1-13 Herceg , Z. and Hainaut P. ( 2008 ) DNA damage response and DNA
repair .

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ISBN: UOM:39015072751723

Category: Cancer

Page:

View: 341

Categories: Cancer

Annual Meeting Proceedings

Annual Meeting Proceedings

The expression of endogeneous miR - 215 was highly elevated in CD133 + / H1
CD44 + colon cancer stem cells compared to CD133 CD44 colon cancer cells ,
suggesting that tumor stem cells may be avoiding cellular and DNA damage ...

Author: American Society of Clinical Oncology. Meeting

Publisher:

ISBN: CHI:82148809

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View: 337

Categories:

The Journal of Cell Biology

The Journal of Cell Biology

The relationship between chromatin and the DDR presented in this study could
help to understand the heterogeneity of cellular responses to DNA damage in
vivo . For instance , a recent study has shown that CD133 * glioma cancer stem
cells ...

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Publisher:

ISBN: UOM:39015072606851

Category: Cytology

Page:

View: 391

No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Categories: Cytology

Biennial Report

Biennial Report

Cell Cycle , 7 ( 24 ) : 3908-14 Lambert MP and Herceg , Z. ( 2008 ) Epigenetics
and Cancer , 2nd IARC Meeting , Lyon . Molecular Oncology ... Journal of
Immunology , In press Ouzounova M , Hernández - Vargas H and Herceg Z. (
2009 ) Epigenetic identity in cancer stem cells . ... to cancer . Mutation Research ,
642 ( 12 ) : 1-13 Herceg , Z. and Hainaut P. ( 2008 ) DNA damage response and
DNA repair .

Author: International Agency for Research on Cancer

Publisher:

ISBN: MINN:31951D031531213

Category: Cancer

Page:

View: 633

Categories: Cancer

Breast Cancer Stem Cells and Radiation

Breast Cancer Stem Cells and Radiation

While increased levels of antioxidants may also help to minimize the initial DNA
damage in cancer stem cells , there may also be increased repair capabilities in
these cells in order to deal with any DNA damage that does result from ionizing ...

Author: Tiffany Marie Phillips

Publisher:

ISBN: UCLA:L0096938907

Category:

Page: 248

View: 615

Categories:

Journal of the National Cancer Institute

Journal of the National Cancer Institute

Following chemotherapy , Kaufmann noted , over - efficient DNA repair permits
the survival of hematopoietic ( blood cell - forming ) stem cells that would
otherwise die , and some of these cells may have DNA damage that will lead to
leukemia ...

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Publisher:

ISBN: NWU:35558003471881

Category: Cancer

Page:

View: 426

"Summaries of papers" contained in the journal accompany each issue, 19--
Categories: Cancer