Applications of Toxicogenomics in Safety Evaluation and Risk Assessment

Author: Darrell R. Boverhof,B. Bhaskar Gollapudi

Publisher: John Wiley & Sons

ISBN: 9781118008980

Category: Science

Page: 392

View: 8085

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This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

Author: National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

Publisher: National Academies Press

ISBN: 9780309178891

Category: Science

Page: 300

View: 7228

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The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways--an effort requiring funding, interagency coordination, and data management strategies.
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Medical Product Safety Evaluation

Biological Models and Statistical Methods

Author: Jie Chen,Joseph Heyse,Tze Leung Lai

Publisher: CRC Press

ISBN: 1351021966

Category: Mathematics

Page: 354

View: 3573

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Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. The book is designed not only for biopharmaceutical professionals, such as statisticians, safety specialists, pharmacovigilance experts, and pharmacoepidemiologists, who can use the book as self-learning materials or in short courses or training programs, but also for graduate students in statistics and biomedical data science for a one-semester course. Each chapter provides supplements and problems as more readings and exercises.
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Casarett & Doull's Essentials of Toxicology, Third Edition

Author: Curtis D. Klaassen,John B. Watkins

Publisher: McGraw Hill Professional

ISBN: 007184709X

Category: Medical

Page: 528

View: 406

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Understand the essential principles of toxicology and how poisons affect the human body with this accessible and engaging summary A Doody's Core Title for 2017! General Principles of Toxicology Disposition of Toxicants Nonorgan-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Casarett & Doull’s Essentials of Toxicology is an easy-to-absorb distillation of the major principles and concepts that were presented in depth in Casarett & Doull’s Toxicology: The Basic Science of Poisons, Eighth Edition, the field’s gold-standard text. Presented in full color, the book concisely describes the science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action on specific organ systems. A summary of key points at the beginning and review questions at the end of each chapter help you study, understand, and memorize the material. Reflecting the expertise of more than sixty renowned contributors, Casarett & Doull’s Essentials of Toxicology is logically divided into seven sections: Succinct and comprehensive, there is no better text for gaining an understanding of essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents than Casarett & Doull’s Essentials of Toxicology.
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Toxicogenomics in Predictive Carcinogenicity

Author: Russell S Thomas,Michael D Waters

Publisher: Royal Society of Chemistry

ISBN: 1782624058

Category: Medical

Page: 524

View: 4562

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Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.
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Risk Assessment for Environmental Health

Author: Mark G. Robson,William A. Toscano

Publisher: John Wiley & Sons

ISBN: 9780787988593

Category: Technology & Engineering

Page: 450

View: 6610

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Written by experts in the field, this important book provides an introduction to current risk assessment practices and procedures and explores the intrinsic complexities, challenges, and controversies associated with analysis of environmental health risks. Environmental Health Risk Assessment for Public Health offers 27 substantial chapters on risk-related topics that include: What Is Risk and Why Study Risk Assessment The Risk Assessment–Risk Management Paradigm Risk Assessment and Regulatory Decision-Making in Environmental Health Toxicological Basis of Risk Assessment The Application of PBPK Modeling to Risk Assessment Probabilistic Models to Characterize Aggregate and Cumulative Risk Molecular Basis of Risk Assessment Comparative Risk Assessment Occupational Risk Radiological Risk Assessment Microbial Risk Assessment Children’s Risk Assessment Life Cycle Risk Environmental Laws and Regulations Precautionary Principles Risk Communication
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Toxicological Risk Assessment of Chemicals

A Practical Guide

Author: Elsa Nielsen,Grete Ostergaard,John Christian Larsen

Publisher: CRC Press

ISBN: 9781420006940

Category: Medical

Page: 448

View: 2317

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Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk assessment of chemical substances. It illustrates each step in the process: hazard identification, a dose response assessment, and exposure assessment. The book also summarizes the basic concepts of interaction of chemicals in mixtures and discusses various approaches to testing such mixtures. Features: Addresses standards from all international regulatory agencies Presents the steps in risk assessment, including hazard identification, exposure assessment, and risk characterization Covers the assessment of multiple chemical exposures or chemical mixtures Contains data from both human and animal studies Explains the linearized multi-stage mathematical model widely used by the US EPA for characterizing
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Handbook of Toxicogenomics

A Strategic View of Current Research and Applications

Author: Jürgen Borlak

Publisher: John Wiley & Sons

ISBN: 3527604510

Category: Science

Page: 705

View: 2639

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Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances. It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies. The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives. Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology."
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Cancer Risk Assessment

Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification

Author: Ching-Hung Hsu,Todd Stedeford

Publisher: John Wiley & Sons

ISBN: 9781118035122

Category: Science

Page: 856

View: 4953

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With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.
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Translational Toxicology

Defining a New Therapeutic Discipline

Author: Claude L. Hughes,Michael D. Waters

Publisher: Humana Press

ISBN: 331927449X

Category: Medical

Page: 380

View: 7636

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Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.
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