Interpretation of Mass Spectra

Author: Fred W. McLafferty,František Tureček

Publisher: University Science Books

ISBN: 9780935702255

Category: Science

Page: 371

View: 9090

Published by University Science Books, 20 Edgehill Rd., Mill Valley, CA 94941. The first edition was published more than 25 years ago, the third, in 1980. Automated computer-matching procedures are still only an aid to, not a replacement for, the skilled interpreter; and the path to that skill, as emphasized in every edition of this text, is practice. Annotation copyright by Book News, Inc., Portland, OR
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Interpretation of Mass Spectra of Organic Compounds

Author: Mynard Hamming

Publisher: Elsevier

ISBN: 0323143148

Category: Science

Page: 708

View: 1822

Interpretation of Mass Spectra of Organic Compounds outlines the basic instrumentation, sample handling techniques, and procedures used in the interpretation of mass spectra of organic compounds. The fundamental concepts of ionization, fragmentation, and rearrangement of ions as found in mass spectra are covered in some detail, along with the rectangular array and interpretation maps. Computerization of mass spectral data is also discussed. This book consists of nine chapters and begins with a historical overview of mass spectrometry and a discussion on some important developments in the field, along with a summary of interpretation objectives and methods. The following chapters focus on instruments, ion sources, and detectors; recording of the mass spectrum and the instrumental and sample variables affecting the mass spectrum; sample introduction systems; and fragmentation reactions. Correlations as applied to interpretations are also considered, with emphasis on applications of the branching rule as well as beta-bond and alpha-bond cleavages. Example interpretations, calculations, data-processing procedures, and computer programs are included. This monograph is intended for organic chemists, biochemists, mass spectroscopists, technicians, managers, and others concerned with the whys and wherefores of mass spectrometry.
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Interpretation von Massenspektren

Author: Fred W. McLafferty,Frantisek Turecek

Publisher: Springer Spektrum

ISBN: 9783642398483

Category: Science

Page: 385

View: 967

Die Interpretation von Massenspektren erlernt man am besten durch Praxis. Mit dieser Überzeugung hat McLafferty die Originalausgabe dieses Buches in mehrere erfolgreiche Auflagen geführt. Schritt für Schritt, anhand zahlreicher Beispiele, führt er den Leser zum Verständnis von Massenspektren und Massenspektrometrie. So schafft dieses Buch die Grundlage für das Verständnis und die optimale Nutzung einer Methode, die als eine der wichtigsten in der analytischen Chemie gilt.
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Interpretation of MS-MS Mass Spectra of Drugs and Pesticides

Author: Wilfried M. A. Niessen,Ricardo A. Correa C.

Publisher: John Wiley & Sons

ISBN: 1118500180

Category: Science

Page: 416

View: 2232

Provides comprehensive coverage of the interpretation of LC–MS–MS mass spectra of 1300 drugs and pesticides Provides a general discussion on the fragmentation of even-electron ions (protonated and deprotonated molecules) in both positive-ion and negative-ion modes This is the reference book for the interpretation of MS–MS mass spectra of small organic molecules Covers related therapeutic classes of compounds such as drugs for cardiovascular diseases, psychotropic compounds, drugs of abuse and designer drugs, antimicrobials, among many others Covers general fragmentation rule as well as specific fragmentation pathways for many chemical functional groups Gives an introduction to MS technology, mass spectral terminology, information contained in mass spectra, and to the identification strategies used for different types of unknowns
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Understanding Mass Spectra

A Basic Approach

Author: R. Martin Smith

Publisher: John Wiley & Sons

ISBN: 0471479349

Category: Science

Page: 372

View: 5404

Understanding Mass Spectra: A Basic Approach, Second Editioncombines coverage of the principles underlying mass spectralanalysis with clear guidelines on how to apply them in a laboratorysetting. Completely revised from the first edition, an updated andunified approach to mass spectral interpretation emphasizes theapplication of basic principles from undergraduate organic,analytical, and physical chemistry courses. A detailed overview of theory and instrumentation, this usefulguide contains step-by-step descriptions of interpretativestrategies and convenient lists and tables detailing theinformation needed to solve unknowns. Other features includereal-world case studies and examples, skill-building problems withclearly explained answers, and easy-to-follow explanations of theimportant mathematical derivations.
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Introduction to Mass Spectrometry

Instrumentation, Applications, and Strategies for Data Interpretation

Author: J. Throck Watson,O. David Sparkman

Publisher: John Wiley & Sons

ISBN: 1118681584

Category: Science

Page: 864

View: 1478

Completely revised and updated, this text provides an easy-to-readguide to the concept of mass spectrometry and demonstrates itspotential and limitations. Written by internationally recognisedexperts and utilising "real life" examples of analyses andapplications, the book presents real cases of qualitative andquantitative applications of mass spectrometry. Unlike other massspectrometry texts, this comprehensive reference providessystematic descriptions of the various types of mass analysers andionisation, along with corresponding strategies for interpretationof data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well asrecent advance in this topic, providing need-to-know informationfor researchers in many disciplines including pharmaceutical,environmental and biomedical analysis who are utilizing massspectrometry
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Massenspektrometrie

Ein Lehrbuch

Author: Jürgen H Gross

Publisher: Springer-Verlag

ISBN: 3827429811

Category: Science

Page: 802

View: 4105

Mit Massenspektrometrie – ein Lehrbuch liegt ein Werk vor, das mit seiner umfassenden, präzisen Darstellung sowie seinen vielen gelungenen Illustrationen und Fotos eine Lücke auf dem deutschsprachigen Markt schließt. Dieses im englischsprachigen Raum bereits gut etablierte Buch führt auf grundlegende Weise an die Massenspektrometrie heran, indem es die Prinzipien, Methoden und Anwendungen logisch aufeinander aufbauend erklärt. Schritt für Schritt lernt der Leser, was diese analytische Methode leisten kann, auf welch vielfältige Art Massenspektrometer isolierte Ionen in der Gasphase erzeugen, selektieren und manipulieren können und wie man aus den resultierenden Massenspektren analytische Information gewinnt. Moderne sanfte Ionisationsmethoden wie ESI, APCI oder MALDI, klassische Verfahren wie EI, CI, FAB oder FD, Oberflächentechniken wie DESI oder DART und elementmassenspektrometrische Verfahren werden didaktisch durchdacht behandelt. Studienanfänger werden von dem Werk ebenso profitieren wie Fortgeschrittene und Praktiker. Ergänzend zum Buch betreibt der Autor eine frei zugängliche (englischsprachige) Internetseite mit zahlreichen Übungsaufgaben, Lösungen und Bonus-Material unter http://www.ms-textbook.com
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Mass Spectrometry

A Textbook

Author: Jürgen H Gross

Publisher: Springer Science & Business Media

ISBN: 354036756X

Category: Science

Page: 518

View: 7381

Mass Spectrometry is an ideal textbook for students and professionals as well as newcomers to the field. Starting from the very first principles of gas-phase ion chemistry and isotopic properties, the textbook takes the reader through the design of mass analyzers and ionization methods all the way to mass spectral interpretation and coupling techniques. Step-by-step, the reader learns how mass spectrometry works and what it can do. The book comprises a balanced mixture of practice-oriented information and theoretical background. It features a clear layout and a wealth of high-quality figures. Exercises and solutions are located on the Springer Global Web.
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Gas Chromatography and Mass Spectrometry

A Practical Guide

Author: Fulton G. Kitson,Barbara S. Larsen,Charles N. McEwen

Publisher: Academic Press

ISBN: 0080532322

Category: Science

Page: 381

View: 4022

This guide provides, under one cover, a wealth of practical information designed to facilitate the effectiveness of the GC/MS user. Separation conditions for numerous compound types are provided along with derivatized and underivatized compounds. A section on how to interpret mass spectral data, an extensive correlation of ion masses and neutral losses with possible structures, and examples of mass spectra are provided to further aid structure determination. Also included are basic information on instrumentation, ionization methods, quantitation, tips on the operation of mass spectrometers, the best derivatization procedures for a variety of compound types, troubleshooting techniques, and a variety of other information found to be useful to the practicing user of GC/MS instrumentation. This guide would be immediately valuable to the novice as well as the experienced GC/MS user who may not have the breadth of experience covered in this book. Key Features * Condenses and organizes recent and essential information for new and experienced GC/MS users * Comprehensively indexed and referenced * Includes practical methods of analysis * Serves as a text reference for short practical courses on the subject
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Gas Chromatography and Mass Spectrometry: A Practical Guide

Author: O. David Sparkman,Zelda Penton,Fulton G. Kitson

Publisher: Academic Press

ISBN: 9780080920153

Category: Science

Page: 632

View: 8333

The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated. Covers the practical instruction necessary for successful operation of GC/MS equipment Reviews the latest advances in instrumentation, ionization methods, and quantitation Includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner A true benchtop reference A guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS) Quick References to data interpretation Ready source for information on new analyses
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Mass Spectrometry Data Analysis in Proteomics

Author: Rune Matthiesen

Publisher: Springer Science & Business Media

ISBN: 1597452750

Category: Science

Page: 320

View: 1547

The intention of Mass Spectrometry Data Analysis in Proteomics is to support researchers in deciding which programs to use in various tasks related to analysis of mass spectrometry data in proteomics. The chapters give a precise description of the theoretical background of each topic followed accurate descriptions of programs and the parameters best suited for different cases.
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Mass Spectrometry for Chemists and Biochemists

Author: Robert Alexander Walker Johnstone,Malcolm E. Rose

Publisher: Cambridge University Press

ISBN: 9780521424974

Category: Science

Page: 501

View: 5356

This book describes the full range of techniques and applications used in mass spectrometry. Researchers in universities and industry laboratories use this versatile technique because of its ability to identify a minute amount of material quickly. The technique solves analytical problems in a huge variety of fields. The authors adopt an instructional approach and make use of recent examples to illustrate important points. This second edition includes new methods and applications that have developed in the past ten years. The authors discuss powerful methods combining mass spectrometry with newer separation techniques, the increased use of computers, and analysis of once difficult polar and large-mass compounds such as proteins using new ionization methods. The book, requiring no previous knowledge of mass spectrometry, is an ideal teaching text at both the undergraduate and postgraduate level, and will also be of considerable interest to research workers.
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Identification of Microorganisms by Mass Spectrometry

Author: Charles L. Wilkins,Jackson O. Lay

Publisher: John Wiley & Sons

ISBN: 0471748633

Category: Science

Page: 352

View: 8466

A multidisciplinary approach to understanding the fundamentals ofmass spectrometry for bacterial analysis From chemotaxonomy to characterization of targeted proteins,Identification of Microorganisms by Mass Spectrometry provides anoverview of both well-established and cutting-edge massspectrometry techniques for identifying microorganisms. A vitaltool for microbiologists, health professionals, and analyticalchemists, the text is designed to help scientists select the mosteffective techniques for use in biomedical, biochemical,pharmaceutical, and bioterror defense applications. Since microbiological applications of mass spectrometry require abasic understanding of both microbiology and analytical chemistry,the editors have incorporated material from both disciplines sothat readers from either field will come to understand thenecessary principles of the other. Featuring contributions fromsome of the most recognized experts in both fields, this volumeprovides specific examples of fundamental methods as well asapproaches developed in the last decade, including: * Metastable atom bombardment pyrolysis mass spectrometry * Matrix-assisted laser desorption/ionization mass spectrometry(MALDI) * MALDI time-of-flight mass spectrometry (MALDI-TOF MS) of intactbacteria * High-resolution Fourier transform mass spectrometry (FTMS) * Electrospray ionization (ESI) mass spectrometry Identification of Microorganisms by Mass Spectrometry representsthe most comprehensive and up-to-date work on the topic currentlyavailable. It is liberally illustrated with figures and tables andcovers every aspect of spectrometric identification ofmicroorganisms, including experimental procedures, various means ofsample preparation, data analysis, and interpretation of complexmass spectral data.
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Mass Spectrometry

Analytical Chemistry by Open Learning

Author: James Barker,David J. Ando,Reg Davis,Martin J. Frearson

Publisher: John Wiley & Sons

ISBN: 9780471967620

Category: Science

Page: 509

View: 8349

This thoroughly updated second edition of the ACOL text on Mass Spectrometry gives a modern approach to those beginning to use or study mass spectrometry. Self assessment questions and solutions are included. Fundamentals and modern instrumental techniques are also covered in this book.
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A Beginner's Guide to Mass Spectral Interpretation

Author: Terrence A. Lee

Publisher: John Wiley & Sons

ISBN: 9780471976295

Category: Science

Page: 186

View: 2373

This book is a logical, step-by-step guide to identification oforganic compounds by mass spectrometry. The book is organized intochapters covering the major types of organic compounds, includingalcohols, acids and esters, aldehydes and ketones, ethers,hydrocarbons, halogenated compounds, amines and amides, andsulfur-containing compounds. In each chapter, the mechanisms of themajor fragmentation pathways are discussed, with reference toseveral simple sample compounds. By teaching the user to recognizetypical fragmentations, the book removes the need to searchdatabases, often limited, of electronic spectra. Key features ofthe book include: * 200 representative spectra of common organic compounds * Functional group approach to mass spectra interpretation * Appendix of 'unknown' spectra with step-by-step guide toidentification This book is a must for anyone who needs to identify organicmolecules by mass spectrometry but does not need to know thedetailed workings of a mass spectrometer.
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Mass Spectrometry

Instrumentation, Interpretation, and Applications

Author: Agnieszka Kraj,Dominic M. Desiderio,Nico M. Nibbering

Publisher: John Wiley & Sons

ISBN: 047039580X

Category: Science

Page: 358

View: 7288

With contributions from noted experts from Europe and North America, Mass Spectrometry Instrumentation, Interpretation, and Applications serves as a forum to introduce students to the whole world of mass spectrometry and to the many different perspectives that each scientific field brings to its use. The book emphasizes the use of this important analytical technique in many different fields, including applications for organic and inorganic chemistry, forensic science, biotechnology, and many other areas. After describing the history of mass spectrometry, the book moves on to discuss instrumentation, theory, and basic applications.
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Interpretation of Organic Spectra

Author: Yong-Cheng Ning

Publisher: John Wiley & Sons

ISBN: 0470828315

Category: Science

Page: 416

View: 4435

Although there are a number of books in this field, most of them lack an introduction of comprehensive analysis of MS and IR spectra, and others do not provide up-to-date information like tandem MS. This book fills the gap. The merit of this book is that the author will not only introduce knowledge for analyzing nuclear magnetic resonance spectra including 1H spectra (Chapter 1), 13C spectra (Chapter 2) and 2D NMR spectra (Chapter 3), he also arms readers systemically with knowledge of Mass spectra (including EI MS spectra and MS spectra by using soft ionizations) (Chapter 4) and IR spectra (Chapter 5). In each chapter the author presents very practical application skills by providing various challenging examples. The last chapter (Chapter 6) provides the strategy, skills and methods on how to identify an unknown compound through a combination of spectra. Based on nearly 40 years researching and teaching experience, the author also proposes some original and creative ideas, which are very practical for spectral interpretation.
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