Organic Synthesis Using Transition Metals

Author: Roderick Bates

Publisher: John Wiley & Sons

ISBN: 1118313666

Category: Science

Page: 464

View: 4391

Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last two decades the subject has mushroomed - established reactions are seeing both technical improvements and increasing numbers of applications, and new reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies, and its importance is underlined by the fact that three Nobel prizes have been awarded for discoveries in this field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Edition considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis, both for pharmaceutical compounds and for natural products. It concentrates on the bond-forming reactions that set transition metal chemistry apart from "classical" organic chemistry. Each chapter is extensively referenced and provides a convenient point of entry to the research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes h3- or p-allyl -allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revised and expanded to reflect the significant improvements and advances in the field since the first edition, as well as the large number of new transition metal-catalysed processes that have come to prominence in the last 10 years – for example the extraordinary progress in coupling reactions using “designer” ligands, catalysis using gold complexes, new opportunities arising from metathesis chemistry, and C-H activation – without neglecting the well established chemistry of metals such as palladium. Organic Synthesis Using Transition Metals, 2nd Edition will find a place on the bookshelves of advanced undergraduates and postgraduates working in organic synthesis, catalysis, medicinal chemistry and drug discovery. It is also useful for practising researchers who want to refresh and enhance their knowledge of the field.
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Organic Synthesis using Transition Metals

Author: Rod Bates

Publisher: Wiley-Blackwell

ISBN: 9781841271071

Category: Science

Page: 200

View: 3548

Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last decade, the subject has mushroomed. Established reactions are seeing both technical improvements and increasing numbers of applications. New reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies. This volume considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis. It concentrates on the bond-forming reactions that set transition metal chemistry apart from "classical" organic chemistry. The book is extensively referenced and so provides a convenient point of entry to the research literature.
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Transition Metal Reagents and Catalysts

Innovations in Organic Synthesis

Author: Jiro Tsuji

Publisher: John Wiley & Sons

ISBN: 9780471560272

Category: Science

Page: 477

View: 7593

Transition Metal Reagents and Catalysts Innovations in OrganicSynthesis Jiro Tsuji Emeritus Professor, Tokyo Institute ofTechnology, Japan Numerous innovative and practical syntheticmethods using transition metal complexes as either catalysts orreagents have been developed over the last 35 years. TransitionMetal Reagents and Catalysts combines the varied applications oftransition metal complexes in a unique and timely book in thisrapidly advancing area of organic synthesis. This text is an easilyunderstandable and enjoyable read for organic chemists who are notyet familiar with organo-transition metal chemistry. TransitionMetal Reagents and Catalysts presents: * Complete coverage of nearly 35 years of transition metal complexchemistry * An in-depth treatment of many innovative syntheticmethodologies * A rational classification of all reactions according tosubstrates and reaction mechanisms * Examples of important applications of transition metal catalysedreactions. A knowledge of organic synthesis using transition metal complexesis a must for all synthetic organic chemists. Written for chemistswho wish to apply novel synthetic methods using transition metalcomplexes to solve problems in organic and pharmaceuticalchemistry, such as synthesis of fine and bulk chemicals and naturalproducts, Transition Metal Reagents and Catalysts is an essentialreference source and an indispensible research companion.
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Application of Transition Metal Catalysts in Organic Synthesis

Author: L. Brandsma,S.F. Vasilevsky,H.D. Verkruijsse

Publisher: Springer Science & Business Media

ISBN: 3642603289

Category: Science

Page: 335

View: 9962

Homogeneous catalysis is an important strategy for the synthesis of high-valued chemicals. L. Brandsma has carefully selected and checked the experimental procedures illustrating the catalytic use of copper, nickel, and palladium compounds in organic synthesis. All procedures are on a preparative scale, make economic use of solvents and catalysts, avoid toxic substances and have high yields.
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Sustainable Synthesis of Pharmaceuticals

Using Transition Metal Complexes as Catalysts

Author: Mariette M. Pereira,Mario J. F. Calvete

Publisher: Royal Society of Chemistry

ISBN: 1788010655

Category: Business & Economics

Page: 286

View: 1511

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.
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Transition Metals in the Synthesis of Complex Organic Molecules

Author: Louis S. Hegedus

Publisher: University Science Books

ISBN: 9781891389047

Category: Science

Page: 337

View: 864

This second edition offers easy access to the field of organotransition metal chemistry. The book covers the basics of transition metal chemistry, giving a practical introduction to organotransition reaction mechanisms.
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Organotransition Metal Chemistry: Applications to Organic Synthesis

Applications to Organic Synthesis

Author: S. G. Davies

Publisher: Elsevier

ISBN: 1483285847

Category: Science

Page: 430

View: 5631

Although organotransition metal chemistry has been developing rapidly over the past 20 years, it is only recently that applications of transition metal complexes to organic synthesis have started to be exploited. This unique book provides an introduction to organometallic chemistry for chemists who have little or no experience in the field, describes the work that has already been done using organotransition metal complexes for synthesis, and indicates to organic and organometallic chemists the type of synthetic problems that can be solved using organometallic compounds. It covers all major advances that have been made in this rapidly expanding area of chemistry, including not only reactions that already have well established applications for synthesis but also many recently discovered potentially useful reactions, providing a survey of recent literature.
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Advances in Transition-Metal Mediated Heterocyclic Synthesis

Author: Daniel Sole,Israel Fernandez

Publisher: Academic Press

ISBN: 9780128116517

Category: Science

Page: 366

View: 3670

Advances in Transition-Metal Mediated Heterocyclic Synthesis provides an overview of recent catalytic reactions involving transition metals to produce heterocyclic compounds. The book is organized according to the type of transformation used to achieve the synthesis of the heterocyclic systems (mainly aza- and oxa-heterocycles). As such, it covers recent applications on the synthesis of heterocycles, also describing the details of the novel transformations in a didactic manner to motivate readers in search of new catalytic processes. The editors have included state-of-the-art strategies, including transition-metal reactions involving unsaturated systems (reactions of allenes, new gold(I)-catalyzed reactions, and Prins reaction). Chapters highlight the versatility of organopalladium chemistry dealing with carbonylative transformations, C-H activation reactions, coupling processes, and the control of the ambiphilic character of organopalladium species. Finally, the book discusses new reactions leading to heterocycles based on C-H activation processes catalyzed by other metals (Rh, Ru, Co). Written by an outstanding team of authors who are leading experts in organometallic chemistry and organic synthesis, this book is a valuable resource not only for chemists mainly focused on synthesis, but also for those interested in reaction mechanisms involving transition metals. Helpfully organized by transformation type to stimulate the search for new synthetic processes Completely illustrated and written by global experts Includes thoughtfully selected strategies chosen by the editors to exemplify the state-of-the-art of the subject, including transition-metal reactions involving unsaturated systems, organopalladium chemistry, and metal-catalyzed C-H activation
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Transition Metal Organometallics in Organic Synthesis

Organic Chemistry: A Series of Monographs, Vol. 33.2

Author: Howard Alper

Publisher: Academic Press

ISBN: 148321592X

Category: Science

Page: 200

View: 9703

Transition Metal Organometallics in Organic Synthesis, Volume II covers chapters on the applications of arene and alkyne complexes, as well as cluster compounds, in organic synthesis. The book discusses the potential utility of transition metal-alkyne complexes and derived cluster compounds as reagents in organic synthesis, as well as the complexation reactions of arenes. The text also describes the oxidation, reduction, rearrangement, and other synthetically useful processes. Chemists will find the book invaluable.
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Transition Metal Catalysis in Aerobic Alcohol Oxidation

Author: Francesca Cardona,Camilla Parmeggiani

Publisher: Royal Society of Chemistry

ISBN: 1849738238

Category: Science

Page: 280

View: 7175

This book deals with the search for environmentally benign procedures for the oxidation of alcohols and gives an overview of their transition-metal-catalyzed aerobic oxidation.
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New Pathways for Organic Synthesis

Practical Applications of Transition Metals

Author: H.M. Colquhoun,J. Holton,D.J. Thompson,M.V. Twigg

Publisher: Springer Science & Business Media

ISBN: 1461326516

Category: Science

Page: 468

View: 3623

The continually growing contribution of transition metal chemistry to synthetic organic chemistry is, of course, widely recognized. Equally well known is the difficulty in keeping up-to-date with the multifarious reactions and procedures that seem to be spawned at an ever-increasing rate. These can certainly be summarized on the basis of reviews under the headings of the individual transition metals. More useful to the bench organic chemist, however, would be the opposite type of concordance based on the structural type of the desired synthetic product. This is the approach taken in the present monograph, which presents for each structural entity a conspectus of the transition metal-mediated processes that can be employed in its production. The resulting comparative survey should be a great help in devising the optimum synthetic approach for a particular goal. It is presented from an essentially practical viewpoint, with detailed direc tions interspersed in the Houben-Weyl style. The wide scope of the volume should certainly encourage synthetic organic chemists to utilize fully the range and versatility of these transition metal-mediated processes. This will certainly be a well-thumbed reference book! R. A. RAPHAEL Cambridge University v Preface In recent years an enormous amount of work has been done on the catalysis of organic reactions by various transition metal species and on the organic reactivity of organo-transition-metal compounds.
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Current Trends in Organic Synthesis

Proceedings of the Fourth International Conference on Organic Synthesis, Tokyo, Japan, 22-27 August 1982

Author: Hitosi Nozaki

Publisher: Elsevier

ISBN: 148327912X

Category: Science

Page: 442

View: 6443

Current Trends in Organic Synthesis is a collection of papers presented at the Fourth International Conference on Organic Synthesis, held in Tokyo, Japan on August 22-27, 1982. This conference brings together the significant achievements in the diversified frontier fields of organic synthesis. This book is composed of 33 chapters. The first chapters focus on the synthesis of biologically active natural compounds, including metabolites of arachidonic acid, erythromycin A, verrucarins, steroids, anthracyclines, terpenes, yeast alanine t-RNA, beta-lactam antibiotics, and palitoxin. Other chapters deal with the central problems in stereoselective and chiral synthesis, as well as processes of high degree of stereochemical control and asymmetric induction. These chapters also describe chiral pool synthesis by means of carbohydrate precursors. This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, small ring hydrogenolysis, annulene synthesis, vicarious nucleophilic substitution of aromatic hydrogen, and dichlorine monoxide mediated powerful chlorination. This book is of value to organic chemists and allied scientists.
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Transition Metal-Catalyzed Heterocycle Synthesis Via C-H Activation

Author: Xiao-Feng Wu

Publisher: John Wiley & Sons

ISBN: 3527338888

Category: Science

Page: 600

View: 1734

Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
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Transition-Metal-Mediated Aromatic Ring Construction

Author: Ken Tanaka

Publisher: John Wiley & Sons

ISBN: 111862999X

Category: Science

Page: 830

View: 2372

State-of-the-science methods, synthetic routes, and strategies to construct aromatic rings The development of new reactions for the synthesis of aromatic compounds is a highly active research area in organic synthesis, providing new functional organic materials, functional reagents, and biologically active compounds. Recently, significant advances in transition-metal-mediated reactions have enabled the efficient and practical construction of new aromatic rings with useful properties and applications. This book draws together and reviews all the latest discoveries and methods in transition-metal-mediated reactions, offering readers promising new routes to design and construct complex aromatic compounds. Integrating metal catalysis with aromatic compound synthesis, Transition-Metal-Mediated Aromatic Ring Construction offers a practical guide to the methods, synthetic routes, and strategies for constructing aromatic compounds. The book's five parts examine: [2+2+2], [2+2+1], and related cycloaddition reactions [4+2], [3+2], and related cycloaddition reactions Electrocyclization reactions Coupling and addition reactions Other important transformations, including methathesis reactions and skeletal rearrangement reactions Edited by Ken Tanaka, an internationally recognized expert in the field of transition-metal catalysis, the book features authors who are leading pioneers and researchers in synthetic reactions. Their contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience developing new aromatic compounds. All chapters end with a summary and outlook, setting forth new avenues of research and forecasting new discoveries. There are also references at the end of each chapter, guiding readers to important original research reports and reviews. In summary, Transition-Metal-Mediated Aromatic Ring Construction offers synthetic chemists a promising new avenue for the development of important new aromatic compounds with a broad range of applications.
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Design and Optimization in Organic Synthesis

Second Revised and Enlarged Edition

Author: Rolf Carlson,Johan E. Carlson

Publisher: Elsevier

ISBN: 0080455271

Category: Science

Page: 596

View: 2620

Revised, and updated Design and Optimization in Organic Synthesis presents strategies to explore experimental conditions and methodologies for systematic studies of entire reaction systems (substrates, reagent(s), catalyst(s), and solvents). Chemical phenomena are not usually the result of a single factor and this book describes how statistically designed methods can be used to analyse and evaluate synthetic procedures. The methodology is based on multivariate statistical techniques. The accompanying CD contains data tables and programmes. This book is essential reading for anyone working in process design and development in fine chemicals or the pharmaceutical industry, and is suitable for those with no experience in the field. * Contains recalculated models and redrawn figures, as well as new chapters on for example, the design of combinatorial libraries * Presents strategies to explore experimental conditions and methodologies * Enables the analysis and prediction of the best synthetic procedures
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Organotransition Metal Chemistry

Fundamental Concepts and Applications

Author: Akio Yamamoto

Publisher: Wiley-Interscience

ISBN: N.A

Category: Science

Page: 455

View: 8488

A systematic, readable treatment of organotransition metal chemistry that provides students, teachers, and practicing chemists with an understanding of basic concepts in catalysis and synthetic procedures using transition metal reagents. Covers basic principles of coordination chemistry, organometallic compounds of transition metals and non-transition metals, reactions, industrial applications, use in synthesis, methods of manipulation for air-sensitive compounds, and an overview of related topics. Well illustrated with figures and formulae.
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Organotransition Metal Chemistry

From Bonding to Catalysis

Author: John Frederick Hartwig

Publisher: Univ Science Books

ISBN: N.A

Category: Science

Page: 1127

View: 3168

Based on the classic text 'Principles and Applications of Organotransition Metal Chemistry', this book provides a comprehensive update of this vital area. It covers the most important developments in the field over the last 20 years.
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Multimetallic Catalysts in Organic Synthesis

Author: Masakatsu Shibasaki,Yoshinori Yamamoto

Publisher: John Wiley & Sons

ISBN: 3527604324

Category: Science

Page: 310

View: 4327

This first book to comprehensively cover this hot topic presents the information hitherto scattered throughout smaller reviews or single book chapters to provide an introduction to this rapidly expanding field. In ten chapters, the international team of expert authors treats asymmetric syntheses, new transformations, and organometallic reactions using homo- and hetero-bimetallic catalysts. Written for advanced researchers, this very timely publication is of significant benefit to organic and organometallic chemists in both academia and industry.
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Ionic Liquids in Synthesis

Author: Peter Wasserscheid,Thomas Welton

Publisher: John Wiley & Sons

ISBN: 3527621202

Category: Science

Page: 776

View: 5299

The second, completely revised and enlarged edition of what has become the standard reference work in this fascinating field brings together the latest developments, supplemented by numerous practical tips, providing those working in both research and industry with an indispensable source of information. New contributions have been added, to reflect the fact that industrial processes are already established, and ionic liquids are now commercially available. A must for everyone working in the field.
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Main Group Metals in Organic Synthesis

Author: Hisashi Yamamoto,Koichiro Oshima

Publisher: John Wiley & Sons

ISBN: 3527605355

Category: Science

Page: 905

View: 3436

This is the first handbook to cover in detail all aspects of this fascinating field of chemistry. In this handy two-volume set, readers will instantly find the information they need, clearly structured according to the individual metals in the main groups, hitherto only accessible after much time-consuming research. The result is in indispensable aid for everyday work in the lab. Alongside all the classical organic reactions, this book focuses on the modern variations as well as novel, current reactions in organic synthesis that are closely linked to main group elements - both stoechiometric and catalytic. With this work the two prizewinning editors have succeeded in producing a comprehensive compendium of the main group metals as reagents for organic reactions. In short, this is a must for every organic chemist, whether as an efficient introduction to current research, for retaining an overview or for looking up detailed information.
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