Carbon 13 NMR Spectroscopy

Carbon 13 NMR Spectroscopy

As in the second edition, the authors survey the large number of 13C NMR applications to organic molecules and natural products in a representative and systematic rather than an exhaustive way.

Author: Eberhard Breitmaier

Publisher: Wiley-VCH

ISBN: UCSD:31822033845629

Category: Science

Page: 515

View: 307

E. Breitmaier, W. Voelter Carbon-13 NMR Spectroscopy High-Resolution Methods and Applications in Organic Chemistry and Biochemistry Third, completely revised edition New techniques and increased use of computers have led to rapid development in 13C NMR spectroscopy with enhanced instrumental sensitivity and improved quality of the spectra. This necessitated a complete revision when the third edition of this successful monograph was prepared. The new methods described include those for multiplicity analysis and two-dimensional homo- or hetero-nuclear shift correlations. As in the second edition, the authors survey the large number of 13C NMR applications to organic molecules and natural products in a representative and systematic rather than an exhaustive way. New sections about coupling constants, organophosphorus and organometallic compounds as well as synthetic polymers have been added. The scope remains limited to high-resolution methods and molecular systems.
Categories: Science

Carbon 13 NMR Spectral Problems

Carbon 13 NMR Spectral Problems

With this in mind, the present work was designed to give advanced undergraduates, graduate students, and practicing chemists a working knowledge of and facility with the use of this valuable technique.

Author: Robert B. Bates

Publisher: Springer Science & Business Media

ISBN: UOM:39015016086509

Category: Science

Page: 259

View: 286

With the advent of Fourier transform spectrometers of great sensitivity, it has become practical to obtain carbon-13 nuclear magnetic resonance (C-13 NMR; l3C NMR; CMR) spectra routinely on organic molecules, and this technique has become one of the highest utility in determining structures of organic unknowns. When the usual spectrometric techniques proton magnetic resonance (H-I NMR; IH NMR; PMR), infrared (lR), mass (MS), and ultraviolet (UV)-do not readily reveal a compound's structure, a C-13 NMR spectrum will often provide sufficient additional information to yield it unequivocally. With this in mind, the present work was designed to give advanced undergraduates, graduate students, and practicing chemists a working knowledge of and facility with the use of this valuable technique. Some familiarity with other spectrometric techniques is assumed (recommended book: Silverstein, Bassler, and Morrill, Spectrometric Identification of Organic Compounds), but no prior knowledge of C-13 NMR -which is treated very lightly, if at all, in the widely used elementary organic texts-is necessary. A discussion of C-13 NMR spectroscopy is followed by 125 problems, each consisting of a molecular formula, two types of C-13 NMR spectra (partially and completely proton decoupled, with connecting lines to facilitate multiplicity assignments), an integrated H-I NMR spectrum, and the most important IR, UV, and MS data. These problems have been very carefully prepared, thoroughly tested by students at the University of Arizona, and we believe that very few errors remain.
Categories: Science

Carbon 13 NMR of Flavonoids

Carbon 13 NMR of Flavonoids

The first part of the book presents background information and discussion of the essential aspects of flavonoids and carbon-13 NMR spectroscopy and demonstrates its significant role in the revision of several earlier established chemical ...

Author: P.K. Agrawal

Publisher: Elsevier

ISBN: 9781483290744

Category: Science

Page: 581

View: 226

This detailed treatise is written for chemists who are not NMR spectroscopists but who wish to use carbon-13 NMR spectroscopy. It shows why measurement of carbon-13 NMR is needed and explains how the method can - or should - be used for rapid characterization of flavonoids, one of the most diverse and widespread groups of natural constituents. The first part of the book presents background information and discussion of the essential aspects of flavonoids and carbon-13 NMR spectroscopy and demonstrates its significant role in the revision of several earlier established chemical structures. It discusses various one- and two-dimensional NMR spectroscopic techniques and other relevant experimental methodologies for the interpretation of spectral details which enable individual resonance lines to be associated with the appropriate carbons in a molecule. The second part provides a comprehensive coverage of the carbon-13 chemical shifts of various classes and subclasses of flavonoids. It also illustrates how to utilize carbon-13 data to gain information for the determination of the nature, number and site of any substituent in flavonoids. Vital information for the differential and complete structure elucidation of the various classes of flavonoids by carbon-13 NMR shielding data is described in-depth in the third part of the book. The book will be welcomed by all those working in natural product chemistry who will appreciate the non-mathematical approach and the fact that such a wealth of theoretical and practical information has been assembled in a single volume.
Categories: Science

Stereochemical Analysis of Alicyclic Compounds by C 13 NMR Spectroscopy

Stereochemical Analysis of Alicyclic Compounds by C 13 NMR Spectroscopy

This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways.

Author: J. A. Whitesell

Publisher: Springer Science & Business Media

ISBN: 9789400931619

Category: Science

Page: 231

View: 333

Through numerous conversations with other synthetic chemists it became apparent that the great power of carbon nuclear magnetic resonance was being significantly underutilized. In our own work we have found that 13C spectroscopy is a more powerful tool than IH NMR spectroscopy, especially for probing subtle stereochemical questions in complicated systems. This is especially true in five membered ring compounds where IH NMR is at a particular disadvantage. The two techniques can be used independently to solve the same question-that of stereochemistry - but they do so in different ways. Advantage can be taken in IH NMR of a relatively consistent relationship between stereochemical orientation and coupling constants between vicinal protons, while in 13C NMR it is the correlation between spatial relationships of non-hydrogen, y substituents and their effect on chemical shift that can be used to assign stereochemistry. It was also clear that the use of 13C NMR required a different approach to problem solving than that typically used with IH NMR. While the latter technique could be employed with a very general approach (e.g., the Karplus equation), 13C NMR would, at least for the immediate future, require a relatively extensive set of model systems from which the consequences of stereochemical changes could be derived for any given carbon framework.
Categories: Science

Carbon 13 NMR Spectroscopy

Carbon 13 NMR Spectroscopy

Organized into four parts encompassing 11 chapters, this book starts with an overview of the characteristics of the NMR signals derived from compounds containing 13C nuclei in natural abundance that are inherently much weaker than those ...

Author: J Stothers

Publisher: Elsevier

ISBN: 9780323145503

Category: Science

Page: 574

View: 199

Carbon-13 NMR Spectroscopy focuses on the potential of 13C techniques and the practical difficulties associated with the detection of 13C NMR absorption. This monograph includes a descriptive presentation of 13C shielding results that has been adopted with emphasis on the structural and stereochemical aspects. Organized into four parts encompassing 11 chapters, this book starts with an overview of the characteristics of the NMR signals derived from compounds containing 13C nuclei in natural abundance that are inherently much weaker than those exhibited by protons. This monograph then compares the primary characteristics of 13C NMR with the more familiar proton methods. Other chapters consider the 13C spectra of pyridine, pyridazine, pyrimidine, pyrazine, s-triazine, and s-tetrazine. The final chapter deals with the effects of solute–solvent interactions on the shieldings of other nuclei. This monograph is intended for organic chemists, graduate students, and researchers in various branches of chemistry with an interest in 13C NMR methods as another approach to chemical problems.
Categories: Science

Carbon 13 NMR Spectroscopy

Carbon 13 NMR Spectroscopy

Author: E. Breitmaier

Publisher: Gordon & Breach Science Pub

ISBN: 0895734931

Category: Science

Page: 515

View: 358

Categories: Science

Carbon 13 NMR Spectroscopy

Carbon 13 NMR Spectroscopy

This work describes these techniques.

Author: Hans-Otto Kalinowski

Publisher: Wiley-Blackwell

ISBN: UOM:39015035231649

Category: Science

Page: 776

View: 999

13C NMR spectroscopy has not only become an established and well documented technique, but is about to yield even more detailed information on increasingly complex organic and biological systems, through the possibilities opened by pulse techniques. This work describes these techniques.
Categories: Science

Carbon 13 NMR Spectroscopy of Biological Systems

Carbon 13 NMR Spectroscopy of Biological Systems

This book is intended to provide an in-depth understanding of 13C NMR as a tool in biological research. 13C NMR has provided unique information concerning complex biological systems, from proteins and nucleic acids to animals and humans.

Author: Nicolau Beckmann

Publisher: Elsevier

ISBN: 9780080528557

Category: Science

Page: 334

View: 634

This book is intended to provide an in-depth understanding of 13C NMR as a tool in biological research. 13C NMR has provided unique information concerning complex biological systems, from proteins and nucleic acids to animals and humans. The subjects addressed include multidimensional heteronuclear techniques for structural studies of molecules in the liquid and solid states, the investigation of interactions in model membranes, the elucidation of metabolic pathwaysin vitro and in vivo on animals, and noninvasive metabolic studies performed on humans. The book is a unique mix of NMR methods and biological applications which makes it a convenient reference for those interested in research in this interdisciplinary area of physics, chemistry, biology, and medicine. An interdisciplinary text with emphasis on both 13C NMR methodology and the relevant biological and biomedical issues State-of-the-art 13C NMR techniques are described; Whenever possible, their advantages over other approaches are emphasized The chapters constitute comprehensive reviews and are written by acknowledged experts in their fields Chapters are written in a clear style, and include a large number of illustrations and comprehensive references
Categories: Science

Interpretation of Carbon 13 NMR Spectra

Interpretation of Carbon 13 NMR Spectra

Updated to reflect instrumental and methodological advances made in the past decade, chapter 1 reviews the basics of carbon-13 NMR.

Author: F. W. Wehrli

Publisher: John Wiley & Sons Incorporated

ISBN: UCSD:31822002409050

Category: Science

Page: 484

View: 908

This is the second edition of a very successful book which provides the conceptual and experimental basis for the interpretation of 13 C NMR spectra.
Categories: Science

Sadtler Standard Carbon 13 NMR Spectra

Sadtler Standard Carbon 13 NMR Spectra

SADTLER standaBD 13c NMR specTRA This edition contains 200 13C NMR
spectra and it is an addition to our ongoing publication in the rapidly developing
field of 13C NMR Spectroscopy. By comparison with the NMR signals generated
by ...

Author: Sadtler Research Laboratories

Publisher:

ISBN: UCSC:32106021092579

Category: Carbon

Page:

View: 369

Categories: Carbon

Organic Structures from Spectra

Organic Structures from Spectra

Many of the compounds were synthesised specifically for this book. In this collection, there are many additional easy problems designed to build confidence and to demonstrate basic principles.

Author: L. D. Field

Publisher: John Wiley & Sons

ISBN: 9781119524809

Category: Science

Page: 560

View: 295

The derivation of structural information from spectroscopic data is now an integral part of organic chemistry courses at all Universities. A critical part of any such course is a suitable set of problems to develop the students’ understanding of how organic structures are determined from spectra. The book builds on the very successful teaching philosophy of learning by hands-on problem solving; carefully graded examples build confidence and develop and consolidate a student’s understanding of organic spectroscopy. Organic Structures from Spectra, 6th Edition is a carefully chosen set of about 250 structural problems employing the major modern spectroscopic techniques, including Mass Spectrometry, 1D and 2D 13C and 1H NMR Spectroscopy and Infrared Spectroscopy. There are 25 problems specifically dealing with the interpretation of spin–spin coupling in proton NMR spectra and 10 problems based on the quantitative analysis of mixtures using proton and carbon NMR spectroscopy. The accompanying text is descriptive and only explains the underlying theory at a level that is sufficient to tackle the problems. The text includes condensed tables of characteristic spectral properties covering the frequently encountered functional groups. The examples themselves have been selected to include all important structural features and to emphasise connectivity arguments and stereochemistry. Many of the compounds were synthesised specifically for this book. In this collection, there are many additional easy problems designed to build confidence and to demonstrate basic principles. The Sixth Edition of this popular textbook: now incorporates many new problems using 2D NMR spectra (C–H Correlation spectroscopy, HMBC, COSY, NOESY and TOCSY); has been expanded and updated to reflect the new developments in NMR spectroscopy; has an additional 40 carefully selected basic problems; provides a set of problems dealing specifically with the quantitative analysis of mixtures using NMR spectroscopy; features proton NMR spectra obtained at 200, 400 and 600 MHz and 13C NMR spectra including routine 2D C–H correlation, HMBC spectra and DEPT spectra; contains a selection of problems in the style of the experimental section of a research paper; includes examples of fully worked solutions in the appendix; has a complete set of solutions available to instructors and teachers from the authors. Organic Structures from Spectra, Sixth Edition will prove invaluable for students of Chemistry, Pharmacy and Biochemistry taking a first course in Organic Chemistry.
Categories: Science