Modern Rhodium-Catalyzed Organic Reactions

Author: P. Andrew Evans

Publisher: John Wiley & Sons

ISBN: 352760409X

Category: Science

Page: 496

View: 6151

Rhodium has proven to be an extremely useful metal due to its ability to catalyze an array of synthetic transformations, with quite often-unique selectivity. Hydrogenation, C-H activation, allylic substitution, and numerous other reactions are catalyzed by this metal, which presumably accounts for the dramatic increase in the number of articles that have recently emerged on the topic. P. Andrew Evans, the editor of this much-needed book, has assembled an internationally renowned team to present the first comprehensive coverage of this important area. The book features contributions from leaders in the field of rhodium-catalyzed reactions, and thereby provides a detailed account of the most current developments, including: Rhodium-Catalyzed Asymmetric Hydrogenation (Zhang) Rhodium-Catalyzed Hydroborations and Related Reactions (Brown) Rhodium-Catalyzed Asymmetric Addition of Organometallic Reagents to Electron Deficient Olefins (Hayashi) Recent Advances in Rhodium(I)-Catalyzed Asymmetric Olefin Isomerization and Hydroacylation Reactions (Fu) Stereoselective Rhodium(I)-Catalyzed Hydroformylation and Silylformylation Reactions and Their Application to Organic Synthesis (Leighton) Carbon-Carbon Bond-Forming Reactions Starting from Rh-H or Rh-Si Species (Matsuda) Rhodium(I)-Catalyzed Cycloisomerization and Cyclotrimerization Reactions (Ojima) The Rhodium(I)-Catalyzed Alder-ene Reaction (Brummond) Rhodium-Catalyzed Nucleophilic Ring Cleaving Reactions of Allylic Ethers and Amines (Fagnou) Rhodium(I)-Catalyzed Allylic Substitution Reactions and their Applications to Target Directed Synthesis (Evans) Rhodium(I)-Catalyzed [2+2+1] and [4+1] Carbocyclization Reactions (Jeong) Rhodium(I)-Catalyzed [4+2] and [4+2+2] Carbocyclizations (Robinson) Rhodium(I)-Catalyzed [5+2], [6+2], and [5+2+1] Cycloadditions: New Reactions for Organic Synthesis (Wender) Rhodium(II)-Stabilized Carbenoids Containing both Donor and Acceptor Substituents (Davies) Chiral Dirhodium(II)Carboxamidates for Asymmetric Cyclopropanation and Carbon-Hydrogen Insertion Reactions (Doyle) Cyclopentane Construction by Rhodium(II)-Mediated Intramolecular C-H Insertion (Taber) Rhodium(II)-Catalyzed Oxidative Amination (DuBois) Rearrangement Processes of Oxonium and Ammonium Ylides Formed by Rhodium(II)-Catalyzed Carbene-Transfer (West) Rhodium(II)-Catalyzed 1,3-Dipolar Cycloaddition Reactions (Austin) "Modern Rhodium-Catalyzed Organic Reactions" is an essential reference text for researchers at all levels in the general area of organic chemistry. This book provides an invaluable overview of the most significant developments in this important area of research, and will no doubt be an essential text for researchers at academic institutions and professionals at pharmaceutical/agrochemical companies.
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Stereoselective Multiple Bond-Forming Transformations in Organic Synthesis

Author: Jean Rodriguez,Damien Bonne

Publisher: John Wiley & Sons

ISBN: 1119006422

Category: Science

Page: 480

View: 8785

Combining the important research topic of multiple bond-forming transformations with green chemistry, this book helps chemists identify recent sustainable stereoselective synthetic sequences. • Combines the important research topic of multiple bond-forming transformations with green chemistry and sustainable development • Offers a valuable resource for preparing compounds with multiple stereogenic centers, an important field for synthetic chemists • Organizes chapters by molecular structure of final products, making for a handbook-style resource • Discusses applications of the synthesis of natural products and of drug intermediates • Brings together otherwise-scattered information about a number of key, efficient chemical reactions
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Handbook of Green Chemistry, Green Catalysis, Homogeneous Catalysis

Author: N.A

Publisher: John Wiley & Sons

ISBN: 3527688668

Category: Science

Page: 431

View: 4796

The shift towards being as environmentally-friendly as possible has resulted in the need for this important volume on homogeneous catalysis. Edited by the father and pioneer of Green Chemistry, Professor Paul Anastas, and by the renowned chemist, Professor Robert Crabtree, this volume covers many different aspects, from industrial applications to atom economy. It explains the fundamentals and makes use of everyday examples to elucidate this vitally important field. An essential collection for anyone wishing to gain an understanding of the world of green chemistry, as well as for chemists, environmental agencies and chemical engineers. The Handbook of Green Chemistry comprises of 9 volumes in total, split into 3 subject-specific sets. The three sets are available individually. All 9 volumes are available individually, too. Set I: Green Catalysis - Volume 1: Homogeneous Catalysis - Volume 2: Heterogeneous Catalysis - Volume 3: Biocatalysis Set II: Green Solvents - Volume 4: Supercritical Solvents - Volume 5: Reactions in Water - Volume 6: Ionic Liquids Set III: Green Processes - Volume 7: Green Synthesis - Volume 8: Green Nanoscience - Volume 9: Designing Safer Chemicals The Handbook of Green Chemistry is also available as Online Edition. Podcasts Listen to two podcasts in which Professor Paul Anastas and Journals Editor Paul Trevorrow discuss the origin and expansion of Green Chemistry and give an overview of The Handbook of Green Chemistry.
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Catalytic Asymmetric Conjugate Reactions

Author: Armando Cordova

Publisher: John Wiley & Sons

ISBN: 9783527632091

Category: Science

Page: 464

View: 6003

This unique and long-awaited handbook on this important topic in the hot field of stereoselective organic synthesis covers several types of nucleophiles. Top international authors deal with modern forms of achieving stereoselective conjugate additions based on the use of chiral auxiliaries or asymmetric catalysis, such as P-N ligands, organocatalysis, domino reactions, Lewis acid and base catalysis. There is also a discussion of the employment of enantioselective conjugate addition transformations in total synthesis of important molecules. With its reliable and previously unpublished experimental procedures, this is a true source of high quality information.
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Science of Synthesis: Houben-Weyl Methods of Molecular Transformations Vol. 40a

Amines and Ammonium Salts

Author: N.A

Publisher: Georg Thieme Verlag

ISBN: 3131783613

Category: Science

Page: 844

View: 7803

Science of Synthesis provides a critical review of the synthetic methodology developed from the early 1800s to date for the entire field of organic and organometallic chemistry. As the only resource providing full-text descriptions of organic transformations and synthetic methods as well as experimental procedures, Science of Synthesis is therefore a unique chemical information tool. Over 1000 world-renowned experts have chosen the most important molecular transformations for a class of organic compounds and elaborated on their scope and limitations. The systematic, logical and consistent organization of the synthetic methods for each functional group enables users to quickly find out which methods are useful for a particular synthesis and which are not. Effective and practical experimental procedures can be implemented quickly and easily in the lab.// The content of this e-book was originally published in November 2008.
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Rhodium-catalyzed C-H amination

mechanistic insights and application to new reaction development

Author: Kristin Williams Fiori,Stanford University,Stanford University. Dept. of Chemistry

Publisher: ProQuest

ISBN: N.A

Category:

Page: 383

View: 908

These valuable insights enabled the development of two robust and important new methods. First, a method was developed to selectively aminate alpha-ethereal C-H bonds, forming N,O-acetals that can be coupled to a variety of nucleophiles. Second, an intermolecular version of the sulfamate insertion reaction was developed to provide access to benzylic amines in one step. The mechanism of this intermolecular C-H amination reaction was investigated and as with the intermolecular reaction, a nitrenoid species was implicated as the active oxidant. Analytical work also uncovered a competing radical-based pathway that leads to catalyst decomposition and undesired side products. It is anticipated that further improvements in catalyst design, coupled with these new mechanistic insights, will enable the continued development of highly efficient and robust C-H oxidation processes.
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Metallorganische Chemie

Author: Norbert Krause

Publisher: N.A

ISBN: 9783865413093

Category: Metallorganische Verbindungen - Organische Synthese - Lehrbuch

Page: 242

View: 8728

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The development of a method for rhodium-catalyzed olefin aziridination and its application to synthesis of the welwitindolinones

Author: Kiran Guthikonda,Stanford University,Stanford University. Dept. of Chemistry

Publisher: ProQuest

ISBN: N.A

Category:

Page: 297

View: 2480

The development of a method for the aziridination of alkenes with Rh(II) dimer catalysts is described. Olefin aziridination is a powerful means of introducing amine functionality into organic substrates, but has only recently found use in organic synthesis. The method described enables the efficient catalytic synthesis of a variety of aziridine products using a novel nitrogen source, 2,2,2-trichloroethylsulfamate (TcesNH2). The utility of these products is displayed through ring-opening reactions of bicyclic aziridines and trichloroethoxysulfonyl (Tces)-protected aziridines. A new application of oxidative aziridine ring opening with Me2SO generates protected alpha-amino ketone products from Tces-aziridines.
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Handbook of Reagents for Organic Synthesis, Catalyst Components for Coupling Reactions

Author: Gary A. Molander

Publisher: John Wiley & Sons Incorporated

ISBN: N.A

Category: Science

Page: 690

View: 2173

The long awaited Handbook for all synthetic chemists working on coupling reactions, compiling all major catalyst components in use in the area. Consists of a compilation of articles taken from the EROS database, with the inclusion of about 20 newly commissioned catalysts/pre-catalysts/ligands that have made an impact in this area of synthetic organic chemistry. Includes catalyst systems used in Heck, Kumada-Tamao-Corriu, Suzuki-Miyaura, Hiyama-Hatanaka, Negishi, Migita-Kosugi-Stille, Buchwald-Hartwig, and Tsuji-Trost coupling reactions.
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Handbook of Reagents for Organic Synthesis, Chiral Reagents for Asymmetric Synthesis

Author: Leo A. Paquette

Publisher: Wiley

ISBN: 9780470856253

Category: Science

Page: 582

View: 2143

Derived from the renowned, Encyclopedia of Reagents for Organic Synthesis (EROS), the related editors have created a new handbook which focuses on chiral reagents used in asymmetric synthesis and is designed for the chemist at the bench. This new handbook follows the same format as the Encyclopedia, including an introduction and an alphabetical arrangement of the reagents. As chiral reagents are the key for the successful asymmetric synthesis, choosing the right reagents is essential, in this handy reference the editors give details on how to prepare, store and use the reagents as well as providing key reactions to demonstrate where reagents have been successfully used. Comprehensive information on 226 reagents Covers 64 reagents which were not included in EROS All information in one easy to use volume – at an affordable price All reagents included will be added to e-EROS – please visit the site where you can gain access to over 50,000 reactions and 3,800 of the most frequently consulted reagents. Visit: www.interscience.wiley.com/eros
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Science of Synthesis: Metal-Catalyzed Cyclization Reactions

Author: Shengming Ma,Shuanhu Gao

Publisher: Georg Thieme Verlag

ISBN: 3131998415

Category: Science

Page: 766

View: 5221

Significant advances in metal-catalyzed reactions, especially cyclizations, have dramatically improved the efficiency of organic synthesis over the last three decades. To date these transformations are widely used in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: Metal-Catalyzed Cyclization Reactions" presents the most commonly used and significant metal-catalyzed reactions for modern organic synthesis. The basic principles, the current state of the art, scope, limitations, and mechanism of these reactions are also discussed. Typical examples of target synthesis are provided to help inspire further applications. Volume 2 covers epoxidations, aziridinations, cyclopropanations, and Pauson-Khand reactions, as well as a wide range of cycloaddition processes, radical cyclizations, and ring-closing metathesis.
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Advanced organic chemistry

Author: Francis A. Carey,Richard J. Sundberg

Publisher: John Wiley & Sons

ISBN: 9783527292172

Category: Science

Page: 1635

View: 9333

Endlich gibt es ein weiterführendes Lehrbuch der Organischen Chemie in deutscher Sprache! Es wird die Studenten auf den Gebieten Reaktionsmechanismen, Stereochemie und insbesondere Organische Synthese bis zum Diplom begleiten, und darüber hinaus ist es ein äußerst nützliches Nachschlagewerk auch für Diplomanden und Doktoranden. Die deutsche Ausgabe wurde gegenüber dem Original nochmals erweitert und aktualisiert. Erste Dozentenstimmen: 'Die erste deutsche Ausgabe des Carey/Sundberg erfüllt alle Erwartungen an ein modernes Lehrbuch der Organischen Chemie.' - 'Es ist zur Zeit das beste Lehrbuch der Organischen Chemie und unentbehrlich für fortgeschrittene Studenten, Diplomanden und Doktoranden.' - 'Endlich! Ich empfehle dieses Buch bereits seit Jahren fortgeschrittenen Studenten.' - 'Es ist bezeichnend, daß es immer besonders motivierte und leistungsstarke Studenten waren, die mich fragten, ob ich ihnen den Carey/Sundberg empfehlen kann. Ich kann es.' - 'Endlich wird es ein ausgewogenes Lehrbuch zur Organischen Chemie für Fortgeschrittene in deutscher Sprache geben. Die Kompetenz der Herausgeber bürgt für hohen Standard.'
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Phosphorus Ligands in Asymmetric Catalysis

Synthesis and Applications

Author: Armin Börner

Publisher: Wiley-VCH

ISBN: 9783527317462

Category: Science

Page: 1546

View: 941

With its list of contributors reading like a who's who, this is the ultimate standard reference on phosphorus in catalysis. Clearly divided into substance classes and spanning three volumes, it provides readers with an excellent introduction to the multitude of applications, backed by examples of optimal solutions. A definite must-have for all chemists working in synthetic chemistry, ranging from natural product synthesis to the production of pharmaceuticals.
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Cyclophan-Chemie

Synthesen, Strukturen, Reaktionen. Einführung und Überblick

Author: N.A

Publisher: Springer-Verlag

ISBN: 3322927881

Category: Technology & Engineering

Page: 593

View: 2299

Der Autor versucht, die Vielfalt der Strukturen und Daten so zu ordnen, daß bestimmte Molekülgruppen gut aufzufinden sind. Mancher Abschnitt wurde zum ersten Mal in dieser Form zusammengestellt oder erscheint erstmals in deutscher Sprache.
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Asymmetric synthesis and application of [alpha]-amino acids

Author: V. A. Soloshonok,Kunisuke Izawa,American Chemical Society. Meeting,American Chemical Society. Division of Organic Chemistry,American Chemical Society. Division of Medicinal Chemistry

Publisher: Oxford University Press, USA

ISBN: 9780841269743

Category: Language Arts & Disciplines

Page: 490

View: 5771

"This book is derived from the ACS Symposium Asymmetric Synthesis of a-Amino-Acids. Novel Developments and Future Directions, as part of the 233rd American Chemical Society (ACS) National Meeting, March 25-29, 2007, Chicago, Illinois"--p. xii.
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