A Course in Mathematical Biology

Quantitative Modeling with Mathematical and Computational Methods

Author: Gerda de Vries,Thomas Hillen,Mark Lewis,Johannes Mller,Birgitt SchÓnfisch

Publisher: SIAM

ISBN: 0898716128

Category: Mathematics

Page: 309

View: 9968

This is the only book that teaches all aspects of modern mathematical modeling and that is specifically designed to introduce undergraduate students to problem solving in the context of biology. Included is an integrated package of theoretical modeling and analysis tools, computational modeling techniques, and parameter estimation and model validation methods, with a focus on integrating analytical and computational tools in the modeling of biological processes. Divided into three parts, it covers basic analytical modeling techniques; introduces computational tools used in the modeling of biological problems; and includes various problems from epidemiology, ecology, and physiology. All chapters include realistic biological examples, including many exercises related to biological questions. In addition, 25 open-ended research projects are provided, suitable for students. An accompanying Web site contains solutions and a tutorial for the implementation of the computational modeling techniques. Calculations can be done in modern computing languages such as Maple, Mathematica, and MATLAB?.
Release

Mathematical Models in Biology

Author: Leah Edelstein-Keshet

Publisher: SIAM

ISBN: 9780898719147

Category: Biology

Page: 586

View: 7312

Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community, it shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in this book are still important and informative. Audience: the book does not assume too much background knowledge--essentially some calculus and high-school algebra. It was originally written with third- and fourth-year undergraduate mathematical-biology majors in mind; however, it was picked up by beginning graduate students as well as researchers in math (and some in biology) who wanted to learn about this field.
Release

Transactions on Computational Systems Biology XIV

Special Issue on Computational Models for Cell Processes

Author: Ion Petre,Erik de Vink

Publisher: Springer

ISBN: 3642355242

Category: Computers

Page: 233

View: 8785

The LNCS journal Transactions on Computational Systems Biology is devoted to inter- and multidisciplinary research in the fields of computer science and life sciences and supports a paradigmatic shift in the techniques from computer and information science to cope with the new challenges arising from the systems oriented point of view of biological phenomena. This, the 14th Transactions on Computational Systems Biology volume, guest edited by Ion Petre and Erik de Vink, focuses on Computational Models for Cell Processes and features a number of carefully selected and enhanced contributions, initially presented at the CompMod workshop, which took place in Aachen, Germany, in September 2011. The papers, written from different points of view and following various approaches, cover a wide range of topics within the field of modeling and analysis of biological systems. In addition, two regular submissions deal with models of self-assembling systems and metabolic constraints on the evolution of genetic codes.
Release

Dynamic Models in Biology

Author: Stephen P. Ellner,John Guckenheimer

Publisher: Princeton University Press

ISBN: 1400840961

Category: Science

Page: 352

View: 6188

From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.
Release

Mathematical Methods in Biology

Author: J. David Logan,William Wolesensky

Publisher: John Wiley & Sons

ISBN: 0470525878

Category: Mathematics

Page: 417

View: 643

A one–of–a–kind guide to using deterministic and probabilistic methods for solving problems in the biological sciences Highlighting the growing relevance of quantitative techniques in scientific research, Mathematical Methods in Biology provides an accessible presentation of the broad range of important mathematical methods for solving problems in the biological sciences. The book reveals the growing connections between mathematics and biology through clear explanations and specific, interesting problems from areas such as population dynamics, foraging theory, and life history theory. The authors begin with an introduction and review of mathematical tools that are employed in subsequent chapters, including biological modeling, calculus, differential equations, dimensionless variables, and descriptive statistics. The following chapters examine standard discrete and continuous models using matrix algebra as well as difference and differential equations. Finally, the book outlines probability, statistics, and stochastic methods as well as material on bootstrapping and stochastic differential equations, which is a unique approach that is not offered in other literature on the topic. In order to demonstrate the application of mathematical methods to the biological sciences, the authors provide focused examples from the field of theoretical ecology, which serve as an accessible context for study while also demonstrating mathematical skills that are applicable to many other areas in the life sciences. The book′s algorithms are illustrated using MATLAB®, but can also be replicated using other software packages, including R, Mathematica®, and Maple; however, the text does not require any single computer algebra package. Each chapter contains numerous exercises and problems that range in difficulty, from the basic to more challenging, to assist readers with building their problem–solving skills. Selected solutions are included at the back of the book, and a related Web site features supplemental material for further study. Extensively class–tested to ensure an easy–to–follow format, Mathematical Methods in Biology is an excellent book for mathematics and biology courses at the upper–undergraduate and graduate levels. It also serves as a valuable reference for researchers and professionals working in the fields of biology, ecology, and biomathematics.
Release

Mathematical Methods in Image Reconstruction

Author: Frank Natterer,Frank Wuebbeling

Publisher: SIAM

ISBN: 0898716225

Category: Computers

Page: 184

View: 7025

This book provides readers with a superior understanding of the mathematical principles behind imaging.
Release

Mathematical Modeling in Systems Biology

An Introduction

Author: Brian P. Ingalls

Publisher: MIT Press

ISBN: 0262315645

Category: Science

Page: 424

View: 9324

Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels.The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3--8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.
Release

Computational Mathematical Modeling

An Integrated Approach Across Scales

Author: Daniela Calvetti,Erkki Somersalo

Publisher: SIAM

ISBN: 1611972477

Category: Mathematics

Page: 234

View: 8486

Interesting real-world mathematical modelling problems are complex and can usually be studied at different scales. The scale at which the investigation is carried out is one of the factors that determines the type of mathematics most appropriate to describe the problem. The book concentrates on two modelling paradigms: the macroscopic, in which phenomena are described in terms of time evolution via ordinary differential equations; and the microscopic, which requires knowledge of random events and probability. The exposition is based on this unorthodox combination of deterministic and probabilistic methodologies, and emphasizes the development of computational skills to construct predictive models. To elucidate the concepts, a wealth of examples, self-study problems, and portions of MATLAB code used by the authors are included. This book, which has been extensively tested by the authors for classroom use, is intended for students in mathematics and the physical sciences at the advanced undergraduate level and above.
Release

Monte Carlo Strategies in Scientific Computing

Author: Jun S. Liu

Publisher: Springer Science & Business Media

ISBN: 0387763716

Category: Mathematics

Page: 344

View: 8934

This book provides a self-contained and up-to-date treatment of the Monte Carlo method and develops a common framework under which various Monte Carlo techniques can be "standardized" and compared. Given the interdisciplinary nature of the topics and a moderate prerequisite for the reader, this book should be of interest to a broad audience of quantitative researchers such as computational biologists, computer scientists, econometricians, engineers, probabilists, and statisticians. It can also be used as a textbook for a graduate-level course on Monte Carlo methods.
Release

Mathematical and Statistical Methods for Genetic Analysis

Author: Kenneth Lange

Publisher: Springer Science & Business Media

ISBN: 1475727399

Category: Mathematics

Page: 265

View: 6875

Geneticists now stand on the threshold of sequencing the genome in its entirety. The unprecedented insights into human disease and evolution offered by mapping and sequencing are transforming medicine and agriculture. This revolution depends vitally on the contributions made by applied mathematicians, statisticians, and computer scientists. Kenneth Lange has written a book to enable graduate students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. Mathematical, statistical, and computational principles relevant to this task are developed hand-in-hand with applications to gene mapping, risk prediction, and the testing of epidemiological hypotheses. The book covers many topics previously only accessible in journal articles, such as pedigree analysis algorithms, Markov chain, Monte Carlo methods, reconstruction of evolutionary trees, radiation hybrid mapping, and models of recombination. The whole is backed by numerous exercise sets.
Release

Continuum Modeling in the Physical Sciences

Author: E. van Groesen,Jaap Molenaar

Publisher: SIAM

ISBN: 9780898718249

Category: Mathematical physics

Page: 228

View: 3294

Mathematical modeling - the ability to apply mathematical concepts and techniques to real-life systems has expanded considerably over the last decades, making it impossible to cover all of its aspects in one course or textbook. Continuum Modeling in the Physical Sciences provides an extensive exposition of the general principles and methods of this growing field with a focus on applications in the natural sciences. The authors present a thorough treatment of mathematical modeling from the elementary level to more advanced concepts. Most of the chapters are devoted to a discussion of central issues such as dimensional analysis, conservation principles, balance laws, constitutive relations, stability, robustness, and variational methods, and are accompanied by numerous real-life examples. Readers will benefit from the exercises placed throughout the text and the challenging problems sections found at the ends of several chapters.
Release

Population Biology

Concepts and Models

Author: Alan Hastings

Publisher: Springer Science & Business Media

ISBN: 1475727313

Category: Science

Page: 220

View: 6860

Population biology has been investigated quantitatively for many decades, resulting in a rich body of scientific literature. Ecologists often avoid this literature, put off by its apparently formidable mathematics. This textbook provides an introduction to the biology and ecology of populations by emphasizing the roles of simple mathematical models in explaining the growth and behavior of populations. The author only assumes acquaintance with elementary calculus, and provides tutorial explanations where needed to develop mathematical concepts. Examples, problems, extensive marginal notes and numerous graphs enhance the book's value to students in classes ranging from population biology and population ecology to mathematical biology and mathematical ecology. The book will also be useful as a supplement to introductory courses in ecology.
Release

The Theoretical Biologist's Toolbox

Quantitative Methods for Ecology and Evolutionary Biology

Author: Marc Mangel

Publisher: Cambridge University Press

ISBN: 1139455869

Category: Science

Page: N.A

View: 5813

Mathematical modelling is widely used in ecology and evolutionary biology and it is a topic that many biologists find difficult to grasp. In this new textbook Marc Mangel provides a no-nonsense introduction to the skills needed to understand the principles of theoretical and mathematical biology. Fundamental theories and applications are introduced using numerous examples from current biological research, complete with illustrations to highlight key points. Exercises are also included throughout the text to show how theory can be applied and to test knowledge gained so far. Suitable for advanced undergraduate courses in theoretical and mathematical biology, this book forms an essential resource for anyone wanting to gain an understanding of theoretical ecology and evolution.
Release

Mathematical and Experimental Modeling of Physical and Biological Processes

Author: H.T. Banks,H.T. Tran

Publisher: CRC Press

ISBN: 9781420073386

Category: Mathematics

Page: 298

View: 735

Through several case study problems from industrial and scientific research laboratory applications, Mathematical and Experimental Modeling of Physical and Biological Processes provides students with a fundamental understanding of how mathematics is applied to problems in science and engineering. For each case study problem, the authors discuss why a model is needed and what goals can be achieved with the model. Exploring what mathematics can reveal about applications, the book focuses on the design of appropriate experiments to validate the development of mathematical models. It guides students through the modeling process, from empirical observations and formalization of properties to model analysis and interpretation of results. The authors also describe the hardware and software tools used to design the experiments so faculty/students can duplicate them. Integrating real-world applications into the traditional mathematics curriculum, this textbook deals with the formulation and analysis of mathematical models in science and engineering. It gives students an appreciation of the use of mathematics and encourages them to further study the applied topics. Real experimental data for projects can be downloaded from CRC Press Online.
Release

Branching Processes in Biology

Author: Marek Kimmel,David Axelrod

Publisher: Springer

ISBN: 1493915592

Category: Mathematics

Page: 280

View: 4859

This book provides a theoretical background of branching processes and discusses their biological applications. Branching processes are a well-developed and powerful set of tools in the field of applied probability. The range of applications considered includes molecular biology, cellular biology, human evolution and medicine. The branching processes discussed include Galton-Watson, Markov, Bellman-Harris, Multitype, and General Processes. As an aid to understanding specific examples, two introductory chapters, and two glossaries are included that provide background material in mathematics and in biology. The book will be of interest to scientists who work in quantitative modeling of biological systems, particularly probabilists, mathematical biologists, biostatisticians, cell biologists, molecular biologists, and bioinformaticians. The authors are a mathematician and cell biologist who have collaborated for more than a decade in the field of branching processes in biology for this new edition. This second expanded edition adds new material published during the last decade, with nearly 200 new references. More material has been added on infinitely-dimensional multitype processes, including the infinitely-dimensional linear-fractional case. Hypergeometric function treatment of the special case of the Griffiths-Pakes infinite allele branching process has also been added. There are additional applications of recent molecular processes and connections with systems biology are explored, and a new chapter on genealogies of branching processes and their applications. Reviews of First Edition: "This is a significant book on applications of branching processes in biology, and it is highly recommended for those readers who are interested in the application and development of stochastic models, particularly those with interests in cellular and molecular biology." (Siam Review, Vol. 45 (2), 2003) “This book will be very interesting and useful for mathematicians, statisticians and biologists as well, and especially for researchers developing mathematical methods in biology, medicine and other natural sciences.” (Short Book Reviews of the ISI, Vol. 23 (2), 2003)
Release

Mathematical Aspects of Geometric Modeling

Author: Charles A. Micchelli

Publisher: SIAM

ISBN: 0898713315

Category: Mathematics

Page: 256

View: 9359

Examines concepts that are useful for the modeling of curves and surfaces and emphasizes the mathematical theory that underlies them.
Release

Transformations

Mathematical Approaches to Culture Change

Author: Colin Renfrew,Kenneth L. Cooke

Publisher: Elsevier

ISBN: 1483277526

Category: Social Science

Page: 538

View: 9862

Transformations: Mathematical Approaches to Culture Change focuses on the application of contemporary mathematical techniques to the study of culture change and formulates problems in archaeology, anthropology, and historiography in such a way that they are susceptible to treatment of a mathematical kind. Mathematical models, extending from the almost purely quantitative methods of physics to the purely verbal conceptual explanations, are described. Emphasis is placed on catastrophe theoretic models that exemplify the use of soft mathematics in situations in which the use of hard quantitative models is not possible. Comprised of 21 chapters, this book begins with an overview of the role of mathematics in theoretical archaeology, followed by a discussion on two general categories of mathematical methods that seem to be suitable for modeling cultural transformations: methods of dynamical systems theory and methods that give greater emphasis on discrete entities and the structural relations or patterns among them. Subsequent chapters deal with the use of mathematics in history; morphogenesis in biological and social systems; simulation of the growth of hierarchies; and logistic trends in Southwest population growth. A reconstruction of political units in the Valley of Mexico during the Toltec period is also presented. This monograph will be of interest to archaeologists, anthropologists, historians, biologists, sociologists, and mathematicians.
Release

Quantitative Ecology and Evolutionary Biology

Integrating models with data

Author: Otso Ovaskainen,Henrik Johan de Knegt,Maria del Mar Delgado

Publisher: Oxford University Press

ISBN: 0191024228

Category: Science

Page: 352

View: 1255

This novel, interdisciplinary text achieves an integration of empirical data and theory with the aid of mathematical models and statistical methods. The emphasis throughout is on spatial ecology and evolution, especially on the interplay between environmental heterogeneity and biological processes. The book provides a coherent theme by interlinking the modelling approaches used for different subfields of spatial ecology: movement ecology, population ecology, community ecology, and genetics and evolutionary ecology (each being represented by a separate chapter). Each chapter starts by describing the concept of each modelling approach in its biological context, goes on to present the relevant mathematical models and statistical methods, and ends with a discussion of the benefits and limitations of each approach. The concepts and techniques discussed throughout the book are illustrated throughout with the help of empirical examples. This is an advanced text suitable for any biologist interested in the integration of empirical data and theory in spatial ecology/evolution through the use of quantitative/statistical methods and mathematical models. The book will also be of relevance and use as a textbook for graduate-level courses in spatial ecology, ecological modelling, theoretical ecology, and statistical ecology.
Release

Mathematical Modeling and Simulation in Enteric Neurobiology

Author: Roustem Miftahof,Hong Gil Nam,David L. Wingate

Publisher: World Scientific

ISBN: 981283480X

Category: Mathematics

Page: 319

View: 3191

The lack of scientists equally trained and prepared to understand both mathematics and biology/medicine hampers the development and application of computer simulation methods in biology and neurogastrobiology. Currently, there are no texts for navigating the extensive and intricate field of mathematical and computational modeling in neurogastrobiology. This book bridges the gap between mathematicians, computer scientists and biologists, and thus assists in the study and analysis of complex biological phenomena that cannot be done through traditional in vivo and in vitro experimental approaches.The book recognizes the complexity of biological phenomena under investigation and treats the subject matter with a degree of mathematical rigor. Special attention is given to computer simulations for interpolation and extrapolation of electromechanical and chemoelectrical phenomena, nonlinear self-sustained electromechanical wave activity, pharmacological effects including co-localization and co-transmission by multiple neurotransmitters, receptor polymodality, and drug interactions.Mathematical Modeling and Simulation in Enteric Neurobiology is an interdisciplinary book and is an essential source of information for biologists and doctors who are interested in knowing about the role and advantages of numerical experimentation in their subjects, as well as for mathematicians who are interested in exploring new areas of applications.
Release