Design and Safety Assessment of Critical Systems

Author: Marco Bozzano,Adolfo Villafiorita

Publisher: CRC Press

ISBN: 9781439803325

Category: Computers

Page: 298

View: 457

Safety-critical systems, by definition those systems whose failure can cause catastrophic results for people, the environment, and the economy, are becoming increasingly complex both in their functionality and their interactions with the environment. Unfortunately, safety assessments are still largely done manually, a time-consuming and error-prone process. The growing complexity of these systems requires an increase in the skill and efficacy of safety engineers and encourages the adoption of formal and standardized techniques. An introduction to the area of design and verification of safety-critical systems, Design and Safety Assessment of Critical Systems focuses on safety assessment using formal methods. Beginning with an introduction to the fundamental concepts of safety and reliability, it illustrates the pivotal issues of design, development, and safety assessment of critical systems. The core of the book covers traditional notations, techniques, and procedures, including Fault Tree Analysis, FMECA, HAZOP, and Event Tree Analysis, and explains in detail how formal methods can be used to realize such procedures. It looks at the development process of safety-critical systems, and highlights influential management and organizational aspects. Finally, it describes verification and validation techniques and new trends in formal methods for safety and concludes with some widely adopted standards for the certification of safety-critical systems. Providing an in-depth and hands-on view of the application of formal techniques to advanced and critical safety assessments in a variety of industrial sectors, such as transportation, avionics and aerospace, and nuclear power, Design and Safety Assessment of Critical Systems allows anyone with a basic background in mathematics or computer science to move confidently into this advanced arena of safety assessment.
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The Safety Critical Systems Handbook

A Straightforward Guide to Functional Safety: IEC 61508 (2010 Edition), IEC 61511 (2015 Edition) and Related Guidance

Author: David J. Smith,Kenneth G. L. Simpson

Publisher: Butterworth-Heinemann

ISBN: 008100897X

Category: Technology & Engineering

Page: 330

View: 9215

The Safety Critical Systems Handbook: A Straightforward Guide to Functional Safety: IEC 61508 (2010 Edition), IEC 61511 (2016 Edition) & Related Guidance, Fourth Edition, presents the latest on the electrical, electronic, and programmable electronic systems that provide safety functions that guard workers and the public against injury or death, and the environment against pollution. The international functional safety standard IEC 61508 was revised in 2010, and authors David Smith and Kenneth Simpson provide a comprehensive guide to the revised standard, as well as the revised IEC 61511 (2016). The book enables engineers to determine if a proposed or existing piece of equipment meets the safety integrity levels (SIL) required by the various standards and guidance, and also describes the requirements for the new alternative route (route 2H), introduced in 2010. A number of other areas have been updated by Smith and Simpson in this new edition, including the estimation of common cause failure, calculation of PFDs and failure rates for redundant configurations, societal risk, and additional second tier guidance documents. As functional safety is applicable to many industries, this book will have a wide readership beyond the chemical and process sector, including oil and gas, machinery, power generation, nuclear, aircraft, and automotive industries, plus project, instrumentation, design, and control engineers. Provides the only comprehensive guide to IEC 61508, updated to cover the 2010 amendments, that will ensure engineers are compliant with the latest process safety systems design and operation standards Addresses the 2016 updates to IEC 61511 to helps readers understand the processes required to apply safety critical systems standards and guidance Presents a real-world approach that helps users interpret new standards, with case studies and best practice design examples throughout
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Mission-Critical and Safety-Critical Systems Handbook

Design and Development for Embedded Applications

Author: Kim Fowler

Publisher: Newnes

ISBN: 9780080942551

Category: Technology & Engineering

Page: 592

View: 7142

This handbook provides a consolidated, comprehensive information resource for engineers working with mission and safety critical systems. Principles, regulations, and processes common to all critical design projects are introduced in the opening chapters. Expert contributors then offer development models, process templates, and documentation guidelines from their own core critical applications fields: medical, aerospace, and military. Readers will gain in-depth knowledge of how to avoid common pitfalls and meet even the strictest certification standards. Particular emphasis is placed on best practices, design tradeoffs, and testing procedures. *Comprehensive coverage of all key concerns for designers of critical systems including standards compliance, verification and validation, and design tradeoffs *Real-world case studies contained within these pages provide insight from experience
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Safety Design for Space Systems

Author: Gary E. Musgrave Ph.D,Axel Larsen,Tommaso Sgobba

Publisher: Butterworth-Heinemann

ISBN: 9780080559223

Category: Technology & Engineering

Page: 992

View: 388

Progress in space safety lies in the acceptance of safety design and engineering as an integral part of the design and implementation process for new space systems. Safety must be seen as the principle design driver of utmost importance from the outset of the design process, which is only achieved through a culture change that moves all stakeholders toward front-end loaded safety concepts. This approach entails a common understanding and mastering of basic principles of safety design for space systems at all levels of the program organisation. Fully supported by the International Association for the Advancement of Space Safety (IAASS), written by the leading figures in the industry, with frontline experience from projects ranging from the Apollo missions, Skylab, the Space Shuttle and the International Space Station, this book provides a comprehensive reference for aerospace engineers in industry. It addresses each of the key elements that impact on space systems safety, including: the space environment (natural and induced); human physiology in space; human rating factors; emergency capabilities; launch propellants and oxidizer systems; life support systems; battery and fuel cell safety; nuclear power generators (NPG) safety; habitat activities; fire protection; safety-critical software development; collision avoidance systems design; operations and on-orbit maintenance. * The only comprehensive space systems safety reference, its must-have status within space agencies and suppliers, technical and aerospace libraries is practically guaranteed * Written by the leading figures in the industry from NASA, ESA, JAXA, (et cetera), with frontline experience from projects ranging from the Apollo missions, Skylab, the Space Shuttle, small and large satellite systems, and the International Space Station. * Superb quality information for engineers, programme managers, suppliers and aerospace technologists; fully supported by the IAASS (International Association for the Advancement of Space Safety)
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Reliability of Safety-Critical Systems

Theory and Applications

Author: Marvin Rausand

Publisher: John Wiley & Sons

ISBN: 1118553381

Category: Technology & Engineering

Page: 466

View: 1341

Presents the theory and methodology for reliability assessments of safety-critical functions through examples from a wide range of applications Reliability of Safety-Critical Systems: Theory and Applications provides a comprehensive introduction to reliability assessments of safety-related systems based on electrical, electronic, and programmable electronic (E/E/PE) technology. With a focus on the design and development phases of safety-critical systems, the book presents theory and methods required to document compliance with IEC 61508 and the associated sector-specific standards. Combining theory and practical applications, Reliability of Safety-Critical Systems: Theory and Applications implements key safety-related strategies and methods to meet quantitative safety integrity requirements. In addition, the book details a variety of reliability analysis methods that are needed during all stages of a safety-critical system, beginning with specification and design and advancing to operations, maintenance, and modification control. The key categories of safety life-cycle phases are featured, including strategies for the allocation of reliability performance requirements; assessment methods in relation to design; and reliability quantification in relation to operation and maintenance. Issues and benefits that arise from complex modern technology developments are featured, as well as: Real-world examples from large industry facilities with major accident potential and products owned by the general public such as cars and tools Plentiful worked examples throughout that provide readers with a deeper understanding of the core concepts and aid in the analysis and solution of common issues when assessing all facets of safety-critical systems Approaches that work on a wide scope of applications and can be applied to the analysis of any safety-critical system A brief appendix of probability theory for reference With an emphasis on how safety-critical functions are introduced into systems and facilities to prevent or mitigate the impact of an accident, this book is an excellent guide for professionals, consultants, and operators of safety-critical systems who carry out practical, risk, and reliability assessments of safety-critical systems. Reliability of Safety-Critical Systems: Theory and Applications is also a useful textbook for courses in reliability assessment of safety-critical systems and reliability engineering at the graduate-level, as well as for consulting companies offering short courses in reliability assessment of safety-critical systems.
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Developing Safety-Critical Software

A Practical Guide for Aviation Software and DO-178C Compliance

Author: Leanna Rierson

Publisher: CRC Press

ISBN: 1351834053

Category: Computers

Page: 610

View: 9569

The amount of software used in safety-critical systems is increasing at a rapid rate. At the same time, software technology is changing, projects are pressed to develop software faster and more cheaply, and the software is being used in more critical ways. Developing Safety-Critical Software: A Practical Guide for Aviation Software and DO-178C Compliance equips you with the information you need to effectively and efficiently develop safety-critical, life-critical, and mission-critical software for aviation. The principles also apply to software for automotive, medical, nuclear, and other safety-critical domains. An international authority on safety-critical software, the author helped write DO-178C and the U.S. Federal Aviation Administration’s policy and guidance on safety-critical software. In this book, she draws on more than 20 years of experience as a certification authority, an avionics manufacturer, an aircraft integrator, and a software developer to present best practices, real-world examples, and concrete recommendations. The book includes: An overview of how software fits into the systems and safety processes Detailed examination of DO-178C and how to effectively apply the guidance Insight into the DO-178C-related documents on tool qualification (DO-330), model-based development (DO-331), object-oriented technology (DO-332), and formal methods (DO-333) Practical tips for the successful development of safety-critical software and certification Insightful coverage of some of the more challenging topics in safety-critical software development and verification, including real-time operating systems, partitioning, configuration data, software reuse, previously developed software, reverse engineering, and outsourcing and offshoring An invaluable reference for systems and software managers, developers, and quality assurance personnel, this book provides a wealth of information to help you develop, manage, and approve safety-critical software more confidently.
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Embedded Software Development for Safety-Critical Systems

Author: Chris Hobbs

Publisher: CRC Press

ISBN: 1351688936

Category: Computers

Page: 344

View: 9852

Safety-critical devices, whether medical, automotive, or industrial, are increasingly dependent on the correct operation of sophisticated software. Many standards have appeared in the last decade on how such systems should be designed and built. Developers, who previously only had to know how to program devices for their industry, must now understand remarkably esoteric development practices and be prepared to justify their work to external auditors. Embedded Software Development for Safety-Critical Systems discusses the development of safety-critical systems under the following standards: IEC 61508; ISO 26262; EN 50128; and IEC 62304. It details the advantages and disadvantages of many architectural and design practices recommended in the standards, ranging from replication and diversification, through anomaly detection to the so-called "safety bag" systems. Reviewing the use of open-source components in safety-critical systems, this book has evolved from a course text used by QNX Software Systems for a training module on building embedded software for safety-critical devices, including medical devices, railway systems, industrial systems, and driver assistance devices in cars. Although the book describes open-source tools for the most part, it also provides enough information for you to seek out commercial vendors if that’s the route you decide to pursue. All of the techniques described in this book may be further explored through hundreds of learned articles. In order to provide you with a way in, the author supplies references he has found helpful as a working software developer. Most of these references are available to download for free.
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Practical Industrial Safety, Risk Assessment and Shutdown Systems

Author: Dave Macdonald

Publisher: Elsevier

ISBN: 9780080473888

Category: Technology & Engineering

Page: 384

View: 873

This is a book for engineers that covers the hardware and software aspects of high-reliability safety systems, safety instrumentation and shutdown systems as well as risk assessment techniques and the wider spectrum of industrial safety. Rather than another book on the discipline of safety engineering, this is a thoroughly practical guide to the procedures and technology of safety in control and plant engineering. This highly practical book focuses on efficiently implementing and assessing hazard studies, designing and applying international safety practices and techniques, and ensuring high reliability in the safety and emergency shutdown of systems in your plant. This book will provide the reader with the most up-to-date standards for and information on each stage of the safety life cycle from the initial evaluation of hazards through to the detailed engineering and maintenance of safety instrumented systems. It will help them develop the ability to plan hazard and risk assessment studies, then design and implement and operate the safety systems and maintain and evaluate them to ensure high reliability. Finally it will give the reader the knowledge to help prevent the massive devastation and destruction that can be caused by today's highly technical computer controlled industrial environments. * Helps readers develop the ability to plan hazard and risk assessment studies, then design, implement and operate the safety systems and maintain and evaluate them to ensure high reliability * Gives the reader the knowledge to help prevent the massive devastation that can be caused by today's highly technical computer controlled industrial environments * Rather than another book on the discipline of safety engineering, this is a thoroughly practical guide to the procedures and technology of safety in control and plant engineering
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Technology and Assessment of Safety-Critical Systems

Proceedings of the Second Safety-critical Systems Symposium, Birmingham, UK, 8–10 February 1994

Author: Felix Redmill,Tom Anderson

Publisher: Springer Science & Business Media

ISBN: 1447120825

Category: Computers

Page: 258

View: 5031

The programme for the Second Safety-critical Systems Symposium was planned to examine the various aspects of technology currently employed in the design of safety-critical systems, as well as to emphasise the importance of safety and risk management in their design and operation. assessment There is an even balance of contributions from academia and industry. Thus, industry is given the opportunity to express its views of the safety-critical domain and at the same time offered a glimpse of the technologies which are currently under development and which, if successful, will be available in the medium-term future. In the field of technology, a subject whose importance is increasingly being recognised is human factors, and there are papers on this from the University of Hertfordshire and Rolls-Royce. Increasingly, PLCs are being employed in safety-critical applications, and this domain is represented by contributions from Nuclear Electric and August Computers. Then there are papers on maintainability, Ada, reverse engineering, social issues, formal methods, and medical systems, all in the context of safety. And, of course, it is not possible to keep the 'new' technologies out of the safety-critical domain: there are papers on neural networks from the University of Exeter and knowledge-based systems from ERA Technology.
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System Safety Engineering and Risk Assessment

A Practical Approach, Second Edition

Author: Nicholas J. Bahr

Publisher: CRC Press

ISBN: 1466551615

Category: Technology & Engineering

Page: 443

View: 1398

We all know that safety should be an integral part of the systems that we build and operate. The public demands that they are protected from accidents, yet industry and government do not always know how to reach this common goal. This book gives engineers and managers working in companies and governments around the world a pragmatic and reasonable approach to system safety and risk assessment techniques. It explains in easy-to-understand language how to design workable safety management systems and implement tested solutions immediately. The book is intended for working engineers who know that they need to build safe systems, but aren’t sure where to start. To make it easy to get started quickly, it includes numerous real-life engineering examples. The book’s many practical tips and best practices explain not only how to prevent accidents, but also how to build safety into systems at a sensible price. The book also includes numerous case studies from real disasters that describe what went wrong and the lessons learned. See What’s New in the Second Edition: New chapter on developing government safety oversight programs and regulations, including designing and setting up a new safety regulatory body, developing safety regulatory oversight functions and governance, developing safety regulations, and how to avoid common mistakes in government oversight Significantly expanded chapter on safety management systems, with many practical applications from around the world and information about designing and building robust safety management systems, auditing them, gaining internal support, and creating a safety culture New and expanded case studies and "Notes from Nick’s Files" (examples of practical applications from the author’s extensive experience) Increased international focus on world-leading practices from multiple industries with practical examples, common mistakes to avoid, and new thinking about how to build sustainable safety management systems New material on safety culture, developing leading safety performance indicators, safety maturity model, auditing safety management systems, and setting up a safety knowledge management system
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Railway Safety, Reliability, and Security: Technologies and Systems Engineering

Technologies and Systems Engineering

Author: Flammini, Francesco

Publisher: IGI Global

ISBN: 146661644X

Category: Technology & Engineering

Page: 487

View: 1571

Human errors, as well as deliberate sabotage, pose a considerable danger to passengers riding on the modern railways and have created disastrous consequences. To protect civilians against both intentional and unintentional threats, rail transportation has become increasingly automated. Railway Safety, Reliability, and Security: Technologies and Systems Engineering provides engineering students and professionals with a collection of state-of-the-art methodological and technological notions to support the development and certification of ‘real-time safety-critical’ railway control systems, as well as the protection of rail transportation infrastructures.
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Advances in Subsea Pipeline Engineering and Technology

Papers presented at Aspect ’90, a conference organized by the Society for Underwater Technology and held in Aberdeen, Scotland, May 30–31, 1990

Author: C.P. Ellinas

Publisher: Springer Science & Business Media

ISBN: 940090617X

Category: Technology & Engineering

Page: 392

View: 2063

Dr C P Ellinas Advanced Mechanics & Engineering Ltd Major advances have been achieved in recent years in subsea pipeline design and installation. Inspection, maintenance and repair have also received much attention. The development of marginal fields has brought with it special problems, which have necessitated novel methods and solutions. In the meanwhile interest in the development of deepwater fields continues with the development of new technology. This Conference has placed emphasis in addressing developments in pipeline technology under four main headings: pipeline/seabed interaction; flexible pipelines; pipeline design, fabrication and installation; deepwater applications. Advances in North Sea technology over the last few years have been concerned mostly with marginal fields, small diameter pipelines and new materials, which are well covered in the first three topics. Economic development of marginal fields requires processing of oil and gas to take place not at the wellhead but at existing facilities, usually some distance away. Hydrocarbons are thus often transported at high pressure and temperature in small diameter pipelines, which need to be protected through trenching. However, such operational practice has brought to the fore a problem that in the past was of little concern namely, upheaval buckling.
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Probabilistic Safety Assessment for Optimum Nuclear Power Plant Life Management (PLiM)

Theory and Application of Reliability Analysis Methods for Major Power Plant Components

Author: Gennadij V Arkadov,Alexander F Getman,Andrei N Rodionov

Publisher: Elsevier

ISBN: 0857093991

Category: Technology & Engineering

Page: 368

View: 3848

Probabilistic safety assessment methods are used to calculate nuclear power plant durability and resource lifetime. Successful calculation of the reliability and ageing of components is critical for forecasting safety and directing preventative maintenance, and Probabilistic safety assessment for optimum nuclear power plant life management provides a comprehensive review of the theory and application of these methods. Part one reviews probabilistic methods for predicting the reliability of equipment. Following an introduction to key terminology, concepts and definitions, formal-statistical and various physico–statistical approaches are discussed. Approaches based on the use of defect-free models are considered, along with those using binomial distribution and models based on the residual defectiveness of structural materials. The practical applications of probabilistic methods for strength reliability are subsequently explored in part two. Probabilistic methods for increasing the reliability and safety of nuclear power plant components are investigated, as are the use of such methods for optimising non-destructive tests, hydraulic tests, technical certification and planned-preventative maintenance. Finally, the book concludes with information on the use of probabilistic methods in ensuring leak tightness of nuclear power plant steam generator heat exchanger pipes. With its distinguished authors, Probabilistic safety assessment for optimum nuclear power plant life management is a valuable reference for all nuclear plant designers, operators, nuclear safety engineers and managers, as well as academics and researchers in this field. Discusses the theory and application of probabilistic safety assessment methods used to calculate nuclear power plant (NPP) durability and lifetime Reviews probabilistic methods in their application to NPP components and ageing pipelines for the forecasting of NPP resource lifetime and safety Addresses the key areas of probabilistic safety analysis, optimization of the operations through in-service inspection (ISI) utilising non-destructive testing, and maintenance, service and repair approaches
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Introduction to Software Project Management

Author: Adolfo Villafiorita

Publisher: CRC Press

ISBN: 1466559535

Category: Business & Economics

Page: 296

View: 1777

Although software development is one of the most complex activities carried out by man, sound development processes and proper project management can help ensure your software projects are delivered on time and under budget. Providing the know-how to manage software projects effectively, Introduction to Software Project Management supplies an accessible introduction to software project management. The book begins with an overview of the fundamental techniques of project management and the technical aspects of software development. This section supplies the understanding of the techniques required to mitigate uncertainty in projects and better control the complexity of software development projects. The second part illustrates the technical activities of software development in a coherent process—describing how to customize this process to fit a wide range of software development scenarios. Examines project management frameworks and software development standards, including ESA and NASA guidelines, PRINCE2®, and PMBOK® Addresses open source development practices and tools so readers can adopt best practices and get started with tools that are available for free Explains how to tailor the development process to different kinds of products and formalities, including the development of web applications Includes access to additional material for both practitioners and teachers at www.spmbook.com Supplying an analysis of existing development and management frameworks, the book describes how to set up an open-source tool infrastructure to manage projects. Since practitioners must be able to mix traditional and agile techniques effectively, the book covers both and explains how to use traditional techniques for planning and developing software components alongside agile methodologies. It does so in a manner that will help you to foster freedom and creativity in assembling the processes that will best serve your needs.
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Safety and Reliability

Proceedings of the ESREL 2003 Conference, Maastricht, the Netherlands, 15-18 June 2003

Author: TIM BEDFORD,P.H.A.J.M. van Gelder

Publisher: CRC Press

ISBN: 9789058095510

Category: Technology & Engineering

Page: 1014

View: 4207

These proceedings contain two hundred and eighteen papers representing the work of authors from countries across the world. They cover a wide range of research and applications in safety and reliability issues that concern all types of systems, processes and structures.
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Advances of Computational Fluid Dynamics in Nuclear Reactor Design and Safety Assessment

Author: Jyeshtharaj Joshi,Arun K Nayak

Publisher: Woodhead Publishing

ISBN: 0081023383

Category: Science

Page: 700

View: 1331

Advances of Computational Fluid Dynamics in Nuclear Reactor Design and Safety Assessment presents the latest computational fluid dynamic technologies. It includes an evaluation of safety systems for reactors using CFD and their design, the modeling of Severe Accident Phenomena Using CFD, Model Development for Two-phase Flows, and Applications for Sodium and Molten Salt Reactor Designs. Editors Joshi and Nayak have an invaluable wealth of experience that enables them to comment on the development of CFD models, the technologies currently in practice, and the future of CFD in nuclear reactors. Readers will find a thematic discussion on each aspect of CFD applications for the design and safety assessment of Gen II to Gen IV reactor concepts that will help them develop cost reduction strategies for nuclear power plants. Presents a thematic and comprehensive discussion on each aspect of CFD applications for the design and safety assessment of nuclear reactors Provides an historical review of the development of CFD models, discusses state-of-the-art concepts, and takes an applied and analytic look toward the future Includes CFD tools and simulations to advise and guide the reader through enhancing cost effectiveness, safety and performance optimization
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Maintaining Mission Critical Systems in a 24/7 Environment

Author: Peter M. Curtis

Publisher: John Wiley & Sons

ISBN: 0470650427

Category: Science

Page: 486

View: 900

This book is meant to offer Architects, Property Mangers, Facility Managers, Building Engineers, Information Technology Professionals, Data Center Personnel, Electrical & Mechanical Technicians and students in undergraduate, graduate, or continuing education programs relevant insight into the Mission Critical Environment with an emphasis on business resiliency, data center efficiency, and green power technology. Industry improvements, standards, and techniques have been incorporated into the text and address the latest issues prevalent in the Mission Critical Industry. An emphasis on green technologies and certifications is presented throughout the book. In addition, a description of the United States energy infrastructure's dependency on oil, in relation to energy security in the mission critical industry, is discussed. In conjunction with this, either a new chapter will be created on updated policies and regulations specifically related to the mission critical industry or updates to policies and regulations will be woven into most chapters. The topics addressed throughout this book include safety, fire protection, energy security and data center cooling, along with other common challenges and issues facing industry engineers today.
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Electronics System Design Techniques for Safety Critical Applications

Author: Luca Sterpone

Publisher: Springer Science & Business Media

ISBN: 1402089791

Category: Technology & Engineering

Page: 146

View: 759

What is exactly “Safety”? A safety system should be defined as a system that will not endanger human life or the environment. A safety-critical system requires utmost care in their specification and design in order to avoid possible errors in their implementation that should result in unexpected system’s behavior during his operating “life”. An inappropriate method could lead to loss of life, and will almost certainly result in financial penalties in the long run, whether because of loss of business or because the imposition of fines. Risks of this kind are usually managed with the methods and tools of the “safety engineering”. A life-critical system is designed to 9 lose less than one life per billion (10 ). Nowadays, computers are used at least an order of magnitude more in safety-critical applications compared to two decades ago. Increasingly electronic devices are being used in applications where their correct operation is vital to ensure the safety of the human life and the environment. These application ranging from the anti-lock braking systems (ABS) in automobiles, to the fly-by-wire aircrafts, to biomedical supports to the human care. Therefore, it is vital that electronic designers be aware of the safety implications of the systems they develop. State of the art electronic systems are increasingly adopting progr- mable devices for electronic applications on earthling system. In particular, the Field Programmable Gate Array (FPGA) devices are becoming very interesting due to their characteristics in terms of performance, dimensions and cost.
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Safety and Reliability of Industrial Products, Systems and Structures

Author: Carlos Guedes Soares

Publisher: CRC Press

ISBN: 0203818652

Category: Technology & Engineering

Page: 472

View: 2213

Safety and Reliability of Industrial Products, Systems and Structures deals with risk assessment, which is a fundamental support for decisions related to the design, construction, operation and maintenance of industrial products, systems and infrastructures. Risks are influenced by design decisions, by the process of construction of systems and infrastructures, and by the way in which they are operated and maintained. The importance of all these aspects vary in the various phases and types of activities, and different methods have been developed to deal with them. Risk analysis, structural reliability and human reliability analysis concentrate on different aspects that complement each other, and in many cases they can be considered separately. As a result of this, and of the different characteristics of the techniques, until today the respective specialists have had little interaction, and not enough efforts have been made to integrate methods. This book, the result of SAFERELNET, a thematic network of 67 organizations from industry, universities and research organizations from 18 countries, is a first attempt to overcome this. Since 2001, SAFERELNET has dealt with providing safe and cost-effective solutions for industrial products, systems, facilities and structures across different industrial sectors. Safety and Reliability of Industrial Products, Systems and Structures covers all aspects of safety issues such as Risk Assessment Methodology; Human and Organisational Factors in Risk Assessments; Integration of Risk and Reliability Formulations; Reliability Based Design; Assessment of Existing Structures and Life Extension; Risk Based Inspection and Maintenance Planning, with a special focus on safety-critical systems in all types of industrial plants, equipment, structural systems, buildings and other civil engineering facilities. The book will be of interest to academia and engineers involved in industrial safety, structural reliability, quantified risk assessment and safety management.
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The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment

Author: Joerg Bluemel,Sven Korte,Emanuel Schenck,Gerhard Weinbauer

Publisher: Academic Press

ISBN: 012417146X

Category: Medical

Page: 716

View: 8457

The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more Includes practical examples on techniques and methods to guide your daily practice Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
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