Dendrimer Based Drug Delivery Systems

Dendrimer Based Drug Delivery Systems

201; (e) Dendrimer Chemistry: Concepts, Syntheses, Properties, Applications, (V ̈ogtle, F., Richardt, G., Werner, N., Eds), Wiley-VCH Verlag GmbH, Weinheim, 2009, p. 354; (f) Carbosilane Dendrimers and Their Use in Polymerisation, ...

Author: Yiyun Cheng

Publisher: John Wiley & Sons

ISBN: 9780470460054

Category: Medical

Page: 542

View: 537

The opportunities and challenges of using dendrimers to improve drug delivery Among pharmaceutical and biomedical researchers, the use of dendrimers in drug delivery systems has attracted increasing interest. In particular, researchers have noted that the volume of a dendrimer increases when it has a positive charge. If this property can be applied effectively, dendrimers have enormous potential in drug delivery systems, directly supplying medication to targeted human organs. With contributions from an international team of pioneers and experts in dendrimer research, this book provides a comprehensive overview of the latest research efforts in designing and optimizing dendrimer-based drug delivery systems. The book analyzes key issues, demonstrating the critical connections that link fundamental concepts, design, synthesis, analytical methodology, and biological assessment to the practical use of dendrimers in drug delivery applications. Topics covered include: Dendrimer history Synthesis Physicochemical properties Principles of drug delivery Applications in diverse biomedical fields Dendrimer-Based Drug Delivery Systems reflects the authors' thorough review and analysis of the current literature as well as their own firsthand experience in the lab. Readers will not only discover the current state of the science, but also gain valuable insights into fruitful directions for future research. References at the end of each chapter serve as a gateway to the growing body of literature in the field, enabling readers to explore each individual topic in greater depth. Pharmaceutical and biomedical researchers will find this book a unique and essential guide to the opportunities, issues, and challenges involved in fully exploiting the potential of dendrimers to improve drug delivery.
Categories: Medical

Dendrimers in Nanomedicine

Dendrimers in Nanomedicine

Effect of core structure on photophysical and hydrodynamic properties of porphyrin dendrimers. Macromolecules, 33(8): 2967–2973. Medina, S.H., Tekumalla, V., Chevliakov, M.V., Shewach, D.S., Ensminger, W.D. and El-Sayed, M.E., 2011.

Author: Neelesh Kumar Mehra

Publisher: CRC Press

ISBN: 9781000333176

Category: Science

Page: 401

View: 850

Dendrimers, hyperbranched macromolecules, emerged just few decades ago but show promising potential as drug delivery nanocarriers, theranostic agents and gene vectors; in the pharmaceutical research and innovation area as well as in other healthcare applications. Although tremendous advancements have been made in dendrimer chemistry and their applications since their emergence, the synthesis, development and design of pure and safe dendrimer-based products have been a major challenge in this area. This book, edited by well-known researchers in the area of nanomaterials and drug-based drug delivery applications, exhaustively covers the nanotechnological aspects, concepts, properties, characterisation, application, biofate and regulatory aspects of dendrimers. It includes sixteen vivid chapters by renowned formulators, researchers and academicians from all over the world, highlighting their specialised areas of interest in the fields of chemistry, biology, pharmacy and nanomedicine. Features: • Highlights dendrimers’ advancements in nanomedicine in the development of safe healthcare and biotechnological products • Covers physicochemical aspects, biofate, drug delivery aspects and gene therapy using dendrimers • Covers biomedical application of dendrimers in the field of biological sciences • Gives examples of dendrimer–guest interaction chemistry Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives provides the comprehensive overview of the latest research efforts in designing, optimising, development and scale-up of dendrimer-mediated delivery systems. It analyses the key challenges of synthesis, design, molecular modelling, fundamental concepts, drug delivery aspects, analytical tools and biological fate as well as regulatory consideration to the practical use of dendrimer application. Dr. Neelesh Kumar Mehra Assistant Professor of Pharmaceutics in the Department of Pharmaceutics at the National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He has authored more than sixty peer-reviewed publications in highly reputed international journals, as well as book chapters and contributions on two patents. Dr. Mehra has 11 years of rich research and teaching experience in the formulation and development of complex, innovative biopharmaceutical products including micro- and nanotechnologies for regulated markets. Dr. Keerti Jain Assistant Professor of Pharmaceutics in the Department of Pharmaceutics, NIPER, Raebareli, India. For more than 10 years, she has been actively engaged in formulation and development of nanomedicines. Dr. Jain has supervised masters and doctoral pharmaceutics students in their research works which have been published in high quality, good impact factor journals. She has also authored more than 60 international manuscripts in peer reviewed high impact journals. In 2019, she was awarded the prestigious ICMR-Amir Shakuntala Award.
Categories: Science

Dendrimers in Medical Science

Dendrimers in Medical Science

Amperometric glutamate biosensor based on self-assembling glutamate dehydrogenase and dendrimer–encapsulated platinum nanoparticles onto carbon nanotubes. Talanta 73,438–443. Crespilho, F.N., Ghica, M.E., Zucolotto, V., Nart, F.C., ...

Author: Zahoor Ahmad Parry

Publisher: CRC Press

ISBN: 9781315341781

Category: Medical

Page: 222

View: 994

This valuable new book offers a new perspective on dendrimers that bridges the gap between basic research and applied nanomedicine. It explores the ultimate effectiveness of dendrimers in theranostics, a promising field that combines therapeutics and diagnostics into single multifunctional formulations used to affect therapy or treatment of a disease state. The authors examine the potential uses of dendrimers, which have proven their capabilities in local/systemic drug delivery, physical stabilization of the drug, solubility enhancement of the poorly soluble drugs, and gene delivery.
Categories: Medical

Phosphorous Dendrimers in Biology and Nanomedicine

Phosphorous Dendrimers in Biology and Nanomedicine

Biswas, S. and Torchilin, V. (2013). Dendrimers for siRNA delivery, Pharmaceuticals, 6, pp. 161–183. 49. Resnier, P., Montier, T., Mathieu, V., Benoit, J.-P., and Passirani, C. (2013). A review of the current status of siRNA ...

Author: Anne-Marie Caminade

Publisher: CRC Press

ISBN: 9781351617307

Category: Medical

Page: 372

View: 632

Dendrimers, which are hyperbranched synthetic macromolecules, have attracted researchers’ increasing interest over the last three decades owing to their numerous properties, in particular, in the fields of biology and nanomedicine. This book is an up-to-date collection of the most recent achievements in the use of dendrimers in nanomedicine, exemplified by phosphorus-containing dendrimers. Starting with the synthesis and characterization of phosphorus dendrimers, the book discusses their use as biomaterials, carriers of biological entities, and anti-inflammatory drugs; in bioimaging; and against prion diseases, Alzheimer’s, HIV, and cancer. It compares phosphorus dendrimers with other types of dendrimers. Supplemented with numerous references and abundant illustrations, the book opens new perspectives for the researchers working on dendrimers.
Categories: Medical

Biomedical Applications of Peptide Glyco and Glycopeptide Dendrimers and Analogous Dendrimeric Structures

Biomedical Applications of Peptide   Glyco  and Glycopeptide Dendrimers  and Analogous Dendrimeric Structures

54(10), 4290–4299 (2010) Gajbhiye, V., Palanirajan, V., Tekade, R., Jain, N.: Dendrimers as therapeutic agents: A systematic review. J. Pharm. Pharmacol. 61(8), 989–1003 (2009) Gonzalez, S.F., Lukacs-Kornek, V., Kuligowski, M.P., ...

Author: Jaroslav Sebestik

Publisher: Springer Science & Business Media

ISBN: 9783709112069

Category: Science

Page: 238

View: 183

Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.
Categories: Science

Analytical Ultracentrifugation V

Analytical Ultracentrifugation V

7 Double-logarithmic plot of sedimentation coecient (1), intrinsic viscosity (2), and translational diusion coecient (3) versus molecular weights MSD, evaluated from the Svedberg equation for LacPAMAM dendrimers 0±5 have a lower ...

Author: H. Cölfen

Publisher: Springer

ISBN: 9783540487036

Category: Technology & Engineering

Page: 223

View: 374

The basis for this volume is the 11th Symposium on Analytical Ultracentrifugation held in March 25-26, 1999 at the University of Potsdam, Germany. This book presents a comprehensive collection of 33 contributions from leading scientists in this field including: Technical and methodological innovations.- Innovations in data analysis.- Hydrodynamics/Modelling.- Synthetic polymers, colloids and supramolecular systems.- Biological systems.- Interacting systems and assemblies. In contrast to the increasing significance of analytical ultracentrifugation, related modern books are very rare. Therefore, this volume will be a helpful source of information to anyone who wants to catch up with the most recent developments and results related to this important analytical method.
Categories: Technology & Engineering

Intelligent Materials

Intelligent Materials

V. Balzani, L. Moggi and F. Scandola, in Supramolecular Photochemistry, ed. ... Dendrimers V: Functional and Hyper- branched Building Blocks, Photophysical Properties, Applications in Materials and Life Sciences. In: Top. Curr.

Author: Mohsen Shahinpoor

Publisher: Royal Society of Chemistry

ISBN: 9780854043354

Category: Science

Page: 555

View: 810

Leading experts in the fields of chemistry, physics and engineering have contributed to this book highlighting the importance of smart material science in the 21st century
Categories: Science

Pharmaceutical Applications of Dendrimers

Pharmaceutical Applications of Dendrimers

pH and generation dependent morphologies of PAMAM dendrimers on a graphene substrate. Soft Matter 2018;14:1925–38. [97] Guerrero-Beltran C, Rodriquez-Izquierdo I, Serramia MJ, Araya-Duran I, Marquez-Miranda V, Gomez R, et al.

Author: Abhay Singh Chauhan

Publisher: Elsevier

ISBN: 9780128145289

Category: Technology & Engineering

Page: 398

View: 155

Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in the imaging of diseased areas. In addition, the anti-inflammatory, antimicrobial and antiviral properties of PPI and PAMAM are also covered, along with a discussion on photosensitizers, such as rose Bengal and protoporphyrin IX that have been delivered using PAMAM and PPI dendrimers for the treatment of cancer. This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery. Explores the role of dendrimers in the design of dendritic nanoplatforms for targeted drug and gene delivery systems Discusses the potential of dendrimers in preformulation and formulation development Addresses both clinical and regulatory challenges in the development of dendrimer-based formulations
Categories: Technology & Engineering

Dendrimers IV

Dendrimers IV

... Ciano M, Balzani V (1992) Angew Chem Int Ed Engl 31:1493–1495 The protected decanuclear dendrimer and its deprotected analog were reported later in a paper describing generalized versions ofthe synthetic strategies: Campagna S, ...

Author: Christoph A. Schalley

Publisher: Springer Science & Business Media

ISBN: 9783540420958

Category: Science

Page: 254

View: 948

With the present issue of Topics in Current Chemistry, the fourth and final volume concluding the mini-series on dendrimer chemistry has appeared. With a focus on the interdisciplinary bridges to neighboring fields, the contributions to this volume focus on coordination, catalysis and self-assembly, nicely balanced by a synthesis-based article on dendritic oligoethers.
Categories: Science

Systems of Nanovesicular Drug Delivery

Systems of Nanovesicular Drug Delivery

Kaanumalle LS, Ramesh R, Murthy Maddipatla VSN, Nithyanandhan J, Jayaraman N, Ramamurthy V. Dendrimers as photochemical reaction media. Photochemical behavior of unimolecular and bimolecular reactions in water-soluble dendrimers.

Author: Amit Kumar Nayak

Publisher: Academic Press

ISBN: 9780323914222

Category: Medical

Page: 468

View: 711

Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applications of various nanovesicles. This volume discusses cubosomes, proniosomes and niosomes, dendrimerosomes and other new and effective approaches for drug delivery. It will be a valuable title and resource for academics and pharmaceutical scientists, including industrial pharmacists, analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailor-made polysaccharides in drug delivery applications. Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource. Provides thorough insights and up-to-date discussions about the various systems of nanovesicular drug delivery Covers advanced trigger-assisted systems (such as iontophoresis, ultra-sound triggering, etc.) and how they have been used for improved drug delivery by nanovesicles Presents recent advances in drug delivery fields by global leaders and experts from academia, research, industry and regulatory agencies Includes an updated literature review of relevant key topics, good quality illustrations, chemical structures, attractive flow charts and well-organized tables
Categories: Medical