Calcium Signalling and Disease

Calcium Signalling and Disease

Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies.

Author: Ernesto Carafoli

Publisher: Springer Science & Business Media

ISBN: 9781402061912

Category: Medical

Page: 592

View: 925

Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Categories: Medical

Stress Physiology Biochemistry and Pathology

Stress  Physiology  Biochemistry  and Pathology

Booth DM, Joseph SK, Hajnoczky G. Subcellular ROS imaging methods:
relevance for the study of calcium signaling. Cell Calcium ... Sundar IK, Sellix MT,
Rahman I. Redox regulation of circadian molecular clock in chronic airway
diseases.

Author: George Fink

Publisher: Academic Press

ISBN: 9780128131473

Category: Science

Page: 420

View: 680

Stress impacts the daily lives of humans and all species on Earth. Physiology, Biochemistry, and Pathology, the third volume of the Handbook of Stress series, covers stress-related or induced physiology, biochemistry, and pathology. Integrated closely with new behavioral findings and relevance to human conditions, the concepts and data in this volume offer readers cutting-edge information on the physiology of stress. A sequel to Elsevier’s Encyclopedia of Stress (2000 and 2007), this Handbook of Stress series covers the many significant advances made since then and comprises self-contained volumes that each focus on a specific area within the field of stress. Targeted at scientific and clinical researchers in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, the social sciences, and stress and its management in the workplace, this volume and series are ideal for graduate students, post-doctoral fellows, and faculty interested in stress and its consequences. Chapters offer impressive scope, with topics addressing stress-related or induced physiology, biochemistry, and pathology Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter has a boxed “Key points call out section The volume is fully indexed All chapters are electronically available via ScienceDirect Affordably priced, self-contained volume for readers specifically interested in the physiology, biochemistry and pathology of stress, avoiding the need to purchase the whole Handbook series
Categories: Science

Biomedical Index to PHS supported Research

Biomedical Index to PHS supported Research

... R01AG-10686-03S1 GLIAL/NEURONAL INTERACTIONS IN
NEURODENGENERATION P01AG-10770-02 0003 MOLECULAR
PATHOGENESIS OF AGE-DEPENDENT CNS DEGENERATION - CALCIUM
REGULATION IN PRION DISEASE ...

Author:

Publisher:

ISBN: STANFORD:36105003101131

Category: Medicine

Page:

View: 394

Categories: Medicine

Genome Stability and Human Diseases

Genome Stability and Human Diseases

This book is written by international leading scientists in the field of genome stability.

Author: Heinz-Peter Nasheuer

Publisher: Springer

ISBN: 9048134706

Category: Medical

Page: 340

View: 515

Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
Categories: Medical

Intracellular Calcium

Intracellular Calcium

Meeker, R. B. (2007) Feline immunodeficiency virus neuropathogenesis: from
cats to calcium. ... Metchnikoff, E. (1905) Immunity in Infective Diseases. ... Miao,
Y.-L. & Williams, C. J. (2012) Calcium signaling in mammalian egg activation and
embryo development: The influence of subcellular localization. Molecular
Reproduction and Development, 79, 742–756. ... Biochem. J., 344, 281–92.
Michell, R. H. (1975) Inositol phospholipids and cell surface receptor function.
Biochim. Biophys.

Author: Anthony K. Campbell

Publisher: John Wiley & Sons

ISBN: 9781118675533

Category: Science

Page: 848

View: 722

Thousands of imaginative scientists, over more than a century,have revealed the fascinating story of intracellular calcium,through a pathway of ingenious invention and discovery. Intracellular Calcium, the definitive book on this topic,reveals: The pathway of discovery and invention of intracellular calciumover more than 100 years. The evidence for intracellular calcium as a universal switch inall animal, plant, fungal and microbial cells How the components required for calcium signalling are namedand classified. The ingenious technology, which has been developed to studyintracellular calcium. How calcium is regulated inside cells and how it works totrigger an event. The role of intracellular calcium in disease, cell injury andcell death. How many drugs work through the calcium signalling system. How intracellular calcium is involved in the action of manynatural toxins. How the intracellular calcium signalling system has evolvedover 4000 million years, showing why it was crucial to the originof life. A key principle presented throughout the book is the molecularvariation upon which the intracellular calcium signalling systemdepends. This variation occurs within the same cell type andbetween cells with different functions, providing the invisiblematrix upon which Darwin and Wallace’s Natural Selectiondepends. Featuring more than 100 figures, including detailed chemicalstructures as well as pictures of key pioneers in the field, abibliography of more than 1500 references, as well asdetailed subject and organism indices, this definitive workprovides a unique source of scholarship for teachers andresearchers in the biomedical sciences and beyond.
Categories: Science

Subcellular Pathology of Systemic Disease

Subcellular Pathology of Systemic Disease

As the membrane moves in this way , new molecular weight chemotactic factor
for the eosino - attachment points to the ... This wave of solation is mediated
Finally , some products of the lipoxygenase pathway by a local increase in
calcium ... fringe , lamellipodium , panied by a series of biochemical events that
have been and a long posterior extension tail , uropod . ... eventually receptor
which generates a signal that is transmitted detaching as the tail retracts towards
the cell body and ...

Author: Timothy J. Peters

Publisher: Chapman & Hall

ISBN: UOM:39015012537398

Category: Medical

Page: 438

View: 226

Categories: Medical

Peterson s Guide to Graduate Programs in the Biological Sciences 1997

Peterson s Guide to Graduate Programs in the Biological Sciences 1997

Thomas Jefferson University THE FACULTY AND THEIR RESEARCH
Biochemistry and Molecular Biology. ... and molecular biology of embryonic
development gene expression; growth factors and signal transduction;
developmental ... diseases; subcellular biochemistry; alcohol metabolism; lipid
and membrane biochemistry; control of cellular calcium homeostasis; hormone
signal transduction mechanisms; developmental aspects of oncology;
biochemical pathology; cardiovascular ...

Author: Peterson's Guides Staff

Publisher: Peterson's Nelnet Company

ISBN: 1560796537

Category: Study Aids

Page: 2672

View: 338

Graduate students depend on this series and ask for it by name. Why? For over 30 years, it's been the only one-stop source that supplies all of their information needs. The new editions of this six-volume set contain the most comprehensive information available on more than 1,500 colleges offering over 31,000 master's, doctoral, and professional-degree programs in more than 350 disciplines.New for 1997 -- Non-degree-granting research centers, institutes, and training programs that are part of a graduate degree program.Five discipline-specific volumes detail entrance and program requirements, deadlines, costs, contacts, and special options, such as distance learning, for each program, if available. Each Guide features "The Graduate Adviser", which discusses entrance exams, financial aid, accreditation, and more.The only source that covers nearly 4,000 programs in such areas as oncology, conservation biology, pharmacology, and zoology.
Categories: Study Aids

Proteases in Health and Disease

Proteases in Health and Disease

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area.

Author: Sajal Chakraborti

Publisher: Springer Science & Business Media

ISBN: 9781461492337

Category: Science

Page: 403

View: 796

In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Categories: Science

Society for Neuroscience Abstracts

Society for Neuroscience Abstracts

182.13 182.14 BIOCHEMICAL AND IMMUNOCYTOCHEMICAL
CHARACTERIZATION OF ATAXIN - 2 . MOTOR NEURON DISEASE IS NOT
AMELIORATED IN MUTANT SOD1 TRANSGENIC L. Kelly , R. Jayasena , V.J.
Turnbull , R. ... The molecular mechanisms by which mutant SOD1 cause
selective motor degendient subcellular fractionation of rat brain ... 70 % lic
calcium signalling , where the role of intracellular calcium release for selective
motoneuron vulhigher compared with ...

Author: Society for Neuroscience. Meeting

Publisher:

ISBN: NWU:35557000123354

Category:

Page:

View: 359

Categories:

British Journal of Biomedical Science

British Journal of Biomedical Science

Ionchannel diseases ( channelopathies ) are caused mostly by single mutations
in the genes that code for the particular channel in question and often are rare . ...
The area of calcium signalling has been one of tremendous research interest .

Author:

Publisher:

ISBN: UCLA:L0084164961

Category: Medical sciences

Page:

View: 858

Categories: Medical sciences

Molecular Biology of the Cell

Molecular Biology of the Cell

Association between early-onset Parkinson's disease and mutations in the parkin
gene. N. Engl. J. Med. 342, 1560–1567. ... K., and Mizuno, Y. (1998).
Pathological and biochemical studies of juvenile parkinsonism linked to
chromosome 6q.

Author:

Publisher:

ISBN: UOM:39015057366133

Category: Cells

Page:

View: 570

Categories: Cells

CSA Neurosciences Abstracts

CSA Neurosciences Abstracts

Today it seems self-evident that neurons make their electrical signals by opening
gates of water-filled pores (ion ... M.A.; Kostkin, V.B.; Krivohenko, A.I. (I.M.
Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian
Academy of ... 9107-3N18 Dynamics of dendritic calcium transients evoked by
quantal release at excitatory hippocampal synapses. ... a member of the
dopamine D2-like receptor family, has been implicated in the pathophysiology of
several diseases and has ...

Author:

Publisher:

ISBN: UOM:39015053959493

Category: Neurology

Page:

View: 637

Categories: Neurology

Proteases in Human Diseases

Proteases in Human Diseases

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases.

Author: Sajal Chakraborti

Publisher: Springer

ISBN: 9789811031625

Category: Medical

Page: 513

View: 483

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.
Categories: Medical

Subcellular Fractions Advances in Research and Application 2011 Edition

Subcellular Fractions  Advances in Research and Application  2011 Edition

Higgins and colleagues published their study in the Journal of Alzheimer's
Disease (Oxidative stress: emerging ... For more information, contact G.C.
Higgins, Monash University, Dept. of Biochemistry and Molecular Biology,
Clayton, Victoria, Australia ... Recruitment of mitochondria into cell death
signalling involves either (or both) induction of specific death responses ... or
pathological conditions considered here (oxidative stress, hypoxic-ischaemic
injury, amyotrophic lateral sclerosis, ...

Author:

Publisher: ScholarlyEditions

ISBN: 9781464921209

Category: Science

Page: 606

View: 976

Subcellular Fractions: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Subcellular Fractions. The editors have built Subcellular Fractions: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Subcellular Fractions in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Subcellular Fractions: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Science

Heart Disease

Heart Disease

Proposed role of increased cytosolic calcium in causing early stunning after
reperfusion and in hypothetically playing a role ... Physiology and
Pathophysiology of the Heart. ... Biochem. Soc Trans. 7:593-617. 1979. 8. Solaro.
R. J.. Wolska, B. M., and Westfall, M.: Regulatory proteins and diastolic relaxation.
... Structural studies of myosin: Nucleotide complexes: A revised model for the
molecular basis of muscle contraction. ... Berridge, M. J.: Inositol trisphosphate
and calcium signalling.

Author: Eugene Braunwald

Publisher: W.B. Saunders Company

ISBN: 0721656641

Category: Cardiovascular system

Page: 1996

View: 269

Categories: Cardiovascular system

The Cellular Basis of Cardiovascular Function in Health and Disease

The Cellular Basis of Cardiovascular Function in Health and Disease

Molecular and Cellular Biochemistry 176 : 135 – 143 , 1997 . ... Rakesh Kakkar ,
Jasim M . Radhi and Rajendra K . Sharma Department of Pathology and
Saskatoon Cancer Centre , College of Medicine , Royal ... that fluxes of CAMP
and Ca2 + during cell activations are closely coupled and that the CaMPDE play
a key role in the signal coupling phenomenon . ... The subcellular localization of
bovine cardiac muscle NMT indicated a majority of the activity was localized in
cytoplasm .

Author: Pawan K. Singal

Publisher: Springer Science & Business Media

ISBN: 0792399749

Category: Science

Page: 353

View: 719

This special issue of Molecular and Cellular Biochemistry contains original research articles and review papers which were invited from the participants of a recent meeting organized to honour the 60th birthday of Naranjan S. Dhalla, Ph.D., M.D.(Hon.). The meeting, organized by Drs. Morris Karmazyn (London), Grant Pierce (Winnipeg) and Balwant Tuana (Ottawa), was held at the Best Western Lakeside Inn in Kenora, Ontario, Canada on August 23-25, 1996. The meeting was entitled The Cellular Basis of Cardiovascular Function in Health and Disease. There were over 40 invited speakers from 15 different countries represented at the meeting, attended by over 280 people. Keynote lectures were presented by Drs. Norman Alpert (Burlington, VT), Robert Jennings (Chapel Hill, NC), Makoto Nagano (Tokyo, Japan), Howard Morgan (Danville, PA), John Solaro (Chicago, IL) and Nobuskira Takeda (Tokyo, Japan). Dr. Henry Friesen, President of the Medical Research Council of Canada, presented Dr. Dhalla with a plaque at the banquet honouring his research accomplishments over his distinguished career. Dr. Dhalla's outstanding research achievements in understanding the subcellular basis of cardiovascular disease were highlighted at the meeting. One of the unique aspects of the meeting was the special effort made by 39 former trainees of Dr. Dhalla to attend the meeting to honour their mentor. The ex-students and trainees came from all over Canada, the United States, Japan, Slovakia, Germany, the Czech Republic, Estonia and the Netherlands. The meeting was judged to be an overwhelming success in terms of the scientific content as well as collaborative interactions initiated.
Categories: Science

Issues in Biochemistry and Geochemistry 2011 Edition

Issues in Biochemistry and Geochemistry  2011 Edition

(2010 MAY 18) Catholic University of Leuven: Intracellular substrate cleavage: a
novel dimension in the biochemistry, biology and pathology of matrix
metalloproteinases Current study results from the report, 'Intracellular ...
proteases in signaling events by liganding and processing hormones, cytokines,
chemokines, adhesion molecules and other membrane receptors. ... and affects
oncogenesis and pathology of cardiac, neurological, protein conformational and
autoimmune diseases, ...

Author:

Publisher: ScholarlyEditions

ISBN: 9781464963889

Category: Science

Page: 2342

View: 396

Issues in Biochemistry and Geochemistry / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biochemistry and Geochemistry. The editors have built Issues in Biochemistry and Geochemistry: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biochemistry and Geochemistry in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biochemistry and Geochemistry / 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Science

Bacterial Invasion into Eukaryotic Cells

Bacterial Invasion into Eukaryotic Cells

Subcellular Biochemistry Tobias A. Oelschlaeger, Jörg H. Hacker ... Further
studies may reveal exactly how environmental signals in the small intestine are
sensed by Salmonella, and ... Salmonellae are bacterial pathogens that have
evolved and diversified in order to infect and cause disease in many ... One
important feature of Salmonella pathogenesis is bacterial entry into intestinal
epithelial cells.

Author: Tobias A. Oelschlaeger

Publisher: Springer Science & Business Media

ISBN: 0306462907

Category: Science

Page: 688

View: 148

Strategies of Bacterial Interaction with Eukaryotic Cells *Tobias A. Oelschlaeger and Jorg Hacker 1. BENEFICIAL BACTERIAL-HOST INTERACTIONS Already during birth and soon thereafter mammals are colonized by bacte­ ria belonging to the resident microbial flora. Cutaneous and mucosal sur­ faces and the gastrointestinal tract are the areas which become colonized. These indigenous or autochthonous bacteria have a variety of beneficial effects on their hosts. They play a protective role by bacterial antagonism in fighting infections (Hoszowski and Truszczynski, 1997; Hentges, 1979). Pro­ duction of vitamin K is another essential contribution of the resident microbial flora to the health of the host (Hill, 1997). Even more important, studies with germ-free animals demonstrated the involvement of the microbial flora on the development of the immune system. Such animals have underdeveloped and relatively undifferentiated lymphoid tissues and low concentrations of serum immune globulins ( Cebra et at., 1998). They TOBIAS A. OELSCHLAEGER and JORG HACKER Institut filr Molekulare lnfektionsbiologie, Universitiit Wiirzburg, 97070 Wiirzburg, Germany. *Corresponding author; Phone: (0)931-312150; FAX: (0)931-312578; E-mail: [email protected] xxix Tobias A. Oelschlaeger and Jorg Hacker also show defects in specific immune responsiveness and in nonspecific resistance induced by endotoxin, which may account for their lowered resis­ tance. A more typical example of symbiotic interaction of bacteria with a host are bacteria like Ruminococcus in the gut of ruminants, essential for degradation of cellulose (Hobson, 1988). The closest benefical bacterial-host interactions are those of intracellular symbiotic bacteria and their host cells.
Categories: Science

Issues in Pathology Diagnostics and Disease 2011 Edition

Issues in Pathology  Diagnostics  and Disease  2011 Edition

Issues in Pathology, Diagnostics, and Disease: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pathology, Diagnostics, and Disease.

Author:

Publisher: ScholarlyEditions

ISBN: 9781464965425

Category: Medical

Page: 944

View: 612

Issues in Pathology, Diagnostics, and Disease: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pathology, Diagnostics, and Disease. The editors have built Issues in Pathology, Diagnostics, and Disease: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pathology, Diagnostics, and Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pathology, Diagnostics, and Disease: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Categories: Medical

Textbook of Rheumatology

Textbook of Rheumatology

Biochem. J. 192:517, 1980. 46. Borregaard, N., Heiple, J. M, Simons, E. R., and
Clark, R. A.: Subcellular localization of the ... Nishizuka, Y.: The role of protein
kinase C in cell surface signal transduction and tumour promotion. ... B., and
Horecker, B. L.: Biochemical responses in activated human neutrophils mediated
by protein kinase C and a Ca:+ -requiring proteinase. ]. ... oxidase of phagocytic
cells and its involvement in the molecular pathology of chronic granulomatous
disease.

Author: William N. Kelley

Publisher:

ISBN: 072163155X

Category: Rheumatism

Page: 1942

View: 882

Categories: Rheumatism