Antimicrobial Peptides

Discovery, Design and Novel Therapeutic Strategies

Author: Guangshun Wang

Publisher: CABI

ISBN: 1845936949

Category: Medical

Page: 230

View: 5649

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The purpose of this book is to provide a comprehensive account on current antimicrobial peptide research in two major directions. The first direction delineates the classic path for peptide development, ranging through identification, design, structure and mode of action studies. The second direction describes novel strategies for developing peptide therapeutics based on our knowledge of host defence antimicrobial peptides discovered in living organisms. Part I provides an overview of nomenclature, classification and bioinformatic analysis of antimicrobial peptides from bacteria, plants and animals. Subsequently, lantibiotics from bacteria and cyclotides from plants are presented. Part II discusses database-aided peptide prediction and design methods, synthetic combinatorial libraries and peptide mimetics that expand the conformational space of natural antimicrobial peptides. Part III covers the biophysical and structural characterization of antimicrobial peptides and their complexes. Finally, Part IV focuses on novel strategies for developing peptide-based therapies.
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Antimicrobial Peptides

Author: Joan Marsh,Jamie A. Goode

Publisher: John Wiley & Sons

ISBN: 0470514663

Category: Science

Page: 292

View: 8194

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Describes the structure and function of important peptides from several different organisms. An exciting development is the use of these peptides or their analogues in the treatment and prevention of infectious diseases. Considers ways in which these peptides may be used to control the insect vectors of key pathogens including the malarial parasite. Discusses the role of antimicrobial peptides in the mammalian immune system and their interaction with other components of that system.
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Antimicrobial Peptides and Human Disease

Author: William Shafer

Publisher: Springer Science & Business Media

ISBN: 3540299165

Category: Medical

Page: 266

View: 7432

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Microbes are in our midst soon after birth. Thankfully, the number of harmless (and often beneficial) microbes far outnumber those that would do us harm. Our ability to ward-off pathogens in our environment, including those that can colonize our exterior and/or interior surfaces, depends on the integrative action of the innate and adaptive immunity systems. This volume of CTMI, entitled Antimicrobial Peptides and Human Disease, is dedicated to the role of antimicrobial peptides (AMPs) in the innate host defense system of homo sapiens.
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Prokaryotic Antimicrobial Peptides

From Genes to Applications

Author: Djamel Drider,Sylvie Rebuffat

Publisher: Springer Science & Business Media

ISBN: 9781441976925

Category: Science

Page: 451

View: 9503

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The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.
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Antimicrobial Peptides

Basics for Clinical Application

Author: Katsumi Matsuzaki

Publisher: Springer

ISBN: 9811335885

Category: MEDICAL

Page: 304

View: 1401

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This book presents an overview of antimicrobial peptides (AMPs), their mechanisms of antimicrobial action, other activities, and various problems that must still be overcome regarding their clinical application. Divided into four major parts, the book begins with a general overview of AMPs (Part I), and subsequently discusses the various mechanisms of antimicrobial action and methods for researching them (Part 2). It then addresses a range of activities other than antimicrobial action, such as cell penetration, antisepsis, anticancer, and immunomodulatory activities (Part 3), and explores the prospects of clinical application from various standpoints such as the selective toxicity, design, and discovery of AMPs (Part 4). A huge number of AMPs have been discovered in plants, insects, and vertebrates including humans, and constitute host defense systems against invading pathogenic microorganisms. Consequently, many attempts have been made to utilize AMPs as antibiotics. AMPs could help to solve the urgent problem of drug-resistant bacteria, and are also promising with regard to sepsis and cancer therapy. Gathering a wealth of information, this book will be a bible for all those seeking to develop antibiotics, anti-sepsis, or anticancer agents based on AMPs.
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Antimicrobial Peptides

Author: David A. Phoenix,Sarah R. Dennison,Frederick Harris

Publisher: John Wiley & Sons

ISBN: 3527652876

Category: Science

Page: 248

View: 1256

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In this text, the small team of expert authors presents the field in a comprehensive and accessible manner that is well suited for students and junior researchers. The result is a highly readable and systematically structured introduction to antimicrobial peptides, their structure, biological function and mode of action. The authors point the way towards a rational design of this potentially highly effective new class of clinical antibiotics on the brink of industrial application. They do this by discussing their design principles, target membranes and structure-activity relationships. The final part of the book describes recent successes in the application of peptides as anticancer agents.
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Antimicrobial Peptides and Innate Immunity

Author: Pieter S. Hiemstra,Sebastian A. J. Zaat

Publisher: Springer Science & Business Media

ISBN: 3034805411

Category: Medical

Page: 384

View: 4354

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Antimicrobial peptides have been the subject of intense research in the past decades, and are now considered as an essential part of the defense system in bacteria, plants, animals and humans. his book provides an update on these effector molecules of the innate immune system both for researchers who are already actively involved in the area, and for those with a general interest in the topic. The book starts with an overview of the evolution of cysteine-containing antimicrobial peptides (including defensins), and the role of these peptides in host defense in plants and micro-organisms. The realization that antimicrobial peptides also display functions distinct from their direct antimicrobial action is the focus of the next chapters, and puts these peptides center stage in immunity and wound repair. Further chapters discuss the role of antimicrobial peptides in disease, by providing an overview of mechanisms in bacterial resistance to antimicrobial peptides and a discussion of their role in inflammatory bowel disease, cystic fibrosis lung disease and chronic obstructive pulmonary disease. Finally, the book shows how knowledge of the function of antimicrobial peptides and their regulation can be used to design new therapies for inflammatory and infectious disorders. This is a very important area of research because of the increase in resistance of micro-organisms to conventional antibiotics. Therefore the use of synthetic or recombinant peptides, or agents that stimulate the endogenous production of antimicrobial peptides, provides an attractive alternative for conventional antibiotics.
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Antimicrobial Peptides: Utility Players in Innate Immunity

Author: Mark W. Robinson,Andrew T. Hutchinson,Sheila Donnelly

Publisher: Frontiers E-books

ISBN: 2889190773

Category:

Page: N.A

View: 2303

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Antimicrobial peptides (AMPs) represent an ancient group of molecules with diverse functions in innate immunity. To date, more than 1000 naturally-occurring AMPs have been identified which display considerable diversity in their primary sequences, lengths, structures and biological activities. Despite this variability, AMPs are broadly classified according to homologous secondary structures as cathelicidins (linear a-helical peptides), defensins (ß-strand peptides connected by disulfide bonds) and bactenecins (loop peptides). Most, but not all, AMPs are cationic with amphipathic faces. These biochemical properties bestow many peptides with potent antimicrobial activity by facilitating interactions with negatively charged microbial cell membrane components, thereby increasing membrane permeability and resulting in microbial death. Other indirect effects on microbial physiology have been reported including inhibition of DNA/RNA synthesis, impaired protein synthesis and folding, disruption of cell wall formation and inhibition of microbial cell metabolism. Thus, with the spread of antibiotic-resistant microbial pathogens, AMPs have emerged as exciting candidates for next generation anti-infective therapies. However, recent studies suggest that AMPs have evolved other mechanisms of pathogen clearance. Immunomodulation is a novel approach to antimicrobial therapy that centres on boosting host immunity rather than direct microbial killing. This is also an attractive means to treat sepsis and other immune-mediated diseases. Whilst several cationic peptides are under investigation as antimicrobial agents, a select few show a remarkable ability to protect against lethal endotoxaemia and clinically-relevant bacterial infections including methicillin-resistant Staphylococcus aureus (MRSA). The molecular mechanisms responsible for this protection are only beginning to emerge but include prevention of innate cell activation by targeting key stages of bacterial endotoxin-mediated cell signalling. In this research topic, hosted by Frontiers in Molecular Innate Immunity, we aim to highlight key areas of AMP research including peptide diversity, structure-function relationships, antimicrobial activity and mechanisms of immune-modulation. We also aim to stimulate discussion on the emerging therapeutic potential of AMPs including antifungal, antiviral and anticancer applications.
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New edge of antibiotic development: antimicrobial peptides and corresponding resistance

Author: Octavio L. Franco,Nádia S. Parachin

Publisher: Frontiers E-books

ISBN: 2889193012

Category:

Page: N.A

View: 8336

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Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.
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Antimicrobial Peptides—Advances in Research and Application: 2012 Edition

ScholarlyPaper

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1481641956

Category: Medical

Page: 17

View: 1648

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Antimicrobial Peptides—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Antimicrobial Peptides in a compact format. The editors have built Antimicrobial Peptides—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antimicrobial Peptides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antimicrobial Peptides—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
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