Industrial Bioseparations

Principles and Practice

Author: Daniel Forciniti

Publisher: Wiley-Blackwell

ISBN: 0813820855

Category: Science

Page: 326

View: 3035

Industrial Bioseparations offers comprehensive coverage of bioseparations including all unit operations. This new book offers a careful balance between the fundamentals of bioseparations processing and the practical applications in industry today. It is laid out in a methodical way with preliminary chapters covering general approaches to bioseparations for commercially important biomacromolecules, thermodynamics and mass transfer principles, and following chapters addressing unit operations such as filtration and chromatography. Lab experiments are included which emphasize obtaining scale up parameters as well as commonly used operating conditions are included.
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Bioseparations engineering

principles, practice, and economics

Author: Michael R. Ladisch

Publisher: Wiley-Interscience

ISBN: N.A

Category: Science

Page: 735

View: 5017

Multidisciplinary resource for graduate studies and the biotechnology industry Knowledge of the genetic basis of biological functioning continues to grow at an astronomical rate, as do the challenges and opportunities of applying this information to the production of therapeutic compounds, specialty biochemicals, functional food ingredients, environmentally friendly biocatalysts, and new bioproducts from renewable resources. While genetic engineering of living organisms transforms the science of genomics into treatments for cancer, diabetes, and heart disease, or products for industry and agriculture, the science and technology of bioseparations are the keys to delivering these products in a purified form suitable for use by people. The methods, theory, and materials that reduce the science of bioseparations to practice, whether in the laboratory or the plant, are the subjects of Bioseparations Engineering. Examples address purification of biomolecules ranging from recombinant proteins to gene therapy products, with footnotes detailing economics of the products. Mechanistic analysis and engineering design methods are given for: * Isocratic and gradient chromatography * Sedimentation, centrifugation, and filtration * Membrane systems * Precipitation and crystallization Topics addressed within this framework are: stationary phase selection; separations development; modeling of ion exchange, size exclusion, reversed phase, hydrophobic interaction, and affinity chromatography; the impact of regulatory issues on chromatography process design; organization of separation strategies into logical sequences of purification steps; and bridges between molecular biology, combinatorial methods, and separations science. A result of teaching and developing the subject matter over ten years, Bioseparations Engineering is an ideal text for graduate students, as well as a timely desk book for process engineers, process scientists, researchers, and research associates in the pharmaceutical, food, and life sciences industries.
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Biotechnology and Biopharmaceuticals

Transforming Proteins and Genes into Drugs

Author: N.A

Publisher: John Wiley & Sons

ISBN: 1118659988

Category: Science

Page: 744

View: 4275

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs, Second Edition addresses the pivotal issues relating to translational science, including preclinical and clinical drug development, regulatory science, pharmaco-economics and cost-effectiveness considerations. The new edition also provides an update on new proteins and genetic medicines, the translational and integrated sciences that continue to fuel the innovations in medicine, as well as the new areas of therapeutic development including cancer vaccines, stem cell therapeutics, and cell-based therapies.
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Monolithic Silicas in Separation Science

Concepts, Syntheses, Characterization, Modeling and Applications

Author: Klaus K. Unger,Nobuo Tanaka,Egidijus Machtejevas

Publisher: John Wiley & Sons

ISBN: 352763326X

Category: Science

Page: 362

View: 4634

Edited by the experts and pioneers in the field, this is the first monograph to cover the topic, containing the must-have information hitherto only scattered among journals. Clearly divided into sections on preparation, characterization and modeling, and applications, this is essential reading for chemists, chromatographers, analytical chemists, biochemists and biologists.
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Manufacturing of Pharmaceutical Proteins

From Technology to Economy

Author: Stefan Behme

Publisher: John Wiley & Sons

ISBN: 3527683097

Category: Science

Page: 456

View: 9498

Structured like a textbook, the second edition of this reference covers all aspects of biopharmaceutical manufacturing, including legal and regulatory issues, production facility design, and quality assurance, with a focus on supply chain management and regulations in emerging markets and cost control. The author has longstanding industrial expertise in biopharmaceutical production and years of experience teaching at universities. As such, this practical book is ideal for use in academia as well as for internal training within companies.
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Process Scale Bioseparations for the Biopharmaceutical Industry

Author: Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam

Publisher: CRC Press

ISBN: 1420016024

Category: Science

Page: 575

View: 2271

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules. Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends. Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.
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Bioseparations Science and Engineering

Author: Roger G. Harrison,Paul W. Todd,Scott R. Rudge,Demetri P. Petrides

Publisher: Oxford University Press

ISBN: 0190213744

Category: Technology & Engineering

Page: 432

View: 746

Designed for undergraduates, graduate students, and industry practitioners, Bioseparations Science and Engineering fills a critical need in the field of bioseparations. Current, comprehensive, and concise, it covers bioseparations unit operations in unprecedented depth. In each of the chapters, the authors use a consistent method of explaining unit operations, starting with a qualitative description noting the significance and general application of the unit operation. They then illustrate the scientific application of the operation, develop the required mathematical theory, and finally, describe the applications of the theory in engineering practice, with an emphasis on design and scaleup. Unique to this text is a chapter dedicated to bioseparations process design and economics, in which a process simular, SuperPro Designer? is used to analyze and evaluate the production of three important biological products. New to this second edition are updated discussions of moment analysis, computer simulation, membrane chromatography, and evaporation, among others, as well as revised problem sets. Unique features include basic information about bioproducts and engineering analysis and a chapter with bioseparations laboratory exercises. Bioseparations Science and Engineering is ideal for students and professionals working in or studying bioseparations, and is the premier text in the field.
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Separation of Molecules, Macromolecules and Particles

Principles, Phenomena and Processes

Author: Kamalesh Sirkar

Publisher: Cambridge University Press

ISBN: 0521895731

Category: Science

Page: 909

View: 3757

A modern separation process textbook written for advanced undergraduate and graduate level courses in chemical engineering.
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Separation Process Principles, 3rd Edition

Author: J. D. Seader,Ernest J. Henley,D. Keith Roper

Publisher: Wiley Global Education

ISBN: 1118139623

Category: Technology & Engineering

Page: 848

View: 4651

Separation Process Principles, 3rd Edition is the most comprehensive and up-to-date treatment of the major separation operations in the chemical industry. This third edition is renamed Separation Process Principles -- Chemical and Biochemical Operations to reflect the inclusion of bioseparations in several chapters. Extraordinary advances that are being made in the biological fields could significantly help solve world problems in the energy, environmental, and health areas. To help provide instruction in the important bioseparations area, a new author has been added for this edition, D. Keith Roper, who has extensive industrial and academic experience in bioseparations. Separation Process Principles, 3rd Edition provides review chapters on thermo and mass transfer, comprehensive discussion of many separation processes, photos, diagrams, and descriptions of process equipment, and challenging, realistic problems. Improved clarity, study questions, and boxed equations and examples in this 3rd edition are especially helpful for students encountering separation processes for the first time. Separation Process Principles, 3rd Edition prepares students for professional practice, and is a reference they'll value as practicing engineers.
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BIOSPERATIONS

PRINCIPLES AND TECHNIQUES

Author: B. SIVASANKAR

Publisher: PHI Learning Pvt. Ltd.

ISBN: 8120326490

Category: Technology & Engineering

Page: 280

View: 8858

This systematically organized and well-balanced book compresses within the covers of a single volume the theoretical principles and techniques involved in bio-separations, also called downstream processing. These techniques are derived from a range of subjects, for example, physical chemistry, analytical chemistry, bio-chemistry, biological science and chemical engineering. Organized in its 15 chapters, the text covers in the first few chapters topics related to chemical engineering unit operations such as filtration, centrifugation, adsorption, extraction and membrane separation as applied to bioseparations. The use of chromatography as practiced at laboratory as well as industrial scale operation and related techniques such as gel filtration, affinity and pseudoaffinity chromatography, ion-exchange chromatography, electrophoresis and related methods have been discussed. The important applications of these techniques have also been highlighted.
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Principles of Bioseparations Engineering

Author: Raja Ghosh

Publisher: World Scientific Publishing Company Incorporated

ISBN: 9789812568922

Category: Medical

Page: 265

View: 1635

Bioseparations engineering deals with the scientific and engineering principles involved in large-scale separation and purification of biological products. This book discusses the underlying principles of bioseparations engineering written from the perspective of an undergraduate course. It covers membrane based bioseparations.
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Centrifugal Separations in Biotechnology

Author: Wallace Woon-Fong Leung

Publisher: Academic Press

ISBN: N.A

Category: Medical

Page: 298

View: 802

The biotechnology industry is growing rapidly and requires the successful separation of proteins, DNA, mitochondria, ribosomes, lysosomes and other cellular elements. Centrifugation is an increasingly-important technique to achieve such separations, and this practical book gives a broad but detailed account of principles, types of centrifuge, applications, testing, selection, sizing, troubleshooting, numerical simulation and membrane use. No other book aimed at the biotech industry achieves this coverage, making this a well-timed and vital book for biotech professionals. * First book to cover this area in depth * Experienced author of international status * Growth area world-wide
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Sci-tech News

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Science

Page: N.A

View: 638

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Mechanical Engineering

The Journal of the American Society of Mechanical Engineers

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Mechanical engineering

Page: N.A

View: 8067

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Van Nostrand's Scientific Encyclopedia

Author: N.A

Publisher: N.A

ISBN: N.A

Category: Engineering

Page: N.A

View: 330

Coverage of major scientific topics including animal life, biosciences, chemistry, earth and atmospheric sciences, energy sources and power technology, mathematics and information sciences, materials and engineering sciences, medicine, anatomy, and physiology, physics, plant sciences, space and planetary sciences. Contains over 7,000 articles contributed by more than 250 experts
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Immobilisierte Biokatalysatoren

Eine Einführung

Author: Winfried Hartmeier

Publisher: Springer-Verlag

ISBN: 3662078627

Category: Science

Page: 206

View: 4693

Obwohl oder gerade weil eine kaum mehr überschaubare Zahl von Publi kationen auf dem Gebiet der Immobilisierung von Biokatalysatoren existiert, ist es für den Anfänger, der einen Einstieg sucht, auf diesem Gebiet oft schwer, geeignete Informationen aus der Flut von Originalarbeiten herauszufinden. Einige gute, fast immer aber eng lischsprachige Monographien sind entweder außerordentlich umfang reich und teuer, oder sie behandeln nur ausgewählte Teilaspekte der Immobilisierung. Dem will die vorliegende Einführung abhelfen. Sie soll dem Leser zu einem raschen Überblick verhelfen und ihm den inzwischen abgesicherten Kenntnisstand nach Art eines kurzen Lehr buches vermitteln. Das Buch ist aus Erfahrungen in Vorlesungen, Praktika und Kursen entstanden. Es soll sich maßgeblich an Lernende wenden, auch wenn "Immobilisierte Biokatalysatoren" bisher noch nicht zum Stan dardrepertoire der Lehre an deutschen Universitäten und Fachhoch schulen gehören. Es ist jedoch die Oberzeugung des Autors, daß sich dies in den kommenden Jahren mit der wachsenden Bedeutung dieses Gebietes und mit der allgemeinen Etablierung der Biotechnologie an den Hochschulen ändern wird. Ober den Kreis der Studenten und Dozen ten hinaus wendet sich die Einführung aber auch an die vielen Natur wissenschaftler und Techniker der industriellen Praxis, die sich mit immobilisierten Biokatalysatoren befassen und sich dazu ein ent sprechendes Grundwissen aneignen wollen.
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Gelchromatographie

Gelfiltration Gelpermeation Molekülsiebe. Ein Laboratoriumsbuch

Author: Helmut Determann

Publisher: Springer-Verlag

ISBN: 9783642499050

Category: Science

Page: 205

View: 4364

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Materialwissenschaften und Werkstofftechnik

Eine Einführung

Author: William D. Callister,David G. Rethwisch

Publisher: John Wiley & Sons

ISBN: 3527330070

Category:

Page: 906

View: 9366

Der 'Callister' bietet den gesamten Stoff der Materialwissenschaften und Werkstofftechnik für Studium und Prüfungsvorbereitung. Hervorragend aufbereitet und in klarer, prägnanter Sprache wird das gesamte Fachgebiet anschaulich dargestellt. Das erprobte didaktische Konzept zielt ab auf 'Verständnis vor Formalismus' und unterstützt den Lernprozess der Studierenden: * ausformulierte Lernziele * regelmäßig eingestreute Verständnisfragen zum gerade vermittelten Stoff * Kapitelzusammenfassungen mit Lernstoff, Gleichungen, Schlüsselwörtern und Querverweisen auf andere Kapitel * durchgerechnete Beispiele, Fragen und Antworten sowie Aufgaben und Lösungen * Exkurse in die industrielle Anwendung * an den deutschen Sprachraum angepasste Einheiten und Werkstoffbezeichnungen * durchgehend vierfarbig illustriert * Verweise auf elektronisches Zusatzmaterial Der 'Callister' ist ein Muss für angehende Materialwissenschaftler und Werkstofftechniker an Universitäten und Fachhochschulen - und ideal geeignet für Studierende aus Physik, Chemie, Maschinenbau und Bauingenieurwesen, die sich mit den Grundlagen des Fachs vertraut machen möchten.
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