Chirality in Industry II

Chirality in Industry II

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections.

Author: A. N. Collins

Publisher: John Wiley & Sons

ISBN: 0471982849

Category: Science

Page: 418

View: 317

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II All new case histories Unique industrial perspective on chiral technology Emphasis on scale-up and process development Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.
Categories: Science

Chirality in Industry The Commercial Manufacture and Applications of Optically Active Compounds and Chirality in Industry II Developments in the Commercial Manufacture and Applications of Optically Active Compounds Two Volume Set

Chirality in Industry  The Commercial Manufacture and Applications of Optically Active Compounds and Chirality in Industry II  Developments in the Commercial Manufacture and Applications of Optically Active Compounds  Two Volume Set

The manufacture and applications of chiral compounds continue to develop. Building on the case studies format of the first volume, this text concentrates on different syntheses and the developments in the field.

Author: A. N. Collins

Publisher: Wiley

ISBN: 0471984175

Category: Science

Page: 844

View: 132

The manufacture and applications of chiral compounds continue to develop. Building on the case studies format of the first volume, this text concentrates on different syntheses and the developments in the field. It presents a comprehensive picture of the technologies required for the production of optically active molecules on the multi-Kg to high tonnage scales, as well as illustrating the breadth of application of the products of these technologies. This volume is divided into sections on physical methods and classical resolutions, biological methods and the chiral pool, and asymmetric synthesis. These are preceded by a chapter dealing with regulatory issues for chiral drugs and two chapters on chiral drug development which illustrates how widely the industrial practitioner must cast the net in pursuit of practical production methods.
Categories: Science

Chirality in Industry II

Chirality in Industry II

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections.

Author: A. N. Collins

Publisher: Wiley

ISBN: 0471966800

Category: Science

Page: 418

View: 203

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II * All new case histories * Unique industrial perspective on chiral technology * Emphasis on scale-up and process development * Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.
Categories: Science

Chirality in Industry II

Chirality in Industry II

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections.

Author: A. N. Collins

Publisher: Wiley

ISBN: 0471982849

Category: Science

Page: 418

View: 100

This second volume of Chirality in Industry contains new case histories from a wide range of contributors from industry or with strong industrial connections. While it is intended that the new volume will stand on its own, Volumes I and II taken together present an up-to-date and comprehensive picture of the technologies required to produce optically active compounds on a multi-kilogramme to high tonnage scale as well as illustrating the breadth of application of these technologies; the pharmaceuticals, agrochemicals, electronics, food, flavour and fragrance industries are all represented. Chirality in Industry II All new case histories Unique industrial perspective on chiral technology Emphasis on scale-up and process development Comparison of biocatalysis, asymmetric synthesis and classical resolution approaches The chiral infrastructure is now largely in place and there is no reason why large-scale production should not be possible for even moderately priced single enantiomer products. The successful industrial application of chiral chemistry depends on the integration of a range of supporting technologies and there are many examples in this volume of how widely the industrial practitioner must cast the net to achieve practical production methods. As with Volume I, this new volume is of particular interest to those professionally involved in the scale-up processes for single enantiomers. However, students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large-scale thinking. An economic solution is still most likely to be a simple, elegant solution.
Categories: Science

Chirality in Industry

Chirality in Industry

The volume includes example of each of the available process options, from classical resolution procedures to asymmetric syntheses with traditional chemical catalysts and enzyme-based technologies.

Author: A. N. Collins

Publisher: Wiley

ISBN: 0471963135

Category: Science

Page: 426

View: 481

The production of optically active intermediates and products as pure enantiomers is a topic of ever-increasing importance to the chemical industry. The economic incentives of improved cost efficiency and enhanced biological activity, together with new regulatory pressures have, in the last decade, brought about a dramatic increase in the number and scope of industrial processes. Chirality in Industry provides an overview of the production of optically active compounds on a large scale wholly from an industrial perspective. The volume includes example of each of the available process options, from classical resolution procedures to asymmetric syntheses with traditional chemical catalysts and enzyme-based technologies. An extended opening chapter, which systematically considers these options and relates them to a series of important targets, is followed by a series of more detailed case histories by industrial authors summarizing the processes which underpin the large-scale production of several important optically pure intermediates. While Chirality in Industry should prove of particular interest to chemists who are professionally involved in the production of pure enantiomers on a practical scale, it is hoped that students and researchers involved in a more academic pursuit of optical activity will also benefit from some of the facets of large scale thinking. An economic solution is more likely to be a simple, elegant solution.
Categories: Science

Chirality in Natural and Applied Science

Chirality in Natural and Applied Science

This book will ensure the reader has a thorough understanding of chirality, its importance and its application This book is for chemists in industry and in academic and research institutions.

Author: W. John Lough

Publisher: Wiley-Blackwell

ISBN: 0632054352

Category: Science

Page: 313

View: 130

An understanding of chirality is central to the study and application of the molecular sciences. Chirality in Natural and Applied Science provides a highly practical overview of the chemical significance of chirality and is particularly relevant for pharmaceutical, natural product, organic and analytical chemists, biochemists and molecular biologists. The book describes the current understanding of all issues relating to chirality, and appraises its impact on much of modern molecular science. It covers the natural occurrence of chirality on a variety of scales, and applications in research and industry. By bringing together the experience of a number of contributors who have played an influential role on the direction of research in this area, the text is well placed to explain the most important insights, developments and applications that have taken place. Chirality will remain a central part of the understanding of all molecular scientists, and there is little doubt that its importance will increase. This book will ensure the reader has a thorough understanding of chirality, its importance and its application
Categories: Science

Chiral Drugs

Chiral Drugs

Crosby, J., in Chirality in Industry, Collins, A.N., Sheldrake, G.N., and Crosby, J. (Eds.), John Wiley & Sons, New York, 1992, p.55. 2.

Author: Cynthia A Challener

Publisher: Routledge

ISBN: 9781351808057

Category: Social Science

Page: 662

View: 352

This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.
Categories: Social Science

Chirotechnology

Chirotechnology

;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, ...

Author: Roger A. Sheldon

Publisher: CRC Press

ISBN: 0824791436

Category: Science

Page: 423

View: 328

This reference provides an introduction to the phenomenon of chirality and its importance in conjunction with biological activity and offers an easy-to-read examination of practical, industrially relevant methods for the synthesis of optically active compounds.;Furnishing hands-on guidelines for the development of economically viable synthetic compounds, Chirotechnology: explains optical isomerism and stereochemistry; gives a general overview of various methods of synthesis; supplies detailed explications of specific techniques, including fermentation, crystallization, the chirality pool, enzymatic methods, and catalytic asymmetric synthesis; illustrates and compares approaches with examples taken directly from industry such as the synthesis of pharmaceuticals, agrochemicals, flavours, and fragrances; and clarifies the importance of determining which approach to use for the synthesis of particular molecules.;With over 1100 literature citations, tables and figures, Chirotechnology is a reference for chemical engineers; industrial, organic and medicinal chemists; and bioprocess technologists, as well as a text for upper-level undergraduate, graduate and continuing-education students in these disciplines.
Categories: Science

Chiral Pollutants

Chiral Pollutants

In the pharmaceutical and drug industries, the existence of chirality became particularly important in the wake of the thalidomide tragedy in the 1960s.

Author: Imran Ali

Publisher: John Wiley & Sons

ISBN: 9780470867815

Category: Science

Page: 368

View: 572

Today, among the various chiral discrimination methods, chromatography and capillary electrophoresis techniques have become powerful tools in environmental analysis. Therefore, there is a need to describe the art of the determination of the chiral pollutants in the environmental matrices. This book provides the complete information on the types of the chiral pollutants, their toxicities and methods of determination by chromatography and capillary electrophoresis.
Categories: Science

Chirality in Agrochemicals

Chirality in Agrochemicals

Written by leading experts from industry and academia, this is the first book devoted to the topic of chirality in agrochemicals, discussing the synthesis, activity and toxicology of chiral agrochemicals.

Author: Norio Kurihara

Publisher: Wiley-Blackwell

ISBN: UCSC:32106014072463

Category: Science

Page: 269

View: 212

Written by leading experts from industry and academia, this is the first book devoted to the topic of chirality in agrochemicals, discussing the synthesis, activity and toxicology of chiral agrochemicals. The importance of using optically pure compounds has long been recognized by the pharmaceutical industry. The discovery that opposite enantiomers can have similarly diverse effects on plants and insects has had no less a revolutionary impact on the agrochemical industry. In this review volume, interesting and topical examples of chiral agrochemicals are brought together. It covers: * Pyrethroid Insecticides * Organophosphorus Insecticides and Fungicides * Aryloxyophenoxypropanoate Herbicides * Acylanilides * Triazoles * Insect Hormones and Pheromones The book will provide invaluable information for all those in the field.
Categories: Science

Chiral Drugs

Chiral Drugs

Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.

Author: Cynthia A Challener

Publisher: Routledge

ISBN: 9781351808040

Category: Social Science

Page: 662

View: 104

This title was first published in 2001: In the early twentieth century the relevance of chirality to the pharmaceutical industry was established by the fact that one enantiomer of hyoscyamine possessed greater pharmacological activity than the other. Today, most new drugs and those under development consist of a single optically active isomer, and chirality is also becoming an issue for the agrochemical and other industries. Regulatory agencies throughout the world are currently reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. New guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries. These scientific and regulatory developments have created the need for a guide for workers in the pharmaceutical and chemical industries seeking information on chiral molecules, processes, and commercially available chiral chemicals. Chiral Drugs is a comprehensive listing of over 2500 chiral drugs, classified by therapeutic class, and including structures and physical properties for each entry in the listing. Its companion volume, Chiral Intermediates, presents the same detailed information for over 4700 commercially available chiral chemicals. The 'Chiral Pool' of readily available, relatively inexpensive chiral compounds has been expanding at a rapid rate as more and more products are produced in large quantities at economical prices. New developments in various technologies for isolating, preparing, and purifying chiral materials have greatly increased the opportunities for utilizing optically pure compounds in commercial applications. Novel techniques for classical resolution, new methodologies for developing selective enzymes for biocatalysis, advances in the application of microorganisms for chemical production, and continued progress in the area of asymmetric synthesis have all contributed to the growth of this field. Part One of each book contains four chapters which provide an introduction to topics relevant to the field of chiral chemistry and includes a brief overview of chirality, a short discussion on the current market drivers in the area of chiral chemistry, and a basic presentation of the various sources and methods for obtaining chiral compounds. Part Two presents entries for over 2500 chiral drugs, classified by therapeutic class. For each main entry, the chemical name and a list of trade names and synonyms is provided; the CAS Registry Number, the European Inventory of Existing Commercial Chemical Substances (EINECS) number, and the Merck Index (12th edition) number are given when available. The physical properties, including specific rotation, of each compound are described and indicated applications are presented. The structure of nearly every compound is provided, and the manufacturers and suppliers of the compounds are also given. Indexes, including a master index of names and synonyms and an index of custom manufacturing services for production of chiral compounds, are appended. Chiral Drugs provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for researchers in the pharmaceutical and biotechnology sectors as well as to those working in the basic biochemical sciences. Chiral Intermediates provides an introduction to the types of sources and methods currently in use for obtaining chiral molecules and is an invaluable resource for information on available chiral molecules. Chiral Intermediates and Chiral Drugs are the most comprehensive and detailed guides to chiral compounds available.
Categories: Social Science

Biocatalysis for the Pharmaceutical Industry

Biocatalysis for the Pharmaceutical Industry

Discovery, Development, and Manufacturing Junhua (Alex) Tao, ... tool for the production of chiral alcohols – part I: processes with isolated enzymes.

Author: Junhua (Alex) Tao

Publisher: John Wiley & Sons

ISBN: 9780470823156

Category: Science

Page: 250

View: 981

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.
Categories: Science

Chirality from Dynamic Kinetic Resolution

Chirality from Dynamic Kinetic Resolution

... John Wiley and Sons, New York, 1993; (c) Stereoselective Synthesis, ed. R. S. Atkinson, Wiley and Sons, New York, 1995. 4. (a) Chirality in Industry, ...

Author: Hélène Pellissier

Publisher: Royal Society of Chemistry

ISBN: 9781849731973

Category: Science

Page: 299

View: 325

The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.
Categories: Science

Sustainable Value Creation in the Fine and Speciality Chemicals Industry

Sustainable Value Creation in the Fine and Speciality Chemicals Industry

Collins A N, Sheldrake G N and Crosby J (1992) Chirality in Industry: The Commercial Manufactureand Applications ofOptically Active Compounds, ...

Author: R. Rajagopal

Publisher: John Wiley & Sons

ISBN: 9781118677896

Category: Science

Page: 312

View: 107

The global fine and speciality chemicals industry is a vitalsegment within the chemical value chain, catering to a multitude of societal and industrial needs.Regulatory, sustainability and consumer forces have been constantlyshaping the business fundamentals of this industry. Developingvalue creation strategies, which embed economic, environmental andsocial sustainability components, will need a comprehensiveassessment of business, scientific and technological challengesfacing the industry. Sustainable Value Creation in the Fine and SpecialityChemicals Industry assesses sustainable value creation optionsagainst the backdrop of global mega trends that are defi ning thepresent and future course of the industry. It discusses innovativestrategies in feedstocks, R&D, technology, manufacturing,resource management and the supply chain as well as thesignificance of the bio-based chemical economy in enablingsustainable value creation in the fine and speciality chemicalsindustry. Topics covered include: • Transformation in the fine and speciality chemicalsbusiness • Sustainable management: evolution, transitions andtools • Research and technology directions • Resource optimization strategies • Bio-based chemicals, specialities and polymers • Sustainable practices in the fine and speciality chemicalsindustry • Sustainable value creation strategies Sustainable Value Creation in the Fine and SpecialityChemicals Industry presents a comprehensive overview of strategic options for sustainability management in theglobal fine and speciality chemicals industry. It will be avaluable resource for chemists and chemical engineers involved inthe design and development of economically, environmentally andsocially sustainable practices for the future.
Categories: Science

Biocatalysis in the Pharmaceutical and Biotechnology Industries

Biocatalysis in the Pharmaceutical and Biotechnology Industries

Rouhi, A.M., Chiral Chemistry, Chem. Eng. News, 82, 47–62, 2004. Bayley, C.R. and Vaidya, N.A., in Chirality in Industry, Collins, A.N., Sheldrake, G.N., ...

Author: Ramesh N. Patel

Publisher: CRC Press

ISBN: 9781420019377

Category: Science

Page: 893

View: 355

Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemicals and chiral intermediates in a variety of pharmaceutical, agrochemical, and other biotechnological applications. Written by internationally recognized scientists in biocatalysis, the authors analyze the synthesis of chiral intermediates for over 60 brand-name pharmaceuticals for a wide range of drug therapies and treatments. From starting material to product, the chapters offer detailed mechanisms that show chiral intermediates and other by-products for each reaction—including hydrolytic, acylation, halogenation, esterification, dehalogenation, oxidation-reduction, oxygenation, hydroxylation, deamination, transamination, and C–C, C–N, C–O bonds formation. Cutting-edge topics include advanced methodologies for gene shuffling and directed evolution of biocatalysts; the custom engineering of enzymes; the use of microbial cells and isolated biocatalysts; the use of renewable starting materials; and generating novel molecules by combinatorial biocatalysis and high-throughput screening. Focusing on industrial applications, the book also considers factors such as bulk processes, instrumentation, solvent selection, and techniques for catalyst immobilization, reusability, and yield optimization throughout. Biocatalysis in the Pharmaceutical and Biotechnology Industries showcases the practical advantages and methodologies for using biocatalysts to develop and produce chiral pharmaceuticals and fine chemicals.
Categories: Science

Comprehensive Chirality

Comprehensive Chirality

This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding.

Author: Hisashi Yamamoto

Publisher: Elsevier Science

ISBN: 0080951678

Category: Science

Page: 5648

View: 718

Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.
Categories: Science