Interpretation of Mass Spectra

Author: Fred W. McLafferty,František Tureček

Publisher: University Science Books

ISBN: 9780935702255

Category: Science

Page: 371

View: 2785

Published by University Science Books, 20 Edgehill Rd., Mill Valley, CA 94941. The first edition was published more than 25 years ago, the third, in 1980. Automated computer-matching procedures are still only an aid to, not a replacement for, the skilled interpreter; and the path to that skill, as emphasized in every edition of this text, is practice. Annotation copyright by Book News, Inc., Portland, OR
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Interpretation of Mass Spectra of Organic Compounds

Author: Mynard Hamming

Publisher: Elsevier

ISBN: 0323143148

Category: Science

Page: 708

View: 7620

Interpretation of Mass Spectra of Organic Compounds outlines the basic instrumentation, sample handling techniques, and procedures used in the interpretation of mass spectra of organic compounds. The fundamental concepts of ionization, fragmentation, and rearrangement of ions as found in mass spectra are covered in some detail, along with the rectangular array and interpretation maps. Computerization of mass spectral data is also discussed. This book consists of nine chapters and begins with a historical overview of mass spectrometry and a discussion on some important developments in the field, along with a summary of interpretation objectives and methods. The following chapters focus on instruments, ion sources, and detectors; recording of the mass spectrum and the instrumental and sample variables affecting the mass spectrum; sample introduction systems; and fragmentation reactions. Correlations as applied to interpretations are also considered, with emphasis on applications of the branching rule as well as beta-bond and alpha-bond cleavages. Example interpretations, calculations, data-processing procedures, and computer programs are included. This monograph is intended for organic chemists, biochemists, mass spectroscopists, technicians, managers, and others concerned with the whys and wherefores of mass spectrometry.
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Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

Author: Wilfried M. A. Niessen,Ricardo A. Correa C.

Publisher: John Wiley & Sons

ISBN: 1118500180

Category: Science

Page: 416

View: 765

Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
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A Beginner's Guide to Mass Spectral Interpretation

Author: Terrence A. Lee

Publisher: John Wiley & Sons

ISBN: 9780471976295

Category: Science

Page: 186

View: 1916

This book is a logical, step-by-step guide to identification oforganic compounds by mass spectrometry. The book is organized intochapters covering the major types of organic compounds, includingalcohols, acids and esters, aldehydes and ketones, ethers,hydrocarbons, halogenated compounds, amines and amides, andsulfur-containing compounds. In each chapter, the mechanisms of themajor fragmentation pathways are discussed, with reference toseveral simple sample compounds. By teaching the user to recognizetypical fragmentations, the book removes the need to searchdatabases, often limited, of electronic spectra. Key features ofthe book include: * 200 representative spectra of common organic compounds * Functional group approach to mass spectra interpretation * Appendix of 'unknown' spectra with step-by-step guide toidentification This book is a must for anyone who needs to identify organicmolecules by mass spectrometry but does not need to know thedetailed workings of a mass spectrometer.
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Understanding Mass Spectra

A Basic Approach

Author: R. Martin Smith

Publisher: John Wiley & Sons

ISBN: 0471479349

Category: Science

Page: 372

View: 4233

Understanding Mass Spectra: A Basic Approach, Second Edition combines coverage of the principles underlying mass spectral analysis with clear guidelines on how to apply them in a laboratory setting. Completely revised from the first edition, an updated and unified approach to mass spectral interpretation emphasizes the application of basic principles from undergraduate organic, analytical, and physical chemistry courses. A detailed overview of theory and instrumentation, this useful guide contains step-by-step descriptions of interpretative strategies and convenient lists and tables detailing the information needed to solve unknowns. Other features include real-world case studies and examples, skill-building problems with clearly explained answers, and easy-to-follow explanations of the important mathematical derivations.
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Mass Spectrometry

Principles and Applications

Author: Edmond de Hoffmann,Vincent Stroobant

Publisher: John Wiley & Sons

ISBN: 1118681940

Category: Science

Page: 504

View: 9559

The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.
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Mass Spectrometry

Instrumentation, Interpretation, and Applications

Author: Agnieszka Kraj,Dominic M. Desiderio,Nico M. Nibbering

Publisher: John Wiley & Sons

ISBN: 047039580X

Category: Science

Page: 358

View: 1612

With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.
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Introduction to Mass Spectrometry

Instrumentation, Applications, and Strategies for Data Interpretation

Author: J. Throck Watson,O. David Sparkman

Publisher: John Wiley & Sons

ISBN: 1118681584

Category: Science

Page: 864

View: 3788

Completely revised and updated, this text provides an easy-to-read guide to the concept of mass spectrometry and demonstrates its potential and limitations. Written by internationally recognised experts and utilising "real life" examples of analyses and applications, the book presents real cases of qualitative and quantitative applications of mass spectrometry. Unlike other mass spectrometry texts, this comprehensive reference provides systematic descriptions of the various types of mass analysers and ionisation, along with corresponding strategies for interpretation of data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well as recent advance in this topic, providing need-to-know information for researchers in many disciplines including pharmaceutical, environmental and biomedical analysis who are utilizing mass spectrometry
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Mass Spectrometry

A Textbook

Author: Jürgen H Gross

Publisher: Springer

ISBN: 3319543989

Category: Science

Page: 968

View: 5411

This book offers a balanced mixture of practice-oriented information and theoretical background as well as numerous references, clear illustrations, and useful data tables. Problems and solutions are accessible via a special website. This new edition has been completely revised and extended; it now includes three new chapters on tandem mass spectrometry, interfaces for sampling at atmospheric pressure, and inorganic mass spectrometry.
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Mass Spectrometry for the Novice

Author: John Greaves,John Roboz

Publisher: CRC Press

ISBN: 1420094203

Category: Science

Page: 309

View: 2665

With usage of mass spectrometry continually expanding, an increasing number of scientists, technicians, students, and physicians are coming into contact with this valuable technique. Mass spectrometry has many uses, both qualitative and quantitative, from analyzing simple gases to environmental contaminants, pharmaceuticals, and complex biopolymers. The extraordinary versatility can make mass spectrometers daunting to novices. Consequently, new users would benefit greatly from an understanding of the basic concepts as well as the processes that occur in these instruments. Mass Spectrometry for the Novice provides exactly that, with detailed, straightforward descriptions and clear illustrations of principles of operations and techniques. The book begins with an overview that includes essential definitions and then provides information on the components of and the strategies used in the most common instruments. The authors discuss the methodologies available, classes of compounds analyzed, and the types of data that can be generated. A group of representative applications from published articles is summarized, demonstrating the diversity of mass spectrometry. The authors also condense the essentials of the topic into one invaluable chapter that provides a set of concise take-home messages on all aspects of mass spectrometry. The final section provides a collection of resources including books, reviews, and useful websites. Using simple language, new color figures, clever cartoons, and assuming no prior knowledge, this book provides a readily understandable entrée to mass spectrometry. A CD-ROM with selected figures and cartoons is included.
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Mass Spectrometry Data Analysis in Proteomics

Author: Rune Matthiesen

Publisher: Springer Science & Business Media

ISBN: 1597452750

Category: Science

Page: 320

View: 9484

The intention of Mass Spectrometry Data Analysis in Proteomics is to support researchers in deciding which programs to use in various tasks related to analysis of mass spectrometry data in proteomics. The chapters give a precise description of the theoretical background of each topic followed accurate descriptions of programs and the parameters best suited for different cases.
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Gas Chromatography and Mass Spectrometry: A Practical Guide

Author: O. David Sparkman,Zelda Penton,Fulton G. Kitson

Publisher: Academic Press

ISBN: 9780080920153

Category: Science

Page: 632

View: 5362

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated. Covers the practical instruction necessary for successful operation of GC/MS equipment Reviews the latest advances in instrumentation, ionization methods, and quantitation Includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner A true benchtop reference A guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS) Quick References to data interpretation Ready source for information on new analyses
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Interpreting Protein Mass Spectra

A Comprehensive Resource

Author: A. Peter Snyder

Publisher: Amer Chemical Society

ISBN: N.A

Category: Science

Page: 522

View: 2599

Interpreting Protein Mass Spectra is a hands-on laboratory guide for a wide range of researchers investigating the structures of proteins an d peptides. The focus is on the interpretation of structural informati on gathered through electrospray ionization-mass spectrometry (ESI-MS) . The book will also provide useful background and protocols for anyon e using matrix-assisted laser desorption/ionization (MALDI), fast atom bombardment (FAB), and secondary ion mass spectrometry (SIMS). The bo ok includes numerous practical examples, detailed discussions of exper imental setups, and valuable hints for troubleshooting both methods an d the handling of materials.
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Interpretation of Organic Spectra

Author: Yong-Cheng Ning

Publisher: John Wiley & Sons

ISBN: 0470828315

Category: Science

Page: 416

View: 7744

Although there are a number of books in this field, most of them lack an introduction of comprehensive analysis of MS and IR spectra, and others do not provide up-to-date information like tandem MS. This book fills the gap. The merit of this book is that the author will not only introduce knowledge for analyzing nuclear magnetic resonance spectra including 1H spectra (Chapter 1), 13C spectra (Chapter 2) and 2D NMR spectra (Chapter 3), he also arms readers systemically with knowledge of Mass spectra (including EI MS spectra and MS spectra by using soft ionizations) (Chapter 4) and IR spectra (Chapter 5). In each chapter the author presents very practical application skills by providing various challenging examples. The last chapter (Chapter 6) provides the strategy, skills and methods on how to identify an unknown compound through a combination of spectra. Based on nearly 40 years researching and teaching experience, the author also proposes some original and creative ideas, which are very practical for spectral interpretation.
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Mass Spectrometry of Natural Products

Plenary Lectures Presented at the International Mass Spectrometry Symposium on Natural Products, Rehovot, Israel, 28 August - 2 September 1977

Author: B. Sklarz

Publisher: Elsevier

ISBN: 1483158748

Category: Science

Page: 320

View: 5771

Mass Spectrometry of Natural Products covers the plenary lectures presented at the International Mass Spectrometry Symposium on Natural Products, held in Rehovot, Israel from August 28 to September 2, 1977. The book focuses on the sequencing, spectroscopy, chromatography, and spectrometry of natural products. The selection first discusses mass spectrometric sequencing of peptides and proteins and mass spectroscopic investigation of nucleic acid degradation products. The book then examines advances in the mass spectrometry of steroids, including sterols with unsaturated side chains and ring D fragmentation of saturated sterols and steranes. The text evaluates the mass spectrometry and language of biological fluids. Topics include separation by glass capillary chromatography and structure of determination of unknown compounds. The book also focuses on structural and sequencing studies on peptides, proteins, and glycopeptide by mass spectrometry and directed fragmentation in mass spectrometry by the introduction of functional groups. The selection is a dependable reference for readers interested in mass spectrometry of natural products.
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Trace Quantitative Analysis by Mass Spectrometry

Author: Robert K. Boyd,Cecilia Basic,Robert A. Bethem

Publisher: John Wiley & Sons

ISBN: 1119964393

Category: Science

Page: 748

View: 2705

This book provides a serious introduction to the subject of mass spectrometry, providing the reader with the tools and information to be well prepared to perform such demanding work in a real-life laboratory. This essential tool bridges several subjects and many disciplines including pharmaceutical, environmental and biomedical analysis that are utilizing mass spectrometry: Covers all aspects of the use of mass spectrometry for quantitation purposes Written in textbook style to facilitate understanding of this topic Presents fundamentals and real-world examples in a ‘learning-though-doing’ style
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Fundamentals of Contemporary Mass Spectrometry

Author: Chhabil Dass

Publisher: John Wiley & Sons

ISBN: 0470118482

Category: Science

Page: 512

View: 8621

Modern mass spectrometry - the instrumentation and applications in diverse fields Mass spectrometry has played a pivotal role in a variety of scientific disciplines. Today it is an integral part of proteomics and drug discovery process. Fundamentals of Contemporary Mass Spectrometry gives readers a concise and authoritative overview of modern mass spectrometry instrumentation, techniques, and applications, including the latest developments. After an introduction to the history of mass spectrometry and the basic underlying concepts, it covers: Instrumentation, including modes of ionization, condensed phase ionization techniques, mass analysis and ion detection, tandem mass spectrometry, and hyphenated separation techniques Organic and inorganic mass spectrometry Biological mass spectrometry, including the analysis of proteins and peptides, oligosaccharides, lipids, oligonucleotides, and other biological materials Applications to quantitative analysis Based on proven teaching principles, each chapter is complete with a concise overview, highlighted key points, practice exercises, and references to additional resources. Hints and solutions to the exercises are provided in an appendix. To facilitate learning and improve problem-solving skills, several worked-out examples are included. This is a great textbook for graduate students in chemistry, and a robust, practical resource for researchers and scientists, professors, laboratory managers, technicians, and others. It gives scientists in diverse disciplines a practical foundation in modern mass spectrometry.
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Field Ionization Mass Spectrometry

International Series of Monographs in Analytical Chemistry

Author: Hans-D. Beckey

Publisher: Elsevier

ISBN: 1483160114

Category: Science

Page: 360

View: 6792

Field Ionization Mass Spectrometry focuses on developments in field ionization (FI) mass spectrometry and describes its applications in physical chemistry, with emphasis on mass spectrometric problems. Physico-chemical problems as well as problems of chemical analysis are considered based on issues such as the probability of field ionization; field dissociation and charge distribution; kinetics of ion decomposition in high fields; negative ions; surface diffusion; activation of FI emitters; and elucidation of the structures of organic compounds. This book is comprised of four chapters and begins with a short review on some of the most important directions of research in FI mass spectrometry. Two main fields of research are discussed: physico-chemical investigations and quantitative analysis or structural determination of organic substances. The next chapter is devoted to focusing and non-focusing sources of FI and covers topics such as methods for production of FI tips and thin wires, together with the use of tips and carbon filaments as FI emitters. The last two chapters focus on the application of the FI mass spectrometer to physico-chemical problems and to quantitative analysis of homologous series of organic substances such as alkanes, alkenes, alkynes, amines, and alcohols. This monograph is intended primarily for chemists and mass spectrometrists.
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