Mild Cognitive Impairment

Mild Cognitive Impairment

In these studies, the density of tau-positive neurofibrillary tangles in mild cognitive impairment was intermediate to the other two subgroups or resembled findings in those with clinical Alzheimer's disease, whereas tau-positive ...

Author: Holly A. Tuokko

Publisher: Psychology Press

ISBN: 9781134953820

Category: Psychology

Page: 336

View: 870

Mild Cognitive Impairment (MCI) has been identified as an important clinical transition between normal aging and the early stages of Alzheimer's disease (AD). Since treatments for AD are most likely to be most effective early in the course of the disease, MCI has become a topic of great importance and has been investigated in different populations of interest in many countries. This book brings together these differing perspectives on MCI for the first time. This volume provides a comprehensive resource for clinicians, researchers, and students involved in the study, diagnosis, treatment, and rehabilitation of people with MCI. Clinical investigators initially defined mild cognitive impairment (MCI) as a transitional condition between normal aging and the early stages of Alzheimer’s disease (AD). Because the prevalence of AD increases with age and very large numbers of older adults are affected worldwide, these clinicians saw a pressing need to identify AD as early as possible. It is at this very early stage in the disease course that treatments to slow the progress and control symptoms are likely to be most effective. Since the first introduction of MCI, research interest has grown exponentially, and the utility of the concept has been investigated from a variety of perspectives in different populations of interest (e.g., clinical samples, volunteers, population-based screening) in many different countries. Much variability in findings has resulted. Although it has been acknowledged that the differences observed between samples may be ‘legitimate variations’, there has been no attempt to understand what it is we have learned about MCI (i.e., common features and differences) from each of these perspectives. This book brings together information about MCI in different populations from around the world. Mild Cognitive Impairment will be an important resource for any clinician, researcher, or student involved in the study, detection, treatment, and rehabilitation of people with MCI.
Categories: Psychology

Cognitive Impairment in Schizophrenia

Cognitive Impairment in Schizophrenia

Yet does the evidence support the view that cognitive processes and impairment are so pervasive, so intrinsic, so tied to the defining psychopathology and functional consequences of schizophrenia that the illness is best understood as a ...

Author: Philip D. Harvey

Publisher: Cambridge University Press

ISBN: 9781139619554

Category: Medical

Page:

View: 766

Although the precise mechanisms and pathways of schizophrenia remain something of a mystery, there is little dispute that cognitive deficits present as some of the clearest and most debilitating symptoms of the disease. This book describes the characteristics of cognitive deficits in schizophrenia, functional implications, the course of impairments, the genetic and biological contributions and reviews management options, including neuropsychological, psychological and pharmacological techniques. Chapters are written by leading experts in the field, in an accessible and highly informative style, ensuring the content is clinically relevant. State-of-the-art information about new developments in the treatment of related features of the illness, such as disability, is provided. The wide ranging focus of this volume will appeal to clinicians and academic researchers working with patients impaired by severe mental illness.
Categories: Medical

Mild Cognitive Impairment

Mild Cognitive Impairment

Our contention is that norms, if they are to be used for detecting mild cognitive impairment, should rely on statistical methods that directly model the probability of having pas) as a function of test performance and age.

Author: Ronald C. Petersen

Publisher: Oxford University Press

ISBN: 9780195123425

Category: Medical

Page: 269

View: 725

This is the first book on mild cognitive impairment (MCI), the transitional period between normal aging and very early Alzheimer's disease (AD). Persons with MCI have an increased risk of developing AD. This book addresses the spectrum of issues involved in MCI, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology, biological markers, diagnostic approaches, and treatment. It is intended for individuals interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, neuropsychologists, and their students and trainees.
Categories: Medical

Vascular Cognitive Impairment in Clinical Practice

Vascular Cognitive Impairment in Clinical Practice

Diagnosing vascular cognitive impairment and dementia: concepts and controversies Vascular Cognitive Impairment in Clinical Practice, ed. Lars-Olof Wahlund, Timo Erkinjuntti and Serge Gauthier. Published by Vascular cognitive ...

Author: Lars-Olof Wahlund

Publisher: Cambridge University Press

ISBN: 9780521875370

Category: Medical

Page: 241

View: 291

Vascular cognitive impairment is the second most common cause of dementia after Alzheimer's disease and is expected to grow in prevalence with the aging global population. The purpose of this authoritative book is to give a broad clinical perspective on vascular cognitive impairment and thus create a foundation for the implementation of good dementia care. The book focuses on pathophysiology, diagnosis, treatment and prevention. It demonstrates the underlying causes of the disorder, such as the manner in which vascular risk-factors influence the onset of vascular cognitive impairment. The concept of mixed forms of vascular dementia, Alzheimer's dementia and other vascular diseases is discussed as well as the influence of vascular changes with regard to the onset of Alzheimer's disease. The detailed section on pathophysiology will enhance clinicians' understanding of this complex disorder. Finally there is a section on pharmacological and neuropsychological treatment of cognitive and psychiatric symptoms.
Categories: Medical

Living with Mild Cognitive Impairment

Living with Mild Cognitive Impairment

Box 1.6 Terms Used to Characterize the Transition Stage between Normal Cognitive Aging and Dementia • Cognitive impairment, no dementia. • Late-life forgetfulness. • Limited cognitive disturbance. • Mild cognitive decline.

Author: Nicole D. Anderson

Publisher: Oxford University Press

ISBN: 9780199978908

Category: Psychology

Page: 384

View: 847

One in ten adults over 65 has some form of mild cognitive impairment or MCI--thinking problems that go beyond those associated with normal aging, but that fall short of the serious impairments experienced by people with Alzheimer's Disease and other dementias. This is the first book written specifically for individuals with MCI, for their loved ones, and for the health care professionals who treat them. Written by three clinicians and researchers who have devoted their careers to MCI patients, this book provides up-to-date and reliable information on the nature of this disorder, how it may affect people, and what can be done about it. The authors explain how MCI is diagnosed and treated and they offer advice on how to improve cognitive health through diet and exercise, through social engagement, and through the use of practical, effective memory strategies. Throughout, case studies illustrate the real-life issues facing people living with MCI. The book includes "Questions to Ask Your Doctor," recommended readings and links to relevant websites, and worksheets to guide readers through healthy lifestyle changes.
Categories: Psychology

Cognitive Impairment and Dementia in Parkinson s Disease

Cognitive Impairment and Dementia in Parkinson s Disease

Assessment of cognition in Parkinson's disease. Neurology 2003; 61: 1222–8. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment.

Author: Murat Emre

Publisher: Oxford University Press, USA

ISBN: 9780199564118

Category: Medical

Page: 272

View: 427

Parkinson's disease has long been perceived as a pure motor disorder, partly due to its initial description by James Parkinson, who suggested that "senses and intellect remain intact", and partly due to the fact that patients with PD did not survive long, before effective treatment became available. As the survival time of patients with Parkinson's disease has substantially increased due to modern treatment, it has become apparent that cognitive deficits and dementia are also frequent features, especially in elderly patients. With the progression of the disease and age, dementia develops in a substantial number of patients and constitutes a major therapeutic challenge. Dementia has thus increasingly been the focus of research and practice in recent years and a large body of knowledge has been accumulated. Despite these developments there has been no single volume dedicated to this topic. This book provides an extensive overview of the current status of knowledge pertaining to cognitive impairment and dementia associated with Parkinson's disease, intended as a reference book for general neurologists, neurology residents and also those with a special interest in movement disorders. In this edited volume experts in the field describe in detail all aspects of cognitive impairment and dementia in Parkinson's disease, including epidemiology, spectrum of clinical features, pathology, neurochemistry and genetics, findings in auxiliary investigations, relation to other neurodegenerative disorders, diagnostic process and management, and rounded up by discussion of future research directions and expectations. The text is complemented and enriched with tables, figures and heavily referenced to encompass all relevant literature.
Categories: Medical

Animal Models of Cognitive Impairment

Animal Models of Cognitive Impairment

Medical College of Georgia Animal models of cognitive impairment are critically important for determining the neural bases of learning, memory, and attention. These cognitive functions are the result of complex interactions of a variety ...

Author: Edward D. Levin

Publisher: CRC Press

ISBN: 9781420004335

Category: Science

Page: 400

View: 768

The costs associated with a drug’s clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications. The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer’s, schizophrenia, and ADHD. Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.
Categories: Science

Cognitive Impairment in Major Depressive Disorder

Cognitive Impairment in Major Depressive Disorder

observed; likewise, no correlation between cognitive measures and depressive symptoms were found. Cognitive impairment at baseline did not differ between patients with first versus recurrent MDEs, suggesting that cognitive deficits in ...

Author: Roger S. McIntyre

Publisher: Cambridge University Press

ISBN: 9781107074583

Category: Medical

Page: 370

View: 847

The first book to comprehensively assemble research, clinical, and public policy perspectives on cognitive dysfunction in major depressive disorder.
Categories: Medical

Diagnosis of Dementia and Cognitive Impairment

Diagnosis of Dementia and Cognitive Impairment

Cordell, C.B.; Borson, S.; Boustani, M.; Chodosh, J.; Reuben, D.; Verghese, J.; Thies, W.; Fried, L.B. Alzheimer's Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual ...

Author: Andrew J. Larner

Publisher: MDPI

ISBN: 9783039218844

Category: Medical

Page: 140

View: 423

In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.
Categories: Medical

Cognitive Impairment and Depression in Older Patients

Cognitive Impairment and Depression in Older Patients

Thus, he is not quite normal cognitively but also not so impaired in functioning that he is demented. This in-between category of “not normal, not demented” has been termed mild cognitive impairment (MCI) and defines a group of people ...

Author: Martin Steinberg

Publisher: Oxford University Press

ISBN: 9780199959556

Category: Medical

Page: 224

View: 331

Cognitive impairment and depression in older people have challenged clinicians and families for decades. These conditions affect well over half of people after age 65 with an incidence that increases with advancing age. Many factors account for this including the aging brain, loss of purpose, social isolation, personal losses, medical morbidity, and others. The mortality, disability, and burdens associated with these conditions, affecting patients, family members, and society at large are legion. Advances in epidemiology, brain science, therapeutics, and in service delivery continue to improve our understanding of these conditions, their causes, and the best ways to treat them. Despite this cognitive impairment and depression in later life remain underdiagnosed and undertreated in the United States. This book provides a single source for clinicians who treat older people to become more effective in the evaluation, diagnosis, and treatment of these challenging late life conditions. It offers a pragmatic, easy-to-use, resource that guides clinicians in how to best evaluate and treat older people with depression and cognitive impairment.
Categories: Medical

Mild Cognitive Impairment

Mild Cognitive Impairment

The Classic Edition of this foundational text includes a new preface from Holly A. Tuokko, examining how the field of Mild Cognitive Impairment (MCI) has developed since first publication.

Author: Holly A. Tuokko

Publisher: Psychology Press

ISBN: 9781000037852

Category: Psychology

Page: 350

View: 567

The Classic Edition of this foundational text includes a new preface from Holly A. Tuokko, examining how the field of Mild Cognitive Impairment (MCI) has developed since first publication. Bringing together research from multiple studies and perspectives from various countries, the volume identifies MCI as an important clinical transition between normal aging and the early stages of Alzheimer's disease (AD). The up-to-date preface highlights the expansion in research, examining the benefits of various pharmacological, cognitive and behavioral approaches to intervention. Influenced by recent findings in neuroplasticity across the lifespan, the book recognizes the importance of intervention at the earliest stages of the decline trajectory. It revisits the contested diagnostic approaches for MCI as well as the varying prevalence of MCI internationally, yet points to the need for further longitudinal studies to fully understand the condition. Mild Cognitive Impairment continues to provide a comprehensive resource for clinicians, researchers and students involved in the study, diagnosis, treatment and rehabilitation of people with MCI.
Categories: Psychology

Vascular Disease Alzheimer s Disease and Mild Cognitive Impairment

Vascular Disease  Alzheimer s Disease  and Mild Cognitive Impairment

Vascular cognitive impairment (VCI) is a clinical syndrome in which there is a decline in neurocognitive functions induced by cerebrovascular disease. This decline can vary in severity, ranging from mild neurocognitive decline to ...

Author: David Libon

Publisher: Oxford University Press, USA

ISBN: 9780190634230

Category: Medical

Page: 504

View: 261

"Cerebrovascular and Alzheimer disease often occur together, but are usually studied apart. This book offers a timely integrated approach to both diseases. Beginning with a section on epidemiology and neuropsychology, this volume goes on to discuss and explore the neuropathological and neurophysiological mechanisms of these disorders. This book then develops a novel concept of an Alzheimer disease/vascular dementia spectrum. Sections on neuroimaging, as well as treatments and interventions follow. The editors have succeeded in gathering an impressive group of clinicians and scientists, who are well qualified by their achievements and leadership to make important contributions to this new integrated approach to dementing disorders. This important book should have broad appeal to anyone studying or caring for patients with dementing disorders, as it is comprehensive, yet focused on a unitary, complementary and pragmatic approach"--
Categories: Medical

Update on Vascular Contributions to Age Related Neurodegenerative Diseases and Cognitive Impairment Research of ISNVD 2020 Meeting

Update on Vascular Contributions to Age Related Neurodegenerative Diseases and Cognitive Impairment   Research of ISNVD 2020 Meeting

TABLE 3 | Univariable logistic regression analyses of the odds of at least mild cognitive impairment (MoCA < 26) and the odds of severe cognitive impairment (MoCA < 19) associated with each covariate in patients after ischemic stroke ...

Author: Yulin Ge

Publisher: Frontiers Media SA

ISBN: 9782889717644

Category: Medical

Page:

View: 933

Categories: Medical

Assessment of Feigned Cognitive Impairment Second Edition

Assessment of Feigned Cognitive Impairment  Second Edition

protect against false- positive errors within the context of severe cognitive impairment or dementia. Much of the literature that is available on the MSVT is based on research with children and research with patients who have dementia ...

Author: Kyle Brauer Boone

Publisher: Guilford Publications

ISBN: 9781462545551

Category: Law

Page: 694

View: 555

The go-to resource for clinical and forensic practice has now been significantly revised with 85% new material, reflecting the tremendous growth of the field. Leading authorities synthesize the state of the science on symptom feigning in cognitive testing and present evidence-based recommendations for distinguishing between credible and noncredible performance. A wide range of performance validity tests (PVTs) and symptom validity tests (SVTs) are critically reviewed and guidelines provided for applying them across differing cognitive domains and medical, neurological, and psychiatric conditions. The book also covers validity testing in forensic settings and with particular populations, such as ethnic and linguistic minority group members. New to This Edition *Numerous new authors, a greatly expanded range of topics, and the latest data throughout. *"Clinical primer" chapter on how to select and interpret appropriate PVTs. *Chapters on methods for validity testing in visual–spatial, processing speed, and language domains and with cognitive screening instruments and personality inventories. *Chapter on methods for interpreting multiple PVTs in combination. *Chapters on additional populations (military personnel, children and adolescents) and clinical problems (dementia, somatoform/conversion disorder). *Chapters on research methods for validating PVTs, base rates of feigned mild traumatic brain injury, and more.
Categories: Law

Mild Cognitive Impairment An Issue of Clinics in Geriatric Medicine

Mild Cognitive Impairment  An Issue of Clinics in Geriatric Medicine

Serial PiB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease. Brain 2009;132:1355–65.

Author: Birju Patel

Publisher: Elsevier Health Sciences

ISBN: 9780323242240

Category: Medical

Page: 192

View: 266

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Mild Cognitive Impairment which includes current information on topics such as Overview of Mild Cognitive Impairment, Aging and Cognition, Classification and Epidemiology of Mild Cognitive Impairment, Neuropsychiatric Symptoms of Mild Cognitive Impairment, Clinical Evaluation of Early Cognitive Symptoms, Emerging Biomarkers Relating to Cognition, Imaging Modalities in Evaluation of Cognition, Current Management Decisions in Mild Cognitive Impairment, Risk Factors for Progression to Dementia, Dealing with Mild Cognitive Impairment: Help for Patients and Caregivers.
Categories: Medical

Cognitive Impairment Therapy Momentum in the Continuum of Life

Cognitive Impairment  Therapy Momentum in the Continuum of Life

COGNITIVE IMPAIRMENT: THERAPY MOMENTUM IN THE CONTINUUM OF LIFE Topic Editors: Artemissia-Phoebe Nifli, University of Thessaly, Greece Magda Tsolaki, Aristotle University of Thessaloniki, Greece Jos Tournoy, KU Leuven, Belgium Kazuki ...

Author: Artemissia-Phoebe Nifli

Publisher: Frontiers Media SA

ISBN: 9782889665723

Category: Science

Page:

View: 800

Categories: Science

Neuropsychiatric Symptoms of Cognitive Impairment and Dementia

Neuropsychiatric Symptoms of Cognitive Impairment and Dementia

This book is an up-to-date, comprehensive review of the neuropsychiatry of different types of cognitive impairment by active authorities in the field. There is an emphasis on diagnostic and management issues.

Author: Ana Verdelho

Publisher: Springer

ISBN: 9783319391380

Category: Medical

Page: 371

View: 595

This book is an up-to-date, comprehensive review of the neuropsychiatry of different types of cognitive impairment by active authorities in the field. There is an emphasis on diagnostic and management issues. Cognitive impairment both with and without criteria for dementia is covered. A critical appraisal of the methodological aspects and limitations of the current research on the neuropsychiatry of cognitive impairment and dementia is included. Unanswered questions and controversies are addressed. Non-pharmacological and pharmacological aspects of management are discussed, to provide robust information on drug dosages, side effects and interaction, in order to enable the reader to manage these patients more safely. Illustrative cases provide real life scenarios that are clinically relevant and engaging to read. Neuropsychiatric Symptoms of Cognitive Impairment and Dementia is aimed at neurologists, psychiatrists, gerontologists, and general physicians. It will also be of interest to intensive care doctors, psychologists and neuropsychologists, research and specialist nurses, clinical researchers and methodologists.
Categories: Medical

Living with Mild Cognitive Impairment

Living with Mild Cognitive Impairment

This book is for individuals with mild cognitive impairment (MCI), their loved ones, and health care professionals who care for these patients.

Author: Nicole D. Anderson

Publisher: Oxford University Press

ISBN: 9780199764822

Category: Health & Fitness

Page: 363

View: 247

This book is for individuals with mild cognitive impairment (MCI), their loved ones, and health care professionals who care for these patients. The text is loaded with up-to-date, scientifically substantiated knowledge about what MCI is, how it affects people, and how to take a proactive approach to health and wellbeing for living with MCI.
Categories: Health & Fitness

Cognitive Impairment in Major Depressive Disorder

Cognitive Impairment in Major Depressive Disorder

Evidence indicates that disturbance in the domain of cognitive function in individuals with MDD is the principal determinant of health outcome. This is the first book to comprehensively explore the domain of cognition in MDD.

Author: Roger S. McIntyre

Publisher: Cambridge University Press

ISBN: 9781316368572

Category: Medical

Page:

View: 416

Major depressive disorder (MDD) is the leading cause of disability globally in both developed and developing nations. The staggering economic costs attributable to MDD are largely a consequence of impairment in role function. Evidence indicates that disturbance in the domain of cognitive function in individuals with MDD is the principal determinant of health outcome. This is the first book to comprehensively explore the domain of cognition in MDD. The literature describing cognitive dysfunction is reviewed with particular focus on clinical determinants, pathophysiology and causative factors. The patient subpopulations most susceptible are defined. A summary of contemporary assessment tools for research and clinical purposes is provided. Multimodality treatments and prevention strategies are described. This book is an invaluable resource for psychiatrists, neuropsychologists and other members of the mental health team, as well as for policy makers, vocation rehabilitation experts, disability providers and other stakeholders interested in improving health outcomes in MDD.
Categories: Medical