Discovering and Developing Molecules with Optimal Drug-Like Properties

Author: Allen C Templeton,Stephen R. Byrn,Roy J Haskell,Thomas E. Prisinzano

Publisher: Springer

ISBN: 1493913999

Category: Medical

Page: 511

View: 7403


This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties. It is a valuable source to access current best practices as well as new research techniques and strategies. Written by leading scientists in their fields, the text consists of fourteen chapters with an underlying theme of early collaborative opportunities between pharmaceutical and discovery sciences. The book explores the practical realities of performing physical pharmaceutical and biopharmaceutical research in the context of drug discovery with short timelines and low compound availability. Chapters cover strategies and tactics to enable discovery as well as predictive approaches to establish, understand and communicate risks in early development. It also examines the detection, characterization, and assessment of risks on the solid state properties of advanced discovery and early development candidates, highlighting the link between solid state properties and critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on linking physiochemical properties of molecules to formulation selection in preclinical and clinical settings.

Discovering Design

Explorations in Design Studies

Author: Richard Buchanan,Victor Margolin

Publisher: University of Chicago Press

ISBN: 9780226078151

Category: Art

Page: 254

View: 3320


Discovering Design reflects the growing recognition that the design of the everyday world deserves attention not only as a professional practice but as a subject of social, cultural, and philosophic investigation. Victor Margolin, cofounder and an editor of the journal Design Issues, and Richard Buchanan, also an editor of the journal, bring together eleven essays by scholars in fields ranging from psychology, sociology, and political theory to technology studies, rhetoric, and philosophy. The essayists share the editors' concern, first made clear in Margolin's Design Discourse: History, Theory, Criticism, with the the development of design studies as a field of interdisciplinary research. The contributors (Gianfranco Zaccai, Albert Borgmann, Richard Buchanan, Augusto Morello, Tufan Orel, Nigel Cross, Victor Margolin, Langdon Winner, Carl Mitcham, Tony Fry, and Ezio Manzini) focus on three broad themes that form a sequence of fundamental issues: how to shape design as a subject matter, how to distinguish the activity of designing in the complex world of action, and how to address the basic questions of value and responsibility that persistently arise in the discussion and practice of design. The editors' introduction provides a useful overview of these questions and offers a multidisciplinary framework for design studies. The essays discuss such topics as the relation of aesthetics to technology, the place of design in social action, the role of the consumer in design decisions, and the need for ethical practice in contemporary design. Manzini's concluding essay shows how the issue of ethics should connect responsible behavior to decisions made every day in the manufacture of objects.

In Silico Drug Design

Repurposing Techniques and Methodologies

Author: Kunal Roy

Publisher: Academic Press

ISBN: 0128163771

Category: Business & Economics

Page: 886

View: 1728


In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

The Business of Healthcare Innovation

Author: Lawton R. Burns,Lawton Robert Burns

Publisher: Cambridge University Press

ISBN: 9780521838986

Category: Business & Economics

Page: 373

View: 8734


The first wide-ranging analysis of business trends in the manufacturing segment of the health care industry.

The God Hypothesis

Discovering Design in Our Just Right Goldilocks Universe

Author: Michael Anthony Corey

Publisher: Rowman & Littlefield

ISBN: 9780742558892

Category: Religion

Page: 347

View: 2760


The God Hypothesis seeks to reverse the profound misunderstanding that science has disproved the existence of God. Drawing on the fairy tale of Goldilocks and The Three Bears, Michael A. Corey believes that the "just right" conditions that created life on earth provide overwhelming evidence of an Intelligent Designer at work.

Enhancing Instruction with Visual Media

Utilizing Video and Lecture Capture

Author: Ellen G. Smyth,John X. Volker

Publisher: IGI Global

ISBN: 1466639636

Category: Education

Page: 315

View: 2719


"This book offers unique approaches for integrating visual media into an instructional environment by covering the impact media has on student learning and various visual options to use in the classroom"--Provided by publisher.

Adventuring with Books

A Reading List for the Elementary Grades

Author: National Council of Teachers of English. Elementary Reading List Committee

Publisher: N.A


Category: Children's literature

Page: 189

View: 2827



Frontiers in Drug Design and Discovery

Author: Atta-ur- Rahman,Gary W. Caldwell

Publisher: Bentham Science Publishers

ISBN: 1608051994

Category: Medical

Page: 360

View: 2996


"Frontiers in Drug Design and Discovery" is an Ebook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery inclu

Discovering Partial Least Squares with JMP

Author: Ian Cox,Marie Gaudard

Publisher: SAS Institute

ISBN: 1612908292

Category: Computers

Page: 308

View: 1678


Partial Least Squares (PLS) is a flexible statistical modeling technique that applies to data of any shape. It models relationships between inputs and outputs even when there are more predictors than observations. Using JMP statistical discovery software from SAS, Discovering Partial Least Squares with JMP explores PLS and positions it within the more general context of multivariate analysis. Ian Cox and Marie Gaudard use a “learning through doing” style. This approach, coupled with the interactivity that JMP itself provides, allows you to actively engage with the content. Four complete case studies are presented, accompanied by data tables that are available for download. The detailed “how to” steps, together with the interpretation of the results, help to make this book unique. Discovering Partial Least Squares with JMP is of interest to professionals engaged in continuing development, as well as to students and instructors in a formal academic setting. The content aligns well with topics covered in introductory courses on: psychometrics, customer relationship management, market research, consumer research, environmental studies, and chemometrics. The book can also function as a supplement to courses in multivariate statistics and to courses on statistical methods in biology, ecology, chemistry, and genomics. While the book is helpful and instructive to those who are using JMP, a knowledge of JMP is not required, and little or no prior statistical knowledge is necessary. By working through the introductory chapters and the case studies, you gain a deeper understanding of PLS and learn how to use JMP to perform PLS analyses in real-world situations. This book motivates current and potential users of JMP to extend their analytical repertoire by embracing PLS. Dynamically interacting with JMP, you will develop confidence as you explore underlying concepts and work through the examples. The authors provide background and guidance to support and empower you on this journey. This book is part of the SAS Press program.

Drug Design

Structure- and Ligand-Based Approaches

Author: Kenneth M. Merz, Jr,Dagmar Ringe,Charles H. Reynolds

Publisher: Cambridge University Press

ISBN: 1107717752

Category: Medical

Page: 286

View: 7649


Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies. A variety of authors from academic and commercial institutions all over the world have contributed to this book, which is illustrated with more than 200 images. This is the only book to cover the subject of structure and ligand-based drug design, and it provides the most up-to-date information on a wide range of topics for the practising computational chemist, medicinal chemist, or structural biologist. Professor Kenneth Merz has been selected as the recipient of the 2010 ACS Award for Computers in Chemical & Pharmaceutical Research that recognizes the advances he has made in the use of quantum mechanics to solve biological and drug discovery problems.