Sigma Receptors

Chemistry, Cell Biology and Clinical Implications

Author: Rae R. Matsumoto,Wayne D. Bowen,Tsung Ping Su

Publisher: Springer Science & Business Media

ISBN: 0387365141

Category: Medical

Page: 413

View: 6518

This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
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The Opiate Receptors

Author: Gavril W. Pasternak

Publisher: Springer Science & Business Media

ISBN: 9781607619932

Category: Medical

Page: 516

View: 2648

This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

Author: Sylvia B. Smith,Tsung-Ping Su

Publisher: Springer

ISBN: 3319501747

Category: Medical

Page: 312

View: 7026

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
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Sigma Receptors

Author: Yossef Itzhak

Publisher: N.A

ISBN: N.A

Category: Medical

Page: 340

View: 6641

This is the 12th in the Neuroscience Perspectives Series. The existence of sigma receptors in the central nervous system has only relatively recently been established. In line with the aims of Neuroscience Perspectives, this volume will cover the historical background of the subject, together with the physiological, molecular biological and pharmacological aspects, with a discussion on the concept of sigma receptors subtypes and their postulated relevance for CNS disorders.
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Cancer Research

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Cancer

Page: N.A

View: 1866

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Receptor Chemistry Towards the Third Millennium

Author: M. Gianella,G. Marucci,W. Quaglia,U. Gulini

Publisher: Elsevier

ISBN: 9780080540405

Category: Science

Page: 280

View: 5358

Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs. This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.
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Delivery Technologies for Biopharmaceuticals

Peptides, Proteins, Nucleic Acids and Vaccines

Author: Lene Jorgensen,Hanne Morck Nielson

Publisher: John Wiley & Sons

ISBN: 0470688408

Category: Science

Page: 442

View: 5989

Advances in biotechnology have provided scientists with anincreasing number of biopharmaceuticals such as novel peptide andprotein drugs as well as nucleic acid based drugs for gene therapy.However, successful delivery of these biopharmaceuticals is a majorchallenge because their molecular properties lead to poor physicaland chemical stability in the body and limited membranepermeability. Therefore researchers are developing a range of newdelivery technologies and materials to enable these new drugs to bedelivered intact to their target sites. Delivery Technologies forBiopharmaceuticals describes strategies to overcome themain barriers for successful delivery of therapeutic peptides,proteins, and nucleic acid-based drugs or vaccines related to thesite of administration and the target site. Many of the approachesdescribed are reported in formulations in current clinical trialsas well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and proteininjectables non-viral chemical vectors and viral technology for delivery ofnucleic acid based drugs immune response, adjuvants and delivery systems forvaccines several examples of delivery systems for differentbiopharmaceuticals a critical assessment of delivery technologies forbiopharmaceuticals Delivery Technologies for Biopharmaceuticals is anessential single-volume introduction to the technologies used byresearchers to ensure efficient delivery of this exciting new classof drugs. It will be of value to researchers and students workingin drug delivery, formulation, biopharmaceuticals, medicinalchemistry, and new materials development.
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Rotordynamik

Eine Einführung

Author: R. Gasch,H. Pfützner

Publisher: Springer-Verlag

ISBN: 3662097869

Category: Technology & Engineering

Page: 188

View: 7095

Während noch vor wenigen Jahrzehnten die Forschung auf dem Gebiet der Maschinendynamik hauptsächlich den Kolbenmaschinen galt, ist mittlerweile eine Akzentverschiebung zu den Maschinen mit ausschließlich rotierenden Teilen, wie Turbomaschinen und Elektro motoren eingetreten. Das hängt einmal damit zusammen, daß Gas turbinen, Turbopumpen, Turboverdichter und Elektromotoren Anwen dungsgebiete erobert haben, die früher Kolbenmaschinen vorbehalten waren. Außerdem sind durch das Bestreben, die Leistungsgewichte durch Drehzahlerhöhungen zu verringern, Probleme aufgetreten, wie beispiels weise Fragen der Laufstabilität, die früher ohne Bedeutung für die Praxis waren. Daher wurde die Forschung auf diesem Gebiet in den letzten Jahren intensiviert. In dieser Einführung in die Dynamik biegeelastischer Läufer haben wir versucht, die Fülle interessanter, oft sogar verblüffender Phänomene am einfachsten Rotormodell darzustellen. Wir haben uns auf die Behand lung des Laval-Läufers - der elastischen Welle mit aufgesetzter Scheibe - beschränkt, an dem sich bereits die wichtigsten Erscheinungen auf zeigen lassen. Da die Zahl der Freiheitsgrade niedrig ist, ist meist noch eine geschlossene Lösung der Bewegungsgleichungen möglich. Mit diesem Buch wenden wir uns an Studenten der Hochschulen und an Ingenieure in der Praxis. Wir hoffen, daß durch den sparsamen Ge brauch der höheren Mathematik das Verständnis auch dem Anfänger wesentlich erleichtert wird. Verbesserungsvorschläge und Hinweise auf Fehler nehmen wir gern entgegen.
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Handbuch der Organischen Chemie (Classic Reprint)

Author: Friedrich Beilstein

Publisher: Forgotten Books

ISBN: 9781390775792

Category: Science

Page: 844

View: 3597

Excerpt from Handbuch der Organischen Chemie Var, weggelassen. Ganz allgemein ist die Bezeichnung Di gewählt und 2 in einzelnen Fällen noeh die Silbe Ri hinzugenommen. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.
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Steroidhormone

Biosynthese, Stoffwechsel, Wirkung

Author: L. Träger

Publisher: Springer-Verlag

ISBN: 3642665292

Category: Science

Page: 352

View: 6793

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Intelligente Zellen

wie Erfahrungen unsere Gene steuern

Author: Bruce H. Lipton

Publisher: N.A

ISBN: 9783936862881

Category: Epigenesistheorie

Page: 236

View: 1268

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Das Krebsproblem

Einführung in die allgemeine Geschwulstlehre für Studierende, Ärzte und Naturwissenschaftler

Author: Karl H. Bauer

Publisher: Springer-Verlag

ISBN: 3642860621

Category: Medical

Page: 1100

View: 3389

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Neurowissenschaften

Eine Einführung

Author: Eric Kandel,James Schwartz,Thomas Jessell

Publisher: Spektrum Akademischer Verlag

ISBN: 9783827429056

Category: Medical

Page: 787

View: 2039

Dieses umfassende Lehrbuch für Studenten und Dozenten der Neurobiologie sowie an der Hirnforschung Interessierter aus Medizin und Psychologie ist die erste integrierende Darstellung der modernen Neurowissenschaften. Zahlreiche Disziplinen versuchen gemeinsam, menschliches Denken und Verhalten sowie deren Störungen auf biologische Strukturen und Vorgänge bzw. ihre Veränderung zurückzuführen. Der 'Kandel/Schwartz/Jessell' setzt nur (Oberstufen-)Schulwissen voraus und entwickelt aus der umfassenden Präsentation der molekularen und zellulären Grundeinheiten und -funktionen des Nervensystems geschickt das Verständnis von Wahrnehmungsprozessen, der Bewegungssteuerung und schließlich der höhreren geistigen Hirnleistungen wie Sprache, Lernen und Gedächtnis. Um das von Studierenden nachgefragte Buch auch weiterhin lieferbar halten zu können, wurde es schwarzweiß gedruckt.
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Issues in Biological and Life Sciences Research: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464963355

Category: Science

Page: 5106

View: 798

Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
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