Organic Synthesis Using Transition Metals

Author: Roderick Bates

Publisher: John Wiley & Sons

ISBN: 1118313666

Category: Science

Page: 464

View: 1174

Transition metals open up new opportunities for synthesis, becausetheir means of bonding and their reaction mechanisms differ fromthose of the elements of the s and p blocks. In the last twodecades the subject has mushroomed - established reactions areseeing both technical improvements and increasing numbers ofapplications, and new reactions are being developed. Thepracticality of the subject is demonstrated by the large number ofpublications coming from the process development laboratories ofpharmaceutical companies, and its importance is underlined by thefact that three Nobel prizes have been awarded for discoveries inthis field in the 21st Century already. Organic Synthesis Using Transition Metals, 2nd Editionconsiders the ways in which transition metals, as catalysts andreagents, can be used in organic synthesis, both for pharmaceuticalcompounds and for natural products. It concentrates on thebond-forming reactions that set transition metal chemistry apartfrom "classical" organic chemistry. Each chapter isextensively referenced and provides a convenient point of entry tothe research literature. Topics covered include: introduction to transition metals in organic synthesis coupling reactions C-H activation carbonylative coupling reactions alkene and alkyne insertion reactions electrophilic alkene and alkyne complexes reactions of alkyne complexes carbene complexes spanstyle="font-family: Symbol; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"h/span3-or spanstyle="font-family: Symbol; font-size: 10pt; mso-fareast-font-family: 'Times New Roman'; mso-bidi-font-family: Arial; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;"p/span-allyl-allyl complexes diene, dienyl and arene complexes cycloaddition and cycloisomerisation reactions For this second edition the text has been extensively revisedand expanded to reflect the significant improvements and advancesin the field since the first edition, as well as the large numberof new transition metal-catalysed processes that have come toprominence in the last 10 years – for example theextraordinary progress in coupling reactions using“designer” ligands, catalysis using gold complexes, newopportunities arising from metathesis chemistry, and C-H activation– without neglecting the well established chemistry of metalssuch as palladium. Organic Synthesis Using Transition Metals, 2nd Editionwill find a place on the bookshelves of advanced undergraduates andpostgraduates working in organic synthesis, catalysis, medicinalchemistry and drug discovery. It is also useful for practisingresearchers who want to refresh and enhance their knowledge of thefield.

Organic Synthesis using Transition Metals

Author: Rod Bates

Publisher: Wiley-Blackwell

ISBN: 9781841271071

Category: Science

Page: 200

View: 2503

Transition metals open up new opportunities for synthesis, because their means of bonding and their reaction mechanisms differ from those of the elements of the s and p blocks. In the last decade, the subject has mushroomed. Established reactions are seeing both technical improvements and increasing numbers of applications. New reactions are being developed. The practicality of the subject is demonstrated by the large number of publications coming from the process development laboratories of pharmaceutical companies. This volume considers the ways in which transition metals, as catalysts and reagents, can be used in organic synthesis. It concentrates on the bond-forming reactions that set transition metal chemistry apart from "classical" organic chemistry. The book is extensively referenced and so provides a convenient point of entry to the research literature.

Transition Metal Reagents and Catalysts

Innovations in Organic Synthesis

Author: Jiro Tsuji

Publisher: John Wiley & Sons

ISBN: 9780471560272

Category: Science

Page: 477

View: 7626

Transition Metal Reagents and Catalysts Innovations in OrganicSynthesis Jiro Tsuji Emeritus Professor, Tokyo Institute ofTechnology, Japan Numerous innovative and practical syntheticmethods using transition metal complexes as either catalysts orreagents have been developed over the last 35 years. TransitionMetal Reagents and Catalysts combines the varied applications oftransition metal complexes in a unique and timely book in thisrapidly advancing area of organic synthesis. This text is an easilyunderstandable and enjoyable read for organic chemists who are notyet familiar with organo-transition metal chemistry. TransitionMetal Reagents and Catalysts presents: * Complete coverage of nearly 35 years of transition metal complexchemistry * An in-depth treatment of many innovative syntheticmethodologies * A rational classification of all reactions according tosubstrates and reaction mechanisms * Examples of important applications of transition metal catalysedreactions. A knowledge of organic synthesis using transition metal complexesis a must for all synthetic organic chemists. Written for chemistswho wish to apply novel synthetic methods using transition metalcomplexes to solve problems in organic and pharmaceuticalchemistry, such as synthesis of fine and bulk chemicals and naturalproducts, Transition Metal Reagents and Catalysts is an essentialreference source and an indispensible research companion.

Organotransition Metal Chemistry: Applications to Organic Synthesis

Applications to Organic Synthesis

Author: S. G. Davies

Publisher: Elsevier

ISBN: 1483285847

Category: Science

Page: 430

View: 2689

Although organotransition metal chemistry has been developing rapidly over the past 20 years, it is only recently that applications of transition metal complexes to organic synthesis have started to be exploited. This unique book provides an introduction to organometallic chemistry for chemists who have little or no experience in the field, describes the work that has already been done using organotransition metal complexes for synthesis, and indicates to organic and organometallic chemists the type of synthetic problems that can be solved using organometallic compounds. It covers all major advances that have been made in this rapidly expanding area of chemistry, including not only reactions that already have well established applications for synthesis but also many recently discovered potentially useful reactions, providing a survey of recent literature.

New Pathways for Organic Synthesis

Practical Applications of Transition Metals

Author: H.M. Colquhoun,J. Holton,D.J. Thompson,M.V. Twigg

Publisher: Springer Science & Business Media

ISBN: 1461326516

Category: Science

Page: 468

View: 8628

The continually growing contribution of transition metal chemistry to synthetic organic chemistry is, of course, widely recognized. Equally well known is the difficulty in keeping up-to-date with the multifarious reactions and procedures that seem to be spawned at an ever-increasing rate. These can certainly be summarized on the basis of reviews under the headings of the individual transition metals. More useful to the bench organic chemist, however, would be the opposite type of concordance based on the structural type of the desired synthetic product. This is the approach taken in the present monograph, which presents for each structural entity a conspectus of the transition metal-mediated processes that can be employed in its production. The resulting comparative survey should be a great help in devising the optimum synthetic approach for a particular goal. It is presented from an essentially practical viewpoint, with detailed direc tions interspersed in the Houben-Weyl style. The wide scope of the volume should certainly encourage synthetic organic chemists to utilize fully the range and versatility of these transition metal-mediated processes. This will certainly be a well-thumbed reference book! R. A. RAPHAEL Cambridge University v Preface In recent years an enormous amount of work has been done on the catalysis of organic reactions by various transition metal species and on the organic reactivity of organo-transition-metal compounds.

Annual Reports in Organic Synthesis 1993


Author: Philip M. Weintraub

Publisher: Elsevier

ISBN: 0080916236

Category: Science

Page: 546

View: 8956

This handy reference tool is an organized annual review of synthetically useful information. It abstracts synthetic reactions from the major chemistry journals of the past year and includes all reactions and methodsthat are new and reasonably general. The reactions are presented in a convenient pictorial format designed for rapid visual retrieval of information. The Journal of the American Chemical Society has aptly described this publication as an"aid to the harassed organic chemist who cannot keep up with the never-diminishing stream of new primary literature"and hails it"an outstandingly good buy." Clearly illustrated structures of compounds in every feasible syntheticpathway A general review of structure/activity information for each synthetic compound Extensive reference information provided for additional publications available for each reactiondiscussed

Grundlagen der metallorganischen Komplexkatalyse

Author: Dirk Steinborn

Publisher: Springer-Verlag

ISBN: 3834893757

Category: Science

Page: 434

View: 5359

Die Katalyse ist als grundlegendes Prinzip zur Überwindung der kinetischen Hemmung chemischer Reaktionen von fundamentaler Bedeutung in der Chemie und die metallorganische Komplexkatalyse ist ein Eckpfeiler der modernen Chemie. Das trifft gleichermaßen für die Grundlagen- und angewandte Forschung wie für industrielle Anwendungen zu. Ausgehend von den Prinzipien der Katalyse und den katalytisch relevanten metallorganischen Elementarschritten werden wichtige metallkomplexkatalysierte Reaktionen behandelt, wobei das mechanistische Verständnis im Vordergrund steht. Besonderer Wert wird dabei auf aktuelle Entwicklungen gelegt. Asymmetrische Synthesen finden ausführlich Berücksichtigung und an ausgewählten Beispielen wird die katalytische Wirkung von Metalloenzymen aufgezeigt. Am Beispiel der Stickstofffixierung werden die drei großen Gebiete der Katalyse – die homogene, die heterogene und die enzymatische Katalyse – vergleichend betrachtet. In der 2. Auflage ist ein neues Kapitel zur Stickstofffixierung hinzugekommen. In diesem werden vergleichend die heterogen katalysierte Reaktion, die enzymatisch katalysierte Reaktion (Nitrogenasen) sowie die homogen katalysierte Reaktion gegenübergestellt.

Metallorganische Chemie

Author: Norbert Krause

Publisher: N.A

ISBN: 9783865413093

Category: Metallorganische Verbindungen - Organische Synthese - Lehrbuch

Page: 242

View: 2986


Transition metals for organic synthesis

building blocks and fine chemicals

Author: Matthias Beller,Carsten Bolm

Publisher: N.A

ISBN: 9783527295012

Category: Science

Page: 467

View: 5331

The application of transition metals in organic synthesis, be it as catalysts or mediators, is one of the most interesting interdisciplinary topics in chemistry. The enormous breadth of transition metals in both research and industry is comprehensively covered by the team of over 70 international experts assembeled for this two-volume set. The title presents the current state of research and application in the economically and scientifically important area of transition metals for organic synthesis and fine chemicals production. The title's high quality contributors, over 1000 figures, well-balanced presentation, and excellent indices all combine to allow the reader easy access to the thorough and topical compilation of the use of transition metals in organic chemistry. The two-volume set 'Transition Metals for Fine Chemicals and Organic Synthesis' is an indispensable tool for everyone working in academic or industrial application of transition metals in chemistry.

Innovative Catalysis in Organic Synthesis

Oxidation, Hydrogenation, and C-X Bond Forming Reactions

Author: Pher G. Andersson

Publisher: John Wiley & Sons

ISBN: 3527330976

Category: Science

Page: 356

View: 1245

C-H, C-O, C-C, and C-Heteroatom bond forming processes by using metal-ligand approaches for the synthesis of organic compounds of biological, pharmacological and organic nanotechnological utility are the key areas addressed in this book. Authored by a European team of leaders in the field, it brings together innovative approaches for a variety of catalysis reactions and processes frequently applied in organic synthesis into a handy reference work. It covers all major types of catalysis, including homogeneous, heterogeneous, and organocatalysis, as well as mechanistic and computational studies. Special attention is paid to the improvements in efficiency and sustainability of important catalytic processes, such as selective oxidations, hydrogenation, and cross-coupling reactions, and to their utilization in industry. The result is a valuable resource for advanced researchers in both academia and industry, as well as graduate students in organic chemistry aiming for chemo-, regio- or stereoselective synthesis of organic compounds by using novel catalytic systems.

Sustainable Synthesis of Pharmaceuticals

Using Transition Metal Complexes as Catalysts

Author: Mariette M. Pereira,Mario J. F. Calvete

Publisher: Royal Society of Chemistry

ISBN: 1788010655

Category: Business & Economics

Page: 286

View: 1559

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.

TRANSITION METALS IN ORGANIC SYNTHESIS. A pratical approach, édition en anglais

Author: Susan E. Gibson

Publisher: Oxford University Press on Demand


Category: Science

Page: 234

View: 9988

This volume is designed to disseminate practical expertise in this important and demanding area of chemistry to undergraduate and postgraduate students in universities and to researchers working in the chemical industry. The authors have considerable practical and teaching experience in the areas they cover. Topics include transition metal-promoted oxidations, palladium-catalysed carbon-carbon bond formation, ferrocene chemistry, applications of organoiron complexes in organic synthesis, applications of titanocene and zirconocene complexes in organic synthesis and arene chromium tricarbonyl chemistry.

Angewandte homogene Katalyse

Author: Arno Behr

Publisher: Wiley-VCH Verlag GmbH

ISBN: 9783527316663

Category: Catalysis

Page: 837

View: 5309

Die homogene Übergangsmetallkatalyse ist noch eine noch junge Wissenschaft, hat aber bereits zahlreiche großindustrielle Anwendungen gefunden. Langkettige Olefine, Essigsäure, Adipodinitril und Aldehyde werden heute überwiegend homogen-katalytisch hergestellt. Die Stärke der homogenen Katalyse liegt aber insbesondere bei der Synthese von Pharma- und Feinchemikalien, wo wenige Syntheseschritte eine lange Anfolge von Stufenreaktionen überflüssig machen. Dieses Buch gibt einen kompakten Überblick über die Prinzipien und Reaktionsmöglichkeiten der Homogenkatalyse, verdeutlicht an ausgesuchten Einzelbeispielen. Studierende, Chemiker und Ingenieure können dieses Buch zum ausführlichen Studium oder als Nachschlagewerk nutzen.

Encyclopedia of Inorganic Chemistry

Author: R. Bruce King

Publisher: Wiley


Category: Science

Page: 6696

View: 1792

The ultimate resource on inorganic chemistry – new and completely revised, 10 years after publication of the First Edition The first edition of the Encyclopedia of Inorganic Chemistry treated the elements of the periodic system in alphabetical order, with multiple entries for key elements. The articles from the First Edition were written more than 10 years ago and all areas of inorganic chemistry have seen such a vigorous development that it was necessary to update most articles and to add a considerable number of new articles. The result of this major work is the proud Encylopedia of Inorganic Chemistry Second Edition (EIC-2). New – now includes colour 30% growth on previous edition – now 6,640 pages, published in 10 volumes EIC-2 continues to present articles in alphabetical order, but the content has been slightly reorganized to the following subject areas: Main Group Elements; Transition Metals and Coordination Chemistry; Organometallic Chemistry; Bioinorganic Chemistry; Solid State, Materials, Nanomaterials and Catalysis; and General Inorganic Chemistry, Theoretical and Computational Methods.

Organotransition Metal Chemistry

Fundamental Concepts and Applications

Author: Akio Yamamoto

Publisher: Wiley-Interscience


Category: Science

Page: 455

View: 7493

A systematic, readable treatment of organotransition metal chemistry that provides students, teachers, and practicing chemists with an understanding of basic concepts in catalysis and synthetic procedures using transition metal reagents. Covers basic principles of coordination chemistry, organometallic compounds of transition metals and non-transition metals, reactions, industrial applications, use in synthesis, methods of manipulation for air-sensitive compounds, and an overview of related topics. Well illustrated with figures and formulae.

Transition Metal Arene P-Complexes in Organic Synthesis and Catalysis

Author: Peter E. Kündig,A. Böttcher

Publisher: Springer Science & Business Media

ISBN: 9783540016045

Category: Science

Page: 232

View: 4170

Metal-arene p-complexes show a rich and varied chemistry. The metal adds a third dimension to the planar aromatic compounds and coordination of a metal to an arene thus not only altering the reactivity of ring-carbons and substituents but also makes possible reactions that lead to chiral non-racemic products. This book, organized in nine chapters and written by leading scientists in the field provides the reader with an up-to-date treatise on the subject organized according to reaction type and use. It covers the wide spectrum of arene activation: from the electrophilic activation of h6-bound areneï⿬ by p-Lewis acid metal complex fragments, to reactions of nucleophilic h2-coordinated arene complexes. The preparation of complexes is detailed, as are the scope, limitations and challenges of reactions in contemporary p-arene metal chemistry with special attention given to asymmetric transformations. The emphasis of the book is on transformations of interest to organic synthesis and on the use of the complexes as catalysts or as chiral ligands. The book is written for academic and industrial researchers in organic, organometallic, and inorganic chemistry as well as for advanced chemistry students

Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules

The Shape of Organic Synthesis to Come

Author: Yuichi Kobayashi

Publisher: Springer

ISBN: 9789811362439

Category: Science

Page: N.A

View: 9715

This book describes cutting-edge organic syntheses of biologically active compounds, isolation of pharmaceutically promising compounds from microorganisms, drug design, and progress on chemical biology. Synthetic strategy and tactics are summarized for super-carbon chain compounds, antitumor polycycles, aryl C-glycoside, antimycins, duocarmycins, cannabinoids, and other compounds. Special chapters are devoted to synthesis and biochemistry of fatty acid metabolites, which play a central role in the initiation and resolution of inflammation. The book provides a quick survey of trending topics in organic synthesis and chemical tools for biological investigation, and furnishes ideas for future research in organic synthesis. In addition, the contents can easily be understood by young chemists, graduate students, and those who are looking for new research based on organic chemistry.