Plant-derived Natural Products

Synthesis, Function, and Application

Author: Anne E. Osbourn,Virginia Lanzotti

Publisher: Springer Science & Business Media

ISBN: 9780387854984

Category: Science

Page: 597

View: 9059

Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
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Plant-Based Natural Products

Derivatives and Applications

Author: Shahid Ul-Islam

Publisher: John Wiley & Sons

ISBN: 1119423872

Category: Science

Page: 240

View: 1025

Intense research has been started all around the world in the past few decades to exploit different agents from natural products as eco-friendly alternative to synthetic and toxic chemicals. Natural products and their derivatives have received increasing attention for their use in many everyday applications ranging from food, medicine, textiles, and healthcare.This new book presents significant research advances about the use of natural products, mainly plant colorants, bioactive compounds and other plant extracts in the textile coloration, food, bioremediation and environmental applications. There are total eight chapters contributed by leading researchers covering the topics such as potential resurgence of natural dyes in applied fields, natural colorants from indigoid plants, phytochemistry of dye yielding plants, irradiation as novel pretreatment methods, dyeing studies with henna plant, phytoremediation of arsenic, and synthesis of curcumin complexes for medicinal and other industrial uses.
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Human Medicinal Agents from Plants

Author: A. Douglas Kinghorn,Manuel F. Balandrin,American Chemical Society. Division of Agricultural and Food Chemistry

Publisher: Amer Chemical Society

ISBN: 9780841227057

Category: Medical

Page: 356

View: 2032

Covers the discovery, development, use and potential use, and regulation of plant-derived drugs. Describes ongoing research for prospective natural drugs with anticancer and anti-infective activities. Features some highly promising compounds, including artemisinin, camptothecin, forskolin, and taxol. Includes coverage of biologically active constituents of terrestrial and marine plants. Also addresses the effects of the destruction of rain forests on drug discovery.
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Studies in Natural Products Chemistry

Chapter 11. Plant-Derived Natural Products for the Treatment of Leishmaniasis

Author: Jens Rohloff,Ariaya Hymete,Yinebeb Tariku

Publisher: Elsevier Inc. Chapters

ISBN: 012808491X

Category: Science

Page: 504

View: 2882

Leishmaniasis is a vector-borne parasitic disease caused by protozoan parasites belonging to the family Trypanosomatidae and genus Leishmania. The disease prevails in 88 subtropical and tropical countries in five continents where about 350 million people live. Approximately two million incidences of new cases are recorded every year, causing high morbidity and mortality with a wide spectrum of clinical manifestations in humans. Treatment for leishmaniasis depends on pentavalent antimonials developed 50 years ago as first-line drugs, whereas a limited range of other drugs such as paromomycin, miltefosine, and amphotericin B exist to supplement them. However, potential toxicity, costs, and emergence of drug-resistant pathogens are the most serious obstacles for successful treatment of the disease in most endemic areas. This demands the development of new antileishmanial agents. In this regard, the search for new drugs from various synthetic products continues, and involves also compounds isolated from natural sources and drugs used for the treatment of other ailments (cancer, viral infections, TB, immunosuppression, etc.) in order to discover compounds with unknown chemical structures and with potential novel modes of action. Medicinal and aromatic plants are a major source of natural organic compounds which are widely used as medicine. The extensive ethnomedicinal knowledge, diversity of plant species, and the disease burden worldwide necessitates the status of natural products in treatments of leishmaniasis to be assessed. This chapter will review plant crude extracts and fractions/active principles obtained from medicinal plants which are used in or have potential for the treatment of leishmaniasis. Plant species are systematically presented by family, bioactive phytochemicals in various classes, and results obtained on specific organisms tested. Recent empirical and rationale approaches for antileishmanial drug targeting and development of novel drugs derived from natural products will be discussed.
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Production of Plant Derived Natural Compounds through Hairy Root Culture

Author: Sonia Malik

Publisher: Springer

ISBN: 3319697692

Category: Science

Page: 216

View: 3988

This book provides the latest information about hairy root culture and its several applications, with special emphasis on potential of hairy roots for the production of bioactive compounds. Due to high growth rate as well as biochemical and genetic stability, it is possible to study the metabolic pathways related to production of bioactive compounds using hairy root culture. Chapters discuss the feasibility of hairy roots for plant derived natural compounds. Advantages and difficulties of hairy roots for up-scaling studies in bioreactors are included as well as successful examples of hairy root culture of plant species producing bioactive compounds used in food, flavors and pharmaceutical industry. This book is a valuable resource for researchers and students working on the area of plant natural products, phytochemistry, plant tissue culture, medicines, and drug discovery.
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Natural Products Isolation

Separation Methods for Antimicrobials, Antivirals and Enzyme Inhibitors

Author: G.H. Wagman,R. Cooper

Publisher: Elsevier

ISBN: 9780080858487

Category: Science

Page: 618

View: 2566

This new book encompasses, in great detail, the most recent progress made in the isolation and separation of natural products. It covers antibiotics, marine and plant-derived substances, enzyme inhibitors and interferons. The most recent separation methodology is described. Although there is a bias toward antibiotics, it was done because this is still the largest natural products area of research. The fourteen chapters are written by experts in their respective fields. The first two chapters are largely devoted to new methodology applied to purification of a variety of compounds. They include an extensive review and new applications of counter-current chromatography and the newly emerging HPLC-photodiode array technology. Chapter 3 provides a review of affinity chromatography applied to the separation of antibiotics for the first time. Next are chapters on antimicrobials with an update on all the most recent &bgr;-lactam (after 1976) discoveries. A comprehensive review of a very important class of antiparasitic agents - the avermectins - follows. An update of isolation and purification of a variety of marine-derived compounds is next. The succeeding chapter is a comprehensive review of the most recent developments in isolation and purification of interferons. This is followed by a discussion of enzyme inhibitors and their isolation and purification and ties in with a chapter on plant-derived natural products, some of which are also in this same category. The final chapter is a futuristic essay indicating the isolation of minute amounts of natural products and the fascinating biological properties which they possess. The book has extensive isolation schemes, tables, figures and chemical structures. In many instances a short summary of the producing organism, brief chemical description and structure and biological activity of the compounds is presented. Detailed information of extraction, separation and purification techniques follow. Each chapter has an extensive bibliography and, where applicable, an appendix showing sources of materials and equipment. A detailed index to the subject matter is included at the end of the book. The book thus offers the reader: up-to-date reviews (including 1988) of specific topics in the natural products field not to be found elsewhere; information on new chromatographic methods and techniques described in sufficient detail to be utilized by investigators in this area of research; and extensive references to enable the serious researcher to pursue particular information. It will appeal to pharmaceutical and natural products researchers and is a valuable acquisition for university chemistry and biochemistry departments.
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Chemistry of Plant Natural Products

Stereochemistry, Conformation, Synthesis, Biology, and Medicine

Author: Sunil Kumar Talapatra,Bani Talapatra

Publisher: Springer

ISBN: 3642454100

Category: Science

Page: 1180

View: 1003

Aimed at advanced undergraduate and graduate students and researchers working with natural products, Professors Sunil and Bani Talapatra provide a highly accessible compilation describing all aspects of plant natural products. Beginning with a general introduction to set the context, the authors then go on to carefully detail nomenclature, occurrence, isolation, detection, structure elucidation (by both degradation and spectroscopic techniques) stereochemistry, conformation, synthesis, biosynthesis, biological activity and commercial applications of the most important natural products of plant origin. Each chapter also includes detailed references (with titles) and a list of recommended books for additional study making this outstanding treatise a useful resource for teachers of chemistry and researchers working in universities, research institutes and industry.
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Pharmacological Assays of Plant-Based Natural Products

Author: Parimelazhagan Thangaraj

Publisher: Springer

ISBN: 3319268112

Category: Medical

Page: 188

View: 2808

This volume provides information on how to select and screen plants for their medicinal properties. It describes phytopharmacological techniques for extracting and qualitatively and quantitatively analyzing a plant’s phytochemicals. After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc. Compound identification and purification techniques include, among others, TLC and column chromatography, as well as molecular docking with specific proteins.
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Natural Products from Plants, Second Edition

Author: Leland J. Cseke,Ara Kirakosyan,Peter B. Kaufman,Sara Warber,James A. Duke,Harry L. Brielmann

Publisher: CRC Press

ISBN: 1420004476

Category: Science

Page: 632

View: 6863

2008 NOMINEE The Council on Botanical and Horticultural Libraries Annual Award for a Significant Work in Botanical or Horticultural Literature From medicinal, industrial, and culinary uses to cutting-edge laboratory techniques in modern research and plant conservation strategies, Natural Products from Plants, Second Edition reveals a vastly expanded understanding of the natural products that plants produce. In a single volume, this bookoffers a thorough inventory of the various types of plant-derived compounds. It covers their chemical composition, structure, and properties alongside the most effective ways to identify, extract, analyze, and characterize new plant-derived compounds. The authors examine new information on the chemical mechanisms plants use to deter predators and pathogens, attract symbiotic organisms, and defend themselves against environmental stress—insights which are key for adapting such mechanisms to human health. Along with updated and revised information from the highly acclaimed first edition, the second edition presents seven new chapters and features more than 50% new material relating to plant constituents, natural product biochemistry, and molecular biology. The book incorporates in-depth treatment of natural product biosynthesis with new collection and extraction protocols, advanced separation and analytical techniques, up-to-date bioassays, as well as modern molecular biology and plant biotechnology for the production of natural products. Unique in its breadth and coverage, Natural Products from Plants, Second Edition belongs on the shelf of interested researchers, policymakers, and consumers— particularly those involved in disease prevention, treatment, and pharmaceutical applications—who need a complete guide to the properties, uses, and study of plant natural products.
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Biodiversity, Natural Products and Cancer Treatment

Author: Victor Kuete,Thomas Efferth

Publisher: World Scientific

ISBN: 9814583529

Category: Science

Page: 412

View: 742

This book is the first of its kind in bringing together biodiversity, chemical ecology, phytochemistry and cancer therapy. The highlight of the book is an exhaustive compilation of scientific data on biodiversity of medicinal plants, biodiversity and metagenomics, chemical ecology of medicinal plants, chemical ecology of marine organisms, natural products from terrestrial microbial organisms with activity towards cancer cells, marine organisms, ethnopharmacology and phytotherapy, contribution of African flora in world fight against cancer, natural products derived from terrestrial plants with activity towards cancer cells and established anticancer drugs from natural origin. The book discusses the state-of-the-art of each topic to serve as reference resource tools for graduate students as well as scientists and scholars in pharmaceutical sciences, pharmacology, organic chemistry and biochemistry, pharmacognosy, phytochemistry, ethnomedicine and ethnopharmacology, complementary and alternative medicine, medical and public health sciences and others. It includes cutting-edge developments in anticancer discovery from both medicinal plants and organisms. Contents:Biodiversity of Medicinal Plants (Kirsten Yacoub, Katharina Cibis and Corinna Risch)Biodiversity and Metagenomics (Eva-Maria Surmann and Thomas Efferth)Chemical Ecology of Medicinal Plants (Christian Kersten, Stephanie Lenz and Janina Wich)Chemical Ecology of Marine Organisms (André Antunes and Thomas Efferth)Natural Products from Terrestrial Microbial Organisms with Cytotoxic Cell Cycle Inhibitors (Theresa Dreis, Caroline Gartner, Julia Krebs and Mathias Schneider)Marine Compounds (Jennifer Honek and Thomas Efferth)Ethnopharmacology and Phytotherapy (Ariane Löhnert, Susanne Löhnert, Viktoriya Mogilevskaya and Sandra Schick)Contribution of African Flora in a Global Fight Against Cancer (Victor Kuete and Thomas Efferth)Natural Products Derived from Terrestrial Plants with Activity Towards Cancer Cells (Sonia Falenska, Ina Kirmes, Stephanie Kletting, Irini Karagianni and Karen Duffy)Established Anticancer Drugs from Natural Origin (Clara Becker, Kerstin Hoffmann, Laura Hoffmann, Tanya King, Franziska Faulstich, Katrin Viertel, Victor Kuete and Thomas Efferth) Readership: Graduate students and scientists in pharmaceutical sciences, pharmacology, organic chemistry, biochemistry, pharmacognosy, phytochemistry, ethnomedicine & ethnopharmacology, compementary & alternative medicine, public health. Key Features:This book is the first of its kind bringing together biodiversity, chemical ecology, phytochemistry and cancer therapyThe book provides the state-of-the-art in anticancer discovery from medicinal plantsThe book also provides the state-of-the-art in anticancer discovery from marine organismsKeywords:Biodiversity;Cancer;Marine Products;Natural Products;Established Drugs
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Natural Products

Drug Discovery and Therapeutic Medicine

Author: Lixin Zhang,Arnold L. Demain

Publisher: Springer Science & Business Media

ISBN: 1592599761

Category: Medical

Page: 386

View: 2128

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
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Discovery and Development of Antidiabetic Agents from Natural Products

Natural Product Drug Discovery

Author: Goutam Brahmachari

Publisher: Elsevier

ISBN: 0128096926

Category: Science

Page: 332

View: 5771

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab
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Lead Molecules from Natural Products

Discovery and New Trends

Author: N.A

Publisher: Elsevier

ISBN: 9780080459332

Category: Science

Page: 448

View: 7552

Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered. The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations. * Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world * Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.
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Bioactive Natural Products

Opportunities and Challenges in Medicinal Chemistry

Author: Goutam Brahmachari

Publisher: World Scientific

ISBN: 9814335371

Category: Science

Page: 670

View: 3282

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.
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Anticancer Plants: Natural Products and Biotechnological Implements

Author: Mohd Sayeed Akhtar,Mallappa Kumara Swamy

Publisher: Springer

ISBN: 981108064X

Category: Science

Page: N.A

View: 9666

This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.
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Natural Products and Drug Discovery

An Integrated Approach

Author: Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi

Publisher: Elsevier

ISBN: 0081021046

Category: Science

Page: 776

View: 7251

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
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Camptothecins New Anticancer Agents

Author: Milan Potmesil,Herbert M. Pinedo

Publisher: CRC Press

ISBN: 9780849347641

Category: Medical

Page: 158

View: 3025

This exciting new book presents the first comprehensive overview of clinical trials of camptothecins, a new class of anticancer agents. Camptothecins are synthetic and semisynthetic derivatives of a plant alkaloid that inhibit a cellular enzyme and trigger a cascade of events leading to programmed cell death. Special attention is given to the adverse effects of camptothecin treatment, as well as to prevention and control. The book boasts contributions by some of the most respected authorities in camptothecin research, who have Conducted much of the pre-clinical work which helped to renew interest in camptothecins Discovered and identified the natural product camptothecin and synthesized most of the anlogues Discovered the mechanism of camptothecin cytotoxicity
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The Benefits of Natural Products for Neurodegenerative Diseases

Author: M. Mohamed Essa,Akbar Mohammed,Gilles Guillemin

Publisher: Springer

ISBN: 3319283839

Category: Medical

Page: 496

View: 3085

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.
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