Clinical Research for Surgeons

Clinical Research for Surgeons

Praise for this book:Readable, relevant, and interesting...this book cuts through jargon, recapitulates key concepts, and clarifies with current examples from the literature...recommend[ed].

Author: Mohit Bhandari

Publisher: Thieme

ISBN: 9783131494511

Category: Medical

Page: 328

View: 617

Praise for this book:Readable, relevant, and interesting...this book cuts through jargon, recapitulates key concepts, and clarifies with current examples from the literature...recommend[ed].--Doody's ReviewClinical Research for Surgeons is a practical guide for understanding, planning, conducting, and evaluating surgical research. It covers the principles of evidence-based surgery and applies these principles to the design of suitable research studies. The reader will come to fully understand important concepts such as case-control study, prospective cohort study, randomized trial, and reliability study. The book provides valuable discussions of the critical appraisal of published clinical studies, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care.Highlights: Insights from experienced surgeons and veteran researchers Easy-to-reference text boxes with Key Concepts, Jargon Simplified, and Examples from the Literature Coverage of both open and minimally-invasive surgical procedures 50 illustrations demonstrating key points This book is a valuable reference for clinicians and residents in a range of disciplines, including general surgery, orthopedic surgery, plastic and reconstructive surgery, urology, neurosurgery, otolaryngology-head and neck surgery, interventional radiology, cardiac surgery.
Categories: Medical

Clinical Research Methods for Surgeons

Clinical Research Methods for Surgeons

CONTENTS ETHICAL RESEARCH: A HISTORICAL PERSPECTIVE THE
INSTITUTIONAL REVIEW BOARD SPECIFIC ETHICAL ISSUES REGARDING
CLINICAL RESEARCH IN SURGERY HIPAA: THE 800-POUND GORILLA OF
CLINICAL ...

Author: David F. Penson

Publisher: Springer Science & Business Media

ISBN: 9781597452304

Category: Medical

Page: 350

View: 783

With his keen analytical mind and penchant for organization, Charles Darwin would have made an excellent clinical investigator. Unfortunately for surgery, his early exposure at Edinburgh to the brutality of operations in 1825 convinced him to reject his father’s plan for his career and pursue his interest in nature. His subsequent observations of how environmental pressures shaped the development of new species provided the essential mechanism to explain evolution and the disappearance of those species that failed to adapt. Today, surgeons face the same reality as new technology, progressive regulation by government and payers, medico-legal risks, and public demands for proof of performance force changes in behavior that our predecessors never imagined. We know that surgeons have always prided themselves on accurate documentation of their results, including their complications and deaths, but observational studies involving a single surgeon or institution have given way to demands for controlled interventional trials despite the inherent difficulty of studying surgical patients by randomized, blinded techniques. That is why this book is so timely and important. In a logical and comprehensive approach, the authors have assembled a group of experienced clinical scientists who can demonstrate the rich variety of techniques in epidemiology and statistics for reviewing existing publications, structuring a clinical study, and analyzing the resulting data.
Categories: Medical

Landmark Papers in General Surgery

Landmark Papers in General Surgery

Critiquing key papers in the field, Landmark Papers in General Surgery gives surgeons and trainees an expert appraisal and contextual discussion of the evidence base behind current clinical practice, all in a clear and easy-access layout.

Author: Graham MacKay

Publisher: Oxford University Press

ISBN: 9780199644254

Category: Medical

Page: 399

View: 654

Critiquing key papers in the field, Landmark Papers in General Surgery gives surgeons and trainees an expert appraisal and contextual discussion of the evidence base behind current clinical practice, all in a clear and easy-access layout.
Categories: Medical

Success in Academic Surgery Clinical Trials

Success in Academic Surgery  Clinical Trials

How can they assure that they are designing and performing high-quality,
standardized research? A recent survey of surgical trialists seeks to provide
insight into how to build a stronger education platform and resources for clinical
trials in ...

Author: Timothy M. Pawlik

Publisher: Springer Science & Business Media

ISBN: 9781447146797

Category: Medical

Page: 183

View: 516

Surgical education is a rapidly expanding area of surgical research and career interest, and as the Association for Academic Surgery (AAS) Fall Courses (www.aasurg.org) and International courses offer more and more specialty tracking there is a greater need for an accompanying textbook to supplement the material presented in the courses.
Categories: Medical

Operative Standards for Cancer Surgery

Operative Standards for Cancer Surgery

Operative Standards for Cancer Surgery clearly describes the surgical activities that occur between skin incision and skin closure that directly affect cancer outcomes.

Author: Matthew Hg Katz

Publisher: LWW

ISBN: 1496337034

Category: Medical

Page: 352

View: 811

Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. First presented by the American College of Surgeons and the Alliance for Clinical Trials in Oncology in 2015, the comprehensive, evidence-based examination of cancer surgery techniques as standards distills the well-defined protocols and procedures that are critical to achieve optimal outcomes in a cancer operation. This unique, one of a kind collaboration between the American College of Surgeons and the Alliance for Clinical Trials in Oncology focuses on best practices and state-of-the-art methodologies. Operative Standards for Cancer Surgery clearly describes the surgical activities that occur between skin incision and skin closure that directly affect cancer outcomes. Quickly grasp the proper technical elements of a cancer operation through clear, practical text and more than 120 illustrations. Benefit from careful analysis of the best evidence available in the literature; gathered here to create the highest quality standards in cancers of the esophagus, stomach, thyroid, rectum, and melanoma. Learn from experts drawn from diverse groups, including the American College of Surgeons, the Alliance for Clinical Trials in Oncology, the National Cancer Institute Cooperative Groups, and the Commission on Cancer, as well as national societies and organizations with an interest in these five cancer types. Enhance Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.
Categories: Medical

Randomized Clinical Trials in Surgical Oncology An Issue of Surgical Oncology Clinics E Book

Randomized Clinical Trials in Surgical Oncology  An Issue of Surgical Oncology Clinics    E Book

necessarily correlate with the clinical impact of a trial. For instance, sorafenib
achieved limited improvement in overall survival (10.7 months vs. 7.9 months)
and did not alter time to symptomatic progression compared with placebo in
advanced ...

Author: Adam C. Yopp

Publisher: Elsevier Health Sciences

ISBN: 9781455700691

Category: Medical

Page: 249

View: 835

This issue of the Surgical Oncology Clinics will review the important clinical trials from the past eight years in following topics: breast cancer, soft tissue sarcoma, rectal and anal carcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma, gastric cancer, esophageal cancer, colon cancer, advanced and metastatic colorectal carcinoma, gastrointestinal stromal tumors, and melanoma.
Categories: Medical

Outcomes Research in Surgical Oncology An Issue of Surgical Oncology Clinics E Book

Outcomes Research in Surgical Oncology  An Issue of Surgical Oncology Clinics   E Book

In addition, this article also addresses the vulnerabilities of practicing based on
clinical trial evidence and how these vulnerabilities might be addressed in the
future. CLINICAL TRIALS: ARE THEY RELEVANT IN SURGERY? The first ...

Author: Clifford Ko

Publisher: Elsevier Health Sciences

ISBN: 9781455747726

Category: Medical

Page: 240

View: 829

In this issue of Surgical Oncology Clinics of North America, Guest Editor Clifford Ko, MD has assembled the top experts concerning Outcomes Research in Oncology. Topics in this issue will include: Currently Available Quality Initiatives in Surgical Oncology; Variation in Mortality After High Risk Cancer Surgery: Failure to Rescue; Readmission as a Quality Measure Following High Risk Cancer Surgery; Randomized Controlled Trials in Surgical Oncology: Where Do We Stand?; Lymph Node Staging in GI Malignancies; Racial and Socioeconomic Disparities in Cancer Care; Patient Safety in Surgical Oncology: Perspective from the Operating Room; Value Based Health Care: A Surgical Oncologist Perspective; Monitoring the Delivery of Cancer Care: Commission on Cancer and National Cancer Data Base; Prediction Tools in Surgical Oncology; Collaboration With the Community Cancer Center: Benefit for All; and Evaluating the Appropriateness of Cancer Care in the United States.
Categories: Medical

Surgical Research

Surgical Research

Identification of Clinical Problems The collection and documentation of data from
patients undergoing concurrent surgical treatment has been one of the most
useful but least used methods of surgical clinical research . The advantages of ...

Author: Hans Troidl

Publisher: Springer Science & Business Media

ISBN: 0387946993

Category: Medical

Page: 695

View: 613

A unique reference manual for academic surgeons, this book discusses every facet of surgical research. From getting grant money to choosing a topic, reviewing the literature, planning and conducting research, and reporting results.
Categories: Medical

Clinical Trials Design in Operative and Non Operative Invasive Procedures

Clinical Trials Design in Operative and Non Operative Invasive Procedures

There are also additional challenges for clinical trials in invasive operative and
nonoperative procedures with a ... Thus, the quality of the performance of a
surgical procedure/intervention changes with the degree of experience of the
operator.

Author: Kamal M.F. Itani

Publisher: Springer

ISBN: 9783319538778

Category: Medical

Page: 495

View: 253

The aim of this text is to provide the framework for building a clinical trial as it pertains to operative and non operative invasive procedures, how to get it funded and how to conduct such a trial up to publication of results The text provides all details of building a scientifically and ethically valid proposal, including how to build the infrastructure for a clinical trial and how to move it forward through various funding agencies. The text also presents various types of clinical trials, the use of implantable devices and FDA requirements, and adjuncts to clinical trials and interaction with industry Clinical Trials Design in Invasive Operative and Non Operative Procedures will be of interest to all specialists of surgery, anesthesiologists, interventional radiologists, gastroenterologists, cardiologists, and pulmonologists
Categories: Medical

Key Topics in Surgical Research and Methodology

Key Topics in Surgical Research and Methodology

Randomised Controlled Trials: What the Surgeon Needs to Know Marcus Flather,
Belinda Lees, and John Pepper 5 55 T. Athanasiou (eds.), Key Topics in Surgical
Research and ... 5.4 What Do I Need to Know Before Starting a Clinical Trial?

Author: Thanos Athanasiou

Publisher: Springer Science & Business Media

ISBN: 3540719156

Category: Medical

Page: 1019

View: 531

Key Topics in Surgical Research and Methodology represents a comprehensive reference text accessible to the surgeon embarking on an academic career. Key themes emphasize and summarize the text. Four key elements are covered, i.e. Surgical Research, Research Methodology, Practical Problems and Solutions on Research as well as Recent Developments and Future Prospects in Surgical Research and Practice.
Categories: Medical

The Oxford Textbook of Clinical Research Ethics

The Oxford Textbook of Clinical Research Ethics

Placebo surgery addresses the question posed by the fundamentalism that
venerates placebo-controlled trials above everything else in clinical medicine.
This is not necessarily the core of evidence-based medicine, which is “the
conscientious ...

Author: Ezekiel J. Emanuel

Publisher: Oxford University Press

ISBN: 9780195168655

Category: Language Arts & Disciplines

Page: 827

View: 751

The Oxford Textbook of Clinical Research Ethics is the first systematic and comprehensive reference on clinical research ethics. Under the editorship of experts from the National Institutes of Health of the United States, the book offers a wide-ranging and systematic examination of all aspects of research with human beings. Considering historical triumphs of research as well as tragedies, the textbook provides a framework for analysing the ethical aspects of research studies with human beings. Through both conceptual analysis and systematic reviews of empirical data, the textbook examines issues ranging from scientific validity, fair subject selection, risk benefit ratio, independent review, and informed consent as well as focused consideration of international research ethics, conflicts of interests and other aspects of responsible conduct of research. The editors of The Oxford Textbook of Clinical Research Ethics offer a work that critically assesses and advances scholarship in the field of human subjects research with human beings.
Categories: Language Arts & Disciplines

Principles and Practice of Research

Principles and Practice of Research

Strategies for Surgical Investigators H. Troidl, W.O. Spitzer, B. McPeek, D.S.
Mulder, Martin F. Bach. conclude that compliant ... as lists of do's and don'ts.
Finally, why should surgeons carry out clinical research on surgical problems
rather ...

Author: H. Troidl

Publisher: Springer Science & Business Media

ISBN: 9783642969423

Category: Medical

Page: 381

View: 588

emerging on the surgical scene to challenge or For some readers, the title of this book will im thodoxy. Although these innovations are often mediately raise the question, what exactly is greeted with great optimism, a factual basis for meant by surgical research? In the very broadest that enthusiasm is sometimes far from secure sense the term can be taken to include all en and much further work is frequently required to deavors, however elementary or limited in discover whether we are dealing with genuine scope, to advance surgical knowledge. Ideally, advances or not. it refers to well-organized attempts to establish The most exciting and attractive scenario for on a proper scientific basis, i. e. , to place beyond surgical research is unquestionably one that de reasonable doubt, the truth or otherwise of any picts a successful attempt by a researcher to es concepts, old or new, within the ambit of sur gery, and, of course, anaesthesia. tablish the accuracy of some bold innovation for which he himself is responsible. Joseph Lister, The methods used to achieve that end vary demonstrating by clinical trial that wound sup enormously, depending on the issue being in vestigated.
Categories: Medical

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book

The surgical oncologist often provides the leadership for cancer care, cancer
research, and cancer teaching within the ... Cancer surgeons have historically
provided significant leadership in the conduct of clinical research, in designing
clinical ...

Author: John E. Niederhuber

Publisher: Elsevier Health Sciences

ISBN: 9781455728817

Category: Medical

Page: 2224

View: 566

Practical and clinically focused, Abeloff’s Clinical Oncology is a trusted medical reference book designed to capture the latest scientific discoveries and their implications for cancer diagnosis and management of cancer in the most accessible manner possible. Abeloff’s equips everyone involved - from radiologists and oncologists to surgeons and nurses - to collaborate effectively and provide the best possible cancer care. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Select the most appropriate tests and imaging studies for cancer diagnosis and staging of each type of cancer, and manage your patients in the most effective way possible by using all of the latest techniques and approaches in oncology. Enhance your understanding of complex concepts with a color art program that highlights key points and illustrates relevant scientific and clinical problems. Stay at the forefront of the latest developments in cancer pharmacology, oncology and healthcare policy, survivorship in cancer, and many other timely topics. See how the most recent cancer research applies to practice through an increased emphasis on the relevance of new scientific discoveries and modalities within disease chapters. Streamline clinical decision making with abundant new treatment and diagnostic algorithms as well as concrete management recommendations. Take advantage of the collective wisdom of preeminent multidisciplinary experts in the field of oncology, including previous Abeloff’s editors John E. Niederhuber, James O. Armitage, and Michael B. Kastan as well as new editors James H. Doroshow from the National Cancer Institute and Joel E. Tepper of Gunderson & Tepper: Clinical Radiation Oncology. Quickly and effortlessly access the key information you need with the help of an even more user-friendly, streamlined format. Access the complete contents anytime, anywhere at Expert Consult, and test your mastery of the latest knowledge with 500 online multiple-choice review questions.
Categories: Medical

Health Services Research and Evidence Based Medicine in Hand Surgery An Issue of Hand Clinics

Health Services Research and Evidence Based Medicine in Hand Surgery  An Issue of Hand Clinics

Hand surgeons are now expected both to use the best available evidence to
guide clinical decisions and to ensure that ... care resources, there is an
opportunity to incorporate economic evaluations into surgical clinical research
and contain ...

Author: Jennifer Waljee

Publisher: Elsevier Health Sciences

ISBN: 9780323320320

Category: Medical

Page: 145

View: 970

This issue focuses on the integration of health services research into clinical practice. It provides an overview of the field of health services research for the practicing hand surgeon and highlights pertinent topics that can inform clinical care in any practice setting.
Categories: Medical

Surgical Limits

Surgical Limits

4 A Private Laboratory, a Second Artificial Kidney, and New Heart Operations
When Murray did his postgraduate medical training in the mid-1920s, clinical
research in general had been a relatively new field. For the clinician, doing
research ...

Author: Shelley McKellar

Publisher: University of Toronto Press

ISBN: 0802037399

Category: Biography & Autobiography

Page: 270

View: 628

A biography of the life of Gordon Murray.
Categories: Biography & Autobiography

Noyes Knee Disorders Surgery Rehabilitation Clinical Outcomes E Book

Noyes  Knee Disorders  Surgery  Rehabilitation  Clinical Outcomes E Book

Advancement of medical care, both surgical and non-surgical, requires carefully
conducted outcome studies that account ... approaches and research, it also
includes the clinical approaches and research results of other leading surgeons
and ...

Author: Frank R. Noyes

Publisher: Elsevier Health Sciences

ISBN: 9781437721188

Category: Medical

Page: 1176

View: 588

Frank R. Noyes, MD—internationally-renowned knee surgeon and orthopaedic sports medicine specialist—presents Noyes’ Knee Disorders, an unparalleled resource on the diagnosis, management, and outcomes analysis for the full range of complex knee disorders. Master the technical details of procedures such as anterior cruciate ligament reconstruction, meniscus repair, articular cartilage restoration, and many others, and implement appropriate post-operative rehabilitation programs and protocols. Analyze and manage gender disparities in anterior cruciate ligament injuries. You can access the full text, as well as downloadable images, PubMed links, and alerts to new research online at www.expertconsult.com. Offers online access to the full text, downloadable images, PubMed links, and alerts to new research online at expertconsult.com through Expert Consult functionality for convenient reference. Presents step-by-step descriptions on the full range of complex soft tissue knee operative procedures for the anterior cruciate ligament reconstruction, meniscus repair, soft tissue transplants, osseous malalignments, articular cartilage restoration, posterior cruciate ligament reconstruction, and more to provide you with guidance for the management of any patient. Relies on Dr. Noyes’ meticulous published clinical studies and outcomes data from other peer-reviewed publications as a scientifically valid foundation for patient care. Features detailed post-operative rehabilitation programs and protocols so that you can apply proven techniques and ease your patients’ progression from one phase to the next. Bonus video available only from the website provides live presentations from the 2009 Advances on the Knee and Shoulder course, step-by-step surgical demonstration of an opening wedge tibial osteotomy, and a 4-part series on the Diagnosis of Knee Ligament Injuries.
Categories: Medical

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research

... undergoing surgery (human) P01NS-12587-14 9007 Head injury clinical and
laboratory research center - Rat surgery / behavioral core P01NS-17111-09 0014
Center for clinical research in epilepsy - Anticonvulsant concentration-response ...

Author:

Publisher:

ISBN: MINN:31951P00029170X

Category: Medicine

Page:

View: 446

Categories: Medicine

Translational Cancer Research for Surgeons an Issue of Surgical Oncology Clinics

Translational Cancer Research for Surgeons  an Issue of Surgical Oncology Clinics

... lymphomas, and leukemias.21,28 Despite an intensive academic research
program, however, optimization and stabi- ... optimized the formulation of IPM as
a stable tris salt system, and conducted several nonclinical and clinical studies.

Author: William G. Cance

Publisher: Elsevier Health Sciences

ISBN: 9780323227445

Category: Medical

Page: 16

View: 409

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
Categories: Medical

Translational Cancer Research for Surgeons An Issue of Surgical Oncology Clinics

Translational Cancer Research for Surgeons  An Issue of Surgical Oncology Clinics

... well as CD81 CTLs. phase 2 clinical studies to facilitate the translational path
for this promising gene/ immunotherapy ... these inhibitors was initially published
in 1971, when Dr Judah Folkman,64,65 as surgeon at Harvard Medical School, ...

Author: William G. Cance

Publisher: Elsevier Health Sciences

ISBN: 9780323227452

Category: Medical

Page: 311

View: 842

This issue of the Surgical Oncology Clinics of North America, Guest Edited by Dr. William G. Cance, is devoted to Translational Cancer Research for Surgeons. Translational Cancer research aims to move bench research to the bedside by applying basic science toward potential therapies. This issue will present the concepts of translational research and development of targeted therapeutics, and its implications for surgeons. It will show clinical applications for surgeons regarding sarcoma/GIST, melanoma, colorectal cancer, breast cancer, and endocrine cancer.
Categories: Medical

Textbook of Surgical Oncology

Textbook of Surgical Oncology

Designing. clinical. trials. in. surgical. oncology: the. importance. of. quality.
Marcel. den. Dulk,. Elma. Meershoek-Klein ... Everyday hundreds of papers are
published in medical literature, but not all reports are based on proper research
and ...

Author: Graeme J. Poston

Publisher: CRC Press

ISBN: 0203003225

Category: Medical

Page: 432

View: 643

Surgery alone cures more than 60% of those patients whose cancer are amenable to curative treatment. Surgical oncology is not universally accepted as a unified discipline worldwide. There are many reasons for this situation, including the drive to anatomic site specialization, but also the need to provide comprehensive 'general' surgical provision to more isolated and rural communities. Textbook of Surgical Oncology, written by a highly acclaimed list of international authors, comprehensively covers the role of the surgical oncologist in the management of patients with solid tumors. This book provides a state of the art review of cancer surgery for senior residents approaching certification at the completion of their training as well as providing an up to date reference work for established clinicians in their day to day practice, including those in general surgery, surgical oncology, urologists, gynecologists, thoracic, neurosurgical, radiation oncologist and medical oncologists.
Categories: Medical