Author: Roderick Bates
Publisher: John Wiley & Sons
View: 1174Transition metals open up new opportunities for synthesis, becausetheir means of bonding and their reaction mechanisms differ fromthose of the elements of the s and p blocks. In the last twodecades the subject has mushroomed - established reactions areseeing both technical improvements and increasing numbers ofapplications, and new reactions are being developed. Thepracticality of the subject is demonstrated by the large number ofpublications coming from the process development laboratories ofpharmaceutical companies, and its importance is underlined by thefact that three Nobel prizes have been awarded for discoveries inthis field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Editionconsiders the ways in which transition metals, as catalysts andreagents, can be used in organic synthesis, both for pharmaceuticalcompounds and for natural products. It concentrates on thebond-forming reactions that set transition metal chemistry apartfrom "classical" organic chemistry. Each chapter isextensively referenced and provides a convenient point of entry tothe research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes spanstyle="font-family: Symbol; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"h/span3-or spanstyle="font-family: Symbol; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"p/span-allyl-allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revisedand expanded to reflect the significant improvements and advancesin the field since the first edition, as well as the large numberof new transition metal-catalysed processes that have come toprominence in the last 10 years – for example theextraordinary progress in coupling reactions using“designer” ligands, catalysis using gold complexes, newopportunities arising from metathesis chemistry, and C-H activation– without neglecting the well established chemistry of metalssuch as palladium. Organic Synthesis Using Transition Metals, 2nd Editionwill find a place on the bookshelves of advanced undergraduates andpostgraduates working in organic synthesis, catalysis, medicinalchemistry and drug discovery. It is also useful for practisingresearchers who want to refresh and enhance their knowledge of thefield.