A Woman's Initiation is a collection of stories about eighteen ordinary women living unexamined, unchallenged lives.
Author: Diana Murphy
Category: Biography & Autobiography
A Woman's Initiation is a collection of stories about eighteen ordinary women living unexamined, unchallenged lives. Then each was diagnosed with breast cancer. After intially struggling with the intruder in her characteristic style, each woman surrendered, allowing cancer to strip her clean of her old skin, making way for a new, more authentic self to emerge.
Cancer Letts.(19): 61–66, 1983. 16. Apaja M: Evaluation of toxicity and carcinogenicity of malonaldehyde. Acta Universitatis Ouluensis, SeriesD. (55):1–61,1980. 17. Marnett LJ, Buck J, Tuttle MA, Basu AK, Bull AW: Distribution and ...
Author: Lawrence J. Marnett
Publisher: Springer Science & Business Media
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E2 (POE), prostacyclin (POI) and thromboxane A2 (TXA), whereas 2 2 2 lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengl Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Looking at the uniqueness of each biological form, I assume that the designs of a biological form must be determined by a regulative system coded by certain groups of invariant proteins.
Author: Mirabotalib Kazemie
Looking at the uniqueness of each biological form, I assume that the designs of a biological form must be determined by a regulative system coded by certain groups of invariant proteins. The mechanism in charge of combining these proteins in specific patterns to produce design programs I call primordialization. A design program determines the design and the layout of the structures of the organism during its embryonic development. The patterns of proteins' combinations in primordial programs cannot be shifted one into another by environmental factors. If the amino acid sequence of any of the participating proteins is altered, the design program will obliterate. In case such an alteration happens inside an egg cell, one of the two possibilities is expected to occur. Either the affected cell is no longer viable and dies out, or develops into a creature with indistinct body design. Alteration of the proteins involved in a design program can occur also at any time during an organism's development and later. In such situations the affected cells can turn into a cancer cell
If repair genes mutate, cells can acquire new genetic alterations, in particular in oncogenes or tumor suppressor genes ... From this picture, it is clear that microevolu- tionary processes can play a major role in cancer initiation and ...
Author: Stephen C. Stearns
Publisher: Oxford University Press
This work explores and analyses the ways in which our ancient genes contend with, and influence, modern human life. It offers coverage of the points of contact between evolutionary biology and medical science.
Virchows Arch. B Cell Pathol. 21, 279-298 (1976) Glinos, A.D.: On the applicability of the two-stage concept of initiation and promotion to chemical carcinogenesis in the liver. Acta Un. int. Cancer 20, 571-572 (1964) Glinos, A.D., ...
initiation (Prasad and Srivastava 2020). Hydroxyl ion plays a critical role in tumor initiation as it is highly diffusible, easily oxidizes nucleotide base-pairs, and forms DNA adducts (Prasad and Srivastava 2020).
Author: Sajal Chakraborti
Publisher: Springer Nature
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
255-268 , 1983 Mouse Skin Tumor Initiation - Promotion and Complete Carcinogenesis Bioassays : Mechanisms and ... mice in an effort to identify carcinogens in these mixtures and to link these materials to the etiology of human cancer .
For understanding the first steps of this interaction, approved methods from quantum theory and solid state physics are applied by the authors. The approach of this book is interdisciplinary. Theoretical models are qualitatively applied.
Author: Janos Ladik
Initiation of cancer in the cell is experimentally related to action of chemicals and radiation. For understanding the first steps of this interaction, approved methods from quantum theory and solid state physics are applied by the authors. The approach of this book is interdisciplinary. Theoretical models are qualitatively applied. Known effects, like oncogene activation, anti-oncogenes, and disturbances of the cell's self-regulation are explained. The authors propose possible points of intervention in the cancer initiation process based on the theoretical considerations.