Handbook of Pharmaceutical Excipients

Author: Raymond C. Rowe

Publisher: N.A

ISBN: N.A

Category: Medical

Page: 918

View: 8682

The Handbook of Pharmaceutical Excipients is a comprehensive guide to the uses, properties and safety of pharmaceutical excipients and is an essential reference for those involved in the development, production, control or regulation of pharmaceutical preparations.
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Handbook of Pharmaceutical Excipients

Author: Raymond C. Rowe,Paul J. Sheskey,Marian E. Quinn

Publisher: N.A

ISBN: 9780853697947

Category: Medical

Page: 888

View: 7100

An internationally acclaimed reference work recognized as one of the most authoritative and comprehensive sources of information on excipients used in pharmaceutical formulation with this new edition providing 340 excipient monographs. Incorporates information on the uses, and chemical and physical properties of excipients systematically collated from a variety of international sources including: pharmacopeias, patents, primary and secondary literature, websites, and manufacturers' data; extensive data provided on the applications, licensing, and safety of excipients; comprehensively cross-referenced and indexed, with many additional excipients described as related substances and an international supplier's directory and detailed information on trade names and specific grades or types of excipients commercially available.
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Handbook of pharmaceutical excipients

Author: Ainley Wade,Pharmaceutical Society of Great Britain

Publisher: Pharmaceutical Press

ISBN: N.A

Category: Medical

Page: 651

View: 8472

Provides data on the additives used to convert pharmacologically active compounds into dosage forms suitable for administration to patients. Data includes: nonproprietary names, functional category, synonyms, chemical names and CAS Registry number, empirical formula, molecular weight, structural formula, commercial availability, method of manufacture,description, pharmacopeial specifications, typical properties, stability and storage conditions, incompatibilities, safety, handling precautions, regulatory acceptance, applications in pharmaceutical formulation or technology, use, related substances, comments, and specific references.
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Handbook of Pharmaceutical Excipients

Author: Arthur H. Kibbe

Publisher: Amer Pharmacists Assn

ISBN: 9780917330964

Category: Medical

Page: 665

View: 6054

Describes the chemical and physical properties of pharmaceutical excipients. Each monograph contains nonproprietary names, synonyms, chemical name and CAS registry number, empirical formula and molecular weight, structural formula, functional category, applications in pharmaceutical formulation or technology, description, pharmacopeial specifications, typical propertics, stability and storage conditions, incompatibilities, method of manufacture, safety, handling precautions, regulatory status, pharmacopeias, related substances, comments, specific references, general references, and authors.
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Pharmaceutical Excipients 2001

Handbook of Pharmaceutical Excipients

Author: Pharmaceutical Press,Raymond C. Rowe,Paul J Sheskey,Paul J Weller

Publisher: N.A

ISBN: 9780853694977

Category: Medical

Page: N.A

View: 1999

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Handbook of Pharmaceutical Excipients

Author: Paul J. Sheskey,Walter G. Cook,Colin G. Cable

Publisher: N.A

ISBN: 9780857112712

Category: Excipients

Page: 1216

View: 5742

The Handbook of Pharmaceutical Excipients contains essential data on the physical properties of excipients, their safe use and potential toxicity.
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Messverfahren und Klassifikationen in der muskuloskelettalen Radiologie

Author: Simone Waldt,Matthias Eiber,Klaus Wörtler

Publisher: Georg Thieme Verlag

ISBN: 3132415154

Category: Medical

Page: 224

View: 8223

Zum raschen Nachschlagen: radiologische Messverfahren und Klassifikationen für orthopädische Erkrankungen. - Das will der Kliniker vom Radiologen wissen: alle wichtigen Klassifikationen, anhand derer Stadium und Prognose festgelegt werden. - Eindrucksvolle Visualisierung mit didaktisch exzellenten Zeichnungen. - Der aktuellste Wissensstand: mit den neueren orthopädischen Krankheitsbildern. - Besonders hilfreich beim Befunden: Strukturierung nach anatomischen Regionen und Krankheitsbildern. - Höchster Klinikbezug: Welche Messverfahren und Klassifikationen bei welchen Krankheitsbildern? Jederzeit zugreifen: Der Inhalt des Buches steht Ihnen ohne weitere Kosten digital in der Wissensplattform eRef zur Verfügung (Zugangscode im Buch). Mit der kostenlosen eRef App haben Sie zahlreiche Inhalte auch offline immer griffbereit.
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Arzneimitteltherapie in der Palliativmedizin

Author: Claudia Bausewein,Constanze Rémi,Robert Twycross,Andrew Wilcock,Paul Howard

Publisher: Elsevier Health Sciences

ISBN: 3437183958

Category: Medical

Page: 1048

View: 7332

Dieses Werk bietet praxisorientierte, konkrete Handlungsanweisungen mit exakten Dosierungsangaben und zahlreichen Tipps für die tägliche Praxis. Es liefert präzise Informationen zu Sonderfällen wie z.B. Anwendungen außerhalb der Zulassung (''off-label use''), alternative Applikationsformen sowie Dosierungsanpassung bei Organinsuffizienz. Das ideale Buch zur kompetenten und sicheren Behandlung von Patienten in der Palliativmedizin. Die deutsche Fassung basiert auf dem renommierten englischen Werk ''Palliative Care Formulary'', wurde aber auf die Erfordernisse im deutschen Sprachraum angepasst. Neu in der 3. Auflage: Aktualisiert und auf Stand des englischen PCF6 gebracht Die S3-Leitlinie Palliativmedizin für Patienten mit einer nicht heilbaren Krebserkrankung wurde ergänzt Weitere relevante deutsche Leitlinien berücksichtigt
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CRC Handbook of Food, Drug, and Cosmetic Excipients

Author: Susan C. Smolinske

Publisher: Routledge

ISBN: 1351457373

Category: Technology & Engineering

Page: 448

View: 1288

CRC Handbook of Food, Drug, and Cosmetic Excipients provides a comprehensive summary of toxicological issues regarding inactive ingredients in pharmaceutical products, cosmetic products, and food additives. Background information on regulations and labeling requirements for each type of product is provided, and 77 articles critically review human and animal data pertinent to a variety of agents and makes judgments regarding the clinical relevance. The book also identifies at-risk populations, such as neonates, patients with renal failure, and atopic patients. Inactive common pharmaceutical agents and/or foods containing certain ingredients are listed to help physicians counsel hypersensitive patients who must avoid products containing these excipients.
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Taschenatlas Pharmakologie

Author: Lutz Hein,Heinz Lüllmann,Klaus Mohr

Publisher: Georg Thieme Verlag

ISBN: 3131516577

Category: Medical

Page: 416

View: 2559

Wirkt sofort! Dieser Taschenatlas hilft. Beschwerden der Verwirrung und Überforderung werden sofort gemildert und weichen dem Gefühl des Verstehens und Begreifens. Die Wirkstoffe Visualisierung und Kompaktheit sind in großen Mengen aktiv. - Über 170 brillante Infografiken illustrieren die Pharmakologie und erleichtern dir den Zugang zu pharmakologischen Sachverhalten. Die kompakten Lerneinheiten eignen sich als Ergänzung zu einem Lehrbuch, zum Vertiefen und Wiederholen. Alle relevanten Informationen zu Wirkstoffgruppen kannst du rasch und gut verständlich nachlesen. Das sinnvolle arzneimitteltherapeutische Vorgehen bei wichtigen Erkrankungen kompakt und auf dem aktuellen Stand. Arzneimittel-Konvertierungslisten helfen dir auf der Suche nach dem Wirkstoff- oder Handelsnamen. Dank Daumenregister und Farbleitsystem kannst du dich schnell orientieren. Du verstehst Zusammenhänge und schaust über den ein oder anderen Tellerrand.
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Handbook of Isolation and Characterization of Impurities in Pharmaceuticals

Author: Satinder Ahuja,Karen Mills Alsante

Publisher: Academic Press

ISBN: 9780120449828

Category: Medical

Page: 414

View: 4953

The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product. This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements. It's objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization. - Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.
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Pharmaceutical Powder Compaction Technology, Second Edition

Author: Metin Çelik

Publisher: CRC Press

ISBN: 1420089188

Category: Medical

Page: 344

View: 3772

Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application. This unique reference covers: The physical structure of pharmaceutical compacts Bonding phenomena that occur during powder compaction Compression mechanisms of pharmaceutical particles Theories and basic principles of powder compaction New topics include: Compaction data analysis techniques The migration of powder constituents into commercial manufacture Instrumentation for compaction Compaction functionality testing, which is likely to become a USP requirement Design space for compaction Metrics required for scalability in tablet compression Interactive compaction and preformulation database for commonly used excipients
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The Challenge of CMC Regulatory Compliance for Biopharmaceuticals

Author: John Geigert

Publisher: Springer Science & Business Media

ISBN: 1461469163

Category: Medical

Page: 338

View: 2449

This book highlights the challenges facing quality assurance/quality control (QA/QC) in today's biopharmaceutical environment and presents the strategic importance and value generated by QA/QC for their involvement in control of manufacturing. It will put into perspective the need for a graded approach to QA/QC from early clinical trials through market approval. Since the first edition published in 2004, there have been more than 50 new regulatory guidances released by the Food and Drug Administration (FDA), European Medicines Agency (EMA) and ICH that affect the CMC regulatory compliance of biopharmaceuticals; also the application of biosimilars has been developed in Europe and is under development in the USA. The revised update will be broadened to include not only biopharmaceuticals (biotech drugs) but also other biologics (vaccines, cell therapy, plasma-derived proteins, etc.)
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Preclinical Development Handbook

ADME and Biopharmaceutical Properties

Author: Shayne Cox Gad

Publisher: John Wiley & Sons

ISBN: 0470249021

Category: Medical

Page: 1352

View: 865

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic, comprehensive reference to prioritizing and optimizing leads, dose formulation, ADME, pharmacokinetics, modeling, and regulations. This authoritative, easy-to-use resource covers all the issues that need to be considered and provides detailed instructions for current methods and techniques. Each chapter is written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor has carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * Modeling and informatics in drug design * Bioanalytical chemistry * Absorption of drugs after oral administration * Transporter interactions in the ADME pathway of drugs * Metabolism kinetics * Mechanisms and consequences of drug-drug interactions Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This publication should be readily accessible to all pharmaceutical scientists involved in preclinical testing, enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.
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Handbook of Pharmaceutical Granulation Technology

Author: Dilip M. Parikh

Publisher: CRC Press

ISBN: 9780824798826

Category: Medical

Page: 528

View: 4623

Integrating the basic principles and industrial practices of pharmaceutical granulation production, this book discusses technologies and demonstrates cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements. Specialists from pharmaceutical companies, academia, and the U.S. Drug Regulatory Affairs agency address current and changing practices in industrial drug granulation production. Text, charts, figures, and photographs illustrate the pros and cons of diverse methods and technologies for accurately achieving strong bonding of particles in tablets and capsules.
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Handbook of Biopolymers and Biodegradable Plastics

Properties, Processing and Applications

Author: Sina Ebnesajjad

Publisher: William Andrew

ISBN: 1455730033

Category: Technology & Engineering

Page: 472

View: 5215

Biopolymers and Biodegradable Plastics are a hot issue across the Plastics industry, and for many of the industry sectors that use plastic, from packaging to medical devices and from the construction indusry to the automotive sector. This book brings together a number of key biopolymer and biodegradable plastics topics in one place for a broad audience of engineers and scientists, especially those designing with biopolymers and biodegradable plastics, or evaluating the options for switching from traditional plastics to biopolymers. Topics covered include preparation, fabrication, applications and recycling (including biodegradability and compostability). Applications in key areas such as films, coatings controlled release and tissue engineering are discussed. Dr Ebnesajjad provides readers with an in-depth reference for the plastics industry – material suppliers and processors, bio-polymer producers, bio-polymer processors and fabricators – and for industry sectors utilizing biopolymers – automotive, packaging, construction, wind turbine manufacturers, film manufacturers, adhesive and coating industries, medical device manufacturers, biomedical engineers, and the recycling industry. Essential information and practical guidance for engineers and scientists working with bioplastics, or evaluating a migration to bioplastics. Includes key published material on biopolymers, updated specifically for this Handbook, and new material including coverage of PLA and Tissue Engineering Scaffolds. Coverage of materials and applications together in one handbook enables engineers and scientists to make informed design decisions.
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Vaccine Development and Manufacturing

Author: Emily P. Wen,Ronald Ellis,Narahari S. Pujar

Publisher: John Wiley & Sons

ISBN: 1118870905

Category: Technology & Engineering

Page: 456

View: 6691

Vaccine Manufacturing and Production is an invaluablereference on how to produce a vaccine - from beginning to end -addressing all classes of vaccines from aprocessing, production, and regulatory viewpoint. It willprovide comprehensive information on the various fields involved inthe production of vaccines, from fermentation, purification,formulation, to regulatory filing and facility designs. In recentyears, there have been tremendous advances in all aspects ofvaccine manufacturing. Improved technology and growth media havebeen developed for the production of cell culture with high celldensity or fermentation. Vaccine Manufacturing andProduction will serve as a reference on all aspects of vaccineproduction by providing an in-depth description of the availabletechnologies for making different types of vaccines and the currentthinking in facility designs and supply issues. This book willprovide insight to the issues scientists face when producing avaccine, the steps that are involved, and will serve asa reference tool regarding state-of-the-art vaccinemanufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a processpoint of view- fermentation to purification to formulationdevelopments; from a production point of view - from facilitydesign to manufacturing; and from a regulatory point of view -requirements from government agencies Authors from different major pharmaceutical and biotechnologycompanies Describes the challenges and issues involved in vaccineproduction and manufacturing of the different classes of vaccines,an area not covered by other books currently on the market
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