This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics.
Author: S. V. Hodgson
Publisher: Cambridge University Press
The 2006 third edition of this very successful book provides a comprehensive and practical guide to the diagnosis and management of inherited disorders conferring susceptibility to cancer. Issues discussed include risk assessment, genetic counselling, predictive testing and organisation of a cancer genetics service. A full reference list gives access to background literature. With molecular information, screening guidelines and management advice, this new edition will provide geneticists and clinicians in all disciplines with an invaluable resource for screening, managing and advising patients.
This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility.
Author: Shirley V. Hodgson
Publisher: Springer Science & Business Media
This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. It is fully updated with much molecular, screening and management information. It covers risk analysis and genetic counselling for individuals with a family history of cancer. It also discusses predictive testing and the organisation of the cancer genetics service. There is information about the genes causing Mendelian cancer predisposing conditions and their mechanism of action. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines.
This extensively updated and expanded edition provides the busy clinician with an essential overview of the latest developments in human cancer genetics--an area that has made significant advances since publication of the first edition. The opening section presents the principles of cancer genetics and introduces the basic concepts and mechanisms of tumorigenesis and inherited predisposition to cancer. The second part of the book provides information, on a systems basis, on the incidence, significance and management of predisposition to individual cancers. The final section deals with specific inherited cancer syndromes, giving practical guidance on clinical investigation, screening and management of affected patients and relatives at risk. The authors also provide up-to-date details of the genetic mapping of inherited cancer syndromes and the molecular genetic changes in individual cancers. Finally, an appendix provides a helpful revision guide to the fundamental principles of genetics. This practical and clear account will benefit clinicians and research workers in oncology, genetics, surgery and general medicine.
Finally meeting the need for a practical guide on human genetics and genomics, this book is the perfect companion title to all major standard textbooks on the subject.
Author: Bahar Taneri
Publisher: John Wiley & Sons
Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard curriculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling.
(2002) Int. J. Cancer, 97, 671. 53. Hodgson, S.V. and Maher, E.R. (1993) In: A Practical Guide to Human Cancer Genetics. Cambridge University Press. Part 3,
p. 157. 54. Gnarra, J.R., Duan, D.R., Weng, Y. et al. (1996) Biochim. Biophys.
Author: Fiona Macdonald
Publisher: Garland Science
Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.
colon as opposed to rectal cancer. ... Key Point 2 The approach to risk
assessment for individuals with a family history of colorectal cancer is similar to
that for individuals with a family ... A practical guide to human cancer genetics,
Author: Ian D. Young
Publisher: Oxford University Press, USA
The process of genetic counseling involves many key components, such as taking a family genetic history, making a diagnosis, and providing communication and support to the family. Among these core processes is the mathematical calculation of the actual risk of a possible genetic disorder. For most physicians and counselors, the mathematics and statistics involved can be major challenge which is not always helped by complex computer programs or lengthy papers full of elaborate formulae. In this clear, reader-friendly guide, Ian Young addresses this problem and demonstrates how risk can be estimated for inherited disorders using a basic knowledge of the laws of probability and their application to clinical problems. The text employs a wealth of clearly explained examples and key points in order to guide the reader to an accurate assessment of the risk of genetic disease. It primarily will appeal to genetic counselors, geneticists, and all those involved in providing medical genetic services. In this new edition, Dr. Young has pruned redundancies and extensively updated the concepts in each of the 10 chapters, and he has included more working examples, a popular feature of the book.
United States public health service clinical practice guideline: treating tobacco
use and dependence. Respir Care. 2000; 45:1200–1262. Hodgson SV, Maher
ER. A Practical Guide To Human Cancer Genetics. Cambridge University Press ...
Author: Miguel H. Bronchud
Publisher: Springer Science & Business Media
At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
Invasive cancer of the uterus was diagnosed 18 months later , following a routine
visit to the bowel surgeon . Ideally if her family ... Testing for the breast cancer
predisposition gene , BRCA1 . ... A Practical Guide to Human Cancer Genetics .
Author: William D. Foulkes
Publisher: Cambridge University Press
This authoritative volume will be of interest to health professionals in the areas of primary care, counselling and cancer risk assessment.
Increasingly, viruses and bacterial infections are being linked to human cancer (
Goon et al., 2009; National Institute Environment Health Services, 2003): r Human papilloma virus with cervical, anal, and head and neck carcinomas r
Hepatitis B ...
Author: Robin L. Bennett
Publisher: John Wiley & Sons
HELPS YOU DEVELOP AND ASSESS PEDIGREES TO MAKE DIAGNOSES, EVALUATE RISK, AND COUNSEL PATIENTS The Second Edition of The Practical Guide to the Genetic Family History not only shows how to take a medical-family history and record a pedigree, but also explains why each bit of information gathered is important. It provides essential support in diagnosing conditions with a genetic component. Moreover, it aids in recommending genetic testing, referring patients for genetic counseling, determining patterns of inheritance, calculating risk of disease, making decisions for medical management and surveillance, and informing and educating patients. Based on the author's twenty-five years as a genetic counselor, the book also helps readers deal with the psychological, social, cultural, and ethical problems that arise in gathering a medical-family history and sharing findings with patients. Featuring a new Foreword by Arno Motulsky, widely recognized as the founder of medical genetics, and completely updated to reflect the most recent findings in genetic medicine, this Second Edition presents the latest information and methods for preparing and assessing a pedigree, including: Value and utility of a thorough medical-family history Directed questions to ask when developing a medical-family history for specific disease conditions Use of pedigrees to identify individuals with an increased susceptibility to cancer Verification of family medical information Special considerations when adoptions or gamete donors are involved Ethical issues that may arise in recording a pedigree Throughout the book, clinical examples based on hypothetical families illustrate key concepts, helping readers understand how real issues present themselves and how they can be resolved. This book will enable all healthcare providers, including physicians, nurses, medical social workers, and physician assistants, as well as genetic counselors, to take full advantage of the pedigree as a primary tool for making a genetic risk assessment and providing counseling for patients and their families.
The second part of A Practical Guide to Human Cancer Genetics deals with
inherited cancers by site of origin , dealing with a range of cancers both common
and uncommon that may arise in a particular system . Each chapter
C . A . GEIDENBERGER School of Public Health Ohio State University Columbus
, OH 43210 A Practical Guide to Human Cancer Genetics , by S . V . Hodgson
and E . R . Maher . Cambridge , England : Cambridge University Press , 1993 .
Author: Raymond Pearl
Includes section "Recent literature useful in the study of human biology."
Hodgson SV , Maher ER : A Practical Guide to Human Cancer Genetics .
Cambridge University Press , 1993 . Hollstein M et al : p53 mutations in human
cancer . Science 1991 ; 253 : 49 . Horsthemke B : Detection of submicroscopic
Author: Margretta Reed Seashore
Publisher: McGraw-Hill/Appleton & Lange
Category: Genetic disorders
Genetics in Primary Care & Clinical Medicine provides medical students, residents, and physicians with an introduction to the fundamental applications of genetics to clinical medicine. Organized by organ systems, this compact book reviews basic genetics in a clear and instructional format and explores the role of genetics in understanding gene alterations, mutations, and diseases.
The book concludes with a listing of online resources on toxicology and risk assessment.
Author: Laura Robinson
Publisher: John Wiley & Sons
Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
in, distinguish between human and animal studies, select certain publication
years, and decide whether you only want ... as genetic counseling) or use a
topicspecific query (if, for instance, you wanted to search only within the Cancer
Author: Ian MacFarlane
Publisher: Oxford University Press
Genetic Counseling Research: A Practical Guide is the first text devoted to research methodology in genetic counseling. This text offers step-by-step guidance for conducting research, from the development of a question to the publication of findings. Genetic counseling examples, user-friendly worksheets, and practical tips guide readers through the research and publication processes. With a highly accessible, pedagogical approach, this book will help promote quality research by genetic counselors and research supervisors--and in turn, increase the knowledge base for genetic counseling practice, other aspects of genetic counseling service delivery, and professional education. It will be an invaluable resource to the next generation of genetic counseling and its surrounding disciplines.
... the human adenomatous A practical guide to human cancer genetics 6986
Absence of ras mutations and low incidence of p53 Allelic loss on chromosome
8p 12-21 in Allelotype analysis in mouse hepatocellular Apoptosis and the cell
Author: MS Robin L. Bennett (CGC.)Publish On: 1999-04-21
The Genetic Basis of Human Cancer . New York : McGraw - Hill , 731 pp . , cost ~
$ 95 , cloth Vogelstein and Kinzler have brought together the experts in this field
to provide a detailed look at the concepts in cancer genetics , the familial cancer
Author: MS Robin L. Bennett (CGC.)
"Compiling the most recent genetic developments in medical specialties, The Practical Guide to the Genetic Family History is a valuable resource which outlines the proper methods for taking and recording a patient's family medical history, allowing primary care physicians to be more efficient in diagnosing conditions with potential genetic components."--BOOK JACKET. "An essential reference for genetics clinics, medical geneticists, and counselors, The Practical Guide to the Genetic Family History is also an invaluable aid for both primary care and specialist physicians who need an up-to-date reference that emphasizes both the science and art of modern clinical genetics."--Jacket.
(2001) The TRAMP mouse as a model for prostate cancer. ... Nelson, J.F.,
Karelus, K., Felicio, L.S. and Johnson, T.E. (1990) Genetic influences on the
timing of puberty in mice. ... K. (2012) Female reproductive tract, in Comparative
Anatomy and Histology a Mouse and Human Atlas (eds P.M. Treuting and S.M.
Dintzis), Academic Press, Amsterdam, pp. ... 106 A practical guide to the
histology of the mouse.
Author: Cheryl L. Scudamore
Publisher: John Wiley & Sons
A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation
The chapter “ Hereditary Breast Cancer Genes " discusses BRCA1 and BRCA2
mutations among Ashkenazi women . Also addresses ... The Molecular Basis of
Human Cancer . Totowa ... A Practical Guide to Human Cancer Genetics . 2d ed .
Author: Bryan D. Ness
Publisher: Salem PressInc
Looks at the field of genetics, covering such topics as autism, DNA, bioethics, cancer, diabetes, eugenics, and pseudogenes.
Using examples drawn from actual cases and emphasizing fundamental principles throughout, this book outlines the scope of clinical cancer genetics and its underlying scientific concepts, reviews the most prevalent syndromes of cancer ...
Author: Kenneth Offit
With a Foreword by Richard D. Klausner, M.D., Director, National Cancer Institute and an Introduction by Henry T. Lynch, M.D., President, Hereditary Cancer Institute and Director, Creighton Cancer Center, Creighton University. When ordering a genetic test to determine whether a patient is susceptible to genetically transmitted cancers, physicians must be prepared to cope with profound medical, psychological, and ethical consequences. They, along with genetic counselors, nurses, psychologists, and other health professionals, must ensure that interpretations of test results are accurate, risk assessments are appropriate, and the communication of risk information is clear, helpful, and productive. Clinical Cancer Genetics: Risk Counseling and Management is a comprehensive practical guide for health professionals responding to the growing demand for clinical cancer genetic services. Using examples drawn from actual cases and emphasizing fundamental principles throughout, this book outlines the scope of clinical cancer genetics and its underlying scientific concepts, reviews the most prevalent syndromes of cancer predisposition, and addresses major issues associated with genetic testing, including: * Use of quantitative methods in risk counseling * Methodologies of genetic testing * Genetic testing of patients with cancer * Reproductive risk counseling of cancer patients * Special psychological, ethical, and legal challenges in clinical cancer genetics Supplemented with practical materials used in cancer genetic counseling programs and an annotated table of selected human cancer predisposition syndromes, Clinical Cancer Genetics: Risk Counseling and Management equips health care professionals with a complete understanding of the benefits and limitations of genetic testing technologies and the ability to integrate genetic information into the management of patients who are at risk or already affected by cancer.