Autoimmune Diseases in Endocrinology

Author: Anthony P. Weetman

Publisher: Springer Science & Business Media

ISBN: 9781597455176

Category: Medical

Page: 434

View: 6042

This is a comprehensive and novel text that examines key features that predispose individuals to autoimmune diseases. The first section details the basic mechanism of autoimmunity and examines immunogenetic and environmental factors in autoimmunity. The next section examines autoimmune thyroid disease. The third section takes a look at Type 1 diabetes mellitus. In the final section, authors explain other autoimmune endocrinopathies.
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Autoimmune Diseases of the Endocrine System

Author: Robert Volpe'

Publisher: CRC Press

ISBN: 9780849368493

Category: Medical

Page: 376

View: 7458

This book is a comprehensive, easy-to-read discussion of the organ-specific autoimmune endocrine diseases emphasizing new contributions and trends for research and management. It begins with a brief chapter introducing the general principles of immunology, followed by discussions covering topics such as immunogenetics and animal models and how they can be applied toward interpreting human autoimmune endocrine diseases, autoimmune thyroid diseases, insulin-dependent diabetes mellitus hypophysitis, and Addison's disease. The book also discusses future trends toward gaining an understanding of these disorders and possible therapeutic principles. It is well-illustrated and will prove to be a useful reference source for internists, endocrinologists, and postgraduate students interested in human autoimmune endocrine diseases.
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Stem Cells in Endocrinology

Author: Linda B. Lester

Publisher: Springer Science & Business Media

ISBN: 1592599001

Category: Medical

Page: 274

View: 2523

A critical review by prominent experts of both the cutting-edge of stem cell biology and the application of stem cells to endocrine diseases, including diabetes, infertility, and liver-associated metabolic disorders. The authors discuss current research to modify stem cells, develop an endocrine-like cell, and use adult bone marrow stem cells to treat autoimmune diseases, including endocrine-based autoimmune diseases. Topics of interest include a review of all stem cell subtypes and their characteristics, approaches to promoting endocrine development from stem cells, and evidence for endocrine cell function from stem cells. The authors also outline how best to develop preclinical studies that will determine the safety and efficacy of stem cell therapies for endocrine disorders.
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Immunologically Mediated Endocrine Diseases

Author: Ronald G. Gill,Joan T. Harmon,Noel K. Maclaren

Publisher: N.A

ISBN: N.A

Category: Medical

Page: 685

View: 6587

Basic immunological principles and methods as they relate to cellular and subcellular processes of the endocrine system are important in understanding the underlying causes of endocrine disorders. Part of the Modern Endocrinology Series, this text covers a wide array of topics including pancreas development, immunogenetics, hypoparathyroidism, Graves' disease and vitiligo. The book is an integrated resource with a bench-to-bedside breadth that is useful to both basic scientists and healthcare professionals interested in endocrine autoimmune diseases.
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Endocrinology: Adult and Pediatric E-Book

Author: J. Larry Jameson,Leslie J. De Groot

Publisher: Elsevier Health Sciences

ISBN: 032332195X

Category: Medical

Page: 2700

View: 4437

Considered the definitive source in its field for over 35 years, Endocrinology: Adult and Pediatric, has been thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology. Unique perspectives from a team of trusted, world-renowned experts ensure this medical reference book remains the most highly-regarded text in the field. Make the best clinical decisions with an enhanced emphasis on evidence-based practice and expert opinions on treatment strategies. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information quickly, while still getting the complete coverage you expect. Expanded coverage for key topics such as pediatric endocrinology and obesity mechanisms and treatment, in addition to today's hot topics in endocrinology, including endocrine disruptors, bariatric surgery, androgen deficiency, genetic causes of obesity, endocrine rhythms, and the use of tyrosine kinase inhibitors in thyroid cancer. New content addressing the latest advances in testosterone and estrogen replacement, as well as the new causes of calcium and phosphate disorders, new molecular causes of endocrine cancers, new genetic causes of reproductive disorders, and more. Updated clinical guidelines for diabetes, lipid disorders, obesity management, osteoporosis, and more, as well as essential treatment updates for the medical management of acromegaly, Cushing's Disease, hypercalcemia, and diabetes mellitus. New Key Points provide snapshots of what to expect in each chapter, or serve as a refresher of what you just read. Consult this title on your favorite e-reader.
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Autoimmune Endocrine Disease

Author: Anthony P. Weetman

Publisher: CUP Archive

ISBN: 9780521401616

Category: Medical

Page: 260

View: 7830

This volume summarizes how recent exciting advances in immunology have cast new light on autoimmune endocrine disease. These diseases range from relatively common disorders such as diabetes & thyroid diseases to much rarer conditions. All pose immense challenges for the scientist & clinician in their endeavors to link the immunological basis of the problem with its medical consequences. Anthony Weetman clearly introduces the etiology & pathogenesis of autoimmunity & explains new developments in immunology & immunogenetics. He then details the autoimmune disorders that can affect individual endocrine organs. This self-contained, accessible account is a vital resource for clinicians, endocrinologists, & immunologists.
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Endocrinology - E-Book

Adult and Pediatric

Author: J. Larry Jameson,Leslie J. De Groot

Publisher: Elsevier Health Sciences

ISBN: 1455711268

Category: Medical

Page: 3064

View: 599

ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.
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Williams Textbook of Endocrinology E-Book

Author: Shlomo Melmed,Kenneth S. Polonsky,P. Reed Larsen,Henry M. Kronenberg

Publisher: Elsevier Health Sciences

ISBN: 1437736009

Category: Medical

Page: 1904

View: 2786

The latest edition of Williams Textbook of Endocrinology edited by Drs. Shlomo Melmed, Kenneth S. Polonsky, P. Reed Larsen, and Henry M. Kronenberg, helps you diagnose and treat your patients effectively with up-to-the minute, practical know-how on all endocrine system disorders. Comprehensive yet accessible, this extensively revised 12th Edition updates you on diabetes, metabolic syndrome, obesity, thyroid disease, testicular disorders, and much more so you can provide your patients with the most successful treatments. Find scientific insight and clinical data interwoven in every chapter, reflecting advances in both areas of this constantly changing discipline, and presented in a truly accessible format. You’ll also access valuable contributions from a dynamic list of expert authors and nearly 2.000 full-color images to help you with every diagnosis. This title has everything you need to manage any and all the clinical endocrinopathies you may encounter. Rely on the one reference that integrates rapidly evolving basic and clinical science in a cohesive, user-friendly format, definitively addresses every topic in the field, and has remained a standard for more than half a century. Update your know-how and skills to diagnose and treat your patients most effectively with exhaustively revised content on diabetes, metabolic disease, thyroid cancer, fertility problems, testicular problems, weight issues, and much more. Apply reliable guidance on endocrine conditions of growing interest like hypothyroidism and testicular disorders, with dedicated new chapters that expound on the latest research findings. Overcome any clinical challenge with comprehensive and easy-to-use coverage of everything from hormone activity, diagnostic techniques, imaging modalities, and molecular genetics, to total care of the patient. Apply the latest practices with guidance from expert authors who contribute fresh perspectives on every topic.
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Endocrine Manifestations of Systemic Autoimmune Diseases

Author: N.A

Publisher: Elsevier

ISBN: 9780080559322

Category: Medical

Page: 340

View: 6627

This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutic management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including effects on the elderly. The perturbations of the HPA axis as a source of altered steroidal synthesis will be discussed and related to some interesting pathological conditions that commonly complicate the autoimmune rheumatic diseases such as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section on pediatrics. *The premier issue evaluating the role of steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutic-biological approaches to the therapy *The book will present therapeutic perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis
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Immunology of Endocrine Diseases

Author: A.M. McGregor

Publisher: Springer Science & Business Media

ISBN: 9400941714

Category: Medical

Page: 224

View: 656

Nineteen eighty-six is a most appropriate year in which to be writing about developments in the organ-specific, autoimmune endocrine diseases. It celebrates the publication 30 years ago in 1956 of the classic papers of Roitt and Doniach and their co-workers I , and of Rose and Witebsky2 and Adams 3 and Purves . These three sets of fundamental observations provided the initial building blocks upon which much of what has been established in the field in the last 30 years was built. No publication of this nature on endocrine autoimmune disease can cover every aspect of the subject. I have chosen to highlight the organs (thyroid and pancreeas) which have attracted the most attention, and the areas of work within these fields within which most research effort is currently focused. There are still some gaps; the insulin and TSH receptors are not considered, nor in any detail are the role of cytotoxic mechanisms in mediating gland destruction. Molecular biology will undoubtedly in the next few years clarify once and for all the controversy that surrounds the structure of the TSH receptor and T cell cloning, the role of cell-mediated cytotoxicity. The pathogenetic mechanisms underlying autoimmunity are increasingly well understood and the search for the aetiology has begun.
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Genetic Diagnosis of Endocrine Disorders

Author: Roy E. Weiss,Samuel Refetoff

Publisher: Academic Press

ISBN: 0128011343

Category: Medical

Page: 472

View: 2875

Genetic Diagnosis of Endocrine Disorders, Second Edition provides users with a comprehensive reference that is organized by endocrine grouping (i.e., thyroid, pancreas, parathyroid, pituitary, adrenal, and reproductive and bone), discussing the genetic and molecular basis for the diagnosis of various disorders. The book emphasizes the practical nature of diagnosing a disease, including which tests should be done for the diagnosis of diabetes mellitus in adults and children, which genes should be evaluated for subjects with congenital hypothyroidism, which genetic tests should be ordered in obese patients or for those with parathyroid carcinoma, and the rationale behind testing for multiple endocrine neoplasias. Offers a clear presentations of pharmacogenetics and the actual assays used in detecting endocrine diseases Teaches the essentials of the genetic basis of disease in each major endocrine organ system Offers expert advice from genetic counselors on how to use genetic information in counseling patients Includes new chapters on the genetics of lipid disorders and glycogen storage diseases, genetics of hypoglycemia, and whole genome/exome sequencing
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Handbook of Clinical Pediatric Endocrinology

Author: Charles G. D. Brook,Mehul Dattani

Publisher: John Wiley & Sons

ISBN: 1119968135

Category: Medical

Page: 288

View: 1569

This revised edition of Charles Brook's Handbook of Clinical Pediatric Endocrinology provides endocrinologists and pediatricians in training with a fully up-to-date clinical guide presenting evidence-based practice in the diagnosis, treatment, and management of pediatric endocrine disorders. New chapters include “Endocrine complications of chronic disease” and “Endocrine neoplasia.” In addition, the chapter structure has been revamped for easier access and now includes: a key points overview, multiple-choice questions for self-assessment, common errors/pitffalls (in treatment, diagnosis, etc.) boxes, a key weblinks box, a table comparing different society guidelines, diagnostic decision trees, therapeutics decision trees, and a summary.
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Advances in Adrenal Insufficiency Research and Treatment: 2011 Edition

ScholarlyPaper

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464961891

Category: Medical

Page: 15

View: 1831

Advances in Adrenal Insufficiency Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Adrenal Insufficiency in a compact format. The editors have built Advances in Adrenal Insufficiency Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Adrenal Insufficiency in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Adrenal Insufficiency Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
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Endocrinologia Pediátrica

Expert Consult - Online and Print

Author: Mark A. Sperling

Publisher: Elsevier Health Sciences

ISBN: 1455759732

Category: Medical

Page: 1080

View: 9504

In a single, convenient volume, Pediatric Endocrinology offers complete coverage of all aspects of basic science and clinical practice, ideal for both pediatricians and endocrinologists. Pediatric endocrinology expert Dr. Mark Sperling teams up with world-renowned authors to bring you up to date with the latest key developments in every area of the field, providing invaluable guidance on how your clinical decision making will be affected by today’s technological and scientific advances. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Determine the best possible course for every patient with easy-to-follow algorithms in every clinical chapter. Stay up to date with today’s hottest topics, including neonatal diabetes mellitus, Type II childhood diabetes, molecular endocrinology, and genetics. Explore the impact of today’s advances and challenges, including explosive growth in molecular biology, sophisticated imaging techniques, and an increase in both pediatric diabetes and obesity. Quickly access the information you need with a new, streamlined organization (Concepts, Endocrine Disorders of the Newborn, Endocrine Disorders of Childhood and Adolescence, and Laboratory Tests and Imaging).
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Endocrine Autoimmunity and Associated Conditions

Author: A.P. Weetman

Publisher: Springer Science & Business Media

ISBN: 9401150443

Category: Medical

Page: 293

View: 6836

Autoimmunity is the most common cause of endocrine disorders. This volume provides an up-to-date summary of recent advances in this important field. In addition, it describes developments in our understanding of conditions such as vitiligo and pernicious anaemia which are frequently associated with autoimmune endocrinopathies. There is a detailed review of animal models of endocrine disease which have contributed greatly to current knowledge. Furthermore, the aetiology, pathogenesis and treatment of the clinical disorders are discussed in depth. The book will be of interest to anyone working in the areas of endocrinology and immunology.
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Endocrinology

Author: I. Hart,R.W. Newton

Publisher: Springer Science & Business Media

ISBN: 9401092982

Category: Medical

Page: 272

View: 9858

Table 19. Local structural effects of endocrine diseases Endocrine symptoms and signs are rarely specific. This fact renders the art of recognizing an endocrine Structure affected Feature disorder in a patient more often one of suspecting rather than 'diagnosing' it. Unlike most other body Hypothalamus Headaches Pituitary Headaches, visual defect 'systems' the very nature of the endocrine system Thyroid Pressure symptoms, dysphagia, ensures that the effects of disordered function in a goitre gland affect the body as a whole and cause diffuse Gonads Testicular lumps, ovarian masses symptoms and signs. Most patients with a cardiac problem present with one or more specific symptoms such as chest pain, palpitations and oedema. The problem then becomes one of resolving whether a cardiac problem exists or not and, if so, what is the nature of the disease process. HISTORY Similarly, most patients with a gastro-enterological and neurological problem will present with a specific Present history symptom - diarrhoea, or tremor - which will direct attention to that organ system.
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