Examines the current state and future prospects of haematopoietic cell therapy, including gene therapy and immunotherapy.
Author: George Morstyn
Publisher: Cambridge University Press
ISBN: 0521473152
Category: Medical
Page: 617
View: 950
Examines the current state and future prospects of haematopoietic cell therapy, including gene therapy and immunotherapy.Cellular Therapy BY DR . KARLHEINZ NEUMANN , COLOGNE A . Introduction It
is as interesting as it is difficult to report on the pharmacological processes
involved in cellular therapy ; difficult , because the material to be studied is very ...
Author: Franz Schmid
Publisher:
ISBN: UCAL:B4356491
Category: Cellular therapy
Page: 573
View: 112
Cellular Therapy of the Nervous System . . . . . Cerebral hemispheres . . . . . . . . . .
Interbrain . . . . . . . . . . . . Neuro - hypophysis . . . . . . . . . . . . . . Cellular Therapy of
the Endocrine Glands . . . . . . . . . . · . . · . · . . · . · . . · . . Epiphysis . Adeno -
hypophysis ...
Author: Paul Niehans
Publisher: Cooper Square Pub
ISBN: UCAL:$B659143
Category: Psychology
Page: 119
View: 320
To find more information about Rowman and Littlefield titles, please visit www.rowmanlittlefield.com.But she did not need to resort to any drugs , whilst before the cell treatment she
constantly lived on drops and tablets . Even in the case of severe
emphysematous bronchitis , we have often noted following cell injections good
results with an ...
Author:
Publisher:
ISBN: UOM:39015002410317
Category: Cellular therapy
Page: 159
View: 378
H. Wekerle, H. Graf, J.D. Turner. © SpringerVerlag Berlin Heidelberg 1997 H.
Wekerle, H. Graf and J. D. Turner (eds.), Cellular Therapy, Ernst Schering
Research Foundation Workshop20, DOI 10.1007/9783662035092_1 ...
Author: H. Wekerle
Publisher: Springer Science & Business Media
ISBN: 9783662035092
Category: Medical
Page: 180
View: 379
The use of cells for the treatment of a variety of diseases is no longer a dream. Today, blood transfusion, bone marrow transplantation, the use of ex vivo cultured skin in wound healing, and peripheral stern cell transplantation, including the ex vivo expansion of hematopoietic stern cells after high-dose chemo/radiation therapy, are routine. This high standard of knowledge and skills in cell transplantation might also re sult in tackling hitherto untreatable diseases. Organ transplantation is presently the only life-saving treatment for a variety of conditions. Important findings in cell and molecular biol ogy, the identification of hematopoietic, mesenchymal and neuronal stern cells, together with breakthroughs in the methodology for isolat ing, purifying, expanding, and storing human cells could make cellular therapy an alternative to organ transplantation in certain diseases within the next decade. Placental blood may be the source of choice in isolating naive progenitor cells for allogeneic transplantation. Immunotherapy is the most hopeful strategy to date for the treat ment of tumors resistant to chemotherapy, radiation therapy, or hor mone therapy. It includes the use of tumor-infiltrating lymphocytes, ex vivo activated memory T lymphocytes, and cell-based vaccines.Cellular. Therapy. Neurotoxicity: Diagnosis. and. Management. Daniel B. Rubin,
Lauren Spendley, and Henrikas Vaitkevicius INTRODUCTION Chimeric antigen
receptor (CAR) T-cell therapy has become an important tool in the treatment of ...
Author: Edwin P. Alyea, III, MD
Publisher: Springer Publishing Company
ISBN: 9780826139948
Category: Medical
Page: 250
View: 365
Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. Concluding chapters address new CAR T-cell therapies, including their mechanisms of action, indications, and unique associated toxicities, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams, and other figures highlight, simplify, and illustrate key concepts. Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston as well as leading experts at other institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies in one quick, point-of-care reference. With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies. Key Features: Provides latest insights and recommendations for managing challenging treatment complications and adverse events Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and diagrams Shares real-world clinical vignette examples, which provide insight into clinical assessment, treatment, and management Emphasizes patient management and best practices Discusses short- and long-term risks for stem cell transplantation and cellular therapyThe amount of each substance in these tests allows us a vision of the active
material that is found in the medicaments of cellular therapy, they also allow us
information of great interest about th e relationship between organic and
inorganic ...
Author: Harvey M. Good
Publisher: Trafford Publishing
ISBN: 9781412072007
Category: Education
Page: 155
View: 443
Stem cell therapy did not just appear from thin air. Before Stem Cell Therapy there were a number of therapies that used fetal, juvenile and even adult cells to stimulate a "change" in the body. Some of these Therapies still exist. This book documents one of these therapies. Cellular Therapy has be around for well over 70 years and the concept of using cell and/or tissue as a medicament has been around since Hippocrates first described his tissue remedies. The manner of preparing fetal tissue and testing these "Preparations" is described in this book. Since the late 40's when Prof. Dr. Paul Niehans first developed the method for Lyophilization with the Nestle corporations Doctors all over the world have used these products. There are many documented successes and cures related to the use of Cellular Therapy and here for the first time is the documentation of "The Medicaments of Cellular Therapy" precursor to what we now know as "Stem Cell Therapy". The famous Revitalization which Niehans used for many years in his clinic in Vevay, Switzerland, treating Popes, Kings and Statesmen is documented with scientific evidence of its efficacy. The interesting fact is that documented positive results have been obtained using tissue/cells from non-human mammalian sources.The concept of cell-based therapy can be traced back to the nineteenth century
when it was discovered that cells were the building blocks of life and that some
cells had the ability to produce other types of cells such as blood cells. The term ...
Author: Li-Ru Zhao
Publisher: Springer
ISBN: 9783319114811
Category: Medical
Page: 337
View: 650
Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addition, it will provide information on cell isolation and culture skills, transplantation methods, and neurological functional evaluations. This is the first book to focus on cellular therapy for stroke and other CNS injuries.Table 8.1 From 1991 to 2008: history of AABB involvement in cellular therapy
through standards-setting Year Event 1991 Standards for Blood Banks and
Transfusion Services, 14th edition addresses bone marrow and peripheral blood
...
Author: Adrian Gee
Publisher: Springer Science & Business Media
ISBN: 0387895841
Category: Science
Page: 256
View: 509
Cell Therapy: cGMP Facilities and Manufacturing is the source for a complete discussion of facility design and operation with practical approaches to a variety of day-to-day activities, such as staff training and competency, cleaning procedures, and environmental monitoring. This in-depth book also includes detailed reviews of quality, the framework of regulations, and professional standards. It meets a previously unmet need for a thorough facility-focused resource, Cell Therapy: cGMP Facilities and Manufacturing will be an important addition to the cell therapy professional’s library. Additional topics in Cell Therapy: cGMP Facilities and Manufacturing...Standard operating procedures - Supply management - Facility equipment - Product manufacturing, review, release and administration - Facility master file.1169 SPECIAL ARTICLE REGULATION OF SOMATIC - CELL THERAPY AND
GENE THERAPY BY THE FOOD AND DRUG ADMINISTRATION DAVID A.
KESSLER , M.D. , J.D. , JAY P. SEGEL , M.D. , PRILIP D. NOGUCHI , M.D. ,
KATHRYN ...
Author: United States
Publisher:
ISBN: UCR:31210014030975
Category: Gene therapy
Page: 160
View: 147
Another important question is whether allogeneic stem cell transplantation can
be a therapeutic alternative to autologous stem cell transplantation , as cellular
therapy patients may not have sufficient numbers of healthy stem cells in their
bone ...
Author: Julia M. Feygin
Publisher:
ISBN: MINN:31951P010570030
Category: Myocardium
Page: 362
View: 596
The basic aim for any nonclinical program is to determine the efficacy and safety
of the product; however, with a cellular therapy, a key challenge can be
determining how to do this. Although cellular therapies can share some of the
same ...
Author: Joaquim Vives
Publisher: Academic Press
ISBN: 9780128031162
Category: Medical
Page: 266
View: 924
Guide to Cell Therapy GxP is a practical guide to the implementation of quality assurance systems for the successful performance of all cell-based clinical trials. The book covers all information that needs to be included in investigational medicinal product dossier (IMPD), the launching point for any clinical investigation, and beyond. Guide to Cell Therapy GxP bridges a knowledge gap with the inclusion of examples of design of GLP-compliant preclinical studies; design of bioprocesses for autologous/allogeneic therapies; and instruction on how to implement GLP/GMP standards in centers accredited with other quality assurance standards. Guide to Cell Therapy GxP is an essential resource for scientists and researchers in hospitals, transfusion centers, tissue banks, and other research institutes who may not be familiar with the good scientific practice regulations that were originally designed for product development in corporate environments. This book is also a thorough resource for PhD students, Post-docs, Principal Investigators, Quality Assurance Units, and Government Inspectors who want to learn more about how quality standards are implemented in public institutions developing cell-based products. Easy access to important information on current regulations, state-of-the-art techniques, and recent advances otherwise scattered on various funding websites, within conference proceedings, or maintained in local knowledge Features protocols, techniques for trouble-shooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Includes practical examples of successful implementation of quality standardsTHE NEW REGULATORY ENVIRONMENT FOR CELLULAR THERAPY
PRODUCTS: CHALLENGES FOR ACADEMIC-BASED MANUFACTURING
FACILITIES E.J. Readl Introduction Scientific advances in transplantation biology,
...
Author: C.Th. Smit Sibinga
Publisher: Springer Science & Business Media
ISBN: 9781475737189
Category: Medical
Page: 223
View: 535
Welcome to the City of Groningen, the center of the North of the Netherlands. Groningen is proud of the long lasting tradition of scientific symposia organised by the Sanquin Blood Bank. These Sanquin International Symposia on Blood Transfusion have become a true traditional event in Groningen, marking the early academic year and have contributed to the specific reputation of Groningen and its University in the scientific field of Transfusion Medicine. The growing tradition has also contributed to initiatives of both University, Province and the City of Groningen to bring science and industry together - BioMedCity Groningen. Such repu- tion does not just happen, but is the result of creative and scientific leadership, of vision and an open mind, to explore in a team spirit horizons. Groningen is particularly proud of this reputation thanks to its leadership, the Sanquin Blood Bank North-East. This year in particular the theme chosen some two years ago is extremely timely as it illustrates the activities and scientific interest of an integrated team which includes our regional Sanquin Blood Bank North-East and fits in the City initiatives within the concept of BioMedCity, Groningen.Thus, continued efforts are being made to address the positive and negative
issues in order for these cell therapies to complete human clinical trials. However
, with these challenges in mind, stem cell therapy remains one of the best “natural
” ...
Author: Cyndy D. Davis
Publisher: Springer Science & Business Media
ISBN: 9781597451475
Category: Medical
Page: 392
View: 960
As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones. This repair and replacement may be due to an administration of exogenous cells itself or the activation of the body’s own endogenous reparative cells by a trophic, immune, or inflammatory response to cell transplantation. However, the precise mechanism of how cell therapy works remains elusive and is c- tinuing to be investigated in terms of molecular and cellular responses, in particular. Moreover, Chapter 11 by Emerich and associates, discusses some of the possibilities of cell immunoisolation and the potential for treating central nervous system diseases.Two of these factors can be influenced within our current clinics—the
complications of an applied treatment and the other therapies that are applied in
addition ... The Disease Some diseases are more responsive than others to
cellular therapy.
Author: Jaap Jan Boelens
Publisher: Springer Science & Business Media
ISBN: 9781461483571
Category: Science
Page: 171
View: 590
Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e.g. gene therapy, iPS, ES) in the field. Beginning with an overview of these diseases, the book covers the breadth of this topic from treatment options, bone marrow transplantation, and alternative treatment options, through long-term outcomes and future perspectives.Benjamin D. Weil and Farlan S. Veraitch Abstract An ever increasing number of
cellular therapies are in development for the treatment of a wide variety of
diseases. One of the major challenges facing the translation of whole cell
products into ...
Author: Mohamed Al-Rubeai
Publisher: Springer Science & Business Media
ISBN: 9789400771963
Category: Medical
Page: 189
View: 574
With the discovery of stem cells capable of multiplying indefinitely in culture and differentiating into many other cell types in appropriate conditions, new hopes were born in repair and replacement of damaged cells and tissues. The features of stem cells may provide treatment for some incurable diseases with some therapies are already in clinics, particularly those from adult stem cells. Some treatments will require large number of cells and may also require multiple doses, generating a growing demand for generating and processing large numbers of cells to meet the need of clinical applications. With this in mind, our aim is to provide a book on the subject of stem cells and cell therapy for researchers and students of cell biotechnology, bioengineering and bioproduction. This book is exceptional as it teaches researchers stem cells and cell therapy in that it covers the concepts and backgrounds necessary so that readers get a good understanding of the production of stem cells. The book covers three topics: The basics of stem cells and cell therapy, the use of stem cells for the treatment of human diseases, and stem cell processing. It includes chapters on neural and vascular stem vascular stem cell therapy, expansion engineering of embryonic stem cells, stem cell based production of blood cells and separation technologies for stem cells and cell therapy products. It is an informed and informative presentation of what modern research, science and engineering have learned about stem cells and their production and therapies. Addressing both the medical and production issues, this book is an invaluable contribution to having an academic and industrial understanding with respect to R&D and manufacturing of clinical grade stem cells.It is closely related chemically to Paris green, and as a therapeutic agent is
destined to occupy an important position in the ... The beneficial action of the
drug, however, goes far to prove the possibility of a ' cellular therapy,' with the
necessary ...
Author:
Publisher:
ISBN: UOM:39015074804553
Category: Medicine
Page:
View: 413
Cellular therapy now offer promise of potential adjunct therapeutic options for treatment of drug-resistant tuberculosis (TB).
Author:
Publisher:
ISBN: OCLC:1052064731
Category:
Page:
View: 474
Cellular therapy now offer promise of potential adjunct therapeutic options for treatment of drug-resistant tuberculosis (TB). We review here the role of Mesenchymal stromal cells, (MSCs), as well as other immune effector cells in the therapy of infectious diseases with a focus on TB. MSCs represent a population of tissue-resident non-hematopoietic adult progenitor cells which home into injured tissues increase the proliferative potential of broncho-alveolar stem cells and restore lung epithelium. MSCs have been shown to be immune-modulatory and anti-inflammatory mediated via cell-cell contacts as well as soluble factors. We discuss the functional profile of MSCs and their potential use for adjunct cellular therapy of multi-drug resistant TB, with the aim of limiting tissue damage, and to convert unproductive inflammatory responses into effective anti-pathogen directed immune responses. Adjunct cellular therapy could potentially offer salvage therapy options for patients with drug-resistant TB, increase clinically relevant anti- M.tuberculosis directed immune responses and possibly shorten the duration of anti-TB therapy.Arsenic in this class of familiarized himself with the various cases promotes
oxidation , that is , it instrychnine and arsenical preparations used creases
cellular activity , and since it is so in medicine , it must be apparent that this
thoroughly ...
Author:
Publisher:
ISBN: UOM:39015070456689
Category: Therapeutics
Page:
View: 546
