MALDI-TOF and Tandem MS for Clinical Microbiology

Author: Haroun N. Shah,Saheer E. Gharbia

Publisher: John Wiley & Sons

ISBN: 1118960254

Category: MEDICAL

Page: 648

View: 3887

This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry

Stupor Mundi

Das Staunen der Welt

Author: Néjib

Publisher: N.A

ISBN: 9783946337348


Page: 288

View: 2175


Nach dem Seitensprung

Wie Sie den Schmerz bewältigen, Selbstvertrauen zurückgewinnen und die richtigen Entscheidungen treffen

Author: Janis Abrahms Spring

Publisher: MVG Verlag

ISBN: 3864159539

Category: Self-Help

Page: 336

View: 8072

Untreue des Partners ist für viele der schwerste Vertrauensbruch in einer Beziehung. In den meisten Fällen löst der Seitensprung eine Krise aus, die die Beziehung gefährdet und schlimmstenfalls zur Trennung führt. Dieser Ratgeber hilft dabei, den Treuebruch emotional zu bewältigen, die Gründe zu verstehen und sich über die eigenen Vorstellungen von Liebe und Partnerschaft bewusst zu werden. Außerdem werden Wege aufgezeigt, wie die Beziehung nach sorgfältiger Verarbeitung und offener Thematisierung des Seitensprungs vertrauensvoll wieder aufgebaut werden kann. Die erfahrene Psychologin und Paartherapeutin Dr. Janis Abrahams Spring richtet sich mit ihrem Buch nicht nur an Menschen, die betrogen wurden, sondern auch an diejenigen, die selbst fremdgegangen sind, aber in ihre bestehende Partnerschaft zurückkehren möchten. Sie thematisiert grundlegende dysfunktionale Denk- und Verhaltensmuster in Beziehungen und legt offen, was eine funktionierende und bewusste Partnerschaft ausmacht.


Fragen und Antworten

Author: Lewis C. Epstein

Publisher: N.A

ISBN: 9783423346825

Category: Physik - Aufgabensammlung

Page: 579

View: 1155


Mass Spectrometry for Microbial Proteomics

Author: Haroun N. Shah,Saheer E. Gharbia

Publisher: John Wiley & Sons

ISBN: 9781119991922

Category: Science

Page: 534

View: 5346

New advances in proteomics, driven largely by developments in mass spectrometry, continue to reveal the complexity and diversity of pathogenic mechanisms among microbes that underpin infectious diseases. Therefore a new era in medical microbiology is demanding a rapid transition from current procedures to high throughput analytical systems for the diagnosis of microbial pathogens. This book covers the broad microbiological applications of proteomics and mass spectrometry. It is divided into six sections that follow the general progression in which most microbiology laboratories are approaching the subject –Transition, Tools, Preparation, Profiling by Patterns, Target Proteins, and Data Analysis.

Issues in Life Sciences—Muscle, Membrane, and General Microbiology: 2013 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1490110097

Category: Science

Page: 1202

View: 7286

Issues in Life Sciences—Muscle, Membrane, and General Microbiology: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Membrane Biology. The editors have built Issues in Life Sciences—Muscle, Membrane, and General Microbiology: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Membrane Biology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences—Muscle, Membrane, and General Microbiology: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Clinical Pathology, An Issue of the Clinics in Laboratory Medicine E-Book

Author: Geza S Bodor

Publisher: Elsevier Health Sciences

ISBN: 0323641040

Category: Medical

Page: N.A

View: 1129

This issue of Clinics in Laboratory Medicine will focus on Clinical Pathology and is edited by Geza S. Bodor. Topics include, but are not limited to, Steroid measurement / Salivary cortisol measurement, Protein testing by LCMSMS, LCMSMS in the Clinical Laboratory, Laboratory Standards for Clinical LCMSMS, The need to teach LCMSMS to clinical laboratory scientists, MALDI-TOF in the clinical laboratory, MALDI TOF MS in the clinical microbiology laboratory, LCMSMS method development consideration in clinical laboratory practice, Cancer diagnosis using mass spectrometry, Adulteration and LCMSMS drug testing, Diagnosis of inherited metabolic disorders using LCMSMS, Harmonization of LCMSMS protein assays, Vitamin D testing by LCMSMS versus by immunoassay, Pain management testing by LCMSMS, and Development of FDA approved clinical mass spectrometer.

Interpretation von Massenspektren

Author: Fred W. McLafferty,Frantisek Turecek

Publisher: Springer Spektrum

ISBN: 9783642398483

Category: Science

Page: 385

View: 2991

Die Interpretation von Massenspektren erlernt man am besten durch Praxis. Mit dieser Überzeugung hat McLafferty die Originalausgabe dieses Buches in mehrere erfolgreiche Auflagen geführt. Schritt für Schritt, anhand zahlreicher Beispiele, führt er den Leser zum Verständnis von Massenspektren und Massenspektrometrie. So schafft dieses Buch die Grundlage für das Verständnis und die optimale Nutzung einer Methode, die als eine der wichtigsten in der analytischen Chemie gilt.

Applications of Mass Spectrometry in Microbiology

From Strain Characterization to Rapid Screening for Antibiotic Resistance

Author: Plamen Demirev,Todd R. Sandrin

Publisher: Springer

ISBN: 3319260707

Category: Science

Page: 336

View: 6081

In the last quarter century, advances in mass spectrometry (MS) have been at the forefront of efforts to map complex biological systems including the human metabolome, proteome, and microbiome. All of these developments have allowed MS to become a well-established molecular level technology for microorganism characterization. MS has demonstrated its considerable advantage as a rapid, accurate, and cost-effective method for microorganism identification, compared to conventional phenotypic techniques. In the last several years, applications of MS for microorganism characterization in research, clinical microbiology, counter-bioterrorism, food safety, and environmental monitoring have been documented in thousands of publications. Regulatory bodies in Europe, the US, and elsewhere have approved MS-based assays for infectious disease diagnostics. As of mid-2015, more than 3300 commercial MS systems for microorganism identification have been deployed worldwide in hospitals and clinical labs. While previous work has covered broader approaches in using MS to characterize microorganisms at the species level or above, this book focuses on strain-level and subtyping applications. In twelve individual chapters, innovators, leaders and practitioners in the field from around the world have contributed to a comprehensive overview of current and next-generation approaches for MS-based microbial characterization at the subspecies and strain levels. Chapters include up-to-date reference lists as well as web-links to databases, recommended software, and other useful tools. The emergence of new, antibiotic-resistant strains of human or animal pathogens is of extraordinary concern not only to the scientific and medical communities, but to the general public as well. Developments of novel MS-based assays for rapid identification of strains of antibiotic-resistant microorganisms are reviewed in the book as well. Microbiologists, bioanalytical scientists, infectious disease specialists, clinical laboratory and public health practitioners as well as researchers in universities, hospitals, government labs, and the pharmaceutical and biotechnology industries will find this book to be a timely and valuable resource.


Ein Lehrbuch

Author: Jürgen H Gross

Publisher: Springer-Verlag

ISBN: 3827429811

Category: Science

Page: 802

View: 3498

Mit Massenspektrometrie – ein Lehrbuch liegt ein Werk vor, das mit seiner umfassenden, präzisen Darstellung sowie seinen vielen gelungenen Illustrationen und Fotos eine Lücke auf dem deutschsprachigen Markt schließt. Dieses im englischsprachigen Raum bereits gut etablierte Buch führt auf grundlegende Weise an die Massenspektrometrie heran, indem es die Prinzipien, Methoden und Anwendungen logisch aufeinander aufbauend erklärt. Schritt für Schritt lernt der Leser, was diese analytische Methode leisten kann, auf welch vielfältige Art Massenspektrometer isolierte Ionen in der Gasphase erzeugen, selektieren und manipulieren können und wie man aus den resultierenden Massenspektren analytische Information gewinnt. Moderne sanfte Ionisationsmethoden wie ESI, APCI oder MALDI, klassische Verfahren wie EI, CI, FAB oder FD, Oberflächentechniken wie DESI oder DART und elementmassenspektrometrische Verfahren werden didaktisch durchdacht behandelt. Studienanfänger werden von dem Werk ebenso profitieren wie Fortgeschrittene und Praktiker. Ergänzend zum Buch betreibt der Autor eine frei zugängliche (englischsprachige) Internetseite mit zahlreichen Übungsaufgaben, Lösungen und Bonus-Material unter

Aromatherapie für Pflege- und Heilberufe

Kursbuch für Ausbildung und Praxis

Author: Eliane Zimmermann

Publisher: Georg Thieme Verlag

ISBN: 3132192716

Category: Medical

Page: 632

View: 6176

Von der Linderung von Krankheiten bis zur Steigerung des Wohlbefindens: Die Aromatherapie bietet ein breites Wirkspektrum und punktet mit ihrer schonenden Therapie. In ihrem Kursbuch bündelt die erfahrene Praktikerin, Ausbilderin und Dozentin Eliane Zimmermann das essenzielle Wissen für die professionelle Anwendung der Aromatherapie. Indikationen, ätherische Öle, Anwendungen, Grundlagen zu Botanik und Biochemie sowie zahlreiche Studienbelege - die ausgewogene Mischung aus fundiertem Fachwissen und konkreten Empfehlungen für die Praxis machen diesen Titel zu einem hilfreichen Begleiter in der Ausbildung und darüber hinaus. Zahlreiche durchgehend farbige Abbildungen veranschaulichen das Gelesene. Neu: Tortendiagramme liefern auf einen Blick Auskunft über die Hauptwirkstoffe der ätherischen Öle.

Maldi MS

A Practical Guide to Instrumentation, Methods and Applications

Author: Franz Hillenkamp,Jasna Peter-Katalinic

Publisher: John Wiley & Sons

ISBN: 3527610472

Category: Science

Page: 362

View: 9838

The introduction of the matrix-assisted laser desorption ionization technique (MALDI) changed mass spectrometry (MS) into a powerful tool for biomedical analysis that is now widely employed in academic as well as industrial laboratories. The 2002 Nobel Prize was awarded for the development of methods for identification and structure analyses of biological macromolecules. MALDI is one of the two mass spectrometric methods besides Electrospray which is universally used for this purpose. This unique book gives an in-depth description of the many different applications of MALDI MS, along with a detailed discussion of the technology itself. It will be a much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.

Die drei ??? Kids, 74, Schienen-Monster (drei Fragezeichen Kids)

Author: Boris Pfeiffer

Publisher: Kosmos

ISBN: 3440155048

Category: Juvenile Fiction

Page: 128

View: 3091

Justus, Peter und Bob dürfen in einem supermodernen Zug mitreisen. Während sie die coole Technik testen, fällt plötzlich im gesamten Zug der Strom aus. Wer steckt dahinter? Die drei Detektive ermitteln in einem neuen Fall!

Biofilm Eradication and Prevention

A Pharmaceutical Approach to Medical Device Infections

Author: Tamilvanan Shunmugaperumal

Publisher: John Wiley & Sons

ISBN: 9781118043554

Category: Science

Page: 440

View: 3491

Biofilm Eradication and Preventions presents the basics of biofilm formation on medical devices, diseases related to this formation, and approaches pharmaceutical researchers need to take to limit this problem. Split into three parts, the first deals with the development and characterization of biofilm on the surfaces of implanted or inserted medical devices. Questions as to why biofilms form over medical device surfaces and what triggers biofilm formation are addressed. In the second section, the author discusses biofilm-mediated chronic infections occurred in various organs (eyes, mouth, wounds) and pharmaceutical and drug delivery knowledge gained from research in these area. The third part explores pharmaceutical approaches like lipid-and polymer-based drug delivery carriers for eradicating biofilm on device-related infections. In addition, this section also explores the topic of novel small molecule (like iron and its complexes/metal chelators) and a quorum-sensing inhibitors to control medical biofilm formation.

Sieben Küsse

Glück und Unglück in der Literatur

Author: Peter von Matt

Publisher: Carl Hanser Verlag GmbH Co KG

ISBN: 3446256237

Category: Fiction

Page: 288

View: 477

Sieben bedeutungsvolle Küsse der Literaturgeschichte von Marguerite Duras bis Heinrich von Kleist hat Peter von Matt für sein neues Buch ausgewählt. Eigentlich ist Küssen ja ein Alltagsgeschäft. Und dennoch sind wir fest davon überzeugt, das Leben nach dem Kuss sei ein besseres als zuvor. Daran hat auch die Literatur ihren Anteil, denn in zahllosen Geschichten nimmt das Schicksal nach dem entscheidenden Kuss einen neuen Lauf. Einmal mehr erweist sich Peter von Matt als Meister der kenntnisreichen und eleganten Interpretation, aus der Neugierige genauso viel lernen wie erfahrene Leser: ob es nun um Literatur geht, die Liebe – oder um Osculologie, die Wissenschaft vom Küssen.

Medical microbiology

a guide to microbial infections : pathogenesis, immunity, laboratory diagnosis, and control

Author: David Greenwood,Richard C. B. Slack,J. F. Peutherer

Publisher: N.A

ISBN: 9780443070778

Category: Medical

Page: 709

View: 6699

This book is divided into six sections: microbial biology, infection immunity, bacterial pathogens and associated diseases, viral pathogens and associate diseases, fungal pathogens and parasitic infections, diagnosis, treatment and control of infection. The major portion provides organism-based systematic coverage of microbiology. Each organism is considered under a standard set of headings: Description, Pathogenesis, Clinical features, Laboratory diagnosis, Treatment and Epidemiology. The section on immunology covers that part of the subject that is of direct relevance to the understanding of microbial infection.

Clinical proteomics

from diagnosis to therapy

Author: Jennifer E. Van Eyk,Michael J. Dunn

Publisher: Vch Verlagsgesellschaft Mbh

ISBN: 9783527316373

Category: Medical

Page: 659

View: 2710

“… an essential multi-authored book (136 authors), edited by two individuals with a large and particularly well-recognized expertise in all 'proteomic fields'… Such an impressive overview of most of the relevant characteristics of clinical proteomics, the quality (as well as the homogeneity) of the texts, the generally beautiful pictures illustrating the different chapters make the book an important source of information for everybody interested in clinical proteomics as well as in translational medicine.” BIOTECHNOLOGY Unparalleled in its scope and depth, this book brings together proteomic approaches use in the discovery and development of diagnostic and prognostic biomarkers that are applicable to all clinical fields. Following an overview of state-of-the-art technologies and strategies currently being applied to clinical proteomics, the book focuses on individual diseases including cancer, diabetes, stroke and cardiopulmonary, renal and autoimmune diseases as well as clinical toxicology finishing with a discussion of the future of clinical proteomics. This new discipline in molecular medicine holds promise to revolutionize the practice of medicine and this book is a first.

1 x 1 der Infektiologie auf Intensivstationen

Diagnostik — Therapie — Prophylaxe

Author: R. Füssle,J. Biscoping,A. Sziegoleit

Publisher: Springer-Verlag

ISBN: 364218247X

Category: Medical

Page: 412

View: 3202

- Die wichtigsten Praxis-Informationen schnell griffbereit - Neueste Antibiotika, Virustatika, Antimykotica - Untersuchungsanleitungen und Hygiene-Maßnahmen

Der Athener.

Author: Steven Pressfield

Publisher: N.A

ISBN: 9783442451005


Page: 574

View: 6277