The Language of Life

DNA and the Revolution in Personalised Medicine

Author: Francis Collins

Publisher: Profile Books

ISBN: 1847652093

Category: Medical

Page: 332

View: 4230

We are in the midst of a medical revolution: in just a few years, we will be able to have our complete DNA sequenced at an affordable cost. Analysing the content of our genomes will allow a powerful estimate of our future risks of illness - from cystic fibrosis and Huntington's disease, to cancer and diabetes - which will help us devise our own personalised blueprint of preventive medicine. This will have enormous implications on everything from our day-to-day choices like diet and exercise, to childbearing and health insurance - and it may even challenge what we thought we knew about our ethnic histories. Combining cutting-edge scientific research with practical advice, Francis Collins examines this remarkable phenomenon, which will transform healthcare worldwide. We now know that the language spoken by our DNA is the language of life itself, and in this important book Collins shows how reading that language will help save lives.
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The Language of Life

DNA and the Revolution in Personalized Medicine

Author: Francis S. Collins

Publisher: Harper Collins

ISBN: 0061733172

Category: Medical

Page: 332

View: 9706

The best-selling author of The Language of God and leader of the Human Genome Project explains how ongoing improvements in DNA testing will usher in a new era of customized medicine. 100,000 first printing.
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The Language of Life

DNA and the Revolution in Personalized Medicine

Author: Francis S. Collins

Publisher: Harper Collins

ISBN: 0061963496

Category: Science

Page: 368

View: 3133

"His groundbreaking work has changed the very ways we consider our health and examine disease.” —Barack Obama From Dr. Francis Collins, director of the National Institute of Health, 2007 recipient of the Presidential Medal of Freedom, and 15-year head of the Human Genome Project, comes one of the most important medical books of the year: The Language of Life. With accessible, insightful prose, Dr. Collins describes the medical, scientific, and genetic revolution that is currently unlocking the secrets of “personalized medicine,” and offers practical advice on how to utilize these discoveries for you and your family’s current and future health and well-being. In the words of Dr. Jerome Groopman (How Doctors Think), The Language of Life “sets out hope without hype, and will enrich the mind and uplift the heart.”
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The Language of Science and Faith

Straight Answers to Genuine Questions

Author: Karl W. Giberson,Francis S. Collins

Publisher: InterVarsity Press

ISBN: 0830868445

Category: Religion

Page: 250

View: 3311

Christians affirm that everything exists because of God--from subatomic quarks to black holes. Science often claims to explain nature without including God at all. And thinking Christians often feel forced to choose between the two. But the good news is that we don't have to make a choice. Science does not overthrow the Bible. Faith does not require rejecting science. World-renowned scientist Francis Collins, author of The Language of God, along with fellow scientist Karl Giberson show how we can embrace both. Their fascinating treatment explains how God cares for and interacts with his creation while science offers a reliable way to understand the world he made. Together they clearly answer dozens of the most common questions people ask about Darwin, evolution, the age of the earth, the Bible, the existence of God and our finely tuned universe. They also consider how their views stack up against the new atheists as well as against creationists and adherents of intelligent design. The authors disentangle the false conclusions of Christians and atheists alike about science and evolution from the actual results of research in astronomy, physics, geology and genetics. In its place they find a story of the grandeur and beauty of a world made by a supremely creative God.
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Belief

Readings on the Reason for Faith

Author: Francis S. Collins

Publisher: Harper Collins

ISBN: 9780061978401

Category: Religion

Page: 352

View: 9704

“A brilliant, wide ranging and powerful series of readings on the possibilities, problems and mysteries of faith. This book belongs on the shelf of every believer—and every serious skeptic.” — Rabbi David Wolpe, author of Why Faith Matters “This life-giving, faith-filled and hard-nosed collection reveals why, as St. Anselm wrote, true faith always seeks to understand.” — Rev. James Martin, author of My Life with the Saints From Dr. Francis Collins, New York Times bestselling author of The Language of God, comes the definitive reader on the rationality of faith.
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The Language of God

A Scientist Presents Evidence for Belief

Author: Francis Collins

Publisher: Simon and Schuster

ISBN: 1847396151

Category: Science

Page: 304

View: 5839

Dr Francis S. Collins, head of the Human Genome Project, is one of the world's leading scientists, working at the cutting edge of the study of DNA, the code of life. Yet he is also a man of unshakable faith in God. How does he reconcile the seemingly unreconcilable? In THE LANGUAGE OF GOD he explains his own journey from atheism to faith, and then takes the reader on a stunning tour of modern science to show that physics, chemistry and biology -- indeed, reason itself -- are not incompatible with belief. His book is essential reading for anyone who wonders about the deepest questions of all: why are we here? How did we get here? And what does life mean?
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Genomics and Personalized Medicine

What Everyone Needs to Know?

Author: Michael Snyder

Publisher: Oxford University Press

ISBN: 0190234784

Category: Science

Page: 240

View: 9284

In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.
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The $1,000 Genome

The Revolution in DNA Sequencing and the New Era of Personalized Medicine

Author: Kevin Davies

Publisher: Simon and Schuster

ISBN: 9781416570189

Category: Science

Page: 352

View: 6462

In 2000, President Bill Clinton signaled the completion of the Human Genome Project at a cost in excess of $2 billion. A decade later, the price for any of us to order our own personal genome sequence—a comprehensive map of the 3 billion letters in our DNA—is rapidly and inevitably dropping to just $1,000. Dozens of men and women—scientists, entrepreneurs, celebrities, and patients—have already been sequenced, pioneers in a bold new era of personalized genomic medicine. The $1,000 genome has long been considered the tipping point that would open the floodgates to this revolution. Do you have gene variants associated with Alzheimer’s or diabetes, heart disease or cancer? Which drugs should you consider taking for various diseases, and at what dosage? In the years to come, doctors will likely be able to tackle all of these questions—and many more—by using a computer in their offices to call up your unique genome sequence, which will become as much a part of your medical record as your blood pressure. Indeed, many experts are advocating that all newborns have a complete genome analysis done so that preventive measures and preemptive medicine can begin early in life. How has this astonishing achievement been accomplished? And what will it mean for our lives? To research the story of this unfolding revolution, critically acclaimed science writer Kevin Davies has spent the past few years traveling to the leading centers and interviewing the entrepreneurs and pioneers in the race to achieve the $1,000 genome. He vividly brings to life the extraordinary drama of this grand scientific achievement, revealing the masterful ingenuity that has transformed the process of decoding DNA and delivering the information it possesses to the public at large. Davies also profiles the future of genomic medicine and thoughtfully explores the many pressing issues raised by the tidal wave of personal genetic information. Will your privacy be protected? Will you be pressured, by insurance companies or by your employer, to get your genome sequenced? What psychological toll might there be to discovering you are at risk for certain diseases like Alzheimer’s? And will the government or the medical establishment come between you and your genome? One thing that is not in question is that we are moving swiftly into the personalized medicine era, and The $1,000 Genome is an essential guide to this brave new future.
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One in a Billion

The Story of Nic Volker and the Dawn of Genomic Medicine

Author: Kathleen Gallagher,Mark Johnson

Publisher: Simon and Schuster

ISBN: 1451661320

Category: Biography & Autobiography

Page: 256

View: 3944

The breathtaking story of a young boy with a never-before-seen disease, and the doctors who take a bold step into the future of medicine to save him—based on the authors’ Pulitzer Prize–winning reporting. In this landmark medical narrative, in the tradition of The Immortal Life of Henrietta Lacks and The Spirit Catches You and You Fall Down, Pulitzer Prize–winning journalists Mark Johnson and Kathleen Gallagher chronicle the story of Nic Volker, the Wisconsin boy at the center of a daring breakthrough in medicine—a complete gene sequencing to discover the cure for an otherwise undiagnosable illness. At just two years old, Nic experienced a searing pain that signaled the awakening of a new and deadly disease, one that would hurl Nic and his family up against the limits of modern medicine. For years, through false starts and failed cures, Nic holds on to life, buoyed up by his mother’s fierce drive to get him the care he needs. But when even the world’s experts are stumped by Nic’s illness, his doctors come up with a radical, long-shot plan: a step into the unknown. The next major scientific frontier, following the completion of the Human Genome Project, was to figure out how to use our new knowledge to save lives—to bring genomic or personalized medicine into reality. It’s a quest that is undertaken by researchers around the world. But it is only when geneticist Howard Jacob hears about young Nic that the finish line finally comes into sight: It’s no longer a race to make history. It’s a race to save this boy’s life. One in a Billion is an unforgettable tale of the lives that converged to launch a medical revolution. As pioneering geneticist Mary-Claire King pronounced upon learning Nic’s story: “It was as if one had heard about Case Zero of AIDS and the cure, all at once.”
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Cracking the Genome

Inside the Race to Unlock Human DNA

Author: Kevin Davies

Publisher: JHU Press

ISBN: 9780801871405

Category: Medical

Page: 327

View: 4449

This newly updated edition sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for generations to come.
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Decoding the Language of God

Can a Scientist Really Be a Believer?

Author: George C. Cunningham

Publisher: Prometheus Books

ISBN: 1615929614

Category: Religion

Page: N.A

View: 6181

In his bestselling book, The Language of God, Francis Collins-the scientist who led the National Institutes of Health's Human Genome Project-attempted to harmonize the findings of scientific research with Christian belief. In this response to Collins's work, fellow geneticist George C. Cunningham presents a point-by-point rebuttal of The Language of God, arguing that there is no scientifically acceptable evidence to support belief in a personal God and much that discredits it.Written with admirable clarity for the nonscientist, Decoding the Language of God covers much of the same ground addressed by Collins in his book:· Do moral behavior, altruism, and similar moral standards across cultures indicate that humans are somehow in touch with a divine lawgiver, as Collins argues? Cunningham cites data from behavioral genetics that suggest a purely naturalistic explanation for morality.· The existence of evil, both natural and human-caused, has always been a major stumbling block for religious apologists. Cunningham points out how Collins fails to adequately address this issue and the difficulty of reconciling belief in a good God with the existence of evil.· Collins refers to the origin of the universe and anthropic coincidences as evidence of God as creator of all of reality. By contrast, Cunningham notes that there are naturalistic interpretations for the big bang and the fine-tuning of the universe, which adequately explain this evidence.Cunningham also devotes chapters to the unreliability of the Bible as a basis for belief; the conflict between naturalistic explanations of reality, which are anchored in scientific research, and supernatural interpretations, which are not; and the many difficulties in conceptualizing the origins of the universe in terms of a personal God.Unlike recent hostile attacks on religious belief, Cunningham's respectful, well-reasoned discussion will appeal to open-minded people across the whole spectrum of belief and unbelief.George C. Cunningham, MD, MPH (San Francisco, CA), now retired, is the former chief of the Genetic Disease Branch of the California State Department of Health Services. He has published more than 150 articles in scientific publications, including the New England Journal of Medicine, Lancet, the American Journal of Human Genetics, and Pediatrics.
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Here Is a Human Being

At the Dawn of Personal Genomics

Author: Misha Angrist

Publisher: Harper Collins

ISBN: 0062010468

Category: Science

Page: 352

View: 4453

Here is a Human Being delivers the first in-depth look at the Personal Genome Project—the effort to construct complete genomic maps of a specific human beings—written by one of the study’s ten human participants. Misha Angrist recounts the project’s fascinating nuances, including the larger-than-life personalities of the research subjects, the entrepreneurial scientists at the helm, the bewildered and overwhelmed physicians and regulators who negotiated for it, the fascinating technology it employed, and the political, social, ethical and familial issues it continues to raise. In the vein of James Shreeve’s The Genome War, Craig J. Ventner’s My Life Decoded, and Francis J. Collins’ The Language of Life, Angrist’s informed exploration of this cutting-edge science is a gripping look at the present and future of genomics.
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Metabolomics and Microbiomics

Personalized Medicine from the Fetus to the Adult

Author: Vassilios Fanos

Publisher: Academic Press

ISBN: 0128054506

Category: Medical

Page: 144

View: 9084

Metabolomics and Microbiomics: Personalized Medicine from the Fetus to the Adult encompasses the most recent advances on the usage of metabolomics and microbiome research to improve disease diagnosis and healthcare. Medicine is changing from epidemiologic, descriptive, reductionist, and reactive approaches to individualized, predictive, and holistic ones by applying microbiomics to understand the functionality of the human body. The book discusses topics such as systems biology approaches, omics technologies, perinatal programming, and personalized medicine. It also discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing. The book is a valuable resource for medical professionals and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine. The book also will appeal to non-specialized professionals who may take advantage of its captivating and simple language. Covers the latest scientific discoveries in order to improve health and early diagnosis of diseases Brings a holistic and perinatal programming approach—from fetus to adulthood—to early and long-term prevention of diseases Provides illustrations and diagrams to facilitate understanding for readers Discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing
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The Age of Genomes

Tales from the Front Lines of Genetic Medicine

Author: Steven Monroe Lipkin,Jon Luoma

Publisher: Beacon Press

ISBN: 0807074586

Category: Science

Page: 256

View: 502

A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. Steven Lipkin and Jon Luoma posit that today’s genomics is like the last century’s nuclear physics: a powerful tool for good if used correctly, but potentially dangerous nonetheless. DNA testing is likely the most exciting advance in a long time for treating serious disease, but sequencing errors, complex biology, and problems properly interpreting genetic data can also cause life-threatening misdiagnoses of patients with debilitating and fatal genetic diseases. DNA testing can also lead to unnecessary procedures and significantly higher health-care costs. And just around the corner is the ability to cure genetic diseases using powerful gene-editing technologies that are already being used in human embryo research. Welcome to the Age of Genomes! The Age of Genomes immerses readers in true stories of patients on the frontier of genomic medicine and explores both the transformative potential and risks of genetic technology. It will inform anxious parents increasingly bombarded by offers of costly new prenatal testing products, and demonstrate how genetic technology, when deployed properly, can significantly improve the lives of patients who have devastating neurological diseases, cancer, and other maladies. Dr. Lipkin explains the science in depth, but in terms a layperson can follow.
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The Personalized Medicine Revolution

How Diagnosing and Treating Disease Are About to Change Forever

Author: Pieter Cullis

Publisher: Greystone Books Ltd

ISBN: 1771640383

Category: Health & Fitness

Page: 176

View: 7871

Every year more than 2 million North Americans are hospitalized, and more than 100,000 lose their lives, because of adverse reactions to drugs. These tragic cases stem from our one-size-fits-all approach to medicine. But who we are-our age, our sex, our size, our ethnic heritage-matters to our health. Shouldn't our medicine be tailored to our differences? Through the stories of researchers, scientists, and patients, The Personalized Medicine Revolution explores the promising new advances in personalized medicine-healthcare based on each person's unique genetic and molecular makeup-and the coming sea change in the way we detect and treat disease. The book also discusses the issues that patients, researchers, and governments will face as we take the next steps into this exciting future and explains what readers can do to take charge of their health.
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Personalized Medicine

Empowered Patients in the 21st Century?

Author: Barbara Prainsack

Publisher: NYU Press

ISBN: 1479856908

Category: Medical

Page: 288

View: 1134

Inside today's data-driven personalized medicine, and the time, effort, and information required from patients to make it a reality Medicine has been personal long before the concept of “personalized medicine” became popular. Health professionals have always taken into consideration the individual characteristics of their patients when diagnosing, and treating them. Patients have cared for themselves and for each other, contributed to medical research, and advocated for new treatments. Given this history, why has the notion of personalized medicine gained so much traction at the beginning of the new millennium? Personalized Medicine investigates the recent movement for patients’ involvement in how they are treated, diagnosed, and medicated; a movement that accompanies the increasingly popular idea that people should be proactive, well-informed participants in their own healthcare. While it is often the case that participatory practices in medicine are celebrated as instances of patient empowerment or, alternatively, are dismissed as cases of patient exploitation, Barbara Prainsack challenges these views to illustrate how personalized medicine can give rise to a technology-focused individualism, yet also present new opportunities to strengthen solidarity. Facing the future, this book reveals how medicine informed by digital, quantified, and computable information is already changing the personalization movement, providing a contemporary twist on how medical symptoms or ailments are shared and discussed in society. Bringing together empirical work and critical scholarship from medicine, public health, data governance, bioethics, and digital sociology, Personalized Medicine analyzes the challenges of personalization driven by patient work and data. This compelling volume proposes an understanding that uses novel technological practices to foreground the needs and interests of patients, instead of being ruled by them.
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The Society of Genes

Author: Itai Yanai,Lercher Martin

Publisher: Harvard University Press

ISBN: 0674425022

Category: Science

Page: 282

View: 3814

Since Dawkins popularized the notion of the selfish gene, the question of how these selfish genes work together to construct an organism remained a mystery. Now, standing atop a wealth of new research, Itai Yanai and Martin Lercher—pioneers in the field of systems biology—provide a vision of how genes cooperate and compete in the struggle for life.
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Essentials of Genomic and Personalized Medicine

Author: Geoffrey S. Ginsburg,Huntington F Willard

Publisher: Academic Press

ISBN: 9780080958118

Category: Science

Page: 850

View: 2357

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science
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Bioethics

An Introduction

Author: Marianne Talbot

Publisher: Cambridge University Press

ISBN: 1107377528

Category: Medical

Page: N.A

View: 4587

Providing readers with the confidence needed to debate key issues in bioethics, this introductory text clearly explains bioethical theories and their philosophical foundations. Over 250 activities introduce topics for personal reflection, and discussion points encourage students to think for themselves and build their own arguments. Highlighting the potential pitfalls for those new to bioethics, each chapter features boxes providing factual information and outlining the philosophical background, along with detailed case studies that offer an insight into real-life examples of bioethical problems. Within-chapter essay questions and quizzes, along with end-of-chapter review questions, allow students to check their understanding and to broaden their thinking about the topics discussed. The accompanying podcasts by the author (two of whose podcasts on iTunesUTM have attracted over 3 million downloads) explain points that might be difficult for beginners. These, along with a range of extra resources for students and instructors, are available at www.cambridge.org/bioethics.
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Genomic and Precision Medicine

Foundations, Translation, and Implementation

Author: Geoffrey S. Ginsburg,Huntington F Willard

Publisher: Academic Press

ISBN: 0128006560

Category: Science

Page: 398

View: 3800

Genomic and Precision Medicine: Translation and Implementation highlights the various points along the continuum from health to disease where genomic information is impacting clinical decision-making and leading to more personalization of health care. The book pinpoints the challenges, barriers, and solutions that have been, or are being, brought forward to enable translation of genome based technologies into health care. A variety of infrastructure (data systems and EMRs), policy (regulatory, reimbursement, privacy), and research (comparative effectiveness research, learning health system approaches) strategies are also discussed. Readers will find this volume to be an invaluable resource for the translational genomics and implementation science that is required to fully realize personalized health care. Provides a comprehensive volume on the translation and implementation of biology into health care provision Presents succinct commentary and key learning points that will assist readers with their local needs for translation and implementation Includes an up-to-date overview on major ‘translational events’ in genomic and personalized medicine, along with lessons learned
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