Biological Sequence Analysis

Probabilistic Models of Proteins and Nucleic Acids

Author: Richard Durbin,Sean R. Eddy,Anders Krogh,Graeme Mitchison

Publisher: Cambridge University Press

ISBN: 113945739X

Category: Science

Page: N.A

View: 8190

Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
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Molekularbiologie

Author: James D. Watson

Publisher: Pearson Deutschland GmbH

ISBN: 9783868940299

Category:

Page: 918

View: 3697

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Algorithmische Grundlagen der Bioinformatik

Modelle, Methoden und Komplexität

Author: Hans-Joachim Böckenhauer,Dirk Bongartz

Publisher: Springer-Verlag

ISBN: 3322800431

Category: Science

Page: 346

View: 9001

Erlernen Sie die Grundlagen der Bioinformatik theoretisch fundiert und zugleich anschaulich mit vielen Beispielen. Die Bioinformatik hat in den vergangenen Jahren eine immer höhere Aufmerksamkeit erhalten. Dazu haben viele Großprojekten wie zum Beispiel das Human Genome Project beigetragen. Dieser Trend setzt sich durch immer neue und verfeinerte Ansätze zur Gewinnung und Analyse molekularbiologischer Daten fort.
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Gentechnologie für Einsteiger

Author: Terence A. Brown

Publisher: Springer

ISBN: 9783827413024

Category:

Page: 409

View: 7062

T. A. Browns "Gentechnologie fA1/4r Einsteiger" hat sich in mehreren Auflagen international als StandardeinfA1/4hrung in die Genklonierung und DNA-Analyse etabliert. Das Grundlagenlehrbuch setzt nur wenig Kenntnisse in Molekularbiologie und Genetik voraus und erlAutert in klarer Sprache sowohl die fundamentalen Prinzipien der wichtigsten gentechnologischen Methoden als auch die immer breiter werdende Palette ihrer Anwendungen. Die groAe Bedeutung der Gentechnologie fA1/4r die Grundlagenforschung und fA1/4r neue Entwicklungen in Biotechnologie und Medizin wird klar herausgearbeitet. Aoeber 250 zweifarbige Illustrationen erleichtern das VerstAndnis des Stoffes und machen die Konzepte und Arbeitstechniken der Gentechnologen anschaulich. Die neue Auflage ist vollstAndig A1/4berarbeitet und enthAlt zwei neue Kapitel. Eines prAsentiert die Methoden, mit denen man ganze Genome sequenziert, und beschreibt, was man aus den gewonnenen Sequenzinformationen ablesen kann. Das zweite widmet sich den Anwendungen der Gentechnologie in der Gerichtsmedizin - ein spannendes und aufschlussreiches Beispiel des Einsatzpotenzials der DNA-Analyse. Der groAen Bedeutung der Polymerasekettenreaktion (PCR) entsprechend wird diese Technik jetzt in einem frA1/4hen Abschnitt des Buches behandelt und durchgehend stArker berA1/4cksichtigt.
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Handbook of Statistical Genetics

Author: David J. Balding,Martin Bishop,Chris Cannings

Publisher: John Wiley & Sons

ISBN: 9780470997628

Category: Science

Page: 1616

View: 7914

The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
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Gen-Medizin

Eine Bestandsaufnahme

Author: A.M. Raem,R.W. Braun,H. Fenger,W. Michaelis,S. Nikol,S. Winter

Publisher: Springer-Verlag

ISBN: 3642568181

Category: Medical

Page: 805

View: 8455

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Computational Intelligence and Pattern Analysis in Biology Informatics

Author: Ujjwal Maulik,Sanghamitra Bandyopadhyay,Jason T. Wang

Publisher: John Wiley & Sons

ISBN: 1118097807

Category: Medical

Page: 372

View: 6325

An invaluable tool in Bioinformatics, this unique volume providesboth theoretical and experimental results, and describes basicprinciples of computational intelligence and pattern analysis whiledeepening the reader's understanding of the ways in which theseprinciples can be used for analyzing biological data in anefficient manner. This book synthesizes current research in the integration ofcomputational intelligence and pattern analysis techniques, eitherindividually or in a hybridized manner. The purpose is to analyzebiological data and enable extraction of more meaningfulinformation and insight from it. Biological data for analysisinclude sequence data, secondary and tertiary structure data, andmicroarray data. These data types are complex and advanced methodsare required, including the use of domain-specific knowledge forreducing search space, dealing with uncertainty, partial truth andimprecision, efficient linear and/or sub-linear scalability,incremental approaches to knowledge discovery, and increased leveland intelligence of interactivity with human experts and decisionmakers Chapters authored by leading researchers in CI in biologyinformatics. Covers highly relevant topics: rational drug design; analysisof microRNAs and their involvement in human diseases. Supplementary material included: program code and relevant datasets correspond to chapters.
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Das fünfte Wunder

Auf der Suche nach dem Ursprung des Lebens

Author: Paul Davies

Publisher: S. Fischer Verlag

ISBN: 3105607579

Category: Self-Help

Page: 320

View: 8427

Paul Davies gibt einen genauen und abwägenden Überblick über die vorhandenen Modelle der Entstehung des Lebens und fügt eine weitere, gut belegte Hypothese hinzu, nämlich die der Lebensentstehung fern von der Erde. (Dieser Text bezieht sich auf eine frühere Ausgabe.)
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Computational Intelligence in Medical Informatics

Author: Arpad Kelemen,Ajith Abraham,Yulan Liang

Publisher: Springer Science & Business Media

ISBN: 3540757678

Category: Medical

Page: 379

View: 2760

Medical Informatics (MI) is an emerging interdisciplinary science. This book deals with the application of computational intelligence in MI. Addressing the various issues of medical informatics using different computational intelligence approaches is the novelty of this edited volume. This volume comprises of 15 chapters selected on the basis of fundamental ideas/concepts including an introductory chapter giving the fundamental definitions and some important research challenges.
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Biomacromolecules

Introduction to Structure, Function and Informatics

Author: C. Stan Tsai

Publisher: John Wiley & Sons

ISBN: 0470080116

Category: Science

Page: 768

View: 2951

This book provides an integrated treatment of the structure and function of nucleic acids, proteins, and glycans, including thorough coverage of relevant computational biochemistry. The text begins with an introduction to the biomacromolecules, followed by discussion of methods of isolation and purification, physiochemical and biochemical properties, and structural characteristics. The next section of the book deals with sequence analysis, analysis of conformation using spectroscopy, chemical synthesis, and computational approaches. The following chapters discuss biomolecular interactions, enzyme action, gene transmission, signal transduction, and biomacromolecular informatics. The author concludes with presenting the latest findings in genomics, proteomics, glycomics, and biomacromolecular evolution. This text is an invaluable resource for research professionals wishing to move into genomics, proteomics, and glycomics research. It is also useful for students in biochemistry, molecular biology, bioengineering, biotechnology, and bioinformatics.
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Handbook of Hidden Markov Models in Bioinformatics

Author: Martin Gollery

Publisher: CRC Press

ISBN: 1420011804

Category: Science

Page: 176

View: 1542

Demonstrating that many useful resources, such as databases, can benefit most bioinformatics projects, the Handbook of Hidden Markov Models in Bioinformatics focuses on how to choose and use various methods and programs available for hidden Markov models (HMMs). The book begins with discussions on key HMM and related profile methods, including the HMMER package, the sequence analysis method (SAM), and the PSI-BLAST algorithm. It then provides detailed information about various types of publicly available HMM databases, such as Pfam, PANTHER, COG, and metaSHARK. After outlining ways to develop and use an automated bioinformatics workflow, the author describes how to make custom HMM databases using HMMER, SAM, and PSI-BLAST. He also helps you select the right program to speed up searches. The final chapter explores several applications of HMM methods, including predictions of subcellular localization, posttranslational modification, and binding site. By learning how to effectively use the databases and methods presented in this handbook, you will be able to efficiently identify features of biological interest in your data.
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Sequence — Evolution — Function

Computational Approaches in Comparative Genomics

Author: Eugene Koonin,Michael Y. Galperin

Publisher: Springer Science & Business Media

ISBN: 9781402072741

Category: Science

Page: 462

View: 6721

Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
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Auferstehung

Roman

Author: Sean Williams

Publisher: N.A

ISBN: 9783453521971

Category: Human cloning

Page: 620

View: 8907

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Bayesian Methods in Structural Bioinformatics

Author: Thomas Hamelryck,Kanti Mardia,Jesper Ferkinghoff-Borg

Publisher: Springer

ISBN: 3642272258

Category: Medical

Page: 386

View: 4720

This book is an edited volume, the goal of which is to provide an overview of the current state-of-the-art in statistical methods applied to problems in structural bioinformatics (and in particular protein structure prediction, simulation, experimental structure determination and analysis). It focuses on statistical methods that have a clear interpretation in the framework of statistical physics, rather than ad hoc, black box methods based on neural networks or support vector machines. In addition, the emphasis is on methods that deal with biomolecular structure in atomic detail. The book is highly accessible, and only assumes background knowledge on protein structure, with a minimum of mathematical knowledge. Therefore, the book includes introductory chapters that contain a solid introduction to key topics such as Bayesian statistics and concepts in machine learning and statistical physics.
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Biologie für Dummies

Author: Rene Fester Kratz,Donna Rae Siegfried

Publisher: John Wiley & Sons

ISBN: 3527805753

Category: Science

Page: 422

View: 5051

Schauen Sie hinter die Kulissen von Mutter Natur. Tauchen Sie ein in die faszinierende Welt der Pflanzen, Tiere, Bakterien und Co. Erfahren Sie von Rene Fester Kratz und Donna Rae Siegfried, wie die Photosynthese abluft, was bei der Zellteilung passiert, wie ein kosystem funktioniert und vieles mehr. Lassen Sie sich die Grundlagen der Genetik und Evolutionslehre erklren und bestaunen Sie die wichtigsten Entdeckungen in der Biologie. Sie werden sehen: Die Wissenschaft des Lebens ist eine spannende Sache!
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Genetik für Dummies

Author: Tara Rodden Robinson

Publisher: John Wiley & Sons

ISBN: 3527811478

Category: Science

Page: 400

View: 3848

Die Genetik ist eine der Naturwissenschaften, deren Wissen am schnellsten wächst und deren Erkenntnisse ständig in Bewegung und in der Diskussion sind. "Genetik für Dummies" erklärt, was überhaupt hinter diesem spannenden Thema steckt. Die Autorin Tara Rodden Robinson erklärt die Grundlagen der Vererbungslehre wie die Mendelschen Regeln, wie Zellen aufgebaut sind und sie sich teilen. Sie zeigt, wie die DNA aufgebaut ist, wie sie kopiert und richtig in Proteine übersetzt wird. Außerdem geht sie auf die Bedeutung der Genetik in der Humanmedizin ein, wie Genmutationen und Erbkrankheiten entstehen. Sie erläutert, was beim Klonen passiert und was sich überhaupt hinter dem Begriff Gentechnik verbirgt. Auch die heißen Themen wie Stammzellentherapie und der Einsatz der Genetik in der Rechtsmedizin werden behandelt.
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Die Sequenz

der Wettlauf um das menschliche Genom

Author: Kevin Davies

Publisher: N.A

ISBN: 9783423340212

Category:

Page: 416

View: 6381

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Das Darwin-Virus

Roman

Author: Greg Bear

Publisher: Heyne Verlag

ISBN: 3641135850

Category: Fiction

Page: N.A

View: 9409

In uns schlummert der Tod In unserem Erbgut schlafen tödliche Krankheiten, die nur darauf warten, wieder zum Leben zu erwachen - so die umstrittene Theorie der Molekularbiologin Kaye Lang. Als in Georgien ein Massengrab gefunden wird, in dem nur schwangere Frauen liegen, in den Alpen eine mumifizierte prähistorische Familie mit verwirrenden biologischen Merkmalen entdeckt wird und in den USA eine rätselhafte Seuche ausbricht, die nur werdende Mütter befällt, scheint sich ihre These zu bewahrheiten ...
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